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Messenger RNA (mRNA) nanoparticle tumour vaccination.

Publication ,  Journal Article
Phua, KKL; Nair, SK; Leong, KW
Published in: Nanoscale
July 21, 2014

Use of mRNA-based vaccines for tumour immunotherapy has gained increasing attention in recent years. A growing number of studies applying nanomedicine concepts to mRNA tumour vaccination show that the mRNA delivered in nanoparticle format can generate a more robust immune response. Advances in the past decade have deepened our understanding of gene delivery barriers, mRNA's biological stability and immunological properties, and support the notion for engineering innovations tailored towards a more efficient mRNA nanoparticle vaccine delivery system. In this review we will first examine the suitability of mRNA for engineering manipulations, followed by discussion of a model framework that highlights the barriers to a robust anti-tumour immunity mediated by mRNA encapsulated in nanoparticles. Finally, by consolidating existing literature on mRNA nanoparticle tumour vaccination within the context of this framework, we aim to identify bottlenecks that can be addressed by future nanoengineering research.

Duke Scholars

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Published In

Nanoscale

DOI

EISSN

2040-3372

Publication Date

July 21, 2014

Volume

6

Issue

14

Start / End Page

7715 / 7729

Location

England

Related Subject Headings

  • Vaccines, DNA
  • RNA, Messenger
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Nanomedicine
  • Lymph Nodes
  • Liver
  • Immunotherapy
  • Cancer Vaccines
 

Citation

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Phua, K. K. L., Nair, S. K., & Leong, K. W. (2014). Messenger RNA (mRNA) nanoparticle tumour vaccination. Nanoscale, 6(14), 7715–7729. https://doi.org/10.1039/c4nr01346h
Phua, Kyle K. L., Smita K. Nair, and Kam W. Leong. “Messenger RNA (mRNA) nanoparticle tumour vaccination.Nanoscale 6, no. 14 (July 21, 2014): 7715–29. https://doi.org/10.1039/c4nr01346h.
Phua KKL, Nair SK, Leong KW. Messenger RNA (mRNA) nanoparticle tumour vaccination. Nanoscale. 2014 Jul 21;6(14):7715–29.
Phua, Kyle K. L., et al. “Messenger RNA (mRNA) nanoparticle tumour vaccination.Nanoscale, vol. 6, no. 14, July 2014, pp. 7715–29. Pubmed, doi:10.1039/c4nr01346h.
Phua KKL, Nair SK, Leong KW. Messenger RNA (mRNA) nanoparticle tumour vaccination. Nanoscale. 2014 Jul 21;6(14):7715–7729.
Journal cover image

Published In

Nanoscale

DOI

EISSN

2040-3372

Publication Date

July 21, 2014

Volume

6

Issue

14

Start / End Page

7715 / 7729

Location

England

Related Subject Headings

  • Vaccines, DNA
  • RNA, Messenger
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Nanomedicine
  • Lymph Nodes
  • Liver
  • Immunotherapy
  • Cancer Vaccines