Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.

Journal Article

Previous research has shown an association between hostility and fasting glucose in African American women. Central nervous system serotonin activity is implicated both in metabolic processes and in hostility related traits.The purpose of this study is to determine whether central nervous system serotonin influences the association between hostility and fasting glucose in African American women.The study consisted of 119 healthy volunteers (36 African American women, 27 White women, 21 White males, and 35 African American males, mean age 34 ± 8.5 years). Serotonin related compounds were measured in cerebrospinal fluid. Hostility was measured by the Cook-Medley Hostility Scale.Hostility was associated with fasting glucose and central nervous system serotonin related compounds in African American women only. Controlling for the serotonin related compounds significantly reduced the association of hostility to glucose.The positive correlation between hostility and fasting glucose in African American women can partly be explained by central nervous system serotonin function.

Full Text

Duke Authors

Cited Authors

  • Boyle, SH; Georgiades, A; Brummett, BH; Barefoot, JC; Siegler, IC; Matson, WR; Kuhn, CM; Grichnik, K; Stafford-Smith, M; Williams, RB; Kaddurah-Daouk, R; Surwit, RS

Published Date

  • February 2015

Published In

Volume / Issue

  • 49 / 1

Start / End Page

  • 49 - 57

PubMed ID

  • 24806470

Electronic International Standard Serial Number (EISSN)

  • 1532-4796

International Standard Serial Number (ISSN)

  • 0883-6612

Digital Object Identifier (DOI)

  • 10.1007/s12160-014-9626-7


  • eng