Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Cardiovascular Disease, Duke University School of Medicine 2006 - 2010
  • Chief Resident, Internal Medicine, Washington University School of Medicine 2005 - 2006
  • Resident, Internal Medicine, Washington University School of Medicine 2003 - 2005
  • Intern, Internal Medicine, Washington University School of Medicine 2002 - 2003
  • M.D., Northwestern University 2002
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2013 - 2017
  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2010 - 2013
  • Instructor Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2010
• Recognition
• 

  In the News

  • SEP 7, 2016

    Researchers Find Molecular Link Behind Aspirins Protective Powers

  • MAR 16, 2016

    New Collaborative Seed Grant Program Gives Eight Awards

  • JUL 8, 2013

    NPR

    Genes may reveal when aspirin won't reduce heart risk

  • JUL 7, 2013

    Is Aspirin Therapy for You?

  • JUL 5, 2013

    Charlotte Observer

    Duke researchers: Aspirin helps only some prevent heart disease, stroke
• Research
• 

  Selected Grants

  • Postdoctoral training in genomic medicine research awarded by National Institutes of Health 2017 - 2022
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • Abbott Diagnostics Collaborative Sponsored Research Agreement awarded by Abbott Laboratories 2016 - 2019
  • Pharmacogenetic Testing: Challenges of Clinical Integration awarded by National Institutes of Health 2011 - 2019
  • Developing An In Vitro Human Myobundle Model Of Rheumatoid Arthritis awarded by National Institutes of Health 2017 - 2019
  • Ex vivo metabolomic profiling of statin-induced myopathy awarded by  American Heart Association 2017 - 2018
  • Rap1 signaling in platelet homeostasis and vascular hemostasis awarded by University of North Carolina - Chapel Hill 2016 - 2018
  • DEVELOPMENT OF PLATELET RNA BIOMARKERS FOR THE RESPONSE TO TICAGRELOR awarded by AstraZeneca Healthcare Foundation 2015 - 2018
  • Development Of Prognostic Platelet RNA Biomarkers To Tailor Antiplatelet Therapy awarded by National Institutes of Health 2013 - 2018
  • URGE awarded by National Institutes of Health 2012 - 2013
  • Phase I Clinical Trial Describing the Pharmacogenomics of Aspirin awarded by National Institutes of Health 2009 - 2012
  • Duke CTSA-KL2 awarded by National Institutes of Health 2006 - 2012
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Li, JH, and Voora, D. "Cardiovascular Pharmacogenetics." In Genomic and Precision Medicine: Cardiovascular Disease: Third Edition, 291-307. November 13, 2017.  Full Text
    • Voora, D. "Pharmacogenetics and Pharmacogenomics." In Genomic and Precision Medicine: Foundations, Translation, and Implementation: Third Edition, 233-246. December 15, 2016.  Full Text

  • Conference Papers

    • Friede, K, Infeld, M, Tan, R-S, Myers, R, and Voora, D. "INFLUENCE OF SEX ON PLATELET RESPONSE TO ASPIRIN AND TICAGRELOR." March 21, 2017.  Link to Item
    • Infeld, M, Friede, K, Myers, RA, Ortel, T, San, TR, and Voora, D. "THE EFFECT OF RACE ON THE ANTIPLATELET EFFECTS OF TICAGRELOR AND ASPIRIN." March 21, 2017.  Link to Item
    • Cavallari, LH, Denny, JC, Lee, CR, Beitelshees, AL, Duarte, JD, Kimmel, SE, Voora, D, McDonough, CW, Gong, Y, Wei, W-Q, Pratt, VM, Chumnumwat, S, Coons, JC, Cooper-DeHoff, RM, Dave, CV, Dillon, C, Hamadeh, IS, Hines, L, Howell, LA, Jeng, LJ, Lee, YM, Skaar, TC, Sriramoju, VB, Stevenson, JM, Vesely, MR, Wake, D, Kreutz, RP, Stouffer, GA, Wilke, RA, Empey, PE, Limdi, NA, Roden, DM, Shuldiner, AR, Johnson, JA, and Peterson, JF. "Prospective Clinical Implementation of CYP2C19-Genotype Guided Antiplatelet Therapy After PCI: a Multi-Site Investigation of MACE Outcomes in a Real-World Setting." December 20, 2016.  Link to Item
    • Songdej, N, Mao, G, Voora, D, Goldfinger, LE, Del Carpio-Cano, F, Myers, R, and Rao, AK. "PCTP (Phosphatidylcholine Transfer Protein) is Regulated By RUNX1 in Platelets/Megakaryocytes and is Associated with Adverse Cardiovascular Events." December 2, 2016.  Link to Item
    • Klarin, D, Ho, Y-L, Gagnon, DR, Honerlaw, J, Vassy, JL, Voora, D, Assimes, T, Rader, DJ, Boden, W, Damrauer, S, Natarajan, P, Kathiresan, S, O'Donnell, CJ, Gaziano, JM, Cho, K, Tsao, PS, and Wilson, PW. "Lipid Reduction Measurements in a Veteran Population - Implications for Genetic Modeling in the Million Veteran Program." November 11, 2016.  Link to Item
    • Voora, D, Perry, E, Singh, K, Trujillo, G, Milazzo, N, Savard, D, Haga, S, Musty, MD, Li, Y-J, and Peyser, B. "SLCO1B1 Genotype-Guided Statin Therapy Lowers LDL Cholesterol in Patients With Statin-Intolerance-A Randomized Controlled Trial." November 11, 2016.  Link to Item
    • Voora, D, Perry, E, Singh, K, Trujillo, G, Milazzo, N, Savard, D, Haga, S, Musty, MD, Li, Y-J, and Peyser, B. "SLCO1B1 Genotype-Guided Statin Therapy Lowers LDL Cholesterol in Patients With Statin-Intolerance-A Randomized Controlled Trial." November 11, 2016.  Link to Item
    • Voora, D, Coles, A, Lee, K, Hoffmann, U, Wingrove, J, Rhees, B, Huang, L, Daniels, S, Monane, M, Rosenberg, S, Mark, D, Shah, S, Kraus, W, Ginsburg, G, and Douglas, P. "AN AGE- AND SEX-SPECIFIC PERIPHERAL BLOOD GENE EXPRESSION SCORE CORRELATES WITH FUTURE CARDIOVASCULAR EVENTS: INSIGHTS FROM THE PROMISE TRIAL." April 2016.  Full Text
    • Li, JH, Suchindran, S, Shah, SH, Kraus, WE, Ginsburg, GS, and Voora, D. "Effect of SLCO1B1*5 on Low-Density Lipoprotein Cholesterol Levels and Long-Term Clinical Events in Patients During Statin Therapy Following Cardiac Catheterization." November 26, 2013.  Link to Item
    • Doss, J, Jima, D, Voora, D, Dave, S, and Chi, J-TA. "Using High-Throughput Sequencing of Red Blood Cells and Platelets to Identify Micrornas Associated with Hematopoiesis." November 16, 2012.  Link to Item
    • Voora, D, Shah, SH, Horton, JR, Shaw, LK, and Newby, LK. "Polymorphisms Associated With in vitro Aspirin Resistance Are Not Associated With Clinical Outcomes During Regular Aspirin Use." November 3, 2009.  Link to Item
    • Voora, D, Koboldt, DC, King, CR, Eby, CS, Porche-Sorbet, R, Deych, E, Lenzini, P, Crankshaw, M, McLeod, HL, Ridker, PM, Milligan, PE, Miller, RD, and Gage, BF. "A comparative genomics approach identifies a polymorphism in calumenin as a predictor of high warfarin dose in African American patients." October 16, 2007.  Link to Item
    • Gage, BF, Eby, CS, Johnson, JA, Rieder, MJ, Ridker, PM, Rettie, AE, Aquilante, C, Milligan, PE, Marsh, S, Voora, D, Langaee, T, Veenstra, DL, Birman-Deych, E, Glynn, R, Nickerson, DA, and McLeod, HL. "Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin." November 16, 2005.  Link to Item

  • Journal Articles

    • Wingrove, JA, Fitch, K, Rhees, B, Rosenberg, S, and Voora, D. "Peripheral blood gene expression signatures which reflect smoking and aspirin exposure are associated with cardiovascular events." BMC medical genomics 11, no. 1 (January 12, 2018): 1-.  Full Text
    • Cavallari, LH, Lee, CR, Beitelshees, AL, Cooper-DeHoff, RM, Duarte, JD, Voora, D, Kimmel, SE, McDonough, CW, Gong, Y, Dave, CV, Pratt, VM, Alestock, TD, Anderson, RD, Alsip, J, Ardati, AK, Brott, BC, Brown, L, Chumnumwat, S, Clare-Salzler, MJ, Coons, JC, Denny, JC, Dillon, C, Elsey, AR, Hamadeh, IS, Harada, S, Hillegass, WB, Hines, L, Horenstein, RB, Howell, LA, Jeng, LJB, Kelemen, MD, Lee, YM, Magvanjav, O, Montasser, M, Nelson, DR, Nutescu, EA, Nwaba, DC, Pakyz, RE, Palmer, K, and Peterson, JF et al. "Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention." JACC. Cardiovascular interventions 11, no. 2 (January 2018): 181-191.  Full Text
    • Mao, G, Songdej, N, Voora, D, Goldfinger, LE, Del Carpio-Cano, FE, Myers, RA, and Rao, AK. "Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants." Circulation 136, no. 10 (September 2017): 927-939.  Full Text
    • Friede, K, and Voora, D. "The need for sex-specific precision biomarkers for antiplatelet therapies." Future cardiology (August 23, 2017).  Full Text
    • Musunuru, K, Ingelsson, E, Fornage, M, Liu, P, Murphy, AM, Newby, LK, Newton-Cheh, C, Perez, MV, Voora, D, Woo, D, American Heart Association Committee on Molecular Determinants of Cardiovascular Health of the Council on Functional Genomics and Translational Biology and Council on Epidemiology and Prevention, Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, and Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology et al. "The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association." Circulation. Cardiovascular genetics 10, no. 4 (August 2017). (Review)  Full Text
    • Cavallari, LH, Beitelshees, AL, Blake, KV, Dressler, LG, Duarte, JD, Elsey, A, Eichmeyer, JN, Empey, PE, Franciosi, JP, Hicks, JK, Holmes, AM, Jeng, L, Lee, CR, Lima, JJ, Limdi, NA, Modlin, J, Obeng, AO, Petry, N, Pratt, VM, Skaar, TC, Tuteja, S, Voora, D, Wagner, M, Weitzel, KW, Wilke, RA, Peterson, JF, and Johnson, JA. "The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting." Clinical and Translational Science 10, no. 3 (May 2017): 143-146. (Review)  Full Text
    • Haga, SB, Moaddeb, J, Mills, R, and Voora, D. "Assessing feasibility of delivering pharmacogenetic testing in a community pharmacy setting." Pharmacogenomics 18, no. 4 (March 2017): 327-335.  Full Text
    • Voora, D, Coles, A, Lee, KL, Hoffmann, U, Wingrove, JA, Rhees, B, Huang, L, Daniels, SE, Monane, M, Rosenberg, S, Shah, SH, Kraus, WE, Ginsburg, GS, and Douglas, PS. "An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial." American heart journal 184 (February 2017): 133-140.  Full Text
    • Friede, K, Li, J, and Voora, D. "Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease." Clinical chemistry 63, no. 1 (January 2017): 177-185. (Review)  Full Text
    • Lucas, JE, Bazemore, TC, Alo, C, Monahan, PB, and Voora, D. "An electronic health record based model predicts statin adherence, LDL cholesterol, and cardiovascular disease in the United States Military Health System." PloS one 12, no. 11 (January 2017): e0187809-.  Full Text
    • Singh, K, Peyser, B, Trujillo, G, Milazzo, N, Savard, D, Haga, SB, Musty, M, and Voora, D. "Rationale and design of the SLCO1B1 genotype guided statin therapy trial." Pharmacogenomics (November 3, 2016).  Full Text
    • Doran, B, and Voora, D. "Circulating extracellular vesicles containing miRNAs may have utility as early biomarkers for cardiac injury." Annals of translational medicine 4, no. Suppl 1 (October 2016): S60-.  Full Text
    • Voora, D, Rao, AK, Jalagadugula, GS, Myers, R, Harris, E, Ortel, TL, and Ginsburg, GS. "Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer." EBioMedicine 11 (September 2016): 157-164.  Full Text
    • Voora, D, and Shah, SH. "Pharmacometabolomics Meets Genetics: A "Natural" Clinical Trial of Statin Effects." Journal of the American College of Cardiology 67, no. 10 (March 2016): 1211-1213.  Full Text
    • Xie, G, Myint, PK, Voora, D, Laskowitz, DT, Shi, P, Ren, F, Wang, H, Yang, Y, Huo, Y, Gao, W, and Wu, Y. "Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort." Atherosclerosis 243, no. 1 (November 2015): 30-37.  Full Text
    • Friede, KA, Ginsburg, GS, and Voora, D. "Gene Expression Signatures and the Spectrum of Coronary Artery Disease." Journal of cardiovascular translational research 8, no. 6 (August 2015): 339-352. (Review)  Full Text
    • Varenhorst, C, Eriksson, N, Johansson, Å, Barratt, BJ, Hagström, E, Åkerblom, A, Syvänen, A-C, Becker, RC, James, SK, Katus, HA, Husted, S, Steg, PG, Siegbahn, A, Voora, D, Teng, R, Storey, RF, Wallentin, L, and PLATO Investigators, . "Effect of genetic variations on ticagrelor plasma levels and clinical outcomes." European heart journal 36, no. 29 (August 2015): 1901-1912.  Full Text
    • Beitelshees, AL, Voora, D, and Lewis, JP. "Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics." Pharmacogenomics and Personalized Medicine 8 (January 2015): 43-61. (Review)  Full Text
    • Li, JH, Suchindran, S, Shah, SH, Kraus, WE, Ginsburg, GS, and Voora, D. "SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization." Pharmacogenomics 16, no. 5 (January 2015): 449-458.  Full Text
    • Rose, JJ, Voora, D, Cyr, DD, Lucas, JE, Zaas, AK, Woods, CW, Newby, LK, Kraus, WE, and Ginsburg, GS. "Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction." PloS one 10, no. 7 (January 2015): e0132259-.  Full Text  Open Access Copy
    • Wang, Z, Maity, A, Hsiao, CK, Voora, D, Kaddurah-Daouk, R, and Tzeng, J-Y. "Module-based association analysis for omics data with network structure." PloS one 10, no. 3 (January 2015): e0122309-.  Full Text
    • Suchindran, S, Himmel, T, Ortel, TL, Becker, RC, Kraus, WE, Newby, LK, Ginsburg, GS, and Voora, D. "Aspirin-Responsive Platelet Genes Are Associated With Platelet Function and Cardiovascular Events." CIRCULATION 130 (November 25, 2014).  Link to Item
    • Alfirevic, A, Neely, D, Armitage, J, Chinoy, H, Cooper, RG, Laaksonen, R, Carr, DF, Bloch, KM, Fahy, J, Hanson, A, Yue, Q-Y, Wadelius, M, Maitland-van Der Zee, AH, Voora, D, Psaty, BM, Palmer, CNA, and Pirmohamed, M. "Phenotype standardization for statin-induced myotoxicity." Clinical pharmacology and therapeutics 96, no. 4 (October 2014): 470-476.  Full Text
    • Alfirevic, A, Neely, D, Armitage, J, Chinoy, H, Cooper, RG, Laaksonen, R, Carr, DF, Bloch, KM, Fahy, J, Hanson, A, Yue, QY, Wadelius, M, Maitland-Van Der Zee, AH, Voora, D, Psaty, BM, Palmer, CNA, and Pirmohamed, M. "Phenotype standardization for statin-induced myotoxicity." Clinical Pharmacology and Therapeutics 96, no. 4 (October 1, 2014): 470-476. (Review)  Full Text
    • Ramsey, LB, Johnson, SG, Caudle, KE, Haidar, CE, Voora, D, Wilke, RA, Maxwell, WD, McLeod, HL, Krauss, RM, Roden, DM, Feng, Q, Cooper-DeHoff, RM, Gong, L, Klein, TE, Wadelius, M, and Niemi, M. "The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update." Clinical pharmacology and therapeutics 96, no. 4 (October 2014): 423-428.  Full Text
    • Ramsey, LB, Johnson, SG, Caudle, KE, Haidar, CE, Voora, D, Wilke, RA, Maxwell, WD, McLeod, HL, Krauss, RM, Roden, DM, Feng, Q, Cooper-Dehoff, RM, Gong, L, Klein, TE, Wadelius, M, and Niemi, M. "The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 Update." Clinical Pharmacology and Therapeutics 96, no. 4 (October 1, 2014): 423-428. (Review)  Full Text
    • Voora, D, and Becker, RC. "A freeze on tailored antiplatelet therapy?." Circulation 129, no. 21 (May 27, 2014): 2088-2090.  Full Text
    • Voora, D, and Becker, RC. "A freeze on tailored antiplatelet therapy?." Circulation 129, no. 21 (May 2014): 2088-2090.  Full Text
    • Kertai, MD, Esper, SA, Akushevich, I, Voora, D, Ginsburg, GS, Stafford-Smith, M, Grichnik, K, Newman, MF, Fontes, ML, Smith, P, Podgoreanu, MV, Mathew, JP, and Cardiothoracic Anesthesia Research Endeavors (CARE) Group, . "Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery." The Journal of thoracic and cardiovascular surgery 147, no. 4 (April 2014): 1368-1375.e3.  Full Text  Open Access Copy
    • Varenhorst, C, Eriksson, N, Johansson, Å, Barratt, B, Åkerblom, A, Hagström, E, Syvänen, A-C, Becker, R, James, S, Katus, H, Husted, S, Steg, G, Siegbahn, A, Voora, D, Storey, R, and Wallentin, L. "TICAGRELOR PLASMA LEVELS BUT NOT CLINICAL OUTCOMES ARE ASSOCIATED WITH TRANSPORTER AND METABOLISM ENZYME GENETIC POLYMORPHISMS." Journal of the American College of Cardiology 63, no. 12 (April 2014): A25-A25.  Full Text
    • Voora, D. "Expression quantitative trait locus analysis identifies novel genes for statin myopathy." Circulation. Cardiovascular genetics 7, no. 2 (April 2014): 220-221.  Full Text
    • Li, JH, Joy, SV, Haga, SB, Orlando, LA, Kraus, WE, Ginsburg, GS, and Voora, D. "Genetically guided statin therapy on statin perceptions, adherence, and cholesterol lowering: a pilot implementation study in primary care patients." Journal of personalized medicine 4, no. 2 (March 27, 2014): 147-162.  Full Text
    • Voora, D. "The Last Line of Defense Against Atherosclerosis." Science Translational Medicine 6, no. 228 (March 19, 2014): 228ec51-228ec51.  Full Text
    • Voora, D. "PREDICTing the Era of Personalized Medicine." Science Translational Medicine 6, no. 222 (February 5, 2014): 222ec26-222ec26.  Full Text
    • Voora, D. "A Powerful (Re)Purpose for Genome-Wide Association Studies." Science Translational Medicine 6, no. 218 (January 8, 2014): 218ec9-218ec9.  Full Text
    • Kertai, MD, Esper, SA, Akushevich, I, Voora, D, Ginsburg, GS, Stafford-Smith, M, Grichnik, K, Newman, MF, Fontes, ML, Smith, P, Podgoreanu, MV, and Mathew, JP. "Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery." Journal of Thoracic and Cardiovascular Surgery 147, no. 4 (January 1, 2014).  Full Text
    • Voora, D, Ginsburg, GS, and Akerblom, A. "Platelet RNA as a novel biomarker for the response to antiplatelet therapy." Future Cardiol 10, no. 1 (January 2014): 9-12.  Full Text  Link to Item
    • Voora, D. "Cardiology: Silencing the sounds of hypertrophic cardiomyopathy." Science Translational Medicine 5, no. 210 (November 6, 2013).  Full Text
    • Voora, D, Cyr, D, Lucas, J, Chi, J-T, Dungan, J, McCaffrey, TA, Katz, R, Newby, LK, Kraus, WE, Becker, RC, Ortel, TL, and Ginsburg, GS. "Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events." Journal of the American College of Cardiology 62, no. 14 (October 2013): 1267-1276.  Full Text
    • Zaas, AK, Burke, T, Chen, M, McClain, M, Nicholson, B, Veldman, T, Tsalik, EL, Fowler, V, Rivers, EP, Otero, R, Kingsmore, SF, Voora, D, Lucas, J, Hero, AO, Carin, L, Woods, CW, and Ginsburg, GS. "A host-based RT-PCR gene expression signature to identify acute respiratory viral infection." Sci Transl Med 5, no. 203 (September 18, 2013): 203ra126-.  Full Text  Link to Item
    • Voora, D. "A transcriptomics-informed genetic association study identifies RHOA in simvastatin-induced low-density lipoprotein cholesterol lowering." Circ Cardiovasc Genet 6, no. 1 (February 2013): 137-138.  Full Text  Link to Item
    • Becker, RC, Voora, D, and Shah, SH. "Hemostasis and Thrombosis." Genomic and Personalized Medicine 2 (2013): 602-611.  Full Text
    • Mills, R, Voora, D, Peyser, B, and Haga, SB. "Delivering pharmacogenetic testing in a primary care setting. (Published online)" Pharmgenomics Pers Med 6 (2013): 105-112.  Full Text  Link to Item
    • Rose, JJ, Voora, D, Cyr, DD, Lucas, JE, Zaas, AK, Newby, LK, Kraus, WE, and Ginsburg, GS. "Blood Gene Expression Profiling Reveals An Association Between Viral Infection, Platelet Function, And Acute Myocardial Infarction." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 187 (2013).  Link to Item
    • Voora, D. "Building the evidentiary framework for pharmacogenetic testing: Is it time to move beyond randomized controlled trials?." Personalized Medicine 10, no. 1 (2013): 1-3.  Full Text
    • Voora, D. "Diagnosis and prognosis a liquid solution for solid tumors." Science Translational Medicine 5, no. 180 (2013).  Full Text
    • Voora, D. "A miR-aculous advance for a rare heart disorder." Science Translational Medicine 5, no. 186 (2013).  Full Text
    • Voora, D. "XiAP-ping castration-resistant prostate cancer." Science Translational Medicine 5, no. 192 (2013).  Full Text
    • Voora, D. "Drug-induced aches and pains." Science Translational Medicine 5, no. 204 (2013).  Full Text
    • Voora, D, Cyr, D, Lucas, J, Chi, J-T, Dungan, J, McCaffrey, T, Katz, R, Newby, LK, Kraus, W, Becker, R, Ortel, T, and Ginsburg, G. "Aspirin Exposure Reveals Novel Genes Associated with Platelet Function and Cardiovascular Events." CIRCULATION 126, no. 21 (November 20, 2012).  Link to Item
    • Voora, D, and Ginsburg, GS. "Clinical application of cardiovascular pharmacogenetics." J Am Coll Cardiol 60, no. 1 (July 3, 2012): 9-20. (Review)  Full Text  Link to Item
    • Wilke, RA, Ramsey, LB, Johnson, SG, Maxwell, WD, McLeod, HL, Voora, D, Krauss, RM, Roden, DM, Feng, Q, Cooper-Dehoff, RM, Gong, L, Klein, TE, Wadelius, M, Niemi, M, and Clinical Pharmacogenomics Implementation Consortium (CPIC), . "The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy." Clin Pharmacol Ther 92, no. 1 (July 2012): 112-117.  Full Text  Link to Item
    • Voora, D, Ortel, TL, Lucas, JE, Chi, J-T, Becker, RC, and Ginsburg, GS. "Time-dependent changes in non-COX-1-dependent platelet function with daily aspirin therapy." J Thromb Thrombolysis 33, no. 3 (April 2012): 246-257.  Full Text  Link to Item
    • Voora, D, Ortel, TL, Lucas, JE, Chi, J-T, Becker, RC, and Ginsburg, GS. "Time-dependent changes in non-COX-1-dependent platelet function with daily aspirin therapy." Journal of Thrombosis and Thrombolysis 33, no. 3 (2012): 246-257.  Full Text
    • Ahmad, T, Voora, D, and Becker, RC. "The pharmacogenetics of antiplatelet agents: towards personalized therapy? (Published online)." Nat Rev Cardiol 8, no. 10 (August 9, 2011): 560-571. (Review)  Full Text  Link to Item
    • Voora, D, and Ginsburg, GS. "A hub for bench-to-bedside pharmacogenomic-based research." Pharmacogenomics 12, no. 8 (August 2011): 1095-1098.  Full Text  Link to Item
    • Voora, D, Horton, J, Shah, SH, Shaw, LK, and Newby, LK. "Polymorphisms associated with in vitro aspirin resistance are not associated with clinical outcomes in patients with coronary artery disease who report regular aspirin use." Am Heart J 162, no. 1 (July 2011): 166-72.e1.  Full Text  Link to Item
    • Ahmad, T, Voora, D, and Becker, RC. "The pharmacogenetics of antiplatelet agents: towards personalized therapy?." Nature Reviews Cardiology (2011).  Full Text
    • Voora, D, Ortel, TL, Lucas, JE, Chi, J-T, Becker, RC, and Ginsburg, GS. "A Whole Blood RNA Signature Accurately Classifies Multiple Measures of Platelet Function on Aspirin in Healthy Volunteers and Highlights a Common Underlying Pathway." CIRCULATION 122, no. 21 (November 23, 2010).  Link to Item
    • Wallace, TW, Atwater, BD, Daubert, JP, Voora, D, Crowley, AL, Bahnson, TD, and Hranitzky, PM. "Prevalence and clinical characteristics associated with left atrial appendage thrombus in fully anticoagulated patients undergoing catheter-directed atrial fibrillation ablation." J Cardiovasc Electrophysiol 21, no. 8 (August 1, 2010): 849-852.  Full Text  Link to Item
    • Ginsburg, GS, and Voora, D. "The long and winding road to warfarin pharmacogenetic testing." J Am Coll Cardiol 55, no. 25 (June 22, 2010): 2813-2815.  Full Text  Link to Item
    • Voora, D, Koboldt, DC, King, CR, Lenzini, PA, Eby, CS, Porche-Sorbet, R, Deych, E, Crankshaw, M, Milligan, PE, McLeod, HL, Patel, SR, Cavallari, LH, Ridker, PM, Grice, GR, Miller, RD, and Gage, BF. "A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans." Clin Pharmacol Ther 87, no. 4 (April 2010): 445-451.  Full Text  Link to Item
    • Kawamoto, K, Orlando, LA, Voora, D, Lobach, DF, Joy, S, Cho, A, and Ginsburg, GS. "Evaluation of the PharmGKB knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays. (Published online)" AMIA Annu Symp Proc 2009 (November 14, 2009): 307-311.  Link to Item
    • Voora, D, Shah, SH, Spasojevic, I, Ali, S, Reed, CR, Salisbury, BA, and Ginsburg, GS. "The SLCO1B1*5 genetic variant is associated with statin-induced side effects." J Am Coll Cardiol 54, no. 17 (October 20, 2009): 1609-1616.  Full Text  Link to Item
    • Voora, D, and Ginsburg, GS. "Pharmacogenetics of the response to statins." Current Cardiovascular Risk Reports 3, no. 6 (2009): 434-440.  Full Text
    • Voora, D, Shah, SH, Reed, CR, Zhai, J, Crosslin, DR, Messer, C, Salisbury, BA, and Ginsburg, GS. "Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response." Circ Cardiovasc Genet 1, no. 2 (December 2008): 100-106.  Full Text  Link to Item
    • Voora, D, Ali, S, Shah, SH, Reed, CR, Salisbury, B, and Ginsburg, GS. "Association of Statin-Induced Musculoskeletal Side Effects with Sex and a Hepatic Uptake Transporter Reduced Function Allele, SLC01B1*5." CIRCULATION 118, no. 18 (October 28, 2008): S326-S326.  Link to Item
    • Gage, BF, Eby, C, Johnson, JA, Deych, E, Rieder, MJ, Ridker, PM, Milligan, PE, Grice, G, Lenzini, P, Rettie, AE, Aquilante, CL, Grosso, L, Marsh, S, Langaee, T, Farnett, LE, Voora, D, Veenstra, DL, Glynn, RJ, Barrett, A, and McLeod, HL. "Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin." Clin Pharmacol Ther 84, no. 3 (September 2008): 326-331.  Full Text  Link to Item
    • Gage, BF, Eby, C, Johnson, JA, Deych, E, Rieder, MJ, Ridker, PM, Milligan, PE, Grice, G, Lenzini, P, Rettie, AE, Aquilante, CL, Grosso, L, Marsh, S, Langaee, T, Farnett, LE, Voora, D, Veenstra, DL, Glynn, RJ, Barrett, A, and McLeod, HL. "Corrigendum: Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin (Clinical Pharmacology Therapeutics (2008) 84, (326-331) DOI: 10.1038/clpt.2008.10)." Clinical Pharmacology and Therapeutics 84, no. 3 (2008): 430--.  Full Text
    • Voora, D, Reed, CR, Zhai, J, Salisbury, BA, Shah, SH, and Ginsburg, GS. "Polymorphisms in ABCA1 predict statin mediated LDL cholesterol lowering and suggest an interaction with CETP." CIRCULATION 116, no. 16 (October 16, 2007): 178-178.  Link to Item
    • Millican, EA, Lenzini, PA, Milligan, PE, Grosso, L, Eby, C, Deych, E, Grice, G, Clohisy, JC, Barrack, RL, Burnett, RSJ, Voora, D, Gatchel, S, Tiemeier, A, and Gage, BF. "Genetic-based dosing in orthopedic patients beginning warfarin therapy." Blood 110, no. 5 (September 1, 2007): 1511-1515.  Full Text  Link to Item
    • Voora, D, and Gage, BF. "Is primary care ready for pharmacogenetics?." Pharmacogenomics 7, no. 1 (January 2006): 1-3.  Full Text  Link to Item
    • Voora, D, McLeod, HL, Eby, C, and Gage, BF. "The pharmacogenetics of coumarin therapy." Pharmacogenomics 6, no. 5 (July 2005): 503-513. (Review)  Full Text  Link to Item
    • Voora, D, Eby, C, Linder, MW, Milligan, PE, Bukaveckas, BL, McLeod, HL, Maloney, W, Clohisy, J, Burnett, RS, Grosso, L, Gatchel, SK, and Gage, BF. "Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype." Thromb Haemost 93, no. 4 (April 2005): 700-705.  Full Text  Link to Item
    • Voora, D, Eby, C, Linder, MW, Milligan, PE, Bukaveckas, BL, McLeod, HL, Maloney, W, Clohisy, J, Burnett, RS, Grosso, L, Gatchel, SK, and Gage, BF. "Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype." Thrombosis and Haemostasis 93, no. 4 (2005): 700-705.  Full Text
    • Voora, D, McLeod, HL, Eby, C, and Gage, BF. "Use of pharmacogenetics to guide warfarin therapy." Drugs Today (Barc) 40, no. 3 (March 2004): 247-257.  Link to Item
    • Voora, D, and Vijayan, A. "Mesenteric vein thrombosis associated with intravaginal contraceptives: a case report and review of the literature." J Thromb Thrombolysis 15, no. 2 (April 2003): 105-108. (Review)  Link to Item
    • Saker, F, Voora, DM, Mahajan, SD, Kiliç, Í, Ismail-Beigi, F, and Kalhan, SC. "Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy." Metabolism: Clinical and Experimental 48, no. 6 (1999): 738-744.  Full Text
    • Bardwell, L, Cook, JG, Zhu-Shimoni, JX, Voora, D, and Thorner, J. "Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins." Proc Natl Acad Sci U S A 95, no. 26 (December 22, 1998): 15400-15405.  Link to Item
    • Bardwell, L, Cook, JG, Voora, D, Baggott, DM, Martinez, AR, and Thorner, J. "Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK." Genes Dev 12, no. 18 (September 15, 1998): 2887-2898.  Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.