Phenotype standardization for statin-induced myotoxicity.
Journal Article (Journal Article)
Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.
Full Text
Duke Authors
Cited Authors
- Alfirevic, A; Neely, D; Armitage, J; Chinoy, H; Cooper, RG; Laaksonen, R; Carr, DF; Bloch, KM; Fahy, J; Hanson, A; Yue, Q-Y; Wadelius, M; Maitland-van Der Zee, AH; Voora, D; Psaty, BM; Palmer, CNA; Pirmohamed, M
Published Date
- October 2014
Published In
Volume / Issue
- 96 / 4
Start / End Page
- 470 - 476
PubMed ID
- 24897241
Pubmed Central ID
- PMC4172546
Electronic International Standard Serial Number (EISSN)
- 1532-6535
Digital Object Identifier (DOI)
- 10.1038/clpt.2014.121
Language
- eng
Conference Location
- United States