John Robert Perfect
James B. Duke Distinguished Professor of Medicine
Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disruptions, differential gene expression screens, and cloning pathogenesis genes. The goal of this work is to use C. neoformans as a model yeast system to identify molecular targets for antifungal drug development. There are a series of clinical trials in fungal infections which are being coordinated through this laboratory and my work also includes a series of antibiotic trials in various aspects of infections. Finally, we have now been awarded a NIH sponsored Mycology Unit for 5 years with 6 senior investigators which is focused on C. neoformans as a pathogenic model system, but will include multiple areas of medical mycology from diagnosis to treatment.
Current Appointments & Affiliations
- James B. Duke Distinguished Professor of Medicine, Medicine, Infectious Diseases, Medicine 2013
- Professor of Medicine, Medicine, Infectious Diseases, Medicine 1996
- Chief, Division of Infectious Diseases, Medicine, Infectious Diseases, Medicine 2008
- Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2016
Contact Information
- Duke Box 102359, Durham, NC 27710
- Hanes House Rm 163, Trent Drive, Durham, NC 27710
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perfe001@mc.duke.edu
(919) 684-4016
- Background
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Education, Training, & Certifications
- Fellow, Infectious Diseases, Duke University School of Medicine 1977 - 1980
- Resident, University of Michigan, Ann Arbor 1975 - 1977
- Intern, Riverside Methodist Hospital 1974 - 1975
- M.D., The University of Toledo 1974
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Previous Appointments & Affiliations
- Associate Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2016
- Associate Professor of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1999 - 2002
- Assistant Professor of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1994 - 1998
- Associate Professor of Medicine with Tenure, Medicine, Infectious Diseases, Medicine 1992 - 1996
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1980 - 1982
- Recognition
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In the News
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JUN 14, 2016 -
JUN 14, 2016 Duke Today -
OCT 5, 2015 -
OCT 3, 2015 -
OCT 2, 2015 Duke Today -
SEP 30, 2015 The Daily Mail -
SEP 30, 2015 The Daily Mail -
APR 18, 2014 U.S. News & World Report -
APR 17, 2014
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Awards & Honors
- Research
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Selected Grants
- Catalysis and inhibition of chitin synthesis from pathogenic fungi awarded by National Institutes of Health 2022 - 2027
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Phase II, study to evaluate the safety of APX001 with Invasive mold infections caused by Aspergillus or rare mold awarded by Amplyx Pharmaceuticals, Inc. 2020 - 2025
- Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV infection in Southeast Asia awarded by National Institutes of Health 2019 - 2025
- Host directed medicine in invasive fungal infection - HDM-FUN awarded by European Union 2020 - 2024
- Biosynthesis of antifungal nucleoside antibiotics awarded by National Institutes of Health 2015 - 2024
- Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG) awarded by National Institutes of Health 2018 - 2023
- Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDS awarded by National Institutes of Health 2011 - 2023
- Mapping of the IgM and IgG antibody responses to Talaromyces marneffei infection in mice and humans - Deciphering acute from reactivated or latent infections (R21) awarded by National Institutes of Health 2021 - 2023
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2023
- Advancing Genomic Technologies to Combat Infectious Disease: Mapping Dynamics within Single Cells, Individual Hosts, and Global Populations (U19) awarded by Broad Institute 2019 - 2023
- Development of a new class of antifungals effective against Cryptococcus awarded by Linnaeus Bioscience Inc. 2019 - 2022
- AM-2-19 Efficacy Testing in a Mouse Model of Cryptococcosis awarded by Sfunga Therapeutics 2022
- Validation of a Novel Fungicidal Approach for Cryptococcal Meningitis awarded by Minnetronix, Inc 2018 - 2022
- Mentoring Patient Oriented Research in Antibiotic-Resistant Bacteria awarded by National Institutes of Health 2011 - 2022
- The Role of Host Inositol in Cryptococcus Biology and Pathogenesis awarded by Rutgers, The State University of New Jersey 2016 - 2021
- Transdisciplinary Program to Identify Novel Antifungal Targets and Inhibitors awarded by National Institutes of Health 2015 - 2021
- Analysis of APX2039 in Rabbit Plasma, CSF and Brain Tissue Samples awarded by National Institutes of Health 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- APX001-201 SURGE awarded by Amplyx Pharmaceuticals, Inc. 2018 - 2020
- Pathobiology of C. neoformans in the Central Nervous System awarded by National Institutes of Health 2014 - 2020
- Study Isavuconazole in a Rabbit Model of Cryptococcal Meningoencephalitis Caused by Cryptococccal gattii awarded by Astellas Pharma Inc. 2017 - 2019
- APX001 with Fluconazole in a Murine Model of Cryptococcosis awarded by Amplyx Pharmaceuticals, Inc. 2016 - 2019
- Validation of a Novel Therapeutic Approach for Cryptococcal Meningitis awarded by Minnetronix, Inc 2017 - 2018
- Mouse Study to Evaluate Efficacy of VL-2397 Against Cryptococcal Meningitis awarded by Vical, Inc. 2018
- T2 Bacteria Panel Pivotal Study awarded by T2 Biosystems, Inc 2016 - 2017
- Cryptococcus Neoformans awarded by Minnetronix, Inc 2015 - 2017
- Cryptococcus Infection Network Cohort study for non-HIV Patients: The CINCH Study awarded by Johns Hopkins University 2014 - 2017
- Cryptococcus Neoformans awarded by Minnetronix, Inc 2015 - 2016
- Institutional Training Grant in Pediatric Infectious Disease awarded by National Institutes of Health 2011 - 2016
- A Computer Modeling Approach to Create an Antifungal to Improve the Treatment of Cryptococcal Infections awarded by Amplyx Pharmaceuticals, Inc. 2015 - 2016
- Evolution of Cryptococcus neoformans strains from patients with HIV/AIDS awarded by National Institutes of Health 2011 - 2016
- VTEU: Option 1-Task Area B: Protocol Development Protocol #14-0053 awarded by National Institutes of Health 2015 - 2016
- Molecular Umbrella-Amphotericin B Conjugates awarded by Lehigh University 2012 - 2016
- Phase I CTU Task Area A: Administrative and Overal Clinical Operations Support and Concept Development awarded by National Institutes of Health 2014 - 2015
- Novel Antifungal Therapeutic Approaches awarded by National Institutes of Health 2001 - 2014
- Ras Signaling in C. neoformans virulence and development awarded by National Institutes of Health 2008 - 2014
- Pulmonary Surfactant and Lung Homeostasis awarded by National Institutes of Health 1993 - 2014
- Mid-Career Investigator Award: Preventing and Diagnosing Fungal Disease in Transplantation awarded by National Institutes of Health 2007 - 2013
- The effects of Nlrp12 and IL-1b in inflammatory disorders awarded by National Institutes of Health 2010 - 2012
- Microfluidic PCR Platform to Detect Microbial DNA awarded by National Institutes of Health 2005 - 2010
- Calcineurin and Aspergillus fumigatus Pathogenesis awarded by National Institutes of Health 2004 - 2010
- Role of Calcineurin in Fungal Virulence awarded by National Institutes of Health 2004 - 2010
- Early Diagnosis of Neonatal Candidiasis awarded by National Institutes of Health 2005 - 2009
- Genetic Determinants of A. Fumigatus Susceptibility awarded by National Institutes of Health 2005 - 2009
- Host-Response relationships in patients with candidemia awarded by National Institutes of Health 2002 - 2008
- Genetic molecular biology of virulence in C. neoformans awarded by National Institutes of Health 1991 - 2008
- Prevention & dx of fungal infxns in transplantation awarded by National Institutes of Health 2002 - 2007
- Mentored Clinical Research Scholar Program awarded by National Institutes of Health 2002 - 2006
- Cryptococcus Neoformans - A Model for Pathogenic Fungi awarded by National Institutes of Health 2001 - 2005
- Cryptococcus neoformans: A model for pathogenic fungi awarded by National Institutes of Health 1999 - 2004
- Genetic Molecular Biology of Virulence in C. Neoformans awarded by National Institutes of Health 1999 - 2004
- same awarded by National Institutes of Health 1999 - 2004
- Same awarded by National Institutes of Health 1998 - 2003
- Ras signaling in C. neoformans virulence and development awarded by National Institutes of Health 2002 - 2003
- Same awarded by National Institutes of Health 1997 - 2001
- Genetic Molecular Biology Of Virulence In C Neoformans awarded by National Institutes of Health 1991 - 2000
- Adult Aids Clinical Trials Unit awarded by National Institutes of Health 1996 - 1999
- Duke University Adult Aids Clinical Trails Unit awarded by National Institutes of Health 1996 - 1999
- Novel Antifungal Drug Targets In Cryptococcus Neoformans awarded by National Institutes of Health 1997 - 1999
- Immunosuppressant Targets In Cryptococcus Neoformans awarded by National Institutes of Health 1997 - 1999
- Genetic & Molecular Biology Of Virulence In C Neoformans awarded by National Institutes of Health 1991 - 1999
- Genetic & Molecular Biology Of Virulence In C. Neoformans awarded by National Institutes of Health 1991 - 1999
- Genetic And Molecular Biology Of Virulence In C Neoformans awarded by National Institutes of Health 1993 - 1994
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External Relationships
- Cidara therapeutics
- Pfizer Inc.
- Up to Date Inc
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Sephton-Clark, Poppy, Jennifer L. Tenor, Dena L. Toffaletti, Nancy Meyers, Charles Giamberardino, Síle F. Molloy, Julia R. Palmucci, et al. “Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome.” Mbio 13, no. 6 (November 10, 2022): e0262622. https://doi.org/10.1128/mbio.02626-22.Full Text Link to Item
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Giamberardino, Charles D., Wiley A. Schell, Jennifer L. Tenor, Dena L. Toffaletti, Julia R. Palmucci, Choiselle Marius, Jane-Valeriane K. Boua, et al. “Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis.” Mbio 13, no. 6 (October 12, 2022): e0234722. https://doi.org/10.1128/mbio.02347-22.Full Text Link to Item
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Hoenigl, Martin, Rosanne Sprute, Amir Arastehfar, John R. Perfect, Cornelia Lass-Flörl, Romuald Bellmann, Juergen Prattes, et al. “Invasive candidiasis: investigational drugs in the clinical development pipeline and mechanisms of action.” Expert Opin Investig Drugs 31, no. 8 (August 2022): 795–812. https://doi.org/10.1080/13543784.2022.2086120.Full Text Link to Item
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Hoenigl, Martin, Danila Seidel, Agostinho Carvalho, Shivaprakash M. Rudramurthy, Amir Arastehfar, Jean-Pierre Gangneux, Nosheen Nasir, et al. “The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries.” Lancet Microbe 3, no. 7 (July 2022): e543–52. https://doi.org/10.1016/S2666-5247(21)00237-8.Full Text Link to Item
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McCrary, L Madeline, Ryan Paulus, J Kyle Melvin, John Perfect, and Becky L. White. “Another case of cryptococcal meningitis in a person without HIV who injects drugs: A possible risk factor in need of further investigation.” Med Mycol Case Rep 36 (June 2022): 35–36. https://doi.org/10.1016/j.mmcr.2022.05.002.Full Text Link to Item
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Thompson, George R., David R. Boulware, Nathan C. Bahr, Cornelius J. Clancy, Thomas S. Harrison, Carol A. Kauffman, Thuy Le, et al. “Noninvasive Testing and Surrogate Markers in Invasive Fungal Diseases.” Open Forum Infect Dis 9, no. 6 (June 2022): ofac112. https://doi.org/10.1093/ofid/ofac112.Full Text Link to Item
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Holcomb, Zachary E., Julie M. Steinbrink, Aimee K. Zaas, Marisol Betancourt, Jennifer L. Tenor, Dena L. Toffaletti, J Andrew Alspaugh, John R. Perfect, and Micah T. McClain. “Transcriptional Profiles Elucidate Differential Host Responses to Infection with Cryptococcus neoformans and Cryptococcus gattii.” J Fungi (Basel) 8, no. 5 (April 22, 2022). https://doi.org/10.3390/jof8050430.Full Text Link to Item
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Driemeyer, Cândida, Diego R. Falci, Martin Hoenigl, Oliver A. Cornely, Arunaloke Chakrabarti, Jean Pierre Gangneux, Esther Segal, et al. “The current state of Clinical Mycology in Eastern and South-Eastern Europe.” Med Mycol 60, no. 4 (March 22, 2022). https://doi.org/10.1093/mmy/myac017.Full Text Link to Item
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Drew, Richard H., and John R. Perfect. “Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement.” J Fungi (Basel) 8, no. 2 (February 21, 2022). https://doi.org/10.3390/jof8020212.Full Text Link to Item
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Perfect, John R., Damian J. Krysan, Maurizio Del Poeta, Anna M. Selmecki, Jessica C. S. Brown, and Leah E. Cowen. “Editorial: Antifungal Pipeline: Build It Strong; Build It Better!.” Front Cell Infect Microbiol 12 (2022): 881272. https://doi.org/10.3389/fcimb.2022.881272.Full Text Link to Item
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Wang, Yina, Maggie Wear, Gurkirat Kohli, Raghav Vij, Charles Giamberardino, Arpun Shah, Dena L. Toffaletti, et al. “Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans.” Mbio 12, no. 6 (December 21, 2021): e0279021. https://doi.org/10.1128/mBio.02790-21.Full Text Link to Item
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Yu, Chen-Hsin, Poppy Sephton-Clark, Jennifer L. Tenor, Dena L. Toffaletti, Charles Giamberardino, Miriam Haverkamp, Christina A. Cuomo, and John R. Perfect. “Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System.” Mbio 12, no. 6 (December 21, 2021): e0231321. https://doi.org/10.1128/mBio.02313-21.Full Text Link to Item
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Chen, Sharon C-A, John Perfect, Arnaldo L. Colombo, Oliver A. Cornely, Andreas H. Groll, Danila Seidel, Kerstin Albus, et al. “Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM.” Lancet Infect Dis 21, no. 12 (December 2021): e375–86. https://doi.org/10.1016/S1473-3099(21)00203-6.Full Text Link to Item
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Messina, Julia A., Eileen K. Maziarz, John Galgiani, Jonathan T. Truong, Aung K. Htoo, Arash Heidari, Royce H. Johnson, et al. “A randomized, double-blind, placebo-controlled clinical trial of fluconazole as early empiric treatment of coccidioidomycosis pneumonia (Valley Fever) in adults presenting with community-acquired pneumonia in endemic areas (FLEET-Valley Fever).” Contemp Clin Trials Commun 24 (December 2021): 100851. https://doi.org/10.1016/j.conctc.2021.100851.Full Text Open Access Copy Link to Item
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Johnson, Melissa D., Russell E. Lewis, Elizabeth S. Dodds Ashley, John R. Perfect, and Dimitrios P. Kontoyiannis. “Reply to Day et al.” J Infect Dis 224, no. 9 (November 16, 2021): 1627–28. https://doi.org/10.1093/infdis/jiab183.Full Text Link to Item
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Narayanasamy, Shanti, Adam R. Williams, Wiley A. Schell, Rebekah W. Moehring, Barbara D. Alexander, Thuy Le, Ramesh A. Bharadwaj, Michelle McGauvran, Jacob N. Schroder, and John R. Perfect. “Curvularia alcornii Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature.” Open Forum Infect Dis 8, no. 11 (November 2021): ofab536. https://doi.org/10.1093/ofid/ofab536.Full Text Open Access Copy Link to Item
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Narayanasamy, Shanti, Vu Quoc Dat, Nguyen Tat Thanh, Vo Trieu Ly, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Chuanyi Ning, et al. “A global call for talaromycosis to be recognised as a neglected tropical disease.” Lancet Glob Health 9, no. 11 (November 2021): e1618–22. https://doi.org/10.1016/S2214-109X(21)00350-8.Full Text Link to Item
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Yang, Dong-Hoon, Matthew R. England, Helene Salvator, Seher Anjum, Yoon-Dong Park, Kieren A. Marr, Laurie A. Chu, et al. “Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection.” Mbio 12, no. 5 (October 26, 2021): e0270821. https://doi.org/10.1128/mBio.02708-21.Full Text Link to Item
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Baddley, John W., Sharon C-A Chen, Carrie Huisingh, Kaitlin Benedict, Emilio E. DeBess, Eleni Galanis, Brendan R. Jackson, et al. “MSG07: An International Cohort Study Comparing Epidemiology and Outcomes of Patients With Cryptococcus neoformans or Cryptococcus gattii Infections.” Clin Infect Dis 73, no. 7 (October 5, 2021): 1133–41. https://doi.org/10.1093/cid/ciab268.Full Text Link to Item
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Rudramurthy, Shivaprakash M., Martin Hoenigl, Jacques F. Meis, Oliver A. Cornely, Valliappan Muthu, Jean Pierre Gangneux, John Perfect, Arunaloke Chakrabarti, and Arunaloke ECMM and ISHAM. “ECMM/ISHAM recommendations for clinical management of COVID-19 associated mucormycosis in low- and middle-income countries.” Mycoses 64, no. 9 (September 2021): 1028–37. https://doi.org/10.1111/myc.13335.Full Text Open Access Copy Link to Item
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Stott, Katharine Elizabeth, Angela Loyse, Joe N. Jarvis, Melanie Alufandika, Thomas Stephen Harrison, Henry C. Mwandumba, Jeremy N. Day, et al. “Cryptococcal meningoencephalitis: time for action.” The Lancet. Infectious Diseases 21, no. 9 (September 2021): e259–71. https://doi.org/10.1016/s1473-3099(20)30771-4.Full Text
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Toplis, Barbra, Caylin Bosch, Marietjie Stander, Malcolm Taylor, John R. Perfect, and Alfred Botha. “A link between urease and polyamine metabolism in Cryptococcus neoformans.” Microb Pathog 158 (September 2021): 105076. https://doi.org/10.1016/j.micpath.2021.105076.Full Text Link to Item
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Thu, Nguyen T. M., Jasper F. W. Chan, Vo Trieu Ly, Hoa T. Ngo, Ha T. A. Hien, Nguyen P. H. Lan, Nguyen V. V. Chau, et al. “Superiority of a Novel Mp1p Antigen Detection Enzyme Immunoassay Compared to Standard BACTEC Blood Culture in the Diagnosis of Talaromycosis.” Clin Infect Dis 73, no. 2 (July 15, 2021): e330–36. https://doi.org/10.1093/cid/ciaa826.Full Text Open Access Copy Link to Item
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Koehler, Philipp, Matteo Bassetti, Arunaloke Chakrabarti, Sharon C. A. Chen, Arnaldo Lopes Colombo, Martin Hoenigl, Nikolay Klimko, et al. “Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance.” Lancet Infect Dis 21, no. 6 (June 2021): e149–62. https://doi.org/10.1016/S1473-3099(20)30847-1.Full Text Open Access Copy Link to Item
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Williams, Wilton B., R Ryan Meyerhoff, R. J. Edwards, Hui Li, Kartik Manne, Nathan I. Nicely, Rory Henderson, et al. “Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.” Cell 184, no. 11 (May 27, 2021): 2955-2972.e25. https://doi.org/10.1016/j.cell.2021.04.042.Full Text Open Access Copy Link to Item
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Fu, Man Shun, Livia C. Liporagi-Lopes, Samuel R. Dos Santos, Jennifer L. Tenor, John R. Perfect, Christina A. Cuomo, and Arturo Casadevall. “Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence.” Mbio 12, no. 2 (April 27, 2021). https://doi.org/10.1128/mBio.00567-21.Full Text Link to Item
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Temfack, Elvis, Jean Joel Bigna Rim, Rene Spijker, Angela Loyse, Tom Chiller, Peter G. Pappas, John Perfect, et al. “Cryptococcal Antigen in Serum and Cerebrospinal Fluid for Detecting Cryptococcal Meningitis in Adults Living With Human Immunodeficiency Virus: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies.” Clin Infect Dis 72, no. 7 (April 8, 2021): 1268–78. https://doi.org/10.1093/cid/ciaa1243.Full Text Link to Item
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Montoya, Marhiah C., Paul M. Magwene, and John R. Perfect. “Associations between Cryptococcus Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review.” J Fungi (Basel) 7, no. 4 (March 30, 2021). https://doi.org/10.3390/jof7040260.Full Text Link to Item
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Adil, Syed M., Sarah E. Hodges, Lefko T. Charalambous, Musa Kiyani, Beiyu Liu, Hui-Jie Lee, Beth A. Parente, John R. Perfect, and Shivanand P. Lad. “Paediatric bacterial meningitis in the USA: outcomes and healthcare resource utilization of nosocomial versus community-acquired infection.” J Med Microbiol 70, no. 1 (January 2021). https://doi.org/10.1099/jmm.0.001276.Full Text Link to Item
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Oliveira, Lana Sarita de Souza, Luciana Magalhães Pinto, Mariana Araújo Paulo de Medeiros, Dena L. Toffaletti, Jennifer L. Tenor, Tânia Fraga Barros, Rejane Pereira Neves, et al. “Comparison of Cryptococcus gattii/neoformans Species Complex to Related Genera (Papiliotrema and Naganishia) Reveal Variances in Virulence Associated Factors and Antifungal Susceptibility.” Front Cell Infect Microbiol 11 (2021): 642658. https://doi.org/10.3389/fcimb.2021.642658.Full Text Link to Item
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Perfect, John R., and Mahmoud Ghannoum. “Emerging Issues in Antifungal Resistance.” Infect Dis Clin North Am 34, no. 4 (December 2020): 921–43. https://doi.org/10.1016/j.idc.2020.05.003.Full Text Link to Item
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Thanh, Lam Tuan, Dena L. Toffaletti, Jennifer L. Tenor, Charles Giamberardino, Gregory D. Sempowski, Yohannes Asfaw, Hai Trieu Phan, et al. “Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam.” Med Mycol 58, no. 8 (November 10, 2020): 1149–61. https://doi.org/10.1093/mmy/myaa013.Full Text Link to Item
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Ly, Vo Trieu, Nguyen Tat Thanh, Nguyen Thi Mai Thu, Jasper Chan, Jeremy N. Day, John Perfect, Cao Ngoc Nga, Nguyen Van Vinh Chau, and Thuy Le. “Occult Talaromyces marneffei Infection Unveiled by the Novel Mp1p Antigen Detection Assay.” Open Forum Infect Dis 7, no. 11 (November 2020): ofaa502. https://doi.org/10.1093/ofid/ofaa502.Full Text Open Access Copy Link to Item
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Donnelly, J Peter, Sharon C. Chen, Carol A. Kauffman, William J. Steinbach, John W. Baddley, Paul E. Verweij, Cornelius J. Clancy, et al. “Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.” Clin Infect Dis 71, no. 6 (September 12, 2020): 1367–76. https://doi.org/10.1093/cid/ciz1008.Full Text Open Access Copy Link to Item
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Rolfe, Robert, Wiley A. Schell, Becky Smith, Jacob Klapper, John R. Perfect, and Julia A. Messina. “Black mold takes hold and story told.” Med Mycol Case Rep 29 (September 2020): 12–14. https://doi.org/10.1016/j.mmcr.2020.05.005.Full Text Link to Item
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Johnson, Melissa D., Russell E. Lewis, Elizabeth S. Dodds Ashley, Luis Ostrosky-Zeichner, Theoklis Zaoutis, George R. Thompson, David R. Andes, et al. “Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium.” J Infect Dis 222, no. Suppl 3 (August 5, 2020): S175–98. https://doi.org/10.1093/infdis/jiaa394.Full Text Link to Item
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Pappas, Peter G., David R. Boulware, Dimitrios P. Kontoyiannis, Marisa H. Miceli, Luis Ostrosky-Zeichner, Andrej Spec, George R. Thompson, Sharon Chen, John R. Perfect, and John R. MSGERC investigators. “Clinical mycology today: A synopsis of the mycoses study group education and research consortium (MSGERC) second biennial meeting, September 27-30, 2018, Big Sky, Montana, a proposed global research agenda.” Med Mycol 58, no. 5 (July 1, 2020): 569–78. https://doi.org/10.1093/mmy/myaa034.Full Text Link to Item
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Toplis, Barbra, Caylin Bosch, Ilan S. Schwartz, Chris Kenyon, Teun Boekhout, John R. Perfect, and Alfred Botha. “The virulence factor urease and its unexplored role in the metabolism of Cryptococcus neoformans.” Fems Yeast Res 20, no. 4 (June 1, 2020). https://doi.org/10.1093/femsyr/foaa031.Full Text Link to Item
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Eichenberger, Emily M., Jennifer Saullo, Danielle Brander, Shih-Hsiu Wang, John R. Perfect, and Julia A. Messina. “A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy.” Med Mycol Case Rep 27 (March 2020): 17–21. https://doi.org/10.1016/j.mmcr.2019.12.007.Full Text Link to Item
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Livengood, S. J., R. H. Drew, and J. R. Perfect. “Combination Therapy for Invasive Fungal Infections.” Current Fungal Infection Reports 14, no. 1 (March 1, 2020): 40–49. https://doi.org/10.1007/s12281-020-00369-4.Full Text
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Steinbrink, Julie M., David K. Hong, Stephen P. Bergin, Rami N. Al-Rohil, John R. Perfect, and Eileen K. Maziarz. “The robust and rapid role of molecular testing in precision fungal diagnostics: A case report.” Med Mycol Case Rep 27 (March 2020): 77–80. https://doi.org/10.1016/j.mmcr.2020.02.003.Full Text Link to Item
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Kiyani, Musa, Beiyu Liu, Lefko T. Charalambous, Syed M. Adil, Sarah E. Hodges, Siyun Yang, Promila Pagadala, John R. Perfect, and Shivanand P. Lad. “The longitudinal health economic impact of viral encephalitis in the United States.” J Med Microbiol 69, no. 2 (February 2020): 270–79. https://doi.org/10.1099/jmm.0.001153.Full Text Link to Item
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Cuomo, Christina A., Terrance Shea, Thu Nguyen, Philip Ashton, John Perfect, and Thuy Le. “Complete Genome Sequences for Two Talaromyces marneffei Clinical Isolates from Northern and Southern Vietnam.” Microbiol Resour Announc 9, no. 2 (January 9, 2020). https://doi.org/10.1128/MRA.01367-19.Full Text Open Access Copy Link to Item
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Baker, Arthur W., Eileen K. Maziarz, Christopher J. Arnold, Melissa D. Johnson, Adrienne D. Workman, John M. Reynolds, John R. Perfect, and Barbara D. Alexander. “Invasive Fungal Infection After Lung Transplantation: Epidemiology in the Setting of Antifungal Prophylaxis.” Clin Infect Dis 70, no. 1 (January 1, 2020): 30–39. https://doi.org/10.1093/cid/ciz156.Full Text Link to Item
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Yu, Chen-Hsin, Yuan Chen, Christopher A. Desjardins, Jennifer L. Tenor, Dena L. Toffaletti, Charles Giamberardino, Anastasia Litvintseva, John R. Perfect, and Christina A. Cuomo. “Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses.” Microb Genom 6, no. 1 (January 2020). https://doi.org/10.1099/mgen.0.000319.Full Text Link to Item
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Hope, William, Neil R. H. Stone, Adam Johnson, Laura McEntee, Nicola Farrington, Anahi Santoro-Castelazo, Xuan Liu, et al. “Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance.” Mbio 10, no. 6 (December 3, 2019). https://doi.org/10.1128/mBio.02575-19.Full Text Link to Item
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So, Yee-Seul, Shinae Maeng, Dong-Hoon Yang, Hyelim Kim, Kyung-Tae Lee, Seong-Ryong Yu, Jennifer L. Tenor, et al. “Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans.” Msphere 4, no. 6 (November 20, 2019). https://doi.org/10.1128/mSphere.00785-19.Full Text Link to Item
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Hommel, Benjamin, Aude Sturny-Leclère, Stevenn Volant, Nathanaël Veluppillai, Magalie Duchateau, Chen-Hsin Yu, Véronique Hourdel, et al. “Correction: Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype.” Plos Pathog 15, no. 9 (September 2019): e1008070. https://doi.org/10.1371/journal.ppat.1008070.Full Text Link to Item
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Kovanda, Laura L., Charles Giamberardino, Laura McEntee, Dena L. Toffaletti, Kelly S. Franke, Andrew Bartuska, Gordon Smilnak, et al. “Pharmacodynamics of Isavuconazole in a Rabbit Model of Cryptococcal Meningoencephalitis.” Antimicrob Agents Chemother 63, no. 9 (September 2019). https://doi.org/10.1128/AAC.00546-19.Full Text Link to Item
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Jaeger, Martin, Vasiliki Matzaraki, Raúl Aguirre-Gamboa, Mark S. Gresnigt, Xiaojing Chu, Melissa D. Johnson, Marije Oosting, et al. “A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.” J Infect Dis 220, no. 5 (July 31, 2019): 862–72. https://doi.org/10.1093/infdis/jiz206.Full Text Link to Item
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Hommel, Benjamin, Aude Sturny-Leclère, Stevenn Volant, Nathanaël Veluppillai, Magalie Duchateau, Chen-Hsin Yu, Véronique Hourdel, et al. “Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype.” Plos Pathog 15, no. 7 (July 2019): e1007945. https://doi.org/10.1371/journal.ppat.1007945.Full Text Link to Item
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Nguyen, M Hong, Cornelius J. Clancy, A William Pasculle, Peter G. Pappas, George Alangaden, George A. Pankey, Bryan H. Schmitt, et al. “Performance of the T2Bacteria Panel for Diagnosing Bloodstream Infections: A Diagnostic Accuracy Study.” Ann Intern Med 170, no. 12 (June 18, 2019): 845–52. https://doi.org/10.7326/M18-2772.Full Text Link to Item
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Ashton, P. M., L. T. Thanh, P. H. Trieu, D. Van Anh, N. M. Trinh, J. Beardsley, F. Kibengo, et al. “Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans.” Nat Commun 10, no. 1 (May 2, 2019): 2035. https://doi.org/10.1038/s41467-019-10092-5.Full Text Link to Item
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Sundermann, Alexander J., Cornelius J. Clancy, A William Pasculle, Guojun Liu, Richard B. Cumbie, Eileen Driscoll, Ashley Ayres, et al. “How Clean Is the Linen at My Hospital? The Mucorales on Unclean Linen Discovery Study of Large United States Transplant and Cancer Centers.” Clin Infect Dis 68, no. 5 (February 15, 2019): 850–53. https://doi.org/10.1093/cid/ciy669.Full Text Link to Item
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Le, Thuy, Vo Trieu Ly, Nguyen Thi Mai Thu, Ashley Nguyen, Nguyen Tat Thanh, Nguyen Van Vinh Chau, Guy Thwaites, John Perfect, Ruwanthi Kolamunnage-Dona, and William Hope. “Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei.” Antimicrob Agents Chemother 63, no. 2 (February 2019). https://doi.org/10.1128/AAC.01739-18.Full Text Open Access Copy Link to Item
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Ponzio, Vinicius, Yuan Chen, Anderson Messias Rodrigues, Jennifer L. Tenor, Dena L. Toffaletti, José Osmar Medina-Pestana, Arnaldo Lopes Colombo, and John R. Perfect. “Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil.” Emerg Microbes Infect 8, no. 1 (2019): 119–29. https://doi.org/10.1080/22221751.2018.1562849.Full Text Link to Item
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Mourad, Ahmad, Jonathan A. Stiber, John R. Perfect, and Melissa D. Johnson. “Real-world implications of QT prolongation in patients receiving voriconazole and amiodarone.” J Antimicrob Chemother 74, no. 1 (January 1, 2019): 228–33. https://doi.org/10.1093/jac/dky392.Full Text Link to Item
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Kluyts, H. -. L., Y. le Manach, D. M. Munlemvo, F. Madzimbamuto, A. Basenero, Y. Coulibaly, S. Rakotoarison, et al. “The ASOS Surgical Risk Calculator: development and validation of a tool for identifying African surgical patients at risk of severe postoperative complications.” Br J Anaesth 121, no. 6 (December 2018): 1357–63. https://doi.org/10.1016/j.bja.2018.08.005.Full Text Link to Item
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Fernandes, Kenya E., Adam Brockway, Miriam Haverkamp, Christina A. Cuomo, Floris van Ogtrop, John R. Perfect, and Dee A. Carter. “Phenotypic Variability Correlates with Clinical Outcome in Cryptococcus Isolates Obtained from Botswanan HIV/AIDS Patients.” Mbio 9, no. 5 (October 23, 2018). https://doi.org/10.1128/mBio.02016-18.Full Text Link to Item
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Messina, Julia A., Cameron R. Wolfe, Marion Hemmersbach-Miller, Carmelo Milano, Jamie L. Todd, John Reynolds, Barbara D. Alexander, Wiley A. Schell, Christina A. Cuomo, and John R. Perfect. “Genomic characterization of recurrent mold infections in thoracic transplant recipients.” Transpl Infect Dis 20, no. 5 (October 2018): e12935. https://doi.org/10.1111/tid.12935.Full Text Link to Item
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Smilnak, Gordon J., Lefko T. Charalambous, Drew Cutshaw, Alykhan M. Premji, Charles D. Giamberardino, Christi G. Ballard, Andrew P. Bartuska, et al. “Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy.” J Infect Dis 218, no. 7 (August 24, 2018): 1147–54. https://doi.org/10.1093/infdis/jiy286.Full Text Open Access Copy Link to Item
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Shaw, Karen Joy, Wiley A. Schell, Jonathan Covel, Gisele Duboc, C. Giamberardino, Mili Kapoor, Molly Moloney, et al. “In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus.” Antimicrobial Agents and Chemotherapy 62, no. 8 (August 1, 2018). https://doi.org/10.1128/ACC00523;e00523-18.Full Text Link to Item
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Cornely, Oliver A., Kathleen M. Mullane, Luis Ostrosky-Zeichner, Rochelle M. Maher, Rodney Croos-Dabrera, Qiaoyang Lu, Christopher Lademacher, et al. “Isavuconazole for treatment of rare invasive fungal diseases.” Mycoses 61, no. 8 (August 2018): 518–33. https://doi.org/10.1111/myc.12778.Full Text Link to Item
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Ponzio, Vinicius, Luis Fernando Camargo, José Medina-Pestana, John Robert Perfect, and Arnaldo Lopes Colombo. “Outcomes of cryptococcosis in renal transplant recipients in a less-resourced health care system.” Transpl Infect Dis 20, no. 4 (August 2018): e12910. https://doi.org/10.1111/tid.12910.Full Text Link to Item
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Shaw, Karen Joy, Wiley A. Schell, Jonathan Covel, Gisele Duboc, C. Giamberardino, Mili Kapoor, Molly Moloney, et al. “In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus.” Antimicrob Agents Chemother 62, no. 8 (August 2018). https://doi.org/10.1128/AAC.00523-18.Full Text Link to Item
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Hussaini, Syed Mohammed Qasim, Deng Madut, Betty C. Tong, Elizabeth N. Pavlisko, Wiley A. Schell, John R. Perfect, and Nathan M. Thielman. “Pulmonary blastomycosis presenting as primary lung cancer.” Bmc Infect Dis 18, no. 1 (July 18, 2018): 336. https://doi.org/10.1186/s12879-018-3244-0.Full Text Open Access Copy Link to Item
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Maskarinec, Stacey A., Zehra Parlak, Qing Tu, Vrad Levering, Stefan Zauscher, Gabriel P. López, Vance G. Fowler, and John R. Perfect. “On-demand release of Candida albicans biofilms from urinary catheters by mechanical surface deformation.” Biofouling 34, no. 6 (July 2018): 595–604. https://doi.org/10.1080/08927014.2018.1474461.Full Text Link to Item
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Perfect, John R., Oliver A. Cornely, Markus Heep, Luis Ostrosky-Zeichner, Kathleen M. Mullane, Rochelle Maher, Rodney Croos-Dabrera, et al. “Isavuconazole treatment for rare fungal diseases and for invasive aspergillosis in patients with renal impairment: Challenges and lessons of the VITAL trial.” Mycoses 61, no. 7 (July 2018): 420–29. https://doi.org/10.1111/myc.12769.Full Text Link to Item
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Garcia-Santamarina, Sarela, Richard A. Festa, Aaron D. Smith, Chen-Hsin Yu, Corinna Probst, Chen Ding, Christina M. Homer, et al. “Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans.” Mol Microbiol 108, no. 5 (June 2018): 473–94. https://doi.org/10.1111/mmi.13960.Full Text Link to Item
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Hommel, Benjamin, Liliane Mukaremera, Radames J. B. Cordero, Carolina Coelho, Christopher A. Desjardins, Aude Sturny-Leclère, Guilhem Janbon, et al. “Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators.” Plos Pathog 14, no. 5 (May 2018): e1006982. https://doi.org/10.1371/journal.ppat.1006982.Full Text Link to Item
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Vasquez, Amber, D. Zavasky, N. A. Chow, L. Gade, E. Zlatanic, S. Elkind, A. P. Litvintseva, et al. “Management of an Outbreak of Exophiala dermatitidis Bloodstream Infections at an Outpatient Oncology Clinic.” Clin Infect Dis 66, no. 6 (March 5, 2018): 959–62. https://doi.org/10.1093/cid/cix948.Full Text Link to Item
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Charalambous, Lefko T., Alykhan Premji, Caroline Tybout, Anastasia Hunt, Drew Cutshaw, Aladine A. Elsamadicy, Siyun Yang, et al. “Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.” J Med Microbiol 67, no. 2 (February 2018): 215–27. https://doi.org/10.1099/jmm.0.000656.Full Text Link to Item
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Mourad, Ahmad, and John R. Perfect. “Tolerability profile of the current antifungal armoury.” J Antimicrob Chemother 73, no. suppl_1 (January 1, 2018): i26–32. https://doi.org/10.1093/jac/dkx446.Full Text Link to Item
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Mourad, Ahmad, and John R. Perfect. “The war on cryptococcosis: A Review of the antifungal arsenal.” Mem Inst Oswaldo Cruz 113, no. 7 (2018): e170391. https://doi.org/10.1590/0074-02760170391.Full Text Link to Item
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Arif, Sana, and John R. Perfect. “Emergence of the Molds Other than Aspergillus in Immunocompromised Patients.” Clin Chest Med 38, no. 3 (September 2017): 555–73. https://doi.org/10.1016/j.ccm.2017.04.014.Full Text Link to Item
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Perfect, John R. “The antifungal pipeline: a reality check.” Nat Rev Drug Discov 16, no. 9 (September 2017): 603–16. https://doi.org/10.1038/nrd.2017.46.Full Text Link to Item
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Rhodes, Johanna, Christopher A. Desjardins, Sean M. Sykes, Mathew A. Beale, Mathieu Vanhove, Sharadha Sakthikumar, Yuan Chen, et al. “Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level.” Genetics 207, no. 1 (September 2017): 327–46. https://doi.org/10.1534/genetics.117.203836.Full Text Link to Item
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McCarthy, Matthew W., Dimitrios P. Kontoyiannis, Oliver A. Cornely, John R. Perfect, and Thomas J. Walsh. “Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.” J Infect Dis 216, no. suppl_3 (August 15, 2017): S474–83. https://doi.org/10.1093/infdis/jix130.Full Text Link to Item
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Miao, Yi, Jennifer L. Tenor, Dena L. Toffaletti, Stacey A. Maskarinec, Jiuyu Liu, Richard E. Lee, John R. Perfect, and Richard G. Brennan. “Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.” Mbio 8, no. 4 (July 25, 2017). https://doi.org/10.1128/mBio.00643-17.Full Text Link to Item
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Desjardins, Christopher A., Charles Giamberardino, Sean M. Sykes, Chen-Hsin Yu, Jennifer L. Tenor, Yuan Chen, Timothy Yang, et al. “Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans.” Genome Res 27, no. 7 (July 2017): 1207–19. https://doi.org/10.1101/gr.218727.116.Full Text Link to Item
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Lestner, Jodi, Laura McEntee, Adam Johnson, Joanne Livermore, Sarah Whalley, Julie Schwartz, John R. Perfect, Thomas Harrison, and William Hope. “Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis.” Antimicrob Agents Chemother 61, no. 6 (June 2017). https://doi.org/10.1128/AAC.00090-17.Full Text Link to Item
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Mourad, A., and J. R. Perfect. “What Can the Clinical Mycology Laboratory Do for Clinicians Today and Tomorrow?” Current Clinical Microbiology Reports 4, no. 2 (June 1, 2017): 96–105. https://doi.org/10.1007/s40588-017-0061-y.Full Text
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Thammahong, Arsa, Srisombat Puttikamonkul, John R. Perfect, Richard G. Brennan, and Robert A. Cramer. “Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.” Microbiol Mol Biol Rev 81, no. 2 (June 2017). https://doi.org/10.1128/MMBR.00053-16.Full Text Link to Item
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Köhler, Julia R., Bernhard Hube, Rosana Puccia, Arturo Casadevall, and John R. Perfect. “Fungi that Infect Humans.” Microbiol Spectr 5, no. 3 (June 2017). https://doi.org/10.1128/microbiolspec.FUNK-0014-2016.Full Text Link to Item
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Chen, Yuan, Rhys A. Farrer, Charles Giamberardino, Sharadha Sakthikumar, Alexander Jones, Timothy Yang, Jennifer L. Tenor, et al. “Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii.” Mbio 8, no. 2 (March 7, 2017). https://doi.org/10.1128/mBio.00166-17.Full Text Open Access Copy Link to Item
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Perfect, John R. “Reply to Argüelles.” Virulence 8, no. 2 (February 17, 2017): 239. https://doi.org/10.1080/21505594.2016.1221249.Full Text Link to Item
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Perfect, John R., Jennifer L. Tenor, Yi Miao, and Richard G. Brennan. “Trehalose pathway as an antifungal target.” Virulence 8, no. 2 (February 17, 2017): 143–49. https://doi.org/10.1080/21505594.2016.1195529.Full Text Link to Item
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Kwon-Chung, Kyung J., John E. Bennett, Brian L. Wickes, Wieland Meyer, Christina A. Cuomo, Kurt R. Wollenburg, Tihana A. Bicanic, et al. “The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis.” Msphere 2, no. 2 (February 2017). https://doi.org/10.1128/mSphere.00357-16.Full Text Link to Item
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Farber, S Harrison, Kelly R. Murphy, Carter M. Suryadevara, Ranjith Babu, Siyun Yang, Liqi Feng, Jichun Xie, John R. Perfect, and Shivanand P. Lad. “Comparing outcomes of early, late, and non-surgical management of intraspinal abscess.” J Clin Neurosci 36 (February 2017): 64–71. https://doi.org/10.1016/j.jocn.2016.10.035.Full Text Link to Item
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Parente, V., R. H. Clark, L. Ku, C. Fennell, M. Johnson, E. Morris, A. Romaine, et al. “Risk factors for group B streptococcal disease in neonates of mothers with negative antenatal testing.” J Perinatol 37, no. 2 (February 2017): 157–61. https://doi.org/10.1038/jp.2016.201.Full Text Link to Item
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Chen, Yuan, and John R. Perfect. “Efficient, Cost-Effective, High-Throughput, Multilocus Sequencing Typing (MLST) Method, NGMLST, and the Analytical Software Program MLSTEZ.” Methods Mol Biol 1492 (2017): 197–202. https://doi.org/10.1007/978-1-4939-6442-0_14.Full Text Link to Item
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Messina, J. A., E. K. Maziarz, A. Spec, D. P. Kontoyiannis, and J. R. Perfect. “Disseminated cryptococcosis with brain involvement in patients with chronic lymphoid malignancies on ibrutinib.” Open Forum Infectious Diseases 4, no. 1 (January 1, 2017). https://doi.org/10.1093/oid/ofw261.Full Text
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Bhatt, Ankeet S., Scott Perkins, Elizabeth McKinnon, and John R. Perfect. “Curious Crosses: Injection-Induced Lesions.” Am J Med 130, no. 1 (January 2017): 31–33. https://doi.org/10.1016/j.amjmed.2016.08.023.Full Text Link to Item
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Kwon-Chung, Kyung J., John E. Bennett, Brian L. Wickes, Wieland Meyer, Christina A. Cuomo, Kurt R. Wollenburg, Tihana A. Bicanic, et al. “The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis.” Msphere 2, no. 1 (2017). https://doi.org/10.1128/mSphere.00357-16.Full Text Link to Item
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Matzaraki, Vasiliki, Mark S. Gresnigt, Martin Jaeger, Isis Ricaño-Ponce, Melissa D. Johnson, Marije Oosting, Lude Franke, et al. “An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility.” Plos One 12, no. 7 (2017): e0180824. https://doi.org/10.1371/journal.pone.0180824.Full Text Link to Item
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Messina, Julia A., Eileen K. Maziarz, Andrej Spec, Dimitrios P. Kontoyiannis, and John R. Perfect. “Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib.” Open Forum Infect Dis 4, no. 1 (2017): ofw261. https://doi.org/10.1093/ofid/ofw261.Full Text Link to Item
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Yu, Yuming, Mary J. Sabulski, Wiley A. Schell, Marcos M. Pires, John R. Perfect, and Steven L. Regen. “Simple Strategy for Taming Membrane-Disrupting Antibiotics.” Bioconjug Chem 27, no. 12 (December 21, 2016): 2850–53. https://doi.org/10.1021/acs.bioconjchem.6b00629.Full Text Link to Item
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Roth, Susanne, Hanna Bergmann, Martin Jaeger, Assa Yeroslaviz, Konstantin Neumann, Paul-Albert Koenig, Clarissa Prazeres da Costa, et al. “Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.” Cell Rep 17, no. 10 (December 6, 2016): 2572–83. https://doi.org/10.1016/j.celrep.2016.11.018.Full Text Link to Item
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Shorman, M., D. Evans, C. Gibson, and J. Perfect. “Cases of disseminated cryptococcosis in intravenous drug abusers without HIV infection: A new risk factor?” Medical Mycology Case Reports 14 (December 1, 2016): 17–19. https://doi.org/10.1016/j.mmcr.2016.12.003.Full Text
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Chang, Christina C., and John R. Perfect. “Repeated therapeutic lumbar punctures in cryptococcal meningitis - necessity and/or opportunity?” Curr Opin Infect Dis 29, no. 6 (December 2016): 539–45. https://doi.org/10.1097/QCO.0000000000000315.Full Text Link to Item
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Lortholary, Olivier, Mario Fernández-Ruiz, and John R. Perfect. “The current treatment landscape: other fungal diseases (cryptococcosis, fusariosis and mucormycosis).” J Antimicrob Chemother 71, no. suppl 2 (November 2016): ii31–36. https://doi.org/10.1093/jac/dkw394.Full Text Link to Item
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Cournoyer, Justin M., Aven P. Garms, Kimberly N. Thiessen, Margaret T. Bowers, Melissa D. Johnson, and Michael V. Relf. “Cardiovascular Disease and HIV: Pathophysiology, Treatment Considerations, and Nursing Implications.” Crit Care Nurse 36, no. 5 (October 2016): 37–46. https://doi.org/10.4037/ccn2016839.Full Text Link to Item
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Schneeweiss, Sebastian, Peggy L. Carver, Kausik Datta, Alicia Galar, Melissa D. Johnson, Matthew G. Johnson, Francisco M. Marty, et al. “Short-term risk of liver and renal injury in hospitalized patients using micafungin: a multicentre cohort study.” J Antimicrob Chemother 71, no. 10 (October 2016): 2938–44. https://doi.org/10.1093/jac/dkw225.Full Text Link to Item
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Steenwyk, Jacob L., John S. Soghigian, John R. Perfect, and John G. Gibbons. “Copy number variation contributes to cryptic genetic variation in outbreak lineages of Cryptococcus gattii from the North American Pacific Northwest.” Bmc Genomics 17, no. 1 (September 2, 2016): 700. https://doi.org/10.1186/s12864-016-3044-0.Full Text Link to Item
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Thompson, George R., Adrian Rendon, Rodrigo Ribeiro Dos Santos, Flavio Queiroz-Telles, Luis Ostrosky-Zeichner, Nkechi Azie, Rochelle Maher, et al. “Isavuconazole Treatment of Cryptococcosis and Dimorphic Mycoses.” Clin Infect Dis 63, no. 3 (August 1, 2016): 356–62. https://doi.org/10.1093/cid/ciw305.Full Text Link to Item
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Marty, Francisco M., Luis Ostrosky-Zeichner, Oliver A. Cornely, Kathleen M. Mullane, John R. Perfect, George R. Thompson, George J. Alangaden, et al. “Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis.” Lancet Infect Dis 16, no. 7 (July 2016): 828–37. https://doi.org/10.1016/S1473-3099(16)00071-2.Full Text Link to Item
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Miao, Yi, Jennifer L. Tenor, Dena L. Toffaletti, Erica J. Washington, Jiuyu Liu, William R. Shadrick, Maria A. Schumacher, Richard E. Lee, John R. Perfect, and Richard G. Brennan. “Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.” Proc Natl Acad Sci U S A 113, no. 26 (June 28, 2016): 7148–53. https://doi.org/10.1073/pnas.1601774113.Full Text Link to Item
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Perfect, John R. “Editorial Commentary: Life-saving Antimicrobial Drugs: What Are We Doing to Pricing and Availability?” Clin Infect Dis 62, no. 12 (June 15, 2016): 1569–70. https://doi.org/10.1093/cid/ciw153.Full Text Link to Item
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Homer, Christina M., Diana K. Summers, Alexi I. Goranov, Starlynn C. Clarke, Darin L. Wiesner, Jolene K. Diedrich, James J. Moresco, et al. “Intracellular Action of a Secreted Peptide Required for Fungal Virulence.” Cell Host Microbe 19, no. 6 (June 8, 2016): 849–64. https://doi.org/10.1016/j.chom.2016.05.001.Full Text Link to Item
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Maskarinec, Stacey A., Melissa D. Johnson, and John R. Perfect. “Genetic Susceptibility to Fungal Infections: What is in the Genes?” Curr Clin Microbiol Rep 3, no. 2 (June 2016): 81–91. https://doi.org/10.1007/s40588-016-0037-3.Full Text Link to Item
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Perfect, John R. “"Is there an emerging need for new antifungals?".” Expert Opin Emerg Drugs 21, no. 2 (June 2016): 129–31. https://doi.org/10.1517/14728214.2016.1155554.Full Text Link to Item
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Maziarz, Eileen K., and John R. Perfect. “Cryptococcosis.” Infect Dis Clin North Am 30, no. 1 (March 2016): 179–206. https://doi.org/10.1016/j.idc.2015.10.006.Full Text Link to Item
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Swamydas, Muthulekha, Ji-Liang Gao, Timothy J. Break, Melissa D. Johnson, Martin Jaeger, Carlos A. Rodriguez, Jean K. Lim, et al. “CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.” Sci Transl Med 8, no. 322 (January 20, 2016): 322ra10. https://doi.org/10.1126/scitranslmed.aac7718.Full Text Link to Item
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Bazemore, Taylor C., Stacey A. Maskarinec, Kahli Zietlow, Edward F. Hendershot, and John R. Perfect. “Familial Adenomatous Polyposis Manifesting as Lactococcus Endocarditis: A Case Report and Review of the Association of Lactococcus with Underlying Gastrointestinal Disease.” Case Rep Infect Dis 2016 (2016): 5805326. https://doi.org/10.1155/2016/5805326.Full Text Link to Item
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Caza, Mélissa, Guanggan Hu, Michael Price, John R. Perfect, and James W. Kronstad. “The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans.” Msphere 1, no. 1 (2016). https://doi.org/10.1128/mSphere.00080-15.Full Text Link to Item
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Janout, Vaclav, Celine Bienvenu, Wiley Schell, John R. Perfect, and Steven L. Regen. “Correction to Molecular Umbrella-Amphotericin B Conjugates.” Bioconjug Chem 26, no. 10 (October 21, 2015): 2168. https://doi.org/10.1021/acs.bioconjchem.5b00517.Full Text Link to Item
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Janout, Vaclav, Wiley A. Schell, Damien Thévenin, Yuming Yu, John R. Perfect, and Steven L. Regen. “Taming Amphotericin B.” Bioconjug Chem 26, no. 10 (October 21, 2015): 2021–24. https://doi.org/10.1021/acs.bioconjchem.5b00463.Full Text Link to Item
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Tenor, Jennifer L., Stefan H. Oehlers, Jialu L. Yang, David M. Tobin, and John R. Perfect. “Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion.” Mbio 6, no. 5 (September 29, 2015): e01425–e01415. https://doi.org/10.1128/mBio.01425-15.Full Text Open Access Copy Link to Item
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Clement, Meredith E., Eileen K. Maziarz, Jacob N. Schroder, Chetan B. Patel, and John R. Perfect. “Scedosporium apiosermum infection of the "Native" valve: Fungal endocarditis in an orthotopic heart transplant recipient.” Med Mycol Case Rep 9 (September 2015): 34–36. https://doi.org/10.1016/j.mmcr.2015.07.005.Full Text Link to Item
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Chen, Yuan, Anastasia P. Litvintseva, Aubrey E. Frazzitta, Miriam R. Haverkamp, Liuyang Wang, Charles Fang, Charles Muthoga, Thomas G. Mitchell, and John R. Perfect. “Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana.” Mol Ecol 24, no. 14 (July 2015): 3559–71. https://doi.org/10.1111/mec.13260.Full Text Open Access Copy Link to Item
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Molefi, Mooketsi, Awilly A. Chofle, Síle F. Molloy, Samuel Kalluvya, John M. Changalucha, Francesca Cainelli, Tshepo Leeme, et al. “AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial.” Trials 16 (June 17, 2015): 276. https://doi.org/10.1186/s13063-015-0799-6.Full Text Link to Item
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Allen, David, Dustin Wilson, Richard Drew, and John Perfect. “Azole antifungals: 35 years of invasive fungal infection management.” Expert Rev Anti Infect Ther 13, no. 6 (June 2015): 787–98. https://doi.org/10.1586/14787210.2015.1032939.Full Text Link to Item
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Perfect, John R., and Tihana Bicanic. “Cryptococcosis diagnosis and treatment: What do we know now.” Fungal Genet Biol 78 (May 2015): 49–54. https://doi.org/10.1016/j.fgb.2014.10.003.Full Text Link to Item
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Jaeger, Martin, Robin van der Lee, Shih-Chin Cheng, Melissa D. Johnson, Vinod Kumar, Aylwin Ng, Theo S. Plantinga, et al. “The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.” Eur J Clin Microbiol Infect Dis 34, no. 5 (May 2015): 963–74. https://doi.org/10.1007/s10096-014-2309-2.Full Text Link to Item
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Hoog, G Sybren de, Vishnu Chaturvedi, David W. Denning, Paul S. Dyer, Jens Christian Frisvad, David Geiser, Yvonne Gräser, et al. “Name changes in medically important fungi and their implications for clinical practice.” J Clin Microbiol 53, no. 4 (April 2015): 1056–62. https://doi.org/10.1128/JCM.02016-14.Full Text Link to Item
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Mandegari, Elham, Ligia Fu, Carolina Arambú, Sandra Montoya, Armando Peña, Kyle M. Johnson, John R. Perfect, and Miguela A. Caniza. “Mucormycosis Rhinosinusitis at Diagnosis of Acute Lymphoblastic Leukemia: Diagnostics and Management Challenges in a Low-Middle-income Country.” J Pediatr Hematol Oncol 37, no. 3 (April 2015): e173–77. https://doi.org/10.1097/MPH.0000000000000198.Full Text Link to Item
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American College of Clinical Pharmacy, Scot, Sarah E. McBane, Anna L. Dopp, Andrew Abe, Sandra Benavides, Elizabeth A. Chester, Dave L. Dixon, et al. “Collaborative drug therapy management and comprehensive medication management-2015.” Pharmacotherapy 35, no. 4 (April 2015): e39–50. https://doi.org/10.1002/phar.1563.Full Text Link to Item
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Arnold, Christopher J., Melissa Johnson, Arnold S. Bayer, Suzanne Bradley, Efthymia Giannitsioti, José M. Miró, Pilar Tornos, et al. “Candida infective endocarditis: an observational cohort study with a focus on therapy.” Antimicrob Agents Chemother 59, no. 4 (April 2015): 2365–73. https://doi.org/10.1128/AAC.04867-14.Full Text Link to Item
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Tiro, A. V., D. J. Springer, R. Irby, F. Averill, A. Ottaviani, J. Heitman, and J. R. Perfect. “A case of cryptococcus gattii in Western Florida: An aggressive pathogen in an immunocompetent host.” Infectious Diseases in Clinical Practice 23, no. 2 (March 12, 2015): 105–8. https://doi.org/10.1097/IPC.0000000000000211.Full Text
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Chen, Yuan, Aubrey E. Frazzitta, Anastasia P. Litvintseva, Charles Fang, Thomas G. Mitchell, Deborah J. Springer, Yun Ding, George Yuan, and John R. Perfect. “Next generation multilocus sequence typing (NGMLST) and the analytical software program MLSTEZ enable efficient, cost-effective, high-throughput, multilocus sequencing typing.” Fungal Genet Biol 75 (February 2015): 64–71. https://doi.org/10.1016/j.fgb.2015.01.005.Full Text Open Access Copy Link to Item
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Molefi, M., A. A. Chofle, S. F. Molloy, S. Kalluvya, J. M. Changalucha, F. Cainelli, T. Leeme, et al. “AMBITION-cm: Intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: Study protocol for a randomized controlled trial.” Trials, 2015. https://doi.org/10.1186/s13063-015-0799-6.Full Text
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Ten Oever, Jaap, Matthijs Kox, Frank L. van de Veerdonk, Khutso M. Mothapo, Adriana Slavcovici, Tim L. Jansen, Lieke Tweehuysen, et al. “The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.” Bmc Immunol 15 (November 19, 2014): 55. https://doi.org/10.1186/s12865-014-0055-y.Full Text Link to Item
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Perfect, John R., Ray Hachem, and John R. Wingard. “Update on epidemiology of and preventive strategies for invasive fungal infections in cancer patients.” Clin Infect Dis 59 Suppl 5 (November 15, 2014): S352–55. https://doi.org/10.1093/cid/ciu639.Full Text Link to Item
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Chowdhary, Anuradha, John Perfect, and G Sybren de Hoog. “Black Molds and Melanized Yeasts Pathogenic to Humans.” Cold Spring Harb Perspect Med 5, no. 8 (November 10, 2014): a019570. https://doi.org/10.1101/cshperspect.a019570.Full Text Link to Item
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Köhler, Julia R., Arturo Casadevall, and John Perfect. “The spectrum of fungi that infects humans.” Cold Spring Harb Perspect Med 5, no. 1 (November 3, 2014): a019273. https://doi.org/10.1101/cshperspect.a019273.Full Text Link to Item
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Duarte, R. F., J. López-Jiménez, O. A. Comely, M. Laverdiere, D. Helfgott, S. Haider, P. Chandrasekar, et al. “Phase 1b study of new posaconazole tablet for prevention of invasive fungal infections in high-risk patients with neutropenia.” Antimicrobial Agents and Chemotherapy 58, no. 10 (October 1, 2014): 5758–65. https://doi.org/10.1128/AAC03050-14.Full Text
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Duarte, Rafael F., Javier López-Jiménez, Oliver A. Cornely, Michel Laverdiere, David Helfgott, Shariq Haider, Pranatharthi Chandrasekar, et al. “Phase 1b study of new posaconazole tablet for prevention of invasive fungal infections in high-risk patients with neutropenia.” Antimicrob Agents Chemother 58, no. 10 (October 2014): 5758–65. https://doi.org/10.1128/AAC.03050-14.Full Text Link to Item
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Kumar, Vinod, Shih-Chin Cheng, Melissa D. Johnson, Sanne P. Smeekens, Agnieszka Wojtowicz, Evangelos Giamarellos-Bourboulis, Juha Karjalainen, et al. “Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.” Nat Commun 5 (September 8, 2014): 4675. https://doi.org/10.1038/ncomms5675.Full Text Link to Item
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Janout, Vaclav, Celine Bienvenu, Wiley Schell, John R. Perfect, and Steven L. Regen. “Molecular umbrella-amphotericin B conjugates.” Bioconjug Chem 25, no. 8 (August 20, 2014): 1408–11. https://doi.org/10.1021/bc500277v.Full Text Link to Item
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Jarvis, Joseph N., Tihana Bicanic, Angela Loyse, Graeme Meintjes, Louise Hogan, Chrissy H. Roberts, Shmuel Shoham, John R. Perfect, Nelesh P. Govender, and Thomas S. Harrison. “Very low levels of 25-hydroxyvitamin D are not associated with immunologic changes or clinical outcome in South African patients with HIV-associated cryptococcal meningitis.” Clin Infect Dis 59, no. 4 (August 15, 2014): 493–500. https://doi.org/10.1093/cid/ciu349.Full Text Link to Item
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Paul DiMondi, V., Mary L. Townsend, Melissa Johnson, and Michael Durkin. “Antifungal catheter lock therapy for the management of a persistent Candida albicans bloodstream infection in an adult receiving hemodialysis.” Pharmacotherapy 34, no. 7 (July 2014): e120–27. https://doi.org/10.1002/phar.1433.Full Text Link to Item
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Kung, Hsiang-Chi, Melissa D. Johnson, Richard H. Drew, Paramita Saha-Chaudhuri, and John R. Perfect. “Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology-oncology patients: a retrospective cohort study.” Cancer Med 3, no. 3 (June 2014): 667–73. https://doi.org/10.1002/cam4.225.Full Text Open Access Copy Link to Item
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Perfect, John R. “Cryptococcosis: a model for the understanding of infectious diseases.” J Clin Invest 124, no. 5 (May 2014): 1893–95. https://doi.org/10.1172/JCI75241.Full Text Link to Item
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Rosentul, Diana C., Theo S. Plantinga, Marius Farcas, Marije Oosting, Omar J. M. Hamza, William K. Scott, Barbara D. Alexander, et al. “Role of autophagy genetic variants for the risk of Candida infections.” Med Mycol 52, no. 4 (May 2014): 333–41. https://doi.org/10.1093/mmy/myt035.Full Text Link to Item
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Smeekens, S. P., R. K. Malireddi, T. S. Plantinga, K. Buffen, M. Oosting, L. A. B. Joosten, B. J. Kullberg, et al. “Autophagy is redundant for the host defense against systemic Candida albicans infections.” Eur J Clin Microbiol Infect Dis 33, no. 5 (May 2014): 711–22. https://doi.org/10.1007/s10096-013-2002-x.Full Text Link to Item
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Inoue, Makoto, Tomohiro Arikawa, Yu-Hsun Chen, Yasuhiro Moriwaki, Michael Price, Michael Brown, John R. Perfect, and Mari L. Shinohara. “T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.” Proc Natl Acad Sci U S A 111, no. 14 (April 8, 2014): 5295–5300. https://doi.org/10.1073/pnas.1321427111.Full Text Link to Item
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Al Thaqafi, Abdul Hakeem O., Fayssal M. Farahat, Maher I. Al Harbi, Abdul Fattah W. Al Amri, and John R. Perfect. “Predictors and outcomes of Candida bloodstream infection: eight-year surveillance, western Saudi Arabia.” Int J Infect Dis 21 (April 2014): 5–9. https://doi.org/10.1016/j.ijid.2013.12.012.Full Text Link to Item
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Janbon, Guilhem, Kate L. Ormerod, Damien Paulet, Edmond J. Byrnes, Vikas Yadav, Gautam Chatterjee, Nandita Mullapudi, et al. “Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.” Plos Genet 10, no. 4 (April 2014): e1004261. https://doi.org/10.1371/journal.pgen.1004261.Full Text Open Access Copy Link to Item
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Jarvis, J. N., T. Bicanic, A. Loyse, G. Meintjes, L. Hogan, C. H. Roberts, S. Shoham, J. R. Perfect, N. Govender, and T. S. Harrison. “Vitamin D deficiency in HIV-infected South Africans: Common, and not associated with susceptibility, immune response, or outcome in HIV-associated cryptococcal meningitis.” International Journal of Infectious Diseases 21 (April 2014): 284–284. https://doi.org/10.1016/j.ijid.2014.03.1010.Full Text
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Alexander, B. D., M. D. Johnson, C. D. Pfeiffer, C. Jiménez-Ortigosa, J. Catania, and R. Booker. “Erratum: Increasing echinocandin resistance in Candida glabrata: Clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations (Clinical Infectious Diseases (2013) 56 (1724-32)).” Clinical Infectious Diseases 58, no. 5 (March 1, 2014): 754. https://doi.org/10.1093/cid/cit956.Full Text
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Chen, Y., D. L. Toffaletti, J. L. Tenor, A. P. Litvintseva, C. Fang, T. G. Mitchell, T. R. McDonald, et al. “The Cryptococcus neoformans transcriptome at the site of human meningitis.” Mbio 5, no. 1 (February 4, 2014). https://doi.org/10.1128/mBio.01087-13.Full Text
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Chen, Yuan, Dena L. Toffaletti, Jennifer L. Tenor, Anastasia P. Litvintseva, Charles Fang, Thomas G. Mitchell, Tami R. McDonald, et al. “The Cryptococcus neoformans transcriptome at the site of human meningitis.” Mbio 5, no. 1 (February 4, 2014): e01087–e01013. https://doi.org/10.1128/mBio.01087-13.Full Text Open Access Copy Link to Item
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Holmer, Stephanie M., Kathy S. Evans, Yohannes G. Asfaw, Divey Saini, Wiley A. Schell, Julie G. Ledford, Richard Frothingham, Jo Rae Wright, Gregory D. Sempowski, and John R. Perfect. “Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis.” Infect Immun 82, no. 2 (February 2014): 683–93. https://doi.org/10.1128/IAI.00855-13.Full Text Link to Item
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Livermore, J., S. J. Howard, A. D. Sharp, J. Goodwin, L. Gregson, T. Felton, J. A. Schwartz, et al. “Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days.” Mbio 5, no. 1 (January 28, 2014). https://doi.org/10.1128/mBio.00725-13.Full Text
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Livermore, Joanne, Susan J. Howard, Andrew D. Sharp, Joanne Goodwin, Lea Gregson, Timothy Felton, Julie A. Schwartz, et al. “Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days.” Mbio 5, no. 1 (January 28, 2014): e00725–e00713. https://doi.org/10.1128/mBio.00725-13.Full Text Link to Item
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Perfect, J. R. “Fungal Infections of the Central Nervous System,” January 1, 2014, 925–45. https://doi.org/10.1016/B978-0-12-407710-2.00046-1.Full Text
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Spivey, J. R., R. H. Drew, and J. R. Perfect. “Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients.” Expert Opinion on Orphan Drugs 2, no. 3 (January 1, 2014): 245–57. https://doi.org/10.1517/21678707.2014.880649.Full Text
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Drew, Richard H., Mary L. Townsend, Melanie W. Pound, Steven W. Johnson, and John R. Perfect. “Recent advances in the treatment of life-threatening, invasive fungal infections.” Expert Opin Pharmacother 14, no. 17 (December 2013): 2361–74. https://doi.org/10.1517/14656566.2013.838217.Full Text Link to Item
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Lionakis, Michail S., Muthulekha Swamydas, Brett G. Fischer, Theo S. Plantinga, Melissa D. Johnson, Martin Jaeger, Nathaniel M. Green, et al. “CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.” J Clin Invest 123, no. 12 (December 2013): 5035–51. https://doi.org/10.1172/JCI71307.Full Text Link to Item
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Oever, J. ten, E. J. Giamarellos-Bourboulis, F. L. van de Veerdonk, F. F. Stelma, A. Simon, M. Janssen, M. Johnson, et al. “Circulating galectin-3 in infections and non-infectious inflammatory diseases.” Eur J Clin Microbiol Infect Dis 32, no. 12 (December 2013): 1605–10. https://doi.org/10.1007/s10096-013-1919-4.Full Text Link to Item
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Frazzitta, Aubrey E., Haily Vora, Michael S. Price, Jennifer L. Tenor, Marisol Betancourt-Quiroz, Dena L. Toffaletti, Nan Cheng, and John R. Perfect. “Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species.” Eukaryot Cell 12, no. 11 (November 2013): 1439–50. https://doi.org/10.1128/EC.00169-13.Full Text Link to Item
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Rubach, M. P., E. N. Pavlisko, and J. R. Perfect. “Pericarditis mediated by respiratory syncytial virus in a hematopoietic stem cell transplant patient.” Transpl Infect Dis 15, no. 4 (August 2013): E152–56. https://doi.org/10.1111/tid.12099.Full Text Link to Item
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O’Connor, Lucy, Joanne Livermore, Andrew D. Sharp, Joanne Goodwin, Lea Gregson, Susan J. Howard, Timothy W. Felton, et al. “Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients.” J Infect Dis 208, no. 2 (July 15, 2013): 351–61. https://doi.org/10.1093/infdis/jit164.Full Text Link to Item
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Bratton, Emily W., Nada El Husseini, Cody A. Chastain, Michael S. Lee, Charles Poole, Til Stürmer, David J. Weber, Jonathan J. Juliano, and John R. Perfect. “Approaches to antifungal therapies and their effectiveness among patients with cryptococcosis.” Antimicrob Agents Chemother 57, no. 6 (June 2013): 2485–95. https://doi.org/10.1128/AAC.01800-12.Full Text Link to Item
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Alexander, Barbara D., Melissa D. Johnson, Christopher D. Pfeiffer, Cristina Jiménez-Ortigosa, Jelena Catania, Rachel Booker, Mariana Castanheira, Shawn A. Messer, David S. Perlin, and Michael A. Pfaller. “Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations.” Clin Infect Dis 56, no. 12 (June 2013): 1724–32. https://doi.org/10.1093/cid/cit136.Full Text Link to Item
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Sudan, Ajay, Joanne Livermore, Susan J. Howard, Zaid Al-Nakeeb, Andrew Sharp, Joanne Goodwin, Lea Gregson, et al. “Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints.” Antimicrob Agents Chemother 57, no. 6 (June 2013): 2793–2800. https://doi.org/10.1128/AAC.00216-13.Full Text Link to Item
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Perfect, John R. “Efficiently killing a sugar-coated yeast.” N Engl J Med 368, no. 14 (April 4, 2013): 1354–56. https://doi.org/10.1056/NEJMe1302038.Full Text Link to Item
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Boehm, R. D., P. R. Miller, W. A. Schell, J. R. Perfect, and R. J. Narayan. “Inkjet printing of amphotericin B onto biodegradable microneedles using piezoelectric inkjet printing.” Jom 65, no. 4 (April 1, 2013): 525–33. https://doi.org/10.1007/s11837-013-0574-7.Full Text
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Pappas, Peter G., Dimitrios P. Kontoyiannis, John R. Perfect, and Tom M. Chiller. “Real-time treatment guidelines: considerations during the Exserohilum rostratum outbreak in the United States.” Antimicrob Agents Chemother 57, no. 4 (April 2013): 1573–76. https://doi.org/10.1128/AAC.00205-13.Full Text Link to Item
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Perfect, John R. “Fungal diagnosis: how do we do it and can we do better?” Curr Med Res Opin 29 Suppl 4 (April 2013): 3–11. https://doi.org/10.1185/03007995.2012.761134.Full Text Link to Item
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DeFreitas, Ashley A., Theresa-Lynda M. D’Souza, Ginille J. Lazaro, Emily M. Windes, Melissa D. Johnson, and Michael V. Relf. “Pharmacological considerations in human immunodeficiency virus-infected adults in the intensive care unit.” Crit Care Nurse 33, no. 2 (April 2013): 46–56. https://doi.org/10.4037/ccn2013854.Full Text Link to Item
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Perfect, J. R., and D. Andes. “Antifungal therapy: current concepts and evidence-based management.” Curr Med Res Opin, January 22, 2013. https://doi.org/10.1185/03007995.2012.761136.Full Text Link to Item
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Smeekens, Sanne P., Aylwin Ng, Vinod Kumar, Melissa D. Johnson, Theo S. Plantinga, Cleo van Diemen, Peer Arts, et al. “Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.” Nat Commun 4 (2013): 1342. https://doi.org/10.1038/ncomms2343.Full Text Link to Item
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Chen, Ying-Lien, Virginia N. Lehman, Anna F. Averette, John R. Perfect, and Joseph Heitman. “Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans.” Plos One 8, no. 3 (2013): e57672. https://doi.org/10.1371/journal.pone.0057672.Full Text Link to Item
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Liu, Tong-Bao, Jong-Chul Kim, Yina Wang, Dena L. Toffaletti, Eliseo Eugenin, John R. Perfect, Kee Jun Kim, and Chaoyang Xue. “Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier.” Plos Pathog 9, no. 4 (2013): e1003247. https://doi.org/10.1371/journal.ppat.1003247.Full Text Link to Item
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Moss, Hart B., W Craig Fowler, Wiley A. Schell, John R. Perfect, and Dan C. Zedek. “Dematiaceous fungi mimicking a conjunctival melanoma.” Ophthalmic Plast Reconstr Surg 29, no. 2 (2013): e65–66. https://doi.org/10.1097/IOP.0b013e31826c2fd7.Full Text Link to Item
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Perfect, John R. “Iatrogenic fungal meningitis: tragedy repeated.” Ann Intern Med 157, no. 11 (December 4, 2012): 825–26. https://doi.org/10.7326/0003-4819-157-11-201212040-00558.Full Text Link to Item
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Plantinga, Theo S., Melissa D. Johnson, William K. Scott, Leo A. B. Joosten, Jos W. M. van der Meer, John R. Perfect, Bart Jan Kullberg, and Mihai G. Netea. “Human genetic susceptibility to Candida infections.” Med Mycol 50, no. 8 (November 2012): 785–94. https://doi.org/10.3109/13693786.2012.690902.Full Text Link to Item
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He, Xiumiao, Daniel M. Lyons, Dena L. Toffaletti, Fuyuan Wang, Yafeng Qiu, Michael J. Davis, Daniel L. Meister, et al. “Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.” Am J Pathol 181, no. 4 (October 2012): 1356–66. https://doi.org/10.1016/j.ajpath.2012.06.012.Full Text Link to Item
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Dodds Ashley, Elizabeth, Richard Drew, Melissa Johnson, Robert Danna, Dominika Dabrowski, Valery Walker, Manishi Prasad, Barbara Alexander, George Papadopoulos, and John Perfect. “Cost of invasive fungal infections in the era of new diagnostics and expanded treatment options.” Pharmacotherapy 32, no. 10 (October 2012): 890–901. https://doi.org/10.1002/j.1875-9114.2012.01124.Full Text Link to Item
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Maruvada, Ravi, Longkun Zhu, Donna Pearce, Yi Zheng, John Perfect, Kyung J. Kwon-Chung, and Kwang Sik Kim. “Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier.” Cell Microbiol 14, no. 10 (October 2012): 1544–53. https://doi.org/10.1111/j.1462-5822.2012.01819.x.Full Text Link to Item
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Schell, W. A., J. L. Benton, P. B. Smith, M. Poore, J. L. Rouse, D. J. Boles, M. D. Johnson, et al. “Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood.” Eur J Clin Microbiol Infect Dis 31, no. 9 (September 2012): 2237–45. https://doi.org/10.1007/s10096-012-1561-6.Full Text Open Access Copy Link to Item
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Spellberg, Brad, Dimitrios P. Kontoyiannis, David Fredricks, Michele I. Morris, John R. Perfect, Peter V. Chin-Hong, Ashraf S. Ibrahim, and Eric P. Brass. “Risk factors for mortality in patients with mucormycosis.” Med Mycol 50, no. 6 (August 2012): 611–18. https://doi.org/10.3109/13693786.2012.669502.Full Text Link to Item
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Geunes-Boyer, Scarlett, Michael F. Beers, John R. Perfect, Joseph Heitman, and Jo Rae Wright. “Surfactant protein D facilitates Cryptococcus neoformans infection.” Infect Immun 80, no. 7 (July 2012): 2444–53. https://doi.org/10.1128/IAI.05613-11.Full Text Link to Item
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Kwon-Chung, Kyung J., John R. Perfect, and Stuart M. Levitz. “A chronological history of the International Conference on Cryptococcus and Cryptococcosis (ICCC), an invaluable forum for growth of the cryptococcal research field and clinical practice.” Mycopathologia 173, no. 5–6 (June 2012): 287–93. https://doi.org/10.1007/s11046-011-9481-z.Full Text Link to Item
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Plantinga, Theo S., Melissa D. Johnson, William K. Scott, Esther van de Vosse, Digna R. Velez Edwards, P Brian Smith, Barbara D. Alexander, et al. “Toll-like receptor 1 polymorphisms increase susceptibility to candidemia.” J Infect Dis 205, no. 6 (March 15, 2012): 934–43. https://doi.org/10.1093/infdis/jir867.Full Text Link to Item
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Maziarz, E. K., and J. R. Perfect. “IRIS and fungal infections: What have we learned?” Current Fungal Infection Reports 6, no. 1 (March 1, 2012): 1–10. https://doi.org/10.1007/s12281-011-0075-5.Full Text
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Rosentul, D. C., T. S. Plantinga, W. K. Scott, B. D. Alexander, N. M. D. van de Geer, J. R. Perfect, B. J. Kullberg, M. D. Johnson, and M. G. Netea. “The impact of caspase-12 on susceptibility to candidemia.” Eur J Clin Microbiol Infect Dis 31, no. 3 (March 2012): 277–80. https://doi.org/10.1007/s10096-011-1307-x.Full Text Open Access Copy Link to Item
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Spellberg, Brad, Ashraf S. Ibrahim, Peter V. Chin-Hong, Dimitrios P. Kontoyiannis, Michele I. Morris, John R. Perfect, David Fredricks, and Eric P. Brass. “The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial.” J Antimicrob Chemother 67, no. 3 (March 2012): 715–22. https://doi.org/10.1093/jac/dkr375.Full Text Link to Item
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Johnson, Melissa D., Theo S. Plantinga, Esther van de Vosse, Digna R. Velez Edwards, P Brian Smith, Barbara D. Alexander, John C. Yang, et al. “Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.” Clin Infect Dis 54, no. 4 (February 15, 2012): 502–10. https://doi.org/10.1093/cid/cir827.Full Text Open Access Copy Link to Item
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O’Sullivan, Amy K., Milton C. Weinstein, Ankur Pandya, David Thompson, Amelia A. Langston, John R. Perfect, and George Papadopoulos. “Cost-effectiveness of posaconazole versus fluconazole for prevention of invasive fungal infections in U.S. patients with graft-versus-host disease.” Am J Health Syst Pharm 69, no. 2 (January 15, 2012): 149–56. https://doi.org/10.2146/ajhp110149.Full Text Link to Item
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Bratton, E. W., N. El Husseini, C. A. Chastain, M. S. Lee, C. Poole, T. Stürmer, J. J. Juliano, D. J. Weber, and J. R. Perfect. “Correction: Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant.” Plos One 7, no. 10 (2012). https://doi.org/10.1371/annotation/a94bc542-6682-4579-a315-57019cef7e0e.Full Text Link to Item
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Bratton, Emily W., Nada El Husseini, Cody A. Chastain, Michael S. Lee, Charles Poole, Til Stürmer, Jonathan J. Juliano, David J. Weber, and John R. Perfect. “Comparison and temporal trends of three groups with cryptococcosis: HIV-infected, solid organ transplant, and HIV-negative/non-transplant.” Plos One 7, no. 8 (2012): e43582. https://doi.org/10.1371/journal.pone.0043582.Full Text Link to Item
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Fang, Wei, Michael S. Price, Dena L. Toffaletti, Jennifer Tenor, Marisol Betancourt-Quiroz, Jennifer L. Price, Wei-hua Pan, Wan-qing Liao, and John R. Perfect. “Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans.” Plos One 7, no. 6 (2012): e38326. https://doi.org/10.1371/journal.pone.0038326.Full Text Link to Item
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Perfect, John R. “The triple threat of cryptococcosis: it's the body site, the strain, and/or the host.” Mbio 3, no. 4 (2012). https://doi.org/10.1128/mBio.00165-12.Full Text Link to Item
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Perfect, John R. “Invasive mycoses: evolving challenges and opportunities in antifungal therapy. Introduction.” Am J Med 125, no. 1 Suppl (January 2012): S1–2. https://doi.org/10.1016/j.amjmed.2011.10.007.Full Text Link to Item
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Perfect, John R. “The impact of the host on fungal infections.” Am J Med 125, no. 1 Suppl (January 2012): S39–51. https://doi.org/10.1016/j.amjmed.2011.10.010.Full Text Link to Item
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Shapiro, Rebecca S., Aimee K. Zaas, Marisol Betancourt-Quiroz, John R. Perfect, and Leah E. Cowen. “The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance.” Plos One 7, no. 9 (2012): e44734. https://doi.org/10.1371/journal.pone.0044734.Full Text Open Access Copy Link to Item
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Tseng, Hsiang-Kuang, Chang-Pan Liu, Michael S. Price, Ambrose Y. Jong, Jui-Chih Chang, Dena L. Toffaletti, Marisol Betancourt-Quiroz, Aubrey E. Frazzitta, Wen-Long Cho, and John R. Perfect. “Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system.” Plos One 7, no. 9 (2012): e45083. https://doi.org/10.1371/journal.pone.0045083.Full Text Link to Item
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Hanson, Kimberly E., Christopher D. Pfeiffer, Erika D. Lease, Alfred H. Balch, Aimee K. Zaas, John R. Perfect, and Barbara D. Alexander. “β-D-glucan surveillance with preemptive anidulafungin for invasive candidiasis in intensive care unit patients: a randomized pilot study.” Plos One 7, no. 8 (2012): e42282. https://doi.org/10.1371/journal.pone.0042282.Full Text Open Access Copy Link to Item
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McCulloh, Russell J., Raina Phillips, John R. Perfect, Edmond J. Byrnes, Joseph Heitman, and Elizabeth Dufort. “Cryptococcus gattii genotype VGI infection in New England.” Pediatr Infect Dis J 30, no. 12 (December 2011): 1111–14. https://doi.org/10.1097/INF.0b013e31822d14fd.Full Text Link to Item
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Goswami, Neela D., Melissa D. Johnson, and Vivian H. Chu. “Ertapenem for treatment of osteomyelitis: a case series.” Bmc Res Notes 4 (November 2, 2011): 478. https://doi.org/10.1186/1756-0500-4-478.Full Text Link to Item
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Semighini, Camile P., Anna F. Averette, John R. Perfect, and Joseph Heitman. “Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner.” Plos Pathog 7, no. 11 (November 2011): e1002364. https://doi.org/10.1371/journal.ppat.1002364.Full Text Link to Item
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Hu, Guanggan, Joyce Wang, Jaehyuk Choi, Won Hee Jung, Iris Liu, Anastasia P. Litvintseva, Tihana Bicanic, et al. “Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.” Bmc Genomics 12 (October 27, 2011): 526. https://doi.org/10.1186/1471-2164-12-526.Full Text Open Access Copy Link to Item
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Byrnes, Edmond J., Karen H. Bartlett, John R. Perfect, and Joseph Heitman. “Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals.” Microbes Infect 13, no. 11 (October 2011): 895–907. https://doi.org/10.1016/j.micinf.2011.05.009.Full Text Link to Item
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Perfect, John R., Michael A. Pfaller, Luis Ostrosky-Zeichner, and Dimitrios P. Kontoyiannis. “Invasive mycoses: evolving challenges and opportunities in antifungal therapy (multimedia activity).” Am J Med 124, no. 10 (October 2011): S2–3. https://doi.org/10.1016/j.amjmed.2011.08.001.Full Text Link to Item
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Rosentul, Diana C., Theo S. Plantinga, Marije Oosting, William K. Scott, Digna R. Velez Edwards, P Brian Smith, Barbara D. Alexander, et al. “Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia.” J Infect Dis 204, no. 7 (October 1, 2011): 1138–45. https://doi.org/10.1093/infdis/jir458.Full Text Link to Item
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Rebong, Rachelle A., Ricardo M. Santaella, Brian E. Goldhagen, Christopher P. Majka, John R. Perfect, William J. Steinbach, and Natalie A. Afshari. “Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis.” Invest Ophthalmol Vis Sci 52, no. 10 (September 21, 2011): 7309–15. https://doi.org/10.1167/iovs.11-7739.Full Text Link to Item
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Pitman, Stuart K., Richard H. Drew, and John R. Perfect. “Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations.” Expert Opin Emerg Drugs 16, no. 3 (September 2011): 559–86. https://doi.org/10.1517/14728214.2011.607811.Full Text Link to Item
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Perfect, J. R. “Azoles: Back to the future.” Current Opinion in Infectious Diseases 24, no. SUPPL. 2 (August 1, 2011). https://doi.org/10.1097/01.qco.0000399605.75891.fc.Full Text
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Pfeiffer, Christopher D., Gregory P. Samsa, Wiley A. Schell, L Barth Reller, John R. Perfect, and Barbara D. Alexander. “Quantitation of Candida CFU in initial positive blood cultures.” J Clin Microbiol 49, no. 8 (August 2011): 2879–83. https://doi.org/10.1128/JCM.00609-11.Full Text Link to Item
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Jazwinski, Alison, Susanna Naggie, and John Perfect. “Immune reconstitution syndrome in a patient with disseminated histoplasmosis and steroid taper: maintaining the perfect balance.” Mycoses 54, no. 3 (May 2011): 270–72. https://doi.org/10.1111/j.1439-0507.2009.01796.x.Full Text Link to Item
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Menzin, Joseph, Juliana L. Meyers, Mark Friedman, Jonathan R. Korn, John R. Perfect, Amelia A. Langston, Robert P. Danna, and George Papadopoulos. “The economic costs to United States hospitals of invasive fungal infections in transplant patients.” Am J Infect Control 39, no. 4 (May 2011): e15–20. https://doi.org/10.1016/j.ajic.2010.06.009.Full Text Link to Item
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Tseng, Hsiang-Kuang, and John R. Perfect. “Strategies to manage antifungal drug resistance.” Expert Opin Pharmacother 12, no. 2 (February 2011): 241–56. https://doi.org/10.1517/14656566.2010.517195.Full Text Link to Item
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Ostrosky-Zeichner, Luis, Bart Jan Kullberg, Eric J. Bow, Susan Hadley, Cristóbal León, Marcio Nucci, Thomas F. Patterson, and John R. Perfect. “Early treatment of candidemia in adults: a review.” Med Mycol 49, no. 2 (February 2011): 113–20. https://doi.org/10.3109/13693786.2010.512300.Full Text Link to Item
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Ngamskulrungroj, Popchai, Jennifer Price, Tania Sorrell, John R. Perfect, and Wieland Meyer. “Cryptococcus gattii virulence composite: candidate genes revealed by microarray analysis of high and less virulent Vancouver island outbreak strains.” Plos One 6, no. 1 (January 13, 2011): e16076. https://doi.org/10.1371/journal.pone.0016076.Full Text Link to Item
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Ashley, E. D., and M. D. Johnson. “Combination antifungal therapy,” January 1, 2011, 153–63. https://doi.org/10.1007/978-1-4419-6640-7_10.Full Text
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Limper, Andrew H., Kenneth S. Knox, George A. Sarosi, Neil M. Ampel, John E. Bennett, Antonino Catanzaro, Scott F. Davies, et al. “An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.” Am J Respir Crit Care Med 183, no. 1 (January 1, 2011): 96–128. https://doi.org/10.1164/rccm.2008-740ST.Full Text Link to Item
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Price, M. S., M. Betancourt-Quiroz, J. L. Price, D. L. Toffaletti, H. Vora, G. Hu, J. W. Kronstad, and J. R. Perfect. “Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.” Mbio 2, no. 3 (January 1, 2011). https://doi.org/10.1128/mBio.00103-11.Full Text
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Price, Michael S., Marisol Betancourt-Quiroz, Jennifer L. Price, Dena L. Toffaletti, Haily Vora, Guanggan Hu, James W. Kronstad, and John R. Perfect. “Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.” Mbio 2, no. 3 (2011): e00103–11. https://doi.org/10.1128/mBio.00103-11.Full Text Link to Item
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Price, Michael S., and John R. Perfect. “Host defenses against cryptococcosis.” Immunol Invest 40, no. 7–8 (2011): 786–808. https://doi.org/10.3109/08820139.2011.605196.Full Text Link to Item
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Johnson, M. D., and M. Netea. “Host Genomics and Bacterial Infections,” December 1, 2010, 744–59. https://doi.org/10.1016/B978-0-12-374934-5.00058-1.Full Text
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Alexander, Barbara D., P Brian Smith, R Duane Davis, John R. Perfect, and L Barth Reller. “The (1,3){beta}-D-glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation.” J Clin Microbiol 48, no. 11 (November 2010): 4083–88. https://doi.org/10.1128/JCM.01183-10.Full Text Link to Item
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Lee, Anthony, Dena L. Toffaletti, Jennifer Tenor, Erik J. Soderblom, J Will Thompson, M Arthur Moseley, Michael Price, and John R. Perfect. “Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis.” Infect Immun 78, no. 10 (October 2010): 4213–25. https://doi.org/10.1128/IAI.00551-10.Full Text Link to Item
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LaFayette, Shantelle L., Cathy Collins, Aimee K. Zaas, Wiley A. Schell, Marisol Betancourt-Quiroz, AA Leslie Gunatilaka, John R. Perfect, and Leah E. Cowen. “PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.” Plos Pathog 6, no. 8 (August 26, 2010): e1001069. https://doi.org/10.1371/journal.ppat.1001069.Full Text Open Access Copy Link to Item
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Puttikamonkul, Srisombat, Sven D. Willger, Nora Grahl, John R. Perfect, Navid Movahed, Brian Bothner, Steven Park, Padmaja Paderu, David S. Perlin, and Robert A. Cramer. “Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.” Mol Microbiol 77, no. 4 (August 2010): 891–911. https://doi.org/10.1111/j.1365-2958.2010.07254.x.Full Text Link to Item
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Pfeiffer, Christopher D., Guillermo Garcia-Effron, Aimee K. Zaas, John R. Perfect, David S. Perlin, and Barbara D. Alexander. “Breakthrough invasive candidiasis in patients on micafungin.” J Clin Microbiol 48, no. 7 (July 2010): 2373–80. https://doi.org/10.1128/JCM.02390-09.Full Text Link to Item
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Johnson, Melissa D., and John R. Perfect. “Use of Antifungal Combination Therapy: Agents, Order, and Timing.” Curr Fungal Infect Rep 4, no. 2 (May 1, 2010): 87–95. https://doi.org/10.1007/s12281-010-0018-6.Full Text Link to Item
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Wulff-Burchfield, Elizabeth, Wiley A. Schell, Allen E. Eckhardt, Michael G. Pollack, Zhishan Hua, Jeremy L. Rouse, Vamsee K. Pamula, et al. “Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens.” Diagn Microbiol Infect Dis 67, no. 1 (May 2010): 22–29. https://doi.org/10.1016/j.diagmicrobio.2009.12.020.Full Text Open Access Copy Link to Item
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Fortwendel, Jarrod R., Praveen R. Juvvadi, B Zachary Perfect, Luise E. Rogg, John R. Perfect, and William J. Steinbach. “Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin.” Antimicrob Agents Chemother 54, no. 4 (April 2010): 1555–63. https://doi.org/10.1128/AAC.00854-09.Full Text Link to Item
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Zaas, Aimee K., Hamza Aziz, Joseph Lucas, John R. Perfect, and Geoffrey S. Ginsburg. “Blood gene expression signatures predict invasive candidiasis.” Sci Transl Med 2, no. 21 (March 3, 2010): 21ra17. https://doi.org/10.1126/scitranslmed.3000715.Full Text Link to Item
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Perfect, John R., William E. Dismukes, Francoise Dromer, David L. Goldman, John R. Graybill, Richard J. Hamill, Thomas S. Harrison, et al. “Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.” Clin Infect Dis 50, no. 3 (February 1, 2010): 291–322. https://doi.org/10.1086/649858.Full Text Open Access Copy Link to Item
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Heil, Emily L., Mary L. Townsend, Kenneth Shipp, Amy Clarke, and Melissa D. Johnson. “Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV Coinfected Patients.” Aids Res Treat 2010 (2010): 856542. https://doi.org/10.1155/2010/856542.Full Text Link to Item
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Cramer, R. A., and J. R. Perfect. “Recent advances in understanding human opportunistic fungal pathogenesis mechanisms,” December 1, 2009, 15–31. https://doi.org/10.1016/B978-1-4160-5680-5.00002-5.Full Text
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Johnson, M. D., and M. Netea. “Host Genomics and Bacterial Infections,” December 1, 2009, 1347–61. https://doi.org/10.1016/B978-0-12-369420-1.00110-4.Full Text
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Wilson, Dustin T., Richard H. Drew, and John R. Perfect. “Antifungal therapy for invasive fungal diseases in allogeneic stem cell transplant recipients: an update.” Mycopathologia 168, no. 6 (December 2009): 313–27. https://doi.org/10.1007/s11046-009-9193-9.Full Text Link to Item
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Ferwerda, Bart, Gerben Ferwerda, Theo S. Plantinga, Janet A. Willment, Annemiek B. van Spriel, Hanka Venselaar, Clara C. Elbers, et al. “Human dectin-1 deficiency and mucocutaneous fungal infections.” N Engl J Med 361, no. 18 (October 29, 2009): 1760–67. https://doi.org/10.1056/NEJMoa0901053.Full Text Link to Item
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Menzin, Joseph, Juliana L. Meyers, Mark Friedman, John R. Perfect, Amelia A. Langston, Robert P. Danna, and George Papadopoulos. “Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients.” Am J Health Syst Pharm 66, no. 19 (October 1, 2009): 1711–17. https://doi.org/10.2146/ajhp080325.Full Text Link to Item
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Ngamskulrungroj, Popchai, Uwe Himmelreich, Julia A. Breger, Christabel Wilson, Methee Chayakulkeeree, Mark B. Krockenberger, Richard Malik, et al. “The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii.” Infect Immun 77, no. 10 (October 2009): 4584–96. https://doi.org/10.1128/IAI.00565-09.Full Text Link to Item
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Dodds Ashley, Elizabeth S., Jay B. Varkey, Gopal Krishna, Donna Vickery, Lei Ma, Xin Yu, Darshana Malavade, Megan Goodwin, John R. Perfect, and Eddie Power. “Pharmacokinetics of posaconazole administered orally or by nasogastric tube in healthy volunteers.” Antimicrob Agents Chemother 53, no. 7 (July 2009): 2960–64. https://doi.org/10.1128/AAC.01178-08.Full Text Link to Item
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Geunes-Boyer, Scarlett, Timothy N. Oliver, Guilhem Janbon, Jennifer K. Lodge, Joseph Heitman, John R. Perfect, and Jo Rae Wright. “Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival.” Infect Immun 77, no. 7 (July 2009): 2783–94. https://doi.org/10.1128/IAI.00088-09.Full Text Link to Item
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Singh, Sheena D., Nicole Robbins, Aimee K. Zaas, Wiley A. Schell, John R. Perfect, and Leah E. Cowen. “Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.” Plos Pathog 5, no. 7 (July 2009): e1000532. https://doi.org/10.1371/journal.ppat.1000532.Full Text Link to Item
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Byrnes, Edmond J., Wenjun Li, Yonathan Lewit, John R. Perfect, Dee A. Carter, Gary M. Cox, and Joseph Heitman. “First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen.” Plos One 4, no. 6 (June 10, 2009): e5851. https://doi.org/10.1371/journal.pone.0005851.Full Text Link to Item
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Johnson, M. D. “Pharmacogenomics of systemic antifungal agents.” Current Fungal Infection Reports 3, no. 2 (June 1, 2009): 111–16. https://doi.org/10.1007/s12281-009-0015-9.Full Text
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Naggie, Susanna, and John R. Perfect. “Molds: hyalohyphomycosis, phaeohyphomycosis, and zygomycosis.” Clin Chest Med 30, no. 2 (June 2009): 337–viii. https://doi.org/10.1016/j.ccm.2009.02.009.Full Text Link to Item
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Shapiro, Rebecca S., Priya Uppuluri, Aimee K. Zaas, Cathy Collins, Heather Senn, John R. Perfect, Joseph Heitman, and Leah E. Cowen. “Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.” Curr Biol 19, no. 8 (April 28, 2009): 621–29. https://doi.org/10.1016/j.cub.2009.03.017.Full Text Link to Item
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Pinchai, Nadthanan, B Zachary Perfect, Praveen Rao Juvvadi, Jarrod R. Fortwendel, Robert A. Cramer, Yohannes G. Asfaw, Joseph Heitman, John R. Perfect, and William J. Steinbach. “Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis.” Eukaryot Cell 8, no. 4 (April 2009): 511–19. https://doi.org/10.1128/EC.00336-08.Full Text Link to Item
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Gittard, S. D., J. R. Perfect, N. A. Monteiro-Riviere, W. Wei, C. Jin, and R. J. Narayan. “Assessing the antimicrobial activity of zinc oxide thin films using disk diffusion and biofilm reactor.” Applied Surface Science 255, no. 11 (March 15, 2009): 5806–11. https://doi.org/10.1016/j.apsusc.2009.01.009.Full Text
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Barkauskas, C. E., and J. R. Perfect. “Candida pneumonia: What we know and what we don't.” Current Fungal Infection Reports 3, no. 1 (March 1, 2009): 21–31. https://doi.org/10.1007/s12281-009-0004-z.Full Text
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Caldwell, Matthew C., John R. Perfect, Alan N. Carlson, and Alan D. Proia. “Candida glabrata endophthalmitis following penetrating keratoplasty.” J Cataract Refract Surg 35, no. 3 (March 2009): 598–602. https://doi.org/10.1016/j.jcrs.2008.08.046.Full Text Link to Item
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Smith, Winter J., Richard H. Drew, and John R. Perfect. “Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update.” Expert Rev Anti Infect Ther 7, no. 2 (March 2009): 165–81. https://doi.org/10.1586/14787210.7.2.165.Full Text Link to Item
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Connelly, Sarah M., Jane V. Trinh, Melissa D. Johnson, Elizabeth S. Dodds-Ashley, Jason Stout, John J. Engemann, N Deborah Friedman, Donald Kaye, and Keith S. Kaye. “Mortality and time to extubation in severe hospital-acquired pneumonia.” Am J Infect Control 37, no. 2 (March 2009): 143–49. https://doi.org/10.1016/j.ajic.2008.03.011.Full Text Link to Item
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Cowen, Leah E., Sheena D. Singh, Julia R. Köhler, Cathy Collins, Aimee K. Zaas, Wiley A. Schell, Hamza Aziz, et al. “Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.” Proc Natl Acad Sci U S A 106, no. 8 (February 24, 2009): 2818–23. https://doi.org/10.1073/pnas.0813394106.Full Text Link to Item
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Fortwendel, Jarrod R., Praveen Rao Juvvadi, Nadthanan Pinchai, B Zachary Perfect, J Andrew Alspaugh, John R. Perfect, and William J. Steinbach. “Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.” Antimicrob Agents Chemother 53, no. 2 (February 2009): 476–82. https://doi.org/10.1128/AAC.01154-08.Full Text Link to Item
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Maschmeyer, Georg, Thierry Calandra, Nina Singh, Joseph Wiley, and John Perfect. “Invasive mould infections: a multi-disciplinary update.” Med Mycol 47, no. 6 (2009): 571–83. https://doi.org/10.1080/13693780902946559.Full Text Link to Item
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Plantinga, T., M. Johnsson, B. Scott, E van de Vosse, D. Velez, JWM van der Meer, J. van Dissel, J. Perfect, B. -. J. Kullberg, and M. G. Netea. “Toll like receptor 1 polymorphisms and susceptibility to invasive candidiasis.” Critical Care (London, England) 13, no. Suppl 4 (January 2009): P28–P28. https://doi.org/10.1186/cc8084.Full Text
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O’Sullivan, Amy K., Ankur Pandya, George Papadopoulos, David Thompson, Amelia Langston, John Perfect, and Milton C. Weinstein. “Cost-effectiveness of posaconazole versus fluconazole or itraconazole in the prevention of invasive fungal infections among neutropenic patients in the United States.” Value Health 12, no. 5 (2009): 666–73. https://doi.org/10.1111/j.1524-4733.2008.00486.x.Full Text Link to Item
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Hachem, R. Y., A. A. Langston, J. R. Graybill, J. R. Perfect, L. D. Pedicone, H. Patino, and I. I. Raad. “Posaconazole as salvage treatment of invasive fungal infections in patients with underlying renal impairment.” J Antimicrob Chemother 62, no. 6 (December 2008): 1386–91. https://doi.org/10.1093/jac/dkn401.Full Text Link to Item
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Singh, Nina, Francoise Dromer, John R. Perfect, and Olivier Lortholary. “Cryptococcosis in solid organ transplant recipients: current state of the science.” Clin Infect Dis 47, no. 10 (November 15, 2008): 1321–27. https://doi.org/10.1086/592690.Full Text Link to Item
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Baddley, J. W., J. R. Perfect, R. A. Oster, R. A. Larsen, G. A. Pankey, H. Henderson, D. W. Haas, et al. “Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease.” Eur J Clin Microbiol Infect Dis 27, no. 10 (October 2008): 937–43. https://doi.org/10.1007/s10096-008-0529-z.Full Text Link to Item
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Alexander, Barbara D., John R. Perfect, Jennifer S. Daly, Angela Restrepo, Angela M. Tobón, Hernando Patino, Catherine J. Hardalo, and John R. Graybill. “Posaconazole as salvage therapy in patients with invasive fungal infections after solid organ transplant.” Transplantation 86, no. 6 (September 27, 2008): 791–96. https://doi.org/10.1097/TP.0b013e3181837585.Full Text Link to Item
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Segal, Brahm H., Raoul Herbrecht, David A. Stevens, Luis Ostrosky-Zeichner, Jack Sobel, Claudio Viscoli, Thomas J. Walsh, et al. “Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria.” Clin Infect Dis 47, no. 5 (September 1, 2008): 674–83. https://doi.org/10.1086/590566.Full Text Link to Item
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Hu, Guanggan, Po-Yan Cheng, Anita Sham, John R. Perfect, and James W. Kronstad. “Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection.” Mol Microbiol 69, no. 6 (September 2008): 1456–75. https://doi.org/10.1111/j.1365-2958.2008.06374.x.Full Text Link to Item
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Cramer, Robert A., B Zachary Perfect, Nadthanan Pinchai, Steven Park, David S. Perlin, Yohannes G. Asfaw, Joseph Heitman, John R. Perfect, and William J. Steinbach. “Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.” Eukaryot Cell 7, no. 7 (July 2008): 1085–97. https://doi.org/10.1128/EC.00086-08.Full Text Link to Item
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Zaas, Aimee K., Guochun Liao, Jason W. Chien, Clarice Weinberg, David Shore, Steven S. Giles, Kieren A. Marr, et al. “Plasminogen alleles influence susceptibility to invasive aspergillosis.” Plos Genet 4, no. 6 (June 20, 2008): e1000101. https://doi.org/10.1371/journal.pgen.1000101.Full Text Link to Item
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De Pauw, Ben, Thomas J. Walsh, J Peter Donnelly, David A. Stevens, John E. Edwards, Thierry Calandra, Peter G. Pappas, et al. “Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.” Clin Infect Dis 46, no. 12 (June 15, 2008): 1813–21. https://doi.org/10.1086/588660.Full Text Link to Item
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Mohr, John, Melissa Johnson, Travis Cooper, James S. Lewis, and Luis Ostrosky-Zeichner. “Current options in antifungal pharmacotherapy.” Pharmacotherapy 28, no. 5 (May 2008): 614–45. https://doi.org/10.1592/phco.28.5.614.Full Text Link to Item
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Nucci, Marcio, and John R. Perfect. “When primary antifungal therapy fails.” Clin Infect Dis 46, no. 9 (May 1, 2008): 1426–33. https://doi.org/10.1086/587101.Full Text Link to Item
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Perfect, John R. “Aerosolized antifungal prophylaxis: the winds of change?” Clin Infect Dis 46, no. 9 (May 1, 2008): 1409–11. https://doi.org/10.1086/586740.Full Text Link to Item
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Geunes-Boyer, Scarlett Gabriel, Timothy N. Oliver, Joseph Heitman, John R. Perfect, and Jo Rae Wright. “Surfactant Protein D enhances phagocytosis of Cryptococcus neoformans hypocapsular strain cap59 Delta by murine macrophages.” Faseb Journal 22 (April 1, 2008).Link to Item
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Varkey, Jay B., and John R. Perfect. “Rare and emerging fungal pulmonary infections.” Semin Respir Crit Care Med 29, no. 2 (April 2008): 121–31. https://doi.org/10.1055/s-2008-1063851.Full Text Link to Item
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Cox, G. M., D. T. Durack, and J. R. Perfect. “Fungal Infections of the Central Nervous System,” January 1, 2008, 899–920. https://doi.org/10.1016/B978-044306707-5.50051-1.Full Text
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Kanafani, Zeina A., and John R. Perfect. “Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact.” Clin Infect Dis 46, no. 1 (January 1, 2008): 120–28. https://doi.org/10.1086/524071.Full Text Link to Item
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Lalani, Tahaniyat, Jay B. Varkey, Richard Drew, Lizzie Harrell, Sarah McGarry, John G. Engemann, Melissa D. Johnson, and Keith S. Kaye. “Analysis of two- and three-year trends in antimicrobial resistance in intensive care units using unit-specific antibiograms.” Scand J Infect Dis 40, no. 8 (2008): 672–74. https://doi.org/10.1080/00365540801971403.Full Text Link to Item
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Giles, Steven S., Aimee K. Zaas, Mike F. Reidy, John R. Perfect, and Jo Rae Wright. “Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms.” Plos One 2, no. 12 (December 26, 2007): e1370. https://doi.org/10.1371/journal.pone.0001370.Full Text Link to Item
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Townsend, Mary L., Stephanie B. Hollowell, Jasmin Bhalodia, Kenneth H. Wilson, Keith S. Kaye, and Melissa D. Johnson. “A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia.” Int J Std Aids 18, no. 12 (December 2007): 851–55. https://doi.org/10.1258/095646207782716974.Full Text Link to Item
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Singh, Nina, and John R. Perfect. “Immune reconstitution syndrome and exacerbation of infections after pregnancy.” Clin Infect Dis 45, no. 9 (November 1, 2007): 1192–99. https://doi.org/10.1086/522182.Full Text Link to Item
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Chayakulkeeree, Methee, Thomas H. Rude, Dena L. Toffaletti, and John R. Perfect. “Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target.” Antimicrob Agents Chemother 51, no. 10 (October 2007): 3537–45. https://doi.org/10.1128/AAC.00442-07.Full Text Link to Item
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Onyewu, Chiatogu, Emily Eads, Wiley A. Schell, John R. Perfect, Yehuda Ullmann, Gil Kaufman, Benjamin A. Horwitz, Israela Berdicevsky, and Joseph Heitman. “Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.” Antimicrob Agents Chemother 51, no. 10 (October 2007): 3743–46. https://doi.org/10.1128/AAC.00492-07.Full Text Link to Item
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Johnson, Melissa D., and John R. Perfect. “Fungal infections of the bones and joints.” Curr Infect Dis Rep 3, no. 5 (October 2007): 450–60. https://doi.org/10.1007/s11908-007-1002-3.Full Text Link to Item
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Waugh, Michael S., John R. Perfect, and Rajesh C. Dash. “Schistosoma haematobium in urine: morphology with ThinPrep method.” Diagn Cytopathol 35, no. 10 (October 2007): 649–50. https://doi.org/10.1002/dc.20694.Full Text Link to Item
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Walsh, T. J., and J. R. Perfect. “Reply to Baden and Marty [2].” Clinical Infectious Diseases 45, no. 5 (September 1, 2007): 665–66. https://doi.org/10.1086/519509.Full Text
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Johnson, M. D., and J. R. Perfect. “Combination antifungal therapy: what can and should we expect?” Bone Marrow Transplant 40, no. 4 (August 2007): 297–306. https://doi.org/10.1038/sj.bmt.1705687.Full Text Link to Item
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Steinbach, William J., Robert A. Cramer, B Zachary Perfect, Christina Henn, Kirsten Nielsen, Joseph Heitman, and John R. Perfect. “Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.” Antimicrob Agents Chemother 51, no. 8 (August 2007): 2979–81. https://doi.org/10.1128/AAC.01394-06.Full Text Link to Item
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Perfect, J. R. “Candida endophthalmitis: Who is looking?” Infectious Diseases in Clinical Practice 15, no. 4 (July 1, 2007): 221–22. https://doi.org/10.1097/IPC.0b013e3180f62aef.Full Text
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Smith, P Brian, Daniel K. Benjamin, Barbara D. Alexander, Melissa D. Johnson, Malcolm A. Finkelman, and William J. Steinbach. “Quantification of 1,3-beta-D-glucan levels in children: preliminary data for diagnostic use of the beta-glucan assay in a pediatric setting.” Clin Vaccine Immunol 14, no. 7 (July 2007): 924–25. https://doi.org/10.1128/CVI.00025-07.Full Text Link to Item
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Steinbach, William J., Rachel M. Addison, Lisa McLaughlin, Quincy Gerrald, Paul L. Martin, Timothy Driscoll, Christopher Bentsen, John R. Perfect, and Barbara D. Alexander. “Prospective Aspergillus galactomannan antigen testing in pediatric hematopoietic stem cell transplant recipients.” Pediatr Infect Dis J 26, no. 7 (July 2007): 558–64. https://doi.org/10.1097/INF.0b013e3180616cbb.Full Text Link to Item
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Singh, Nina, and John R. Perfect. “Immune reconstitution syndrome associated with opportunistic mycoses.” Lancet Infect Dis 7, no. 6 (June 2007): 395–401. https://doi.org/10.1016/S1473-3099(07)70085-3.Full Text Link to Item
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Steinbach, William J., Jennifer L. Reedy, Robert A. Cramer, John R. Perfect, and Joseph Heitman. “Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.” Nat Rev Microbiol 5, no. 6 (June 2007): 418–30. https://doi.org/10.1038/nrmicro1680.Full Text Link to Item
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Zaas, A. K., and J. R. Perfect. “Pulmonary fungal infections: Making the diagnosis.” Infections in Medicine 24, no. 4 (April 1, 2007): 156–68.
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Dodds Ashley, E. S., A. K. Zaas, A. F. Fang, B. Damle, and J. R. Perfect. “Comparative pharmacokinetics of voriconazole administered orally as either crushed or whole tablets.” Antimicrob Agents Chemother 51, no. 3 (March 2007): 877–80. https://doi.org/10.1128/AAC.01263-06.Full Text Link to Item
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Wormley, Floyd L., John R. Perfect, Chad Steele, and Gary M. Cox. “Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain.” Infect Immun 75, no. 3 (March 2007): 1453–62. https://doi.org/10.1128/IAI.00274-06.Full Text Link to Item
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Alexander, Barbara D., Terry C. Byrne, Kelly L. Smith, Kimberly E. Hanson, Kevin J. Anstrom, John R. Perfect, and L Barth Reller. “Comparative evaluation of Etest and sensititre yeastone panels against the Clinical and Laboratory Standards Institute M27-A2 reference broth microdilution method for testing Candida susceptibility to seven antifungal agents.” J Clin Microbiol 45, no. 3 (March 2007): 698–706. https://doi.org/10.1128/JCM.01840-06.Full Text Link to Item
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Perfect, John R. “Management of cryptococcosis: How are we doing?” Plos Medicine 4, no. 2 (February 1, 2007): 232–33. https://doi.org/10.1371/journal.pmed.0040047.Full Text Link to Item
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Perfect, John R. “Management of cryptococcosis: how are we doing?” Plos Med 4, no. 2 (February 2007): e47. https://doi.org/10.1371/journal.pmed.0040047.Full Text Link to Item
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Segal, Brahm H., Nikolaos G. Almyroudis, Minoo Battiwalla, Raoul Herbrecht, John R. Perfect, Thomas J. Walsh, and John R. Wingard. “Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts.” Clin Infect Dis 44, no. 3 (February 1, 2007): 402–9. https://doi.org/10.1086/510677.Full Text Link to Item
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Smith, P. B., W. J. Steinbach, C. M. Cotten, W. A. Schell, J. R. Perfect, T. J. Walsh, and D. K. Benjamin. “Caspofungin for the treatment of azole resistant candidemia in a premature infant.” J Perinatol 27, no. 2 (February 2007): 127–29. https://doi.org/10.1038/sj.jp.7211637.Full Text Link to Item
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Cornely, Oliver A., Johan Maertens, Drew J. Winston, John Perfect, Andrew J. Ullmann, Thomas J. Walsh, David Helfgott, et al. “Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.” N Engl J Med 356, no. 4 (January 25, 2007): 348–59. https://doi.org/10.1056/NEJMoa061094.Full Text Link to Item
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Idnurm, Alexander, Steven S. Giles, John R. Perfect, and Joseph Heitman. “Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans.” Eukaryot Cell 6, no. 1 (January 2007): 60–72. https://doi.org/10.1128/EC.00214-06.Full Text Link to Item
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Walsh, Thomas J., Issam Raad, Thomas F. Patterson, Pranatharthi Chandrasekar, Gerald R. Donowitz, Richard Graybill, Reginald E. Greene, et al. “Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial.” Clin Infect Dis 44, no. 1 (January 1, 2007): 2–12. https://doi.org/10.1086/508774.Full Text Link to Item
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Cramer, Robert A., Jason E. Stajich, Yvonne Yamanaka, Fred S. Dietrich, William J. Steinbach, and John R. Perfect. “Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus.” Gene 383 (November 15, 2006): 24–32. https://doi.org/10.1016/j.gene.2006.07.008.Full Text Link to Item
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Zaas, Aimee K., Elizabeth S. Dodds Ashley, Barbara D. Alexander, Melissa D. Johnson, and John R. Perfect. “Caspofungin for invasive candidiasis at a tertiary care medical center.” Am J Med 119, no. 11 (November 2006): 993.e1-993.e6. https://doi.org/10.1016/j.amjmed.2006.02.029.Full Text Link to Item
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Anaissie, Elias J., Brahm H. Segal, John R. Graybill, Carola Arndt, John R. Perfect, Michael Kleinberg, Peter Pappas, et al. “Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt.” Clin Infect Dis 43, no. 8 (October 15, 2006): 1031–39. https://doi.org/10.1086/509116.Full Text Link to Item
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Petzold, Elizabeth Wills, Uwe Himmelreich, Eleftherios Mylonakis, Thomas Rude, Dena Toffaletti, Gary M. Cox, Jackie L. Miller, and John R. Perfect. “Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans.” Infect Immun 74, no. 10 (October 2006): 5877–87. https://doi.org/10.1128/IAI.00624-06.Full Text Link to Item
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Giles, Steven S., Jason E. Stajich, Connie Nichols, Quincy D. Gerrald, J Andrew Alspaugh, Fred Dietrich, and John R. Perfect. “The Cryptococcus neoformans catalase gene family and its role in antioxidant defense.” Eukaryot Cell 5, no. 9 (September 2006): 1447–59. https://doi.org/10.1128/EC.00098-06.Full Text Link to Item
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Chayakulkeeree, Methee, and John R. Perfect. “Cryptococcosis.” Infect Dis Clin North Am 20, no. 3 (September 2006): 507–vi. https://doi.org/10.1016/j.idc.2006.07.001.Full Text Link to Item
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Steinbach, William J., Robert A. Cramer, B Zachary Perfect, Yohannes G. Asfaw, Theodor C. Sauer, Laura K. Najvar, William R. Kirkpatrick, et al. “Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus.” Eukaryot Cell 5, no. 7 (July 2006): 1091–1103. https://doi.org/10.1128/EC.00139-06.Full Text Link to Item
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Raad, Issam I., John R. Graybill, Ana Beatriz Bustamante, Oliver A. Cornely, Veronica Gaona-Flores, Claude Afif, Donald R. Graham, et al. “Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections.” Clin Infect Dis 42, no. 12 (June 15, 2006): 1726–34. https://doi.org/10.1086/504328.Full Text Link to Item
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Cramer, Robert A., Michael P. Gamcsik, Rhea M. Brooking, Laura K. Najvar, William R. Kirkpatrick, Thomas F. Patterson, Carl J. Balibar, et al. “Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.” Eukaryot Cell 5, no. 6 (June 2006): 972–80. https://doi.org/10.1128/EC.00049-06.Full Text Link to Item
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Perfect, John R. “Cryptococcus neoformans: the yeast that likes it hot.” Fems Yeast Res 6, no. 4 (June 2006): 463–68. https://doi.org/10.1111/j.1567-1364.2006.00051.x.Full Text Link to Item
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Turner, Michelle S., Richard H. Drew, and John R. Perfect. “Emerging echinocandins for treatment of invasive fungal infections.” Expert Opin Emerg Drugs 11, no. 2 (May 2006): 231–50. https://doi.org/10.1517/14728214.11.2.231.Full Text Link to Item
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Chayakulkeeree, M., M. A. Ghannoum, and J. R. Perfect. “Zygomycosis: the re-emerging fungal infection.” Eur J Clin Microbiol Infect Dis 25, no. 4 (April 2006): 215–29. https://doi.org/10.1007/s10096-006-0107-1.Full Text Link to Item
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Alexander, B. D., E. S. Dodds Ashley, R. M. Addison, J. A. Alspaugh, N. J. Chao, and J. R. Perfect. “Non-comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation.” Transpl Infect Dis 8, no. 1 (March 2006): 13–20. https://doi.org/10.1111/j.1399-3062.2006.00125.x.Full Text Link to Item
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Johnson, Melissa D., Michael Kleinberg, Larry Danziger, and Luis Ostrosky-Zeichner. “Pharmacoeconomics of antifungal pharmacotherapy--challenges and future directions.” Expert Opin Pharmacother 6, no. 15 (December 2005): 2617–32. https://doi.org/10.1517/14656566.6.15.2617.Full Text Link to Item
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Pope, Scott D., Melissa D. Johnson, and D Byron May. “Pharmacotherapy for human immunodeficiency virus-associated nephropathy.” Pharmacotherapy 25, no. 12 (December 2005): 1761–72. https://doi.org/10.1592/phco.2005.25.12.1761.Full Text Link to Item
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Bahn, Yong-Sun, Gary M. Cox, John R. Perfect, and Joseph Heitman. “Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence.” Curr Biol 15, no. 22 (November 22, 2005): 2013–20. https://doi.org/10.1016/j.cub.2005.09.047.Full Text Link to Item
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Ribeiro, Mariceli A., C. R. Paula, R. John, John R. Perfect, and Gary M. Cox. “Phenotypic and genotypic evaluation of fluconazole resistance in vaginal Candida strains isolated from HIV-infected women from Brazil.” Med Mycol 43, no. 7 (November 2005): 647–50. https://doi.org/10.1080/13693780500093838.Full Text Link to Item
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Fraser, James A., Steven S. Giles, Emily C. Wenink, Scarlett G. Geunes-Boyer, Jo Rae Wright, Stephanie Diezmann, Andria Allen, et al. “Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak.” Nature 437, no. 7063 (October 27, 2005): 1360–64. https://doi.org/10.1038/nature04220.Full Text Link to Item
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Wise, Gilbert J. “Do not abandon amphotericin B as an antifungal bladder irrigant.” Clin Infect Dis 41, no. 7 (October 1, 2005): 1073–74. https://doi.org/10.1086/444384.Full Text Link to Item
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Drew, R. H., R. R. Arthur, and J. R. Perfect. “Reply to Wise.” Clinical Infectious Diseases 41, no. 7 (October 1, 2005): 1074–1074. https://doi.org/10.1086/444385.Full Text
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Steinbach, William J., John R. Perfect, Christopher H. Cabell, Vance G. Fowler, G Ralph Corey, Jennifer S. Li, Aimee K. Zaas, and Daniel K. Benjamin. “A meta-analysis of medical versus surgical therapy for Candida endocarditis.” J Infect 51, no. 3 (October 2005): 230–47. https://doi.org/10.1016/j.jinf.2004.10.016.Full Text Link to Item
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Alexander, Barbara D., Wiley A. Schell, Jackie L. Miller, Gwynn D. Long, and John R. Perfect. “Candida glabrata fungemia in transplant patients receiving voriconazole after fluconazole.” Transplantation 80, no. 6 (September 27, 2005): 868–71. https://doi.org/10.1097/01.tp.0000173771.47698.7b.Full Text Link to Item
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Perfect, J. R. “Weird fungi.” Asm News 71, no. 9 (September 1, 2005): 407–11.
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Perfect, John R. “Cryptococcus neoformans: a sugar-coated killer with designer genes.” Fems Immunol Med Microbiol 45, no. 3 (September 1, 2005): 395–404. https://doi.org/10.1016/j.femsim.2005.06.005.Full Text Link to Item
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Wormley, F. L., G. Heinrich, J. L. Miller, J. R. Perfect, and G. M. Cox. “Identification and characterization of an SKN7 homologue in Cryptococcus neoformans.” Infect Immun 73, no. 8 (August 2005): 5022–30. https://doi.org/10.1128/IAI.73.8.5022-5030.2005.Full Text Link to Item
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Nielsen, Kirsten, Gary M. Cox, Anastasia P. Litvintseva, Eleftherios Mylonakis, Stephanie D. Malliaris, Daniel K. Benjamin, Steven S. Giles, et al. “Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection.” Infect Immun 73, no. 8 (August 2005): 4922–33. https://doi.org/10.1128/IAI.73.8.4922-4933.2005.Full Text Link to Item
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Chang, Christopher Y., Wiley A. Schell, John R. Perfect, and Gregory F. Hulka. “Novel use of a swimming pool biocide in the treatment of a rare fungal mastoiditis.” Laryngoscope 115, no. 6 (June 2005): 1065–69. https://doi.org/10.1097/01.MLG.0000163338.45700.FE.Full Text Link to Item
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Drew, Richard H., Rebekah R. Arthur, and John R. Perfect. “Is it time to abandon the use of amphotericin B bladder irrigation?” Clin Infect Dis 40, no. 10 (May 15, 2005): 1465–70. https://doi.org/10.1086/429722.Full Text Link to Item
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Baddour, Larry M., John R. Perfect, and Luis Ostrosky-Zeichner. “Successful use of amphotericin B lipid complex in the treatment of cryptococcosis.” Clin Infect Dis 40 Suppl 6 (May 1, 2005): S409–13. https://doi.org/10.1086/429337.Full Text Link to Item
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Perfect, J. R. “Nuances of new anti-Aspergillus antifungals.” Med Mycol 43 Suppl 1 (May 2005): S271–76. https://doi.org/10.1080/13693780400020071.Full Text Link to Item
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Perfect, John R. “Treatment of non-Aspergillus moulds in immunocompromised patients, with amphotericin B lipid complex.” Clin Infect Dis 40 Suppl 6 (May 1, 2005): S401–8. https://doi.org/10.1086/429331.Full Text Link to Item
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Gibbs, Winter J., Richard H. Drew, and John R. Perfect. “Liposomal amphotericin B: clinical experience and perspectives.” Expert Rev Anti Infect Ther 3, no. 2 (April 2005): 167–81. https://doi.org/10.1586/14787210.3.2.167.Full Text Link to Item
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Larsen, Robert A., Peter G. Pappas, John Perfect, Judith A. Aberg, Arturo Casadevall, Gretchen A. Cloud, Robert James, Scott Filler, and William E. Dismukes. “Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis.” Antimicrob Agents Chemother 49, no. 3 (March 2005): 952–58. https://doi.org/10.1128/AAC.49.3.952-958.2005.Full Text Link to Item
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Georgopapadakou, N., H. Broxterman, E. Arts, J. Perfect, and S. Ward. “Eight years of Drug Resistance Updates.” Drug Resistance Updates 8, no. 1–2 (February 1, 2005): 1–2. https://doi.org/10.1016/j.drup.2005.04.004.Full Text
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Cornely, O. A., and J. R. Perfect. “Posaconazole: A viewpoint.” Drugs 65, no. 11 (January 1, 2005): 1568. https://doi.org/10.2165/00003495-200565110-00008.Full Text
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Gibbs, W. J., R. H. Drew, and J. R. Perfect. “Liposomal amphotericin B: Clinical experience and perspectives.” Expert Review of Anti Infective Therapy 3, no. 2 (2005): 167–81. https://doi.org/10.1586/14737140.3.2.167.Full Text
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Giles, Steven S., Ines Batinic-Haberle, John R. Perfect, and Gary M. Cox. “Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth.” Eukaryot Cell 4, no. 1 (January 2005): 46–54. https://doi.org/10.1128/EC.4.1.46-54.2005.Full Text Link to Item
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Giles, Steven S., John R. Perfect, and Gary M. Cox. “Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans.” Fungal Genet Biol 42, no. 1 (January 2005): 20–29. https://doi.org/10.1016/j.fgb.2004.09.003.Full Text Link to Item
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Perfect, John R. “Posaconazole.” Drugs 65, no. 11 (2005): 1568–69. https://doi.org/10.2165/00003495-200565110-00009.Full Text
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Venkatesan, Priya, John R. Perfect, and Sarah A. Myers. “Evaluation and management of fungal infections in immunocompromised patients.” Dermatol Ther 18, no. 1 (2005): 44–57. https://doi.org/10.1111/j.1529-8019.2005.05001.x.Full Text Link to Item
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Wormley, Floyd L., Gary M. Cox, and John R. Perfect. “Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain.” Microb Pathog 38, no. 2–3 (2005): 113–23. https://doi.org/10.1016/j.micpath.2004.12.007.Full Text Link to Item
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Wormley, Floyd L., and John R. Perfect. “Immunology of infection caused by Cryptococcus neoformans.” Methods Mol Med 118 (2005): 193–98. https://doi.org/10.1385/1-59259-943-5:193.Full Text Link to Item
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Onyewu, Chiatogu, Floyd L. Wormley, John R. Perfect, and Joseph Heitman. “The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.” Infect Immun 72, no. 12 (December 2004): 7330–33. https://doi.org/10.1128/IAI.72.12.7330-7333.2004.Full Text Link to Item
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Perfect, John R. “Antifungal resistance: the clinical front.” Oncology (Williston Park) 18, no. 14 Suppl 13 (December 2004): 15–22.Link to Item
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Steinbach, William J., Nina Singh, Jackie L. Miller, Daniel K. Benjamin, Wiley A. Schell, Joseph Heitman, and John R. Perfect. “In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.” Antimicrob Agents Chemother 48, no. 12 (December 2004): 4922–25. https://doi.org/10.1128/AAC.48.12.4922-4925.2004.Full Text Link to Item
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Perfect, John R. “Use of newer antifungal therapies in clinical practice: what do the data tell us?” Oncology (Williston Park) 18, no. 13 Suppl 7 (November 2004): 15–23.Link to Item
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Perfect, John R. “Management of invasive mycoses in hematology patients: current approaches.” Oncology (Williston Park) 18, no. 13 Suppl 7 (November 2004): 5–14.Link to Item
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Perfect, John R., Elizabeth Dodds Ashley, and Richard Drew. “Design of aerosolized amphotericin b formulations for prophylaxis trials among lung transplant recipients.” Clin Infect Dis 39 Suppl 4 (October 15, 2004): S207–10. https://doi.org/10.1086/421958.Full Text Link to Item
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Kraus, Peter R., Marie-Josée Boily, Steven S. Giles, Jason E. Stajich, Andria Allen, Gary M. Cox, Fred S. Dietrich, John R. Perfect, and Joseph Heitman. “Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray.” Eukaryot Cell 3, no. 5 (October 2004): 1249–60. https://doi.org/10.1128/EC.3.5.1249-1260.2004.Full Text Link to Item
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Jiménez-Expósito, M. J., G. Torres, A. Baraldés, N. Benito, F. Marco, J. C. Paré, A. Moreno, et al. “Native valve endocarditis due to Candida glabrata treated without valvular replacement: a potential role for caspofungin in the induction and maintenance treatment.” Clin Infect Dis 39, no. 7 (October 1, 2004): e70–73. https://doi.org/10.1086/424018.Full Text Link to Item
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Steinbach, William J., Daniel K. Benjamin, Scott A. Trasi, Jackie L. Miller, Wiley A. Schell, Aimee K. Zaas, W Michael Foster, and John R. Perfect. “Value of an inhalational model of invasive aspergillosis.” Med Mycol 42, no. 5 (October 2004): 417–25. https://doi.org/10.1080/13693780410001712034.Full Text Link to Item
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Toffaletti, Dena L., Kirsten Nielsen, Fred Dietrich, Joseph Heitman, and John R. Perfect. “Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence.” Curr Genet 46, no. 4 (October 2004): 193–204. https://doi.org/10.1007/s00294-004-0521-9.Full Text Link to Item
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Steinbach, William J., John R. Perfect, Wiley A. Schell, Thomas J. Walsh, and Daniel K. Benjamin. “In vitro analyses, animal models, and 60 clinical cases of invasive Aspergillus terreus infection.” Antimicrob Agents Chemother 48, no. 9 (September 2004): 3217–25. https://doi.org/10.1128/AAC.48.9.3217-3225.2004.Full Text Link to Item
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Arthur, Rebekah R., Richard H. Drew, and John R. Perfect. “Novel modes of antifungal drug administration.” Expert Opin Investig Drugs 13, no. 8 (August 2004): 903–32. https://doi.org/10.1517/13543784.13.8.903.Full Text Link to Item
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Miwa, Takuya, Yukinobu Takagi, Makiko Shinozaki, Cheol-Won Yun, Wiley A. Schell, John R. Perfect, Hidehiko Kumagai, and Hisanori Tamaki. “Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans.” Eukaryot Cell 3, no. 4 (August 2004): 919–31. https://doi.org/10.1128/EC.3.4.919-931.2004.Full Text Link to Item
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Odds, Frank C., Mary Motyl, Roberto Andrade, Jacques Bille, Emilia Cantón, Manuel Cuenca-Estrella, Amanda Davidson, et al. “Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species.” J Clin Microbiol 42, no. 8 (August 2004): 3475–82. https://doi.org/10.1128/JCM.42.8.3475-3482.2004.Full Text Link to Item
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Steinbach, William J., Daniel K. Benjamin, Dimitrios P. Kontoyiannis, John R. Perfect, Irja Lutsar, Kieren A. Marr, Michail S. Lionakis, Harrys A. Torres, Hasan Jafri, and Thomas J. Walsh. “Infections due to Aspergillus terreus: a multicenter retrospective analysis of 83 cases.” Clin Infect Dis 39, no. 2 (July 15, 2004): 192–98. https://doi.org/10.1086/421950.Full Text Link to Item
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Olszewski, Michal A., Mairi C. Noverr, Gwo-Hsiao Chen, Galen B. Toews, Gary M. Cox, John R. Perfect, and Gary B. Huffnagle. “Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion.” Am J Pathol 164, no. 5 (May 2004): 1761–71. https://doi.org/10.1016/S0002-9440(10)63734-0.Full Text Link to Item
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Steinbach, William J., Wiley A. Schell, Jill R. Blankenship, Chiatogu Onyewu, Joseph Heitman, and John R. Perfect. “In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.” Antimicrob Agents Chemother 48, no. 5 (May 2004): 1664–69. https://doi.org/10.1128/AAC.48.5.1664-1669.2004.Full Text Link to Item
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Gallagher, Jason C., Conan MacDougall, Elizabeth S Dodds Ashley, and John R. Perfect. “Recent advances in antifungal pharmacotherapy for invasive fungal infections.” Expert Rev Anti Infect Ther 2, no. 2 (April 2004): 253–68. https://doi.org/10.1586/14787210.2.2.253.Full Text Link to Item
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Perfect, J. R. “Our current understanding of therapies for invasive fungal infections.” Advanced Studies in Medicine 4, no. 4 A (April 1, 2004).
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Johnson, Melissa D., Conan MacDougall, Luis Ostrosky-Zeichner, John R. Perfect, and John H. Rex. “Combination antifungal therapy.” Antimicrob Agents Chemother 48, no. 3 (March 2004): 693–715. https://doi.org/10.1128/AAC.48.3.693-715.2004.Full Text Link to Item
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Lodge, Barbara Alexander, Elizabeth Dodds Ashley, Mark P. Steele, and John R. Perfect. “Aspergillus fumigatus empyema, arthritis, and calcaneal osteomyelitis in a lung transplant patient successfully treated with posaconazole.” J Clin Microbiol 42, no. 3 (March 2004): 1376–78. https://doi.org/10.1128/JCM.42.3.1376-1378.2004.Full Text Link to Item
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Miller, J. L., W. A. Schell, E. A. Wills, D. L. Toffaletti, M. Boyce, D. K. Benjamin, J. Bartroli, and J. R. Perfect. “In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans.” Antimicrob Agents Chemother 48, no. 2 (February 2004): 384–87. https://doi.org/10.1128/AAC.48.2.384-387.2004.Full Text Link to Item
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Drew, Richard H., Elizabeth Dodds Ashley, Daniel K. Benjamin, R. Duane Davis, Scott M. Palmer, and John R. Perfect. “Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients.” Transplantation 77, no. 2 (January 27, 2004): 232–37. https://doi.org/10.1097/01.TP.0000101516.08327.A9.Full Text Link to Item
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Georgopapadakou, N., H. Broxterman, E. Arts, J. Perfect, and S. Ward. “Reviews and commentaries in antimicrobial and anticancer chemotherapy: Editorial.” Drug Resistance Updates 7, no. 1 (January 1, 2004): 1. https://doi.org/10.1016/j.drup.2004.02.002.Full Text
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Steinbach, W. J., W. A. Schell, J. L. Miller, J. R. Perfect, and P. L. Martin. “Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients.” J Infect 48, no. 1 (January 2004): 112–16. https://doi.org/10.1016/s0163-4453(03)00134-8.Full Text Link to Item
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Benjamin, Daniel K., Jose M. Miro, Bruno Hoen, William J. Steinbach, Vance G. Fowler, Lars Olaison, Gilbert Habib, et al. “Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD).” Scand J Infect Dis 36, no. 6–7 (2004): 453–55. https://doi.org/10.1080/00365540410020703.Full Text Link to Item
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Steinbach, William J., Thomas G. Mitchell, Wiley A. Schell, Ana Espinel-Ingroff, Richard F. Coico, Thomas J. Walsh, and John R. Perfect. “Status of medical mycology education.” Med Mycol 41, no. 6 (December 2003): 457–67. https://doi.org/10.1080/13693780310001631322.Full Text Link to Item
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Steen, B. R., S. Zuyderduyn, D. L. Toffaletti, M. Marra, S. J. M. Jones, J. R. Perfect, and J. Kronstad. “Cryptococcus neoformans gene expression during experimental cryptococcal meningitis.” Eukaryot Cell 2, no. 6 (December 2003): 1336–49. https://doi.org/10.1128/EC.2.6.1336-1349.2003.Full Text Link to Item
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Steinbach, W. J., and J. R. Perfect. “Scedosporium species infections and treatments.” J Chemother 15 Suppl 2 (November 2003): 16–27. https://doi.org/10.1179/joc.2003.15.Supplement-2.16.Full Text Link to Item
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Zaas, Aimee K., Molly Boyce, Wiley Schell, Barbara Alexander Lodge, Jackie L. Miller, and John R. Perfect. “Risk of fungemia due to Rhodotorula and antifungal susceptibility testing of Rhodotorula isolates.” J Clin Microbiol 41, no. 11 (November 2003): 5233–35. https://doi.org/10.1128/JCM.41.11.5233-5235.2003.Full Text Link to Item
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Akhter, Shamima, Henry C. McDade, Jenifer M. Gorlach, Garrett Heinrich, Gary M. Cox, and John R. Perfect. “Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans.” Infect Immun 71, no. 10 (October 2003): 5794–5802. https://doi.org/10.1128/IAI.71.10.5794-5802.2003.Full Text Link to Item
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Zaas, A. K., and J. R. Perfect. “Pulmonary fungal infections: Making the diagnosis.” Journal of Respiratory Diseases 24, no. 10 (October 1, 2003): 433–44.
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Luberto, Chiara, Beatriz Martinez-Mariño, Daniel Taraskiewicz, Benjamin Bolaños, Pasquale Chitano, Dena L. Toffaletti, Gary M. Cox, et al. “Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans.” J Clin Invest 112, no. 7 (October 2003): 1080–94. https://doi.org/10.1172/JCI18309.Full Text Link to Item
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Nielsen, Kirsten, Gary M. Cox, Ping Wang, Dena L. Toffaletti, John R. Perfect, and Joseph Heitman. “Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates.” Infect Immun 71, no. 9 (September 2003): 4831–41. https://doi.org/10.1128/IAI.71.9.4831-4841.2003.Full Text Link to Item
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Steinbach, William J., Wiley A. Schell, Jackie L. Miller, and John R. Perfect. “Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide.” J Clin Microbiol 41, no. 8 (August 2003): 3981–85. https://doi.org/10.1128/JCM.41.8.3981-3985.2003.Full Text Link to Item
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Trinh, Jane V., William J. Steinbach, Wiley A. Schell, Joanne Kurtzberg, Steven S. Giles, and John R. Perfect. “Cerebral phaeohyphomycosis in an immunodeficient child treated medically with combination antifungal therapy.” Med Mycol 41, no. 4 (August 2003): 339–45. https://doi.org/10.1080/369378031000137369.Full Text Link to Item
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Colombo, A. L., J. Perfect, M. DiNubile, K. Bartizal, M. Motyl, P. Hicks, R. Lupinacci, C. Sable, and N. Kartsonis. “Global distribution and outcomes for Candida species causing invasive candidiasis: results from an international randomized double-blind study of caspofungin versus amphotericin B for the treatment of invasive candidiasis.” Eur J Clin Microbiol Infect Dis 22, no. 8 (August 2003): 470–74. https://doi.org/10.1007/s10096-003-0973-8.Full Text Link to Item
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Davidson, Robert C., Connie B. Nichols, Gary M. Cox, John R. Perfect, and Joseph Heitman. “A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans.” Mol Microbiol 49, no. 2 (July 2003): 469–85. https://doi.org/10.1046/j.1365-2958.2003.03563.x.Full Text Link to Item
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Gottfredsson, Magnús, James J. Vredenburgh, Jianping Xu, Wiley A. Schell, and John R. Perfect. “Candidemia in women with breast carcinoma treated with high-dose chemotherapy and autologous bone marrow transplantation.” Cancer 98, no. 1 (July 1, 2003): 24–30. https://doi.org/10.1002/cncr.11470.Full Text Link to Item
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Blankenship, Jill R., Floyd L. Wormley, Molly K. Boyce, Wiley A. Schell, Scott G. Filler, John R. Perfect, and Joseph Heitman. “Calcineurin is essential for Candida albicans survival in serum and virulence.” Eukaryot Cell 2, no. 3 (June 2003): 422–30. https://doi.org/10.1128/EC.2.3.422-430.2003.Full Text Link to Item
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Perfect, John R., Kieren A. Marr, Thomas J. Walsh, Richard N. Greenberg, Bertrand DuPont, Juliàn de la Torre-Cisneros, Gudrun Just-Nübling, et al. “Voriconazole treatment for less-common, emerging, or refractory fungal infections.” Clin Infect Dis 36, no. 9 (May 1, 2003): 1122–31. https://doi.org/10.1086/374557.Full Text Link to Item
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Johnson, Melissa D., and John R. Perfect. “Caspofungin: first approved agent in a new class of antifungals.” Expert Opin Pharmacother 4, no. 5 (May 2003): 807–23. https://doi.org/10.1517/14656566.4.5.807.Full Text Link to Item
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Toffaletti, Dena L., Maurizio Del Poeta, Thomas H. Rude, Fred Dietrich, and John R. Perfect. “Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment.” Microbiology (Reading) 149, no. Pt 4 (April 2003): 1041–49. https://doi.org/10.1099/mic.0.26021-0.Full Text Link to Item
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Brown, Adam L., and James R. Greig. “Caspofungin versus amphotericin B for invasive candidiasis.” N Engl J Med 348, no. 13 (March 27, 2003): 1287–88. https://doi.org/10.1056/NEJM200303273481315.Full Text Link to Item
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Noverr, Mairi C., Gary M. Cox, John R. Perfect, and Gary B. Huffnagle. “Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production.” Infect Immun 71, no. 3 (March 2003): 1538–47. https://doi.org/10.1128/IAI.71.3.1538-1547.2003.Full Text Link to Item
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Steinbach, William J., and John R. Perfect. “Newer antifungal therapy for emerging fungal pathogens.” Int J Infect Dis 7, no. 1 (March 2003): 5–20. https://doi.org/10.1016/s1201-9712(03)90037-3.Full Text Link to Item
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Blankenship, Jill R., William J. Steinbach, John R. Perfect, and Joseph Heitman. “Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.” Curr Opin Investig Drugs 4, no. 2 (February 2003): 192–99.Link to Item
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Johnson, Melissa D., Carol D. Hamilton, Richard H. Drew, Linda L. Sanders, Gennethel J. Pennick, and John R. Perfect. “A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.” J Antimicrob Chemother 51, no. 2 (February 2003): 453–57. https://doi.org/10.1093/jac/dkg089.Full Text Link to Item
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Gallagher, Jason C., Elizabeth S. Dodds Ashley, Richard H. Drew, and John R. Perfect. “Antifungal pharmacotherapy for invasive mould infections.” Expert Opin Pharmacother 4, no. 2 (February 2003): 147–64. https://doi.org/10.1517/14656566.4.2.147.Full Text Link to Item
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Cox, Gary M., Thomas S. Harrison, Henry C. McDade, Carlos P. Taborda, Garrett Heinrich, Arturo Casadevall, and John R. Perfect. “Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages.” Infect Immun 71, no. 1 (January 2003): 173–80. https://doi.org/10.1128/IAI.71.1.173-180.2003.Full Text Link to Item
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Mora-Duarte, Jorge, Robert Betts, Coleman Rotstein, Arnaldo Lopes Colombo, Luis Thompson-Moya, Juanita Smietana, Robert Lupinacci, et al. “Comparison of caspofungin and amphotericin B for invasive candidiasis.” N Engl J Med 347, no. 25 (December 19, 2002): 2020–29. https://doi.org/10.1056/NEJMoa021585.Full Text Link to Item
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Perfect, John R., and Arturo Casadevall. “Cryptococcosis.” Infect Dis Clin North Am 16, no. 4 (December 2002): 837–vi. https://doi.org/10.1016/s0891-5520(02)00036-3.Full Text Link to Item
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Safdar, A., P. L. McEvoy, R. G. Burns, and J. R. Perfect. “Clinical microbiological case: severe relapsing septal panniculitis in a healthy man from the south-eastern USA.” Clin Microbiol Infect 8, no. 12 (December 2002): 801–2. https://doi.org/10.1046/j.1469-0691.2002.00565.x.Full Text Link to Item
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Safdar, A., P. L. McEvoy, R. G. Burns, and J. R. Perfect. “Clinical microbiological case: severe relapsing septal panniculitis in a healthy man from the south-eastern USA.” Clinical Microbiology and Infection 8, no. 12 (December 2002): 830–32. https://doi.org/10.1046/j.1469-0691.2002.00606.x.Full Text
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Mylonakis, Eleftherios, Frederick M. Ausubel, John R. Perfect, Joseph Heitman, and Stephen B. Calderwood. “Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.” Proc Natl Acad Sci U S A 99, no. 24 (November 26, 2002): 15675–80. https://doi.org/10.1073/pnas.232568599.Full Text Link to Item
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Loeffler, Ann M., Richard H. Drew, John R. Perfect, Nadine I. Grethe, J. W. Stephens, Sharon L. Gray, and George H. Talbot. “Safety and efficacy of quinupristin/dalfopristin for treatment of invasive Gram-positive infections in pediatric patients.” Pediatr Infect Dis J 21, no. 10 (October 2002): 950–56. https://doi.org/10.1097/00006454-200210000-00013.Full Text Link to Item
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Rude, Thomas H., Dena L. Toffaletti, Gary M. Cox, and John R. Perfect. “Relationship of the glyoxylate pathway to the pathogenesis of Cryptococcus neoformans.” Infect Immun 70, no. 10 (October 2002): 5684–94. https://doi.org/10.1128/IAI.70.10.5684-5694.2002.Full Text Link to Item
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Bohjanen, Paul R., Melissa D. Johnson, Lynda A. Szczech, Dannah W. Wray, William P. Petros, Cameron R. Miller, and Charles B. Hicks. “Steady-state pharmacokinetics of lamivudine in human immunodeficiency virus-infected patients with end-stage renal disease receiving chronic dialysis.” Antimicrob Agents Chemother 46, no. 8 (August 2002): 2387–92. https://doi.org/10.1128/AAC.46.8.2387-2392.2002.Full Text Link to Item
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Lu, Irene, Elizabeth Dodds, and John Perfect. “New antifungal agents.” Semin Respir Infect 17, no. 2 (June 2002): 140–50. https://doi.org/10.1053/srin.2002.33445.Full Text Link to Item
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Pound, Melanie W., Richard H. Drew, and John R. Perfect. “Recent advances in the epidemiology, prevention, diagnosis, and treatment of fungal pneumonia.” Curr Opin Infect Dis 15, no. 2 (April 2002): 183–94. https://doi.org/10.1097/00001432-200204000-00014.Full Text Link to Item
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Wang, Ping, Connie B. Nichols, Klaus B. Lengeler, Maria E. Cardenas, Gary M. Cox, John R. Perfect, and Joseph Heitman. “Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.” Eukaryot Cell 1, no. 2 (April 2002): 257–72. https://doi.org/10.1128/EC.1.2.257-272.2002.Full Text Link to Item
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Walsh, Thomas J., Irja Lutsar, Timothy Driscoll, Bertrand Dupont, Maureen Roden, Parvis Ghahramani, Michael Hodges, Andreas H. Groll, and John R. Perfect. “Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children.” Pediatr Infect Dis J 21, no. 3 (March 2002): 240–48. https://doi.org/10.1097/00006454-200203000-00015.Full Text Link to Item
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Cruz, M Cristina, Alan L. Goldstein, Jill R. Blankenship, Maurizio Del Poeta, Dana Davis, Maria E. Cardenas, John R. Perfect, John H. McCusker, and Joseph Heitman. “Calcineurin is essential for survival during membrane stress in Candida albicans.” Embo J 21, no. 4 (February 15, 2002): 546–59. https://doi.org/10.1093/emboj/21.4.546.Full Text Link to Item
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Alspaugh, J Andrew, Read Pukkila-Worley, Toshiaki Harashima, Lora M. Cavallo, Deanna Funnell, Gary M. Cox, John R. Perfect, James W. Kronstad, and Joseph Heitman. “Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans.” Eukaryot Cell 1, no. 1 (February 2002): 75–84. https://doi.org/10.1128/EC.1.1.75-84.2002.Full Text Link to Item
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Schiappa, D., A. Gueyikian, S. Kakar, J. A. Alspaugh, J. R. Perfect, and P. R. Williamson. “An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow.” Med Mycol 40, no. 1 (February 2002): 1–5. https://doi.org/10.1080/mmy.40.1.1.5.Full Text Link to Item
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Walsh, Thomas J., Peter Pappas, Drew J. Winston, Hillard M. Lazarus, Finn Petersen, John Raffalli, Saul Yanovich, et al. “Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever.” N Engl J Med 346, no. 4 (January 24, 2002): 225–34. https://doi.org/10.1056/NEJM200201243460403.Full Text Link to Item
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Gorlach, J. M., H. C. McDade, J. R. Perfect, and G. M. Cox. “Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy.” Microbiology 148, no. 1 (2002): 213–19.
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Gorlach, Jenifer M., Henry C. McDade, John R. Perfect, and Gary M. Cox. “Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy.” Microbiology (Reading) 148, no. Pt 1 (January 2002): 213–19. https://doi.org/10.1099/00221287-148-1-213.Full Text Link to Item
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Hadjiliadis, Denis, Thomas A. Sporn, John R. Perfect, Victor F. Tapson, R Duane Davis, and Scott M. Palmer. “Outcome of lung transplantation in patients with mycetomas.” Chest 121, no. 1 (January 2002): 128–34. https://doi.org/10.1378/chest.121.1.128.Full Text Link to Item
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Perfect, J. R. “New antifungal agents.” Transpl Infect Dis 4 Suppl 3 (2002): 52–61. https://doi.org/10.1034/j.1399-3062.4.s3.8.x.Full Text Link to Item
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Perfect, J. R., G. M. Cox, J. Y. Lee, C. A. Kauffman, L. de Repentigny, S. W. Chapman, V. A. Morrison, et al. “The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis.” Clin Infect Dis 33, no. 11 (December 1, 2001): 1824–33. https://doi.org/10.1086/323900.Full Text Link to Item
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Cruz, M. C., A. L. Goldstein, J. Blankenship, M. Del Poeta, J. R. Perfect, J. H. McCusker, Y. L. Bennani, M. E. Cardenas, and J. Heitman. “Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.” Antimicrob Agents Chemother 45, no. 11 (November 2001): 3162–70. https://doi.org/10.1128/AAC.45.11.3162-3170.2001.Full Text Link to Item
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Gottfredsson, M., C. J. Jessup, G. M. Cox, J. R. Perfect, and M. A. Ghannoum. “Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B.” Antimicrob Agents Chemother 45, no. 11 (November 2001): 3231–33. https://doi.org/10.1128/AAC.45.11.3231-3233.2001.Full Text Link to Item
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Pappas, P. G., J. R. Perfect, G. A. Cloud, R. A. Larsen, G. A. Pankey, D. J. Lancaster, H. Henderson, et al. “Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy.” Clin Infect Dis 33, no. 5 (September 1, 2001): 690–99. https://doi.org/10.1086/322597.Full Text Link to Item
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Palmer, S. M., R. H. Drew, J. D. Whitehouse, V. F. Tapson, R. D. Davis, R. R. McConnell, S. S. Kanj, and J. R. Perfect. “Safety of aerosolized amphotericin B lipid complex in lung transplant recipients.” Transplantation 72, no. 3 (August 15, 2001): 545–48. https://doi.org/10.1097/00007890-200108150-00036.Full Text Link to Item
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Wang, P., M. E. Cardenas, G. M. Cox, J. R. Perfect, and J. Heitman. “Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans.” Embo Rep 2, no. 6 (June 2001): 511–18. https://doi.org/10.1093/embo-reports/kve109.Full Text Link to Item
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Stephens, C. E., F. Tanious, S. Kim, W. D. Wilson, W. A. Schell, J. R. Perfect, S. G. Franzblau, and D. W. Boykin. “Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.” J Med Chem 44, no. 11 (May 24, 2001): 1741–48. https://doi.org/10.1021/jm000413a.Full Text Link to Item
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D’Souza, C. A., J. A. Alspaugh, C. Yue, T. Harashima, G. M. Cox, J. R. Perfect, and J. Heitman. “Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.” Mol Cell Biol 21, no. 9 (May 2001): 3179–91. https://doi.org/10.1128/MCB.21.9.3179-3191.2001.Full Text Link to Item
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Wills, E. A., I. S. Roberts, M. Del Poeta, J. Rivera, A. Casadevall, G. M. Cox, and J. R. Perfect. “Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity.” Mol Microbiol 40, no. 3 (May 2001): 610–20. https://doi.org/10.1046/j.1365-2958.2001.02401.x.Full Text Link to Item
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Hu, G., S. Yi, B. C. Roberts, C. E. Hayes, W. A. Schell, J. R. Perfect, and W. C. Fowler. “In vitro susceptibilities of ocular isolates in fungal keratitis to posaconazole, a new triazole antifungal agent.” Investigative Ophthalmology & Visual Science 42, no. 4 (March 15, 2001): S580–S580.Link to Item
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Luberto, C., D. L. Toffaletti, E. A. Wills, S. C. Tucker, A. Casadevall, J. R. Perfect, Y. A. Hannun, and M. Del Poeta. “Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans.” Genes Dev 15, no. 2 (January 15, 2001): 201–12. https://doi.org/10.1101/gad.856001.Full Text Link to Item
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Cox, G. M., H. C. McDade, S. C. Chen, S. C. Tucker, M. Gottfredsson, L. C. Wright, T. C. Sorrell, et al. “Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans.” Mol Microbiol 39, no. 1 (January 2001): 166–75. https://doi.org/10.1046/j.1365-2958.2001.02236.x.Full Text Link to Item
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Lengeler, K. B., P. Wang, G. M. Cox, J. R. Perfect, and J. Heitman. “Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct.” Proc Natl Acad Sci U S A 97, no. 26 (December 19, 2000): 14455–60. https://doi.org/10.1073/pnas.97.26.14455.Full Text Link to Item
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Dodds, E. S., R. H. Drew, and J. R. Perfect. “Antifungal pharmacodynamics: review of the literature and clinical applications.” Pharmacotherapy 20, no. 11 (November 2000): 1335–55. https://doi.org/10.1592/phco.20.17.1335.34901.Full Text Link to Item
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Drew, R. H., J. R. Perfect, L. Srinath, E. Kurkimilis, M. Dowzicky, and G. H. Talbot. “Treatment of methicillin-resistant staphylococcus aureus infections with quinupristin-dalfopristin in patients intolerant of or failing prior therapy. For the Synercid Emergency-Use Study Group.” J Antimicrob Chemother 46, no. 5 (November 2000): 775–84. https://doi.org/10.1093/jac/46.5.775.Full Text Link to Item
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Perfect, J. R., and G. M. Cox. “Virulence mechanisms for fungi, Part II.” Clinical Microbiology Newsletter 22, no. 16 (August 15, 2000): 121–25. https://doi.org/10.1016/S0196-4399(01)80001-5.Full Text
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Perfect, J. R., and G. M. Cox. “Virulence mechanisms for fungi, Part I.” Clinical Microbiology Newsletter 22, no. 15 (August 1, 2000): 113–19. https://doi.org/10.1016/S0196-4399(00)90003-5.Full Text
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Görlach, J., D. S. Fox, N. S. Cutler, G. M. Cox, J. R. Perfect, and J. Heitman. “Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.” Embo J 19, no. 14 (July 17, 2000): 3618–29. https://doi.org/10.1093/emboj/19.14.3618.Full Text Link to Item
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Wills, E. A., M. R. Redinbo, J. R. Perfect, and M. Del Poeta. “New potential targets for antifungal development.” Expert Opinion on Therapeutic Targets 4, no. 3 (June 1, 2000): 265–96. https://doi.org/10.1517/14728222.4.3.265.Full Text
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Alspaugh, J. A., L. M. Cavallo, J. R. Perfect, and J. Heitman. “RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans.” Mol Microbiol 36, no. 2 (April 2000): 352–65. https://doi.org/10.1046/j.1365-2958.2000.01852.x.Full Text Link to Item
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Luna, B., R. H. Drew, and J. R. Perfect. “Agents for treatment of invasive fungal infections.” Otolaryngol Clin North Am 33, no. 2 (April 2000): 277–99. https://doi.org/10.1016/s0030-6665(00)80005-5.Full Text Link to Item
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Saag, M. S., R. J. Graybill, R. A. Larsen, P. G. Pappas, J. R. Perfect, W. G. Powderly, J. D. Sobel, and W. E. Dismukes. “Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America.” Clin Infect Dis 30, no. 4 (April 2000): 710–18. https://doi.org/10.1086/313757.Full Text Link to Item
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Del Poeta, M., M. C. Cruz, M. E. Cardenas, J. R. Perfect, and J. Heitman. “Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.” Antimicrob Agents Chemother 44, no. 3 (March 2000): 739–46. https://doi.org/10.1128/AAC.44.3.739-746.2000.Full Text Link to Item
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Cox, G. M., J. Mukherjee, G. T. Cole, A. Casadevall, and J. R. Perfect. “Urease as a virulence factor in experimental cryptococcosis.” Infect Immun 68, no. 2 (February 2000): 443–48. https://doi.org/10.1128/IAI.68.2.443-448.2000.Full Text Link to Item
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Klein, R. S., J. H. Arnsten, and J. D. Sobel. “Oropharyngeal Candida colonization and human immunodeficiency virus type 1 infection.” J Infect Dis 181, no. 2 (February 2000): 812–13. https://doi.org/10.1086/315290.Full Text Link to Item
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Cruz, M. C., M. Del Poeta, P. Wang, R. Wenger, G. Zenke, V. F. Quesniaux, N. R. Movva, J. R. Perfect, M. E. Cardenas, and J. Heitman. “Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.” Antimicrob Agents Chemother 44, no. 1 (January 2000): 143–49. https://doi.org/10.1128/AAC.44.1.143-149.2000.Full Text Link to Item
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Deepe, G. S., L. Romani, V. L. Calich, G. Huffnagle, C. Arruda, E. E. Molinari-Madlum, and J. R. Perfect. “Knockout mice as experimental models of virulence.” Med Mycol 38 Suppl 1 (2000): 87–98.Link to Item
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Gottfredsson, M., and J. R. Perfect. “Fungal meningitis.” Semin Neurol 20, no. 3 (2000): 307–22. https://doi.org/10.1055/s-2000-9394.Full Text Link to Item
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Nichols, W. G., R. L. McCann, and J. R. Perfect. “Tuberculous pseudoaneurysm of the thoracoabdominal aorta: Case and review.” Infectious Diseases in Clinical Practice 9, no. 1 (January 1, 2000): 3–9. https://doi.org/10.1097/00019048-200009010-00004.Full Text
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Wang, P., J. R. Perfect, and J. Heitman. “The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.” Mol Cell Biol 20, no. 1 (January 2000): 352–62. https://doi.org/10.1128/MCB.20.1.352-362.2000.Full Text Link to Item
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Hadjiliadis, D., D. N. Howell, R. D. Davis, C. M. Lawrence, J. B. Rea, V. F. Tapson, J. R. Perfect, and S. M. Palmer. “Anastomotic infections in lung transplant recipients.” Ann Transplant 5, no. 3 (2000): 13–19.Link to Item
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Powderly, W. G., J. E. Gallant, M. A. Ghannoum, K. H. Mayer, E. E. Navarro, and J. R. Perfect. “Oropharyngeal candidiasis in patients with HIV: suggested guidelines for therapy.” Aids Res Hum Retroviruses 15, no. 18 (December 10, 1999): 1619–23. https://doi.org/10.1089/088922299309658.Full Text Link to Item
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Del Poeta, M., S. F. Chen, D. Von Hoff, C. C. Dykstra, M. C. Wani, G. Manikumar, J. Heitman, M. E. Wall, and J. R. Perfect. “Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.” Antimicrob Agents Chemother 43, no. 12 (December 1999): 2862–68. https://doi.org/10.1128/AAC.43.12.2862.Full Text Link to Item
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Yue, C., L. M. Cavallo, J. A. Alspaugh, P. Wang, G. M. Cox, J. R. Perfect, and J. Heitman. “The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans.” Genetics 153, no. 4 (December 1999): 1601–15. https://doi.org/10.1093/genetics/153.4.1601.Full Text Link to Item
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Powderly, W. G., K. H. Mayer, and J. R. Perfect. “Diagnosis and treatment of oropharyngeal candidiasis in patients infected with HIV: a critical reassessment.” Aids Res Hum Retroviruses 15, no. 16 (November 1, 1999): 1405–12. https://doi.org/10.1089/088922299309900.Full Text Link to Item
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Cardenas, M. E., M. C. Cruz, M. Del Poeta, N. Chung, J. R. Perfect, and J. Heitman. “Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action.” Clin Microbiol Rev 12, no. 4 (October 1999): 583–611. https://doi.org/10.1128/CMR.12.4.583.Full Text Link to Item
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Del Poeta, M., A. S. Bixel, F. Barchiesi, R. R. Tidwell, D. Boykin, G. Scalise, and J. R. Perfect. “In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp.” J Antimicrob Chemother 44, no. 2 (August 1999): 223–28. https://doi.org/10.1093/jac/44.2.223.Full Text Link to Item
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Gottfredsson, M., G. M. Cox, O. S. Indridason, G. M. de Almeida, A. E. Heald, and J. R. Perfect. “Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization.” J Infect Dis 180, no. 2 (August 1999): 534–37. https://doi.org/10.1086/314887.Full Text Link to Item
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Perfect, John R., and Gary M. Cox. “Drug resistance in Cryptococcus neoformans.” Drug Resist Updat 2, no. 4 (August 1999): 259–69. https://doi.org/10.1054/drup.1999.0090.Full Text Link to Item
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Cruz, M. C., L. M. Cavallo, J. M. Görlach, G. Cox, J. R. Perfect, M. E. Cardenas, and J. Heitman. “Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.” Mol Cell Biol 19, no. 6 (June 1999): 4101–12. https://doi.org/10.1128/MCB.19.6.4101.Full Text Link to Item
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Asai, K., N. Tsuchimori, K. Okonogi, J. R. Perfect, O. Gotoh, and Y. Yoshida. “Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450.” Antimicrob Agents Chemother 43, no. 5 (May 1999): 1163–69. https://doi.org/10.1128/AAC.43.5.1163.Full Text Link to Item
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Del Poeta, M., D. L. Toffaletti, T. H. Rude, C. C. Dykstra, J. Heitman, and J. R. Perfect. “Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target.” Genetics 152, no. 1 (May 1999): 167–78. https://doi.org/10.1093/genetics/152.1.167.Full Text Link to Item
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Poeta, M. del, D. L. Toffaletti, T. H. Rude, S. D. Sparks, J. Heitman, and J. R. Perfect. “Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein.” Infect Immun 67, no. 4 (April 1999): 1812–20. https://doi.org/10.1128/IAI.67.4.1812-1820.1999.Full Text Link to Item
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Gottfredsson, M., and J. R. Perfect. “Use of antifungal agents in the intensive care unit.” Current Opinion in Critical Care 5, no. 5 (January 1, 1999): 381–90. https://doi.org/10.1097/00075198-199910000-00008.Full Text
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Thompson, J. R., C. M. Douglas, W. Li, C. K. Jue, B. Pramanik, X. Yuan, T. H. Rude, D. L. Toffaletti, J. R. Perfect, and M. Kurtz. “A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function.” J Bacteriol 181, no. 2 (January 1999): 444–53. https://doi.org/10.1128/JB.181.2.444-453.1999.Full Text Link to Item
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Heitman, J., A. Casadevall, J. K. Lodge, and J. R. Perfect. “The Cryptococcus neoformans genome sequencing project.” Mycopathologia 148, no. 1 (1999): 1–7. https://doi.org/10.1023/a:1007136602930.Full Text Link to Item
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Perfect, J. R., B. Wong, Y. C. Chang, K. J. Kwon-Chung, and P. R. Williamson. “Cryptococcus neoformans: Virulence and host defences.” Journal of Medical and Veterinary Mycology 3 (December 1, 1998): 79–86.
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Gottfredsson, M., G. M. Cox, and J. R. Perfect. “Molecular methods for epidemiological and diagnostic studies of fungal infections.” Pathology 30, no. 4 (November 1998): 405–18. https://doi.org/10.1080/00313029800169726.Full Text Link to Item
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Del Poeta, M., W. A. Schell, C. C. Dykstra, S. K. Jones, R. R. Tidwell, A. Kumar, D. W. Boykin, and J. R. Perfect. “In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles.” Antimicrob Agents Chemother 42, no. 10 (October 1998): 2503–10. https://doi.org/10.1128/AAC.42.10.2503.Full Text Link to Item
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Palmer, S. M., J. R. Perfect, D. N. Howell, C. M. Lawrence, A. P. Miralles, R. D. Davis, and V. F. Tapson. “Candidal anastomotic infection in lung transplant recipients: successful treatment with a combination of systemic and inhaled antifungal agents.” J Heart Lung Transplant 17, no. 10 (October 1998): 1029–33.Link to Item
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Alspaugh, J. A., J. R. Perfect, and J. Heitman. “Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans.” Fungal Genet Biol 25, no. 1 (October 1998): 1–14. https://doi.org/10.1006/fgbi.1998.1079.Full Text Link to Item
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Del Poeta, M., W. A. Schell, C. C. Dykstra, S. Jones, R. R. Tidwell, A. Czarny, M. Bajic, A. Kumar, D. Boykin, and J. R. Perfect. “Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.” Antimicrob Agents Chemother 42, no. 10 (October 1998): 2495–2502. https://doi.org/10.1128/AAC.42.10.2495.Full Text Link to Item
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Schell, W. A., G. M. De Almeida, R. K. Dodge, K. Okonogi, and J. R. Perfect. “In vitro and in vivo efficacy of the triazole TAK-187 against Cryptococcus neoformans.” Antimicrob Agents Chemother 42, no. 10 (October 1998): 2630–32. https://doi.org/10.1128/AAC.42.10.2630.Full Text Link to Item
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Schell, Wiley A., Katharine Liu, David N. Howell, and John R. Perfect. “The Phenomenon of Adventitious Sporulation.” American Journal of Clinical Pathology 110, no. 1 (July 1, 1998): 129–129. https://doi.org/10.1093/ajcp/110.1.129.Full Text
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Walsh, T. J., J. W. Hiemenz, N. L. Seibel, J. R. Perfect, G. Horwith, L. Lee, J. L. Silber, et al. “Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases.” Clin Infect Dis 26, no. 6 (June 1998): 1383–96. https://doi.org/10.1086/516353.Full Text Link to Item
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Firestine, S. M., S. Misialek, D. L. Toffaletti, T. J. Klem, J. R. Perfect, and V. J. Davisson. “Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.” Arch Biochem Biophys 351, no. 1 (March 1, 1998): 123–34. https://doi.org/10.1006/abbi.1997.0512.Full Text Link to Item
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Perfect, J. R., B. Wong, Y. C. Chang, K. J. Kwon-Chung, and P. R. Williamson. “Cryptococcus neoformans: virulence and host defences.” Med Mycol 36 Suppl 1 (1998): 79–86.Link to Item
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Johnson, M. D., R. H. Drew, and J. R. Perfect. “Chest discomfort associated with liposomal amphotericin B: report of three cases and review of the literature.” Pharmacotherapy 18, no. 5 (1998): 1053–61.Link to Item
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Liu, K., D. N. Howell, J. R. Perfect, and W. A. Schell. “Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology.” Am J Clin Pathol 109, no. 1 (January 1998): 45–54. https://doi.org/10.1093/ajcp/109.1.45.Full Text Link to Item
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Anderson, N., R. Drew, S. Hayward, J. Perfect, and C. D. Hamilton. “A successful program to optimize use of Amphotericin B Lipid Complex (ABLC) at an academic medical center.” Clinical Infectious Diseases 25, no. 2 (December 1, 1997): 434.
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Pappas, P., J. Perfect, H. Henderson, C. Kauffman, M. Saccente, D. Haas, G. Pankey, et al. “Cryptococcosis in non-HIV infected patients: A multicemer survey.” Clinical Infectious Diseases 25, no. 2 (December 1, 1997): 379.
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Alspaugh, J. A., J. R. Perfect, and J. Heitman. “Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.” Genes Dev 11, no. 23 (December 1, 1997): 3206–17. https://doi.org/10.1101/gad.11.23.3206.Full Text Link to Item
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Alspaugh, J. A., J. R. Perfect, and J. Heitman. “GPA1 regulates capsule formation, melanin production, mating, and virulence in Cryptococcus neoformans.” Clinical Infectious Diseases 25, no. 2 (December 1, 1997): 356.
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Toffaletti, D. L., and J. R. Perfect. “Study of Cryptococcus neoformans actin gene regulation with a β-galactosidase-actin fusion.” Journal of Medical and Veterinary Mycology 35, no. 5 (November 24, 1997): 313–20.
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Alexander, B. D., and J. R. Perfect. “Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches.” Drugs 54, no. 5 (November 1997): 657–78. https://doi.org/10.2165/00003495-199754050-00002.Full Text Link to Item
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Del Poeta, M., W. A. Schell, and J. R. Perfect. “In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds.” Antimicrob Agents Chemother 41, no. 8 (August 1997): 1835–36. https://doi.org/10.1128/AAC.41.8.1835.Full Text Link to Item
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Odom, A., S. Muir, E. Lim, D. L. Toffaletti, J. Perfect, and J. Heitman. “Calcineurin is required for virulence of Cryptococcus neoformans.” Embo J 16, no. 10 (May 15, 1997): 2576–89. https://doi.org/10.1093/emboj/16.10.2576.Full Text Link to Item
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Alspaugh, J. A., and J. R. Perfect. “Infections due to zygomycetes and other rare fungal opportunists.” Seminars in Respiratory and Critical Care Medicine 18, no. 3 (January 1, 1997): 265–79. https://doi.org/10.1055/s-2008-1070996.Full Text
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Odom, A., M. Del Poeta, J. Perfect, and J. Heitman. “The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.” Antimicrob Agents Chemother 41, no. 1 (January 1997): 156–61. https://doi.org/10.1128/AAC.41.1.156.Full Text Link to Item
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Toffaletti, D. L., and J. R. Perfect. “Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion.” J Med Vet Mycol 35, no. 5 (1997): 313–20.Link to Item
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Hajjar, S. al-, J. Perfect, F. Hashem, H. Tufenkeji, and S. Kayes. “Orbitofascial conidiobolomycosis in a child.” Pediatr Infect Dis J 15, no. 12 (December 1996): 1130–32. https://doi.org/10.1097/00006454-199612000-00018.Full Text Link to Item
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Perfect, J. R., T. H. Rude, B. Wong, T. Flynn, V. Chaturvedi, and W. Niehaus. “Identification of a Cryptococcus neoformans gene that directs expression of the cryptic Saccharomyces cerevisiae mannitol dehydrogenase gene.” J Bacteriol 178, no. 17 (September 1996): 5257–62. https://doi.org/10.1128/jb.178.17.5257-5262.1996.Full Text Link to Item
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Salas, S. D., J. E. Bennett, K. J. Kwon-Chung, J. R. Perfect, and P. R. Williamson. “Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans.” J Exp Med 184, no. 2 (August 1, 1996): 377–86. https://doi.org/10.1084/jem.184.2.377.Full Text Link to Item
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Perfect, J. R., G. M. Cox, R. K. Dodge, and W. A. Schell. “In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans.” Antimicrob Agents Chemother 40, no. 8 (August 1996): 1910–13. https://doi.org/10.1128/AAC.40.8.1910.Full Text Link to Item
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Perfect, J. R. “Fungal virulence genes as targets for antifungal chemotherapy.” Antimicrob Agents Chemother 40, no. 7 (July 1996): 1577–83. https://doi.org/10.1128/AAC.40.7.1577.Full Text Link to Item
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Cohen, A., M. Tepperberg, B. Waters-Pick, D. Coniglio, J. Perfect, W. P. Peters, C. Gilbert, C. Morgan, and J. J. Vredenburgh. “The significance of microbial cultures of the hematopoietic support for patients receiving high-dose chemotherapy.” J Hematother 5, no. 3 (June 1996): 289–94. https://doi.org/10.1089/scd.1.1996.5.289.Full Text Link to Item
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Heinz, T., J. Perfect, W. Schell, E. Ritter, G. Ruff, and D. Serafin. “Soft-tissue fungal infections: surgical management of 12 immunocompromised patients.” Plast Reconstr Surg 97, no. 7 (June 1996): 1391–99. https://doi.org/10.1097/00006534-199606000-00011.Full Text Link to Item
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Bodily, K., J. R. Perfect, G. Procop, M. K. Washington, and J. Affronti. “Small intestinal histoplasmosis: successful treatment with itraconazole in an immunocompetent host.” Gastrointest Endosc 43, no. 5 (May 1996): 518–21. https://doi.org/10.1016/s0016-5107(96)70300-0.Full Text Link to Item
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Schell, W. A., and J. R. Perfect. “Fatal, disseminated Acremonium strictum infection in a neutropenic host.” J Clin Microbiol 34, no. 5 (May 1996): 1333–36. https://doi.org/10.1128/jcm.34.5.1333-1336.1996.Full Text Link to Item
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Kanj, S. S., K. Welty-Wolf, J. Madden, V. Tapson, M. A. Baz, R. D. Davis, and J. R. Perfect. “Fungal infections in lung and heart-lung transplant recipients. Report of 9 cases and review of the literature.” Medicine (Baltimore) 75, no. 3 (May 1996): 142–56. https://doi.org/10.1097/00005792-199605000-00004.Full Text Link to Item
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Perfect, J. R., and W. A. Schell. “The new fungal opportunists are coming.” Clin Infect Dis 22 Suppl 2 (May 1996): S112–18. https://doi.org/10.1093/clinids/22.supplement_2.s112.Full Text Link to Item
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Heald, A. E., G. M. Cox, W. A. Schell, J. A. Bartlett, and J. R. Perfect. “Oropharyngeal yeast flora and fluconazole resistance in HIV-infected patients receiving long-term continuous versus intermittent fluconazole therapy.” Aids 10, no. 3 (March 1996): 263–68. https://doi.org/10.1097/00002030-199603000-00004.Full Text Link to Item
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Cox, G. M., D. L. Toffaletti, and J. R. Perfect. “Dominant selection system for use in Cryptococcus neoformans.” Journal of Medical and Veterinary Mycology 34, no. 6 (January 1, 1996): 385–91. https://doi.org/10.1080/02681219680000691.Full Text
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Kauffman, C. A., P. G. Pappas, D. S. McKinsey, R. A. Greenfield, J. R. Perfect, G. A. Cloud, C. J. Thomas, and W. E. Dismukes. “Treatment of lymphocutaneous and visceral sporotrichosis with fluconazole.” Clin Infect Dis 22, no. 1 (January 1996): 46–50. https://doi.org/10.1093/clinids/22.1.46.Full Text Link to Item
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Cox, G. M., D. L. Toffaletti, and J. R. Perfect. “Dominant selection system for use in Cryptococcus neoformans.” J Med Vet Mycol 34, no. 6 (1996): 385–91.Link to Item
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Fuller, R. E., R. H. Drew, and J. R. Perfect. “Treatment of vancomycin-resistant enterococci, with a focus on quinupristin-dalfopristin.” Pharmacotherapy 16, no. 4 (1996): 584–92.Link to Item
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Perfect, John R. “Molecular targets for new antifungal drugs.” Canadian Journal of Botany 73, no. S1 (December 31, 1995): 1187–91. https://doi.org/10.1139/b95-377.Full Text
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Morris, A., W. A. Schell, D. McDonagh, S. Chaffee, and J. R. Perfect. “Pneumonia due to Fonsecaea pedrosoi and cerebral abscesses due to Emericella nidulans in a bone marrow transplant recipient.” Clin Infect Dis 21, no. 5 (November 1995): 1346–48. https://doi.org/10.1093/clinids/21.5.1346.Full Text Link to Item
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Mitchell, T. G., and J. R. Perfect. “Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans.” Clin Microbiol Rev 8, no. 4 (October 1995): 515–48. https://doi.org/10.1128/CMR.8.4.515.Full Text Link to Item
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Pappas, P. G., C. A. Kauffman, J. Perfect, P. C. Johnson, D. S. McKinsey, D. M. Bamberger, R. Hamill, P. K. Sharkey, S. W. Chapman, and J. D. Sobel. “Alopecia associated with fluconazole therapy.” Ann Intern Med 123, no. 5 (September 1, 1995): 354–57. https://doi.org/10.7326/0003-4819-123-5-199509010-00006.Full Text Link to Item
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Berg, D., J. A. Garcia, W. A. Schell, J. R. Perfect, and J. C. Murray. “Cutaneous infection caused by Curvularia pallescens: a case report and review of the spectrum of disease.” J Am Acad Dermatol 32, no. 2 Pt 2 (February 1995): 375–78. https://doi.org/10.1016/0190-9622(95)90408-5.Full Text Link to Item
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Cox, G. M., T. H. Rude, C. C. Dykstra, and J. R. Perfect. “The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis.” J Med Vet Mycol 33, no. 4 (1995): 261–66. https://doi.org/10.1080/02681219580000521.Full Text Link to Item
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Lodge, J. K., E. Jackson-Machelski, D. L. Toffaletti, J. R. Perfect, and J. I. Gordon. “Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans.” Proc Natl Acad Sci U S A 91, no. 25 (December 6, 1994): 12008–12. https://doi.org/10.1073/pnas.91.25.12008.Full Text Link to Item
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Casadevall, A., J. Mukherjee, R. Yuan, and J. Perfect. “Management of injuries caused by Cryptococcus neoformans--contaminated needles.” Clin Infect Dis 19, no. 5 (November 1994): 951–53. https://doi.org/10.1093/clinids/19.5.951.Full Text Link to Item
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DENNING, D. W., J. Y. LEE, J. S. HOSTETLER, P. PAPPAS, C. A. KAUFFMAN, D. H. DEWSNUP, J. N. GALGIANI, et al. “NIAID MYCOSES STUDY-GROUP MULTICENTER TRIAL OF ORAL ITRACONAZOLE THERAPY FOR INVASIVE ASPERGILLOSIS (VOL 97, PG 135, 1994).” American Journal of Medicine 97, no. 5 (November 1, 1994): 497–497.Link to Item
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Cox, G. M., W. A. Schell, R. L. Scher, and J. R. Perfect. “First report of involvement of Nodulisporium species in human disease.” J Clin Microbiol 32, no. 9 (September 1994): 2301–4. https://doi.org/10.1128/jcm.32.9.2301-2304.1994.Full Text Link to Item
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Denning, D. W., J. Y. Lee, J. S. Hostetler, P. Pappas, C. A. Kauffman, D. H. Dewsnup, J. N. Galgiani, J. R. Graybill, A. M. Sugar, and A. Catanzaro. “NIAID Mycoses Study Group Multicenter Trial of Oral Itraconazole Therapy for Invasive Aspergillosis.” Am J Med 97, no. 2 (August 1994): 135–44. https://doi.org/10.1016/0002-9343(94)90023-x.Full Text Link to Item
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Gilbert, C., B. Meisenberg, J. Vredenburgh, M. Ross, A. Hussein, J. Perfect, and W. P. Peters. “Sequential prophylactic oral and empiric once-daily parenteral antibiotics for neutropenia and fever after high-dose chemotherapy and autologous bone marrow support.” J Clin Oncol 12, no. 5 (May 1994): 1005–11. https://doi.org/10.1200/JCO.1994.12.5.1005.Full Text Link to Item
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Denning, D. W., J. Y. Lee, J. S. Hostetler, P. Pappas, C. A. Kauffman, D. H. Dewsnup, J. N. Galgiani, et al. “Erratum: NIAID mycoses study group multicenter trial of oral itraconazole therapy for invasive aspergillosis (American Journal of Medicine (August 1994) 97 (135-144)).” American Journal of Medicine 97, no. 5 (January 1, 1994): 497. https://doi.org/10.1016/0002-9343(94)90341-7.Full Text
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Lortholary, O., J. Robert, and J. Le Bras. “[Epidemiology of chemoresistant Plasmodium falciparum].” Ann Med Interne (Paris) 145, no. 6 (1994): 429–32.Link to Item
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Perfect, J. R. “Role of classic dimorphic pathogens in contemporary mycoses.” Infectious Diseases in Clinical Practice 3 (January 1, 1994): S68–77. https://doi.org/10.1097/00019048-199403002-00005.Full Text
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Perfect, J. R., and K. A. Wright. “Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis.” J Antimicrob Chemother 33, no. 1 (January 1994): 73–81. https://doi.org/10.1093/jac/33.1.73.Full Text Link to Item
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Ingram, C. W., H. B. Haywood, V. M. Morris, R. L. Allen, and J. R. Perfect. “Cryptococcal ventricular-peritoneal shunt infection: clinical and epidemiological evaluation of two closely associated cases.” Infect Control Hosp Epidemiol 14, no. 12 (December 1993): 719–22. https://doi.org/10.1086/646675.Full Text Link to Item
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Perfect, J. R., N. Ketabchi, G. M. Cox, C. W. Ingram, and C. L. Beiser. “Karyotyping of Cryptococcus neoformans as an epidemiological tool.” J Clin Microbiol 31, no. 12 (December 1993): 3305–9. https://doi.org/10.1128/jcm.31.12.3305-3309.1993.Full Text Link to Item
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Cameron, M. L., W. A. Schell, S. Bruch, J. A. Bartlett, H. A. Waskin, and J. R. Perfect. “Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1.” Antimicrob Agents Chemother 37, no. 11 (November 1993): 2449–53. https://doi.org/10.1128/AAC.37.11.2449.Full Text Link to Item
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Perfect, J. R., D. L. Toffaletti, and T. H. Rude. “The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid.” Infect Immun 61, no. 10 (October 1993): 4446–51. https://doi.org/10.1128/iai.61.10.4446-4451.1993.Full Text Link to Item
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Sharkey-Mathis, P. K., C. A. Kauffman, J. R. Graybill, D. A. Stevens, J. S. Hostetler, G. Cloud, and W. E. Dismukes. “Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group.” Am J Med 95, no. 3 (September 1993): 279–85. https://doi.org/10.1016/0002-9343(93)90280-3.Full Text Link to Item
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Perfect, J. R., D. V. Savani, and D. T. Durack. “Uptake of itraconazole by alveolar macrophages.” Antimicrob Agents Chemother 37, no. 4 (April 1993): 903–4. https://doi.org/10.1128/AAC.37.4.903.Full Text Link to Item
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Toffaletti, D. L., T. H. Rude, S. A. Johnston, D. T. Durack, and J. R. Perfect. “Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA.” J Bacteriol 175, no. 5 (March 1993): 1405–11. https://doi.org/10.1128/jb.175.5.1405-1411.1993.Full Text Link to Item
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Perfect, J. R. “Antifungal prophylaxis: to prevent or not.” Am J Med 94, no. 3 (March 1993): 233–34. https://doi.org/10.1016/0002-9343(93)90053-r.Full Text Link to Item
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Cox, G. M., and J. R. Perfect. “Fungal infections.” Current Opinion in Infectious Diseases 6, no. 3 (January 1, 1993): 422–26.
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PERFECT, J. R. “Uptake of itraconazole by alveolar macrophages.” Antimicrob Agents Chemother 37 (1993): 903–4.
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Perfect, J. R., W. A. Schell, and M. G. Rinaldi. “Uncommon invasive fungal pathogens in the acquired immunodeficiency syndrome.” J Med Vet Mycol 31, no. 2 (1993): 175–79. https://doi.org/10.1080/02681219380000211.Full Text Link to Item
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Perfect, J. R., T. H. Rude, L. M. Penning, and S. A. Johnson. “Cloning the Cryptococcus neoformans TRP1 gene by complementation in Saccharomyces cerevisiae.” Gene 122, no. 1 (December 1, 1992): 213–17. https://doi.org/10.1016/0378-1119(92)90053-r.Full Text Link to Item
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Perfect, J. R. “Fungal infections.” Current Opinion in Infectious Diseases 5, no. 3 (June 19, 1992): 433–36. https://doi.org/10.1097/00001432-199206000-00020.Full Text
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Perfect, J. R., M. E. Klotman, C. C. Gilbert, D. D. Crawford, G. L. Rosner, K. A. Wright, and W. P. Peters. “Prophylactic intravenous amphotericin B in neutropenic autologous bone marrow transplant recipients.” J Infect Dis 165, no. 5 (May 1992): 891–97. https://doi.org/10.1093/infdis/165.5.891.Full Text Link to Item
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Carlson, A. N., G. N. Foulks, J. R. Perfect, and J. H. Kim. “Fungal scleritis after cataract surgery. Successful outcome using itraconazole.” Cornea 11, no. 2 (March 1992): 151–54. https://doi.org/10.1097/00003226-199203000-00010.Full Text Link to Item
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Goodwin, S. D., J. Fiedler-Kelly, T. H. Grasela, W. A. Schell, and J. R. Perfect. “A nationwide survey of clinical laboratory methodologies for fungal infections.” J Med Vet Mycol 30, no. 2 (1992): 153–60. https://doi.org/10.1080/02681219280000201.Full Text Link to Item
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Perfect, J. R., M. H. Lindsay, and R. H. Drew. “Adverse drug reactions to systemic antifungals. Prevention and management.” Drug Saf 7, no. 5 (1992): 323–63. https://doi.org/10.2165/00002018-199207050-00003.Full Text Link to Item
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Persons, D. A., M. Laughlin, D. Tanner, J. Perfect, J. P. Gockerman, and J. W. Hathorn. “Fluconazole and Candida krusei fungemia.” N Engl J Med 325, no. 18 (October 31, 1991): 1315.Link to Item
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PERFECT, J. R., M. G. RINALDI, M. G. WALSH, G. LOPEZBERESTEIN, R. SARAL, and R. D. DIAMOND. “FUNGAL-INFECTIONS IN THE IMMUNOCOMPROMISED HOST - DISCUSSION.” Reviews of Infectious Diseases 13, no. 3 (May 1, 1991): 504–8.Link to Item
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Perfect, J. R. “Discussion: Fungal infections in the immunocompromised host.” Reviews of Infectious Diseases 13, no. 3 (January 1, 1991): 504–8.
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Perfect, J. R. “Management of the immunocompromised patient: impact of fungal infections. Introduction.” Rev Infect Dis 13, no. 3 (1991): 473.Link to Item
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Perfect, J. R., W. W. Pickard, D. L. Hunt, B. Palmer, and W. A. Schell. “The use of amphotericin B in nosocomial fungal infection.” Rev Infect Dis 13, no. 3 (1991): 474–79. https://doi.org/10.1093/clinids/13.3.474.Full Text Link to Item
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Wright, K. A., J. R. Perfect, and W. Ritter. “The pharmacokinetics of BAY R3783 and its efficacy in the treatment of experimental cryptococcal meningitis.” J Antimicrob Chemother 26, no. 3 (September 1990): 387–97. https://doi.org/10.1093/jac/26.3.387.Full Text Link to Item
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Hobbs, M. M., J. R. Perfect, D. L. Granger, and D. T. Durack. “Opsonic activity of cerebrospinal fluid in experimental cryptococcal meningitis.” Infect Immun 58, no. 7 (July 1990): 2115–19. https://doi.org/10.1128/iai.58.7.2115-2119.1990.Full Text Link to Item
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Wong, B., J. R. Perfect, S. Beggs, and K. A. Wright. “Production of the hexitol D-mannitol by Cryptococcus neoformans in vitro and in rabbits with experimental meningitis.” Infect Immun 58, no. 6 (June 1990): 1664–70. https://doi.org/10.1128/iai.58.6.1664-1670.1990.Full Text Link to Item
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Dukes, C. S., and J. R. Perfect. “Amphotericin B-induced malignant hypertensive episodes.” J Infect Dis 161, no. 3 (March 1990): 588. https://doi.org/10.1093/infdis/161.3.588.Full Text Link to Item
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Granger, D. L., J. B. Hibbs, J. R. Perfect, and D. T. Durack. “Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.” J Clin Invest 85, no. 1 (January 1990): 264–73. https://doi.org/10.1172/JCI114422.Full Text Link to Item
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Perfect, J. R. “Antifungal therapy and its use in surgical treatment.” Surg Gynecol Obstet 171 Suppl (1990): 41–48.Link to Item
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Perfect, J. R. “Antifungal therapy for infections of the compromised host.” Current Opinion in Infectious Diseases 3, no. 2 (January 1, 1990): 221–24. https://doi.org/10.1097/00001432-199004000-00014.Full Text
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Perfect, J. R. “Fluconazole therapy for experimental cryptococcosis and candidiasis in the rabbit.” Rev Infect Dis 12 Suppl 3 (1990): S299–302. https://doi.org/10.1093/clinids/12.supplement_3.s299.Full Text Link to Item
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Shaunak, S., W. A. Schell, and J. R. Perfect. “Cryptococcal meningitis with normal cerebrospinal fluid.” J Infect Dis 160, no. 5 (November 1989): 912. https://doi.org/10.1093/infdis/160.5.912.Full Text Link to Item
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Perfect, J. R., K. A. Wright, M. M. Hobbs, and D. T. Durack. “Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304.” Antimicrob Agents Chemother 33, no. 10 (October 1989): 1735–40. https://doi.org/10.1128/AAC.33.10.1735.Full Text Link to Item
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Perfect, J. R., M. M. Hobbs, K. A. Wright, and D. T. Durack. “Treatment of experimental disseminated candidiasis with cilofungin.” Antimicrob Agents Chemother 33, no. 10 (October 1989): 1811–12. https://doi.org/10.1128/AAC.33.10.1811.Full Text Link to Item
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Perfect, J. R., B. B. Magee, and P. T. Magee. “Separation of chromosomes of Cryptococcus neoformans by pulsed field gel electrophoresis.” Infect Immun 57, no. 9 (September 1989): 2624–27. https://doi.org/10.1128/iai.57.9.2624-2627.1989.Full Text Link to Item
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Perfect, J. R. “Cryptococcosis.” Infect Dis Clin North Am 3, no. 1 (March 1989): 77–102.Link to Item
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Herzog, W., J. Perfect, and L. Roberts. “Intervertebral diskitis due to Candida tropicalis.” South Med J 82, no. 2 (February 1989): 270–73. https://doi.org/10.1097/00007611-198902000-00029.Full Text Link to Item
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Perfect, J. R. “Antifungal therapy 1989.” Current Opinion in Infectious Diseases 2, no. 4 (January 1, 1989): 568–71. https://doi.org/10.1097/00001432-198908000-00012.Full Text
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Sane, A., S. Manzi, J. Perfect, A. J. Herzberg, and J. O. Moore. “Deferoxamine treatment as a risk factor for zygomycete infection.” J Infect Dis 159, no. 1 (January 1989): 151–52. https://doi.org/10.1093/infdis/159.1.151.Full Text Link to Item
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Ingram, C. W., J. Sennesh, J. N. Cooper, and J. R. Perfect. “Disseminated zygomycosis: report of four cases and review.” Rev Infect Dis 11, no. 5 (1989): 741–54. https://doi.org/10.1093/clinids/11.5.741.Full Text Link to Item
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Kaplan, A. H., D. J. Weber, E. Z. Oddone, and J. R. Perfect. “Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review.” Rev Infect Dis 11, no. 1 (1989): 46–63. https://doi.org/10.1093/clinids/11.1.46.Full Text Link to Item
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Kim, J. H., and J. R. Perfect. “Infection and cyclosporine.” Rev Infect Dis 11, no. 5 (1989): 677–90. https://doi.org/10.1093/clinids/11.5.677.Full Text Link to Item
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Yadav, S. S., J. Perfect, and A. H. Friedman. “Successful treatment of cryptococcal ventriculoatrial shunt infection with systemic therapy alone.” Neurosurgery 23, no. 3 (September 1988): 372–73. https://doi.org/10.1227/00006123-198809000-00017.Full Text
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Drew, R. H., J. R. Perfect, and H. A. Gallis. “Use of fluconazole in a patient with documented malabsorption of ketoconazole.” Clin Pharm 7, no. 8 (August 1988): 622–23.Link to Item
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Granger, D. L., J. B. Hibbs, J. R. Perfect, and D. T. Durack. “Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.” J Clin Invest 81, no. 4 (April 1988): 1129–36. https://doi.org/10.1172/JCI113427.Full Text Link to Item
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Perfect, J. R., M. M. Hobbs, D. L. Granger, and D. T. Durack. “Cerebrospinal fluid macrophage response to experimental cryptococcal meningitis: relationship between in vivo and in vitro measurements of cytotoxicity.” Infect Immun 56, no. 4 (April 1988): 849–54. https://doi.org/10.1128/iai.56.4.849-854.1988.Full Text Link to Item
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Hobbs, M., J. Perfect, and D. Durack. “Evaluation of in vitro antifungal activity of LY121019.” Eur J Clin Microbiol Infect Dis 7, no. 1 (February 1988): 77–80. https://doi.org/10.1007/BF01962182.Full Text Link to Item
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Perfect, J. R. “Antifungal therapy.” Current Opinion in Infectious Diseases 1, no. 4 (January 1, 1988): 590–94. https://doi.org/10.1097/00001432-198807000-00012.Full Text
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Kim, J. H., and J. R. Perfect. “To help the sick: an historical and ethical essay concerning the refusal to care for patients with AIDS.” Am J Med 84, no. 1 (January 1988): 135–38. https://doi.org/10.1016/0002-9343(88)90021-6.Full Text Link to Item
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Perfect, J. R. “Mycobacterium avium-intracellulare complex infections in the acquired immunodeficiency syndrome.” J Electron Microsc Tech 8, no. 1 (January 1988): 105–13. https://doi.org/10.1002/jemt.1060080107.Full Text Link to Item
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Perfect, J. R., D. L. Granger, and D. T. Durack. “Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells.” J Infect Dis 156, no. 2 (August 1987): 316–23. https://doi.org/10.1093/infdis/156.2.316.Full Text Link to Item
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Gross, M. H., W. W. Pickard, and J. R. Perfect. “Retrospective review of amphotericin B use in a tertiary-care medical center.” Am J Hosp Pharm 44, no. 6 (June 1987): 1353–57.Link to Item
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Lallinger, G. J., S. L. Reiner, D. W. Cooke, D. L. Toffaletti, J. R. Perfect, D. L. Granger, and D. T. Durack. “Efficacy of immune therapy in early experimental Naegleria fowleri meningitis.” Infect Immun 55, no. 5 (May 1987): 1289–93. https://doi.org/10.1128/iai.55.5.1289-1293.1987.Full Text Link to Item
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Savani, D. V., J. R. Perfect, L. M. Cobo, and D. T. Durack. “Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis.” Antimicrob Agents Chemother 31, no. 1 (January 1987): 6–10. https://doi.org/10.1128/AAC.31.1.6.Full Text Link to Item
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Granger, D. L., J. R. Perfect, and D. T. Durack. “Macrophage-mediated fungistasis: requirement for a macromolecular component in serum.” J Immunol 137, no. 2 (July 15, 1986): 693–701.Link to Item
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Perfect, J. R., D. V. Savani, and D. T. Durack. “Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.” Antimicrob Agents Chemother 29, no. 4 (April 1986): 579–83. https://doi.org/10.1128/AAC.29.4.579.Full Text Link to Item
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Granger, D. L., J. R. Perfect, and D. T. Durack. “Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity.” J Immunol 136, no. 2 (January 1986): 672–80.Link to Item
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PERFECT, J. R. “Comparison of itraconazole and flucanazole in the treatment of cryptococcal meningitis and Candida pyelonephritis in rabbits.” Antimicr Agents Chemoth 29 (1986): 579–83.
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Perfect, J. R., and D. T. Durack. “Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis.” Antimicrob Agents Chemother 28, no. 6 (December 1985): 751–55. https://doi.org/10.1128/AAC.28.6.751.Full Text Link to Item
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Perfect, J. R., and D. T. Durack. “Effects of cyclosporine in experimental cryptococcal meningitis.” Infect Immun 50, no. 1 (October 1985): 22–26. https://doi.org/10.1128/iai.50.1.22-26.1985.Full Text Link to Item
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Granger, D. L., J. R. Perfect, and D. T. Durack. “Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide.” J Clin Invest 76, no. 2 (August 1985): 508–16. https://doi.org/10.1172/JCI112000.Full Text Link to Item
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Perfect, J. R., and D. T. Durack. “Penetration of imidazoles and triazoles into cerebrospinal fluid of rabbits.” J Antimicrob Chemother 16, no. 1 (July 1985): 81–86. https://doi.org/10.1093/jac/16.1.81.Full Text Link to Item
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Perfect, J. R., and B. A. Seaworth. “Penile cryptococcosis with review of mycotic infections of penis.” Urology 25, no. 5 (May 1985): 528–31. https://doi.org/10.1016/0090-4295(85)90469-8.Full Text Link to Item
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Perfect, J. R., and D. T. Durack. “Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis.” Sabouraudia 23, no. 1 (February 1985): 37–45. https://doi.org/10.1080/00362178585380071.Full Text Link to Item
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Smego, R. A., P. W. Devoe, H. A. Sampson, J. R. Perfect, C. M. Wilfert, and R. H. Buckley. “Candida meningitis in two children with severe combined immunodeficiency.” J Pediatr 104, no. 6 (June 1984): 902–4. https://doi.org/10.1016/s0022-3476(84)80493-x.Full Text Link to Item
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Smego, R. A., J. R. Perfect, and D. T. Durack. “Combined therapy with amphotericin B and 5-fluorocytosine for Candida meningitis.” Rev Infect Dis 6, no. 6 (1984): 791–801. https://doi.org/10.1093/clinids/6.6.791.Full Text Link to Item
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Kerr, C. M., J. R. Perfect, P. C. Craven, J. H. Jorgensen, D. J. Drutz, J. D. Shelburne, H. A. Gallis, and R. A. Gutman. “Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis.” Ann Intern Med 99, no. 3 (September 1983): 334–36. https://doi.org/10.7326/0003-4819-99-3-334.Full Text Link to Item
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Washburn, D. E., J. R. Perfect, and D. T. Durack. “Pharmacokinetics of N-formimidoyl thienamycin and influence of a renal dipeptidase inhibitor in experimental meningitis.” J Antimicrob Chemother 12, no. 1 (July 1983): 39–45. https://doi.org/10.1093/jac/12.1.39.Full Text Link to Item
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Seaworth, B. J., K. J. Kwon-Chung, J. D. Hamilton, and J. R. Perfect. “Brain abscess caused by a variety of cladosporium trichoides.” Am J Clin Pathol 79, no. 6 (June 1983): 747–52. https://doi.org/10.1093/ajcp/79.6.747.Full Text Link to Item
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Perfect, J. R., D. T. Durack, and H. A. Gallis. “Cryptococcemia.” Medicine (Baltimore) 62, no. 2 (March 1983): 98–109. https://doi.org/10.1097/00005792-198303000-00003.Full Text Link to Item
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Curiel, T. J., J. R. Perfect, and D. T. Durack. “Leukocyte subpopulations in cerebrospinal fluid of normal rabbits.” Lab Anim Sci 32, no. 6 (December 1982): 622–24.Link to Item
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Cohen, J., J. R. Perfect, and D. T. Durack. “Method for the purification of Filobasidiella neoformans basidiospores by flow cytometry.” Sabouraudia 20, no. 3 (September 1982): 245–49.Link to Item
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Perfect, J. R., and D. T. Durack. “Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine, and ketoconazole.” J Infect Dis 146, no. 3 (September 1982): 429–35. https://doi.org/10.1093/infdis/146.3.429.Full Text Link to Item
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Perfect, J. R., D. T. Durack, J. D. Hamilton, and H. A. Gallis. “Failure of ketoconazole in cryptococcal meningitis.” Jama 247, no. 24 (June 25, 1982): 3349–51.Link to Item
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Cohen, J., J. R. Perfect, and D. T. Durack. “Cryptococcosis and the basidiospore.” Lancet 1, no. 8284 (June 5, 1982): 1301. https://doi.org/10.1016/s0140-6736(82)92861-6.Full Text Link to Item
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Cohen, J., J. R. Perfect, and D. T. Durack. “Method for the purification of filobasidiella neoformans basidiospores by flow cytometry.” Medical Mycology 20, no. 3 (January 1, 1982): 245–49. https://doi.org/10.1080/00362178285380351.Full Text
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Durack, D., J. Perfect, J. Hess, and J. Dankert. “Tolerance in viridans streptococci exerts a major influence on efficacy of penicillin in vivo.” Clinical Research 30, no. 2 (January 1, 1982).
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Durack, D. T., G. R. Corey, and J. R. Perfect. “Trimethoprim-sulfamethoxazole vs. ampicillin in the treatment of experimental meningitis due to Streptococcus pneumoniae.” Rev Infect Dis 4, no. 2 (1982): 311–14. https://doi.org/10.1093/clinids/4.2.311.Full Text Link to Item
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Perfect, J. R., S. D. Lang, and D. T. Durack. “Influence of agglutinating antibody in experimental cryptococcal meningitis.” Br J Exp Pathol 62, no. 6 (December 1981): 595–99.Link to Item
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Perfect, J. R., and D. T. Durack. “Pharmacokinetics of cefoperazone, moxalactam, cefotaxime, trimethoprim and sulphamethoxazole in experimental meningitis.” J Antimicrob Chemother 8, no. 1 (July 1981): 49–58. https://doi.org/10.1093/jac/8.1.49.Full Text Link to Item
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Durack, D. T., and J. R. Perfect. “Potential value of cefoperazone in bacterial meningitis: experimental studies.” Drugs 22 Suppl 1 (1981): 60–64. https://doi.org/10.2165/00003495-198100221-00013.Full Text Link to Item
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Perfect, J. R. “Mediastinitis complicating cellulitis of the head and neck.” South Med J 73, no. 10 (October 1980): 1378–80. https://doi.org/10.1097/00007611-198010000-00025.Full Text Link to Item
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Perfect, J. R., S. D. Lang, and D. T. Durack. “Chronic cryptococcal meningitis: a new experimental model in rabbits.” Am J Pathol 101, no. 1 (October 1980): 177–94.Link to Item
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Perfect, J. R., S. D. Lang, and D. T. Durack. “Comparison of cotrimoxazole, ampicillin, and chloramphenicol in treatment of experimental Haemophilus influenzae type B meningitis.” Antimicrob Agents Chemother 17, no. 1 (January 1980): 43–48. https://doi.org/10.1128/AAC.17.1.43.Full Text Link to Item
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Perfect, J. R., S. D. R. Lang, and D. T. Durack. “Comparison of cotrimoxazole (TMP/SMX), ampicillin (AMP) and chloramphenicol (CHLORO) in treatment of experimental Haemophilus influenzae type B (HITB) meningitis.” Clinical Research 27, no. 2 (January 1, 1979).
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Book Sections
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Shoff, C. J., and J. R. Perfect. “Uncommon yeasts and molds causing human disease.” In Encyclopedia of Mycology, 813–34, 2021. https://doi.org/10.1016/B978-0-12-809633-8.21023-6.Full Text
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Perfect, J. R. “Fungal Infections of the Central Nervous System.” In Aminoff’s Neurology and General Medicine, 803–19, 2021. https://doi.org/10.1016/B978-0-12-819306-8.00045-9.Full Text
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Perfect, John, and Ahmad Mourad. “Management of Phaeohyphomycosis.” In Antifungal Therapy. CRC Press, 2019.
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Perfect, John, and Ahmad Mourad. “Management of Mucormycoses.” In Antifungal Therapy. CRC Press, 2019.
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Köhler, J. R., B. Hube, R. Puccia, A. Casadevall, and J. R. Perfect. “Fungi that infect humans.” In The Fungal Kingdom, 813–43, 2017. https://doi.org/10.1128/9781555819583.ch39.Full Text
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Maziarz, E. K., and J. R. Perfect. “Cryptococcosis.” In Diagnosis and Treatment of Fungal Infections, 175–93, 2015. https://doi.org/10.1007/9783319130903_15.Full Text
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Perfect, J. R. “Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii).” In Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 2:2934–48, 2014. https://doi.org/10.1016/B978-1-4557-4801-3.00264-2.Full Text
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Horan, J. L., and J. R. Perfect. “Fungal meningitis.” In Infections of the Central Nervous System: Fourth Edition, 2014.
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Byrnes, E. J., W. Li, Y. Lewit, J. R. Perfect, D. A. Carter, G. M. Cox, and J. Heitman. “Tourism implications of cryptococcus gattii in the southeastern USA.” In Hospitality and Health: Issues and Developments, 144–58, 2011.
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Perfect, J. R., B. D. Alexander, and W. A. Schell. “Phaeohyphomycoses (brown-black moulds).” In Essentials of Clinical Mycology: Second Edition, 305–17, 2011. https://doi.org/10.1007/978-1-4419-6640-7_17.Full Text
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Cramer, R. A., and J. R. Perfect. “Recent advances in understanding human opportunistic fungal pathogenesis mechanisms.” In Clinical Mycology with CD-ROM, 15–31, 2009. https://doi.org/10.1016/B978-1-4160-5680-5/00002-5.Full Text
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Cox, G. M., D. T. Durack, and J. R. Perfect. “Fungal Infections of the Central Nervous System.” In Neurology and General Medicine: Expert Consult, 899–920, 2007. https://doi.org/10.1016/B978-044306707-5.50051-1.Full Text
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Chayakulkeeree, M., and J. R. Perfect. “Diagnosis of cryptococcosis.” In Diagnosis of Fungal Infections, 239–66, 2007.
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Drew, R. H., M. D. Johnson, E. D. Ashley, and J. R. Perfect. “Rational use of antifungals for invasive fungal infections in the institutional setting.” In Antibiotic Optimization: Concepts and Strategies in Clinical Practice, 577–644, 2004.
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Gottfredsson, M., and J. R. Perfect. “Fungal infections in cancer patients.” In Infections in Cancer Patients, 419–50, 2004.
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Other Articles
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Gottfredsson, M., G. M. Cox, and J. R. Perfect. “Reply.” J Infect Dis, February 2000. https://doi.org/10.1086/315295.Full Text Link to Item
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Conference Papers
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Mourad, A., melissa Johnson, and john Perfect. “Predictors of Mortality in Patients Receiving Voriconazole.” Atlanta, GA: American Society of Microbiology - Microbe, 2018.
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Mourad, A., Melissa Johnson, and John Perfect. “A Decade of Voriconazole Use at Duke University Medical Center: What are the Challenges with Dosing?” New Orleans, LA: American Society of Microbiology - Microbe, 2017.
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Davies, Marie L., Melissa D. Johnson, Jamie N. Brown, William E. Bryan, and Mary L. Townsend. “Predictors of glycaemic control among HIV-positive veterans with diabetes.” In Int J Std Aids, 26:262–67, 2015. https://doi.org/10.1177/0956462414535207.Full Text Link to Item
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Vehreschild, Maria J. G. T., J Janne Vehreschild, Francisco M. Marty, John R. Perfect, Luis Ostrosky-Zeichner, Galia Rahav, Bernhardt Zeiher, et al. “Primary Treatment of Invasive Mucormycosis (IM) with Isavuconazole (VITAL Study) or Amphotericin Formulations (FungiScope (TM)): Case Matched Analysis.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.Link to Item
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Perfect, J. R. “2010 IDSA cryptococcal guidelines: a dynamic document; does it need updating?” In Mycoses, 57:28–28. WILEY-BLACKWELL, 2014.Link to Item
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Tseng, H. K., W. L. Cho, C. P. Liu, J. Y. Jong, and J. R. Perfect. “Verification of Cryptococcus neoformans Gene deletion mutants related to traverse the blood-brain barrier.” In Mycoses, 57:55–56. WILEY-BLACKWELL, 2014.Link to Item
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O’Sullivan, Amy K., Ankur Pandya, David Thompson, George Papadopoulos, Milton C. Weinstein, John R. Perfect, and Amelia Langston. “Cost-Effectiveness of Posaconazole Versus Standard Azole Therapy in the Prevention of Invasive Fungal Infections among High-Risk Neutropenic Patients in the U.S.” In Blood, 108:3311–3311. American Society of Hematology, 2006. https://doi.org/10.1182/blood.v108.11.3311.3311.Full Text
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Ashley, E. S. D., B. D. Alexander, J. R. Perfect, and R. H. Drew. “Cost-avoidance associated with infectious diseases clinical research.” In Pharmacotherapy, 23:415–415. PHARMACOTHERAPY PUBLICATIONS INC, 2003.Link to Item
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Omer, I., J. R. Perfect, R. M. Warren, R. J. Hamill, C. A. Kauffman, and P. G. Pappas. “Cryptococcosis without central nervous system or pulmonary involvement in HIV-negative patients.” In Clinical Infectious Diseases, 31:219–219. UNIV CHICAGO PRESS, 2000.Link to Item
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Perfect, J. R., I. Lutsar, and A. Gonzalez-Ruiz. “Voriconazole (VORI) for the treatment of resistant and rare fungal pathogens.” In Clinical Infectious Diseases, 31:265–265. UNIV CHICAGO PRESS, 2000.Link to Item
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Schlamm, H. T., L. Corey, J. Brown, and J. R. Perfect. “Voriconazole for salvage treatment of invasive aspergillosis.” In Clinical Infectious Diseases, 31:265–265. UNIV CHICAGO PRESS, 2000.Link to Item
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PERFECT, J. R. “CILOFUNGIN.” In Recent Progress in Antifungal Chemotherapy, edited by H. YAMAGUCHI, G. J. KOBAYASHI, and H. TAKAHASHI, 355–67. MARCEL DEKKER, 1992.Link to Item
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PERFECT, J. R., K. A. WRIGHT, and R. F. HECTOR. “SYNERGISTIC INTERACTION OF NIKKOMYCIN AND CILOFUNGIN AGAINST DIVERSE FUNGI.” In Recent Progress in Antifungal Chemotherapy, edited by H. YAMAGUCHI, G. J. KOBAYASHI, and H. TAKAHASHI, 369–79. MARCEL DEKKER, 1992.Link to Item
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GRANGER, D. L., J. B. HIBBS, J. R. PERFECT, and D. T. DURACK. “MACROPHAGE OXIDATION OF L-ARGININE IS LINKED TO FUNGISTATIC CAPABILITY.” In Microbial Determinants of Virulence and Host Response, edited by E. M. AYOUB and G. H. CASSELL, 147–62. AMER SOC MICROBIOLOGY, 1990.Link to Item
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GRANGER, D. L., J. B. HIBBS, J. R. PERFECT, and D. T. DURACK. “ARGININE-DEPENDENT MICROBIOSTATIC PATHWAY OF MACROPHAGES PRODUCING NO-2/NO-3.” In Clinical Research, 35:A615–A615. SLACK INC, 1987.Link to Item
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GRANGER, D. L., J. R. PERFECT, and D. T. DURACK. “REQUIREMENTS FOR THE EXPRESSION OF THE MICROBIOSTATIC ACTION OF MACROPHAGES.” In Journal of Cellular Biochemistry, 113–113. WILEY-LISS, 1987.Link to Item
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GRANGER, D. L., J. R. PERFECT, and D. T. DURACK. “INHIBITION OF FUNGAL CELL REPLICATION BY MACROPHAGES - REQUIREMENT FOR SERUM FACTOR(S).” In Zentralblatt Fur Bakteriologie Mikrobiologie Und Hygiene Series a Medical Microbiology Infectious Diseases Virology Parasitology, 262:58–58. GUSTAV FISCHER VERLAG, 1986.Link to Item
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PERFECT, J. R., and D. T. DURACK. “THE ANTIFUNGAL ACTIVITY OF THE TRIANGLE UK-49,858 IN THE TREATMENT OF EXPERIMENTAL CANDIDA PYELONEPHRITIS AND CRYPTOCOCCAL MENINGITIS.” In Zentralblatt Fur Bakteriologie Mikrobiologie Und Hygiene Series a Medical Microbiology Infectious Diseases Virology Parasitology, 262:153–54. GUSTAV FISCHER VERLAG, 1986.Link to Item
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GRANGER, D. L., J. R. PERFECT, and D. T. DURACK. “ROLE OF IRON AND HEME BINDING SERUM-PROTEINS IN MACROPHAGE FUNGISTASIS.” In Clinical Research, 34:A658–A658. SLACK INC, 1986.Link to Item
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PERFECT, J. R., M. M. HOBBS, D. L. GRANGER, and D. T. DURACK. “DYNAMICS OF CEREBROSPINAL-FLUID MACROPHAGE ACTIVATION IN EXPERIMENTAL CRYPTOCOCCAL MENINGITIS.” In Clinical Research, 34:A678–A678. SLACK INC, 1986.Link to Item
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GRANGER, D. L., J. R. PERFECT, and D. T. DURACK. “SERUM FACTOR(S) WHICH PROMOTES MACROPHAGE FUNGISTATIC ACTION.” In Journal of Leukocyte Biology, 38:133–133. FEDERATION AMER SOC EXP BIOL, 1985.Link to Item
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GRANGER, D. L., J. R. PERFECT, and D. T. DURACK. “MACROPHAGES REQUIRE A SERUM FACTOR(S) FOR EFFICIENT FUNGISTASIS.” In Clinical Research, 33:A565–A565. SLACK INC, 1985.Link to Item
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LALLINGER, G. J., S. L. REINER, J. R. PERFECT, D. L. GRANGER, and D. T. DURACK. “SERUM THERAPY OF EXPERIMENTAL NAEGLERIA FOWLERI MENINGITIS.” In Clinical Research, 33:A408–A408. SLACK INC, 1985.Link to Item
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GRANGER, D. L., J. R. PERFECT, and D. T. DURACK. “CARBON-DIOXIDE REGULATES CAPSULE PRODUCTION BY CRYPTOCOCCUS-NEOFORMANS.” In Clinical Research, 32:A369–A369. SLACK INC, 1984.Link to Item
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PERFECT, J. R., D. L. GRANGER, and D. T. DURACK. “CYCLOSPORINE PREDISPOSES TO EXPERIMENTAL CRYPTOCOCCAL MENINGITIS.” In Clinical Research, 32:A379–A379. SLACK INC, 1984.Link to Item
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PERFECT, J. R., D. T. DURACK, and H. A. GALLIS. “CRYPTOCOCCEMIA.” In Clinical Research, 29:A393–A393. SLACK INC, 1981.Link to Item
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PERFECT, J. R., S. D. R. LANG, and D. T. DURACK. “INFLUENCE OF HUMORAL IMMUNITY ON CRYPTOCOCCAL MENINGITIS IN RABBITS.” In Clinical Research, 28:A376–A376. SLACK INC, 1980.Link to Item
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