Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Cardiovascular Disease, Duke University School of Medicine 2006 - 2010
  • Chief Resident, Internal Medicine, Washington University School of Medicine 2005 - 2006
  • Resident, Internal Medicine, Washington University School of Medicine 2003 - 2005
  • Intern, Internal Medicine, Washington University School of Medicine 2002 - 2003
  • M.D., Northwestern University 2002
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2013 - 2017
  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2010 - 2013
  • Instructor Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2010
• Recognition
• 

  In the News

  • SEP 7, 2016

    Researchers Find Molecular Link Behind Aspirins Protective Powers

  • MAR 16, 2016

    New Collaborative Seed Grant Program Gives Eight Awards

  • JUL 8, 2013

    NPR

    Genes may reveal when aspirin won't reduce heart risk

  • JUL 7, 2013

    Is Aspirin Therapy for You?

  • JUL 5, 2013

    Charlotte Observer

    Duke researchers: Aspirin helps only some prevent heart disease, stroke
• Research
• 

  Selected Grants

  • Building and Deploying a Genomic-Medicine Risk Assessment Model for Diverse Primary Care Populations. awarded by National Institutes of Health 2018 - 2023
  • Abbott Diagnostics Collaborative Sponsored Research Agreement awarded by Abbott Laboratories 2016 - 2022
  • Human Platelet Defects in Transcription Factor RUNX1 Haplodeficiency awarded by Temple University 2019 - 2021
  • Identifying on and off-target effects of ticagrelor on megakaryocytic gene expression awarded by AstraZeneca AB 2019 - 2021
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2021
  • Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
  • Pharmacogenetic Testing: Challenges of Clinical Integration awarded by National Institutes of Health 2011 - 2020
  • Ex vivo metabolomic profiling of statin-induced myopathy awarded by  American Heart Association 2017 - 2019
  • Developing An In Vitro Human Myobundle Model Of Rheumatoid Arthritis awarded by National Institutes of Health 2017 - 2019
  • Rap1 signaling in platelet homeostasis and vascular hemostasis awarded by University of North Carolina - Chapel Hill 2016 - 2019
  • Development of Prognostic Platelet RNA Biomarkers To Tailor Antiplatelet Therapy awarded by National Institutes of Health 2013 - 2019
  • DEVELOPMENT OF PLATELET RNA BIOMARKERS FOR THE RESPONSE TO TICAGRELOR awarded by AstraZeneca Healthcare Foundation 2015 - 2018
  • Understanding the Response to Fesoterodine through Genetic Evaluation in the Elderly (URGE) awarded by National Institutes of Health 2012 - 2013
  • Phase I Clinical Trial Describing the Pharmacogenomics of Aspirin awarded by National Institutes of Health 2009 - 2012
  • Duke CTSA-KL2 awarded by National Institutes of Health 2006 - 2012
• 

  External Relationships

  • Genome Medical
  • United Healthcare
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Infeld, Margaret, Kevin A. Friede, Tan Ru San, Holly J. Knickerbocker, Geoffrey S. Ginsburg, Thomas L. Ortel, and Deepak Voora. “Platelet reactivity in response to aspirin and ticagrelor in African-Americans and European-Americans.” J Thromb Thrombolysis 51, no. 2 (February 2021): 249–59. https://doi.org/10.1007/s11239-020-02327-w.
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    • Patel, Jai N., Deepak Voora, Gillian Bell, Jill Bates, Amber Cipriani, Lisa Bendz, Amber Frick, et al. “North Carolina's multi-institutional pharmacogenomics efforts with the North Carolina Precision Health Collaborative.” Pharmacogenomics 22, no. 2 (January 2021): 73–80. https://doi.org/10.2217/pgs-2020-0156.
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    • Hull, Leland E., Jason L. Vassy, Annjanette Stone, Catherine C. Chanfreau-Coffinier, Craig W. Heise, Victoria M. Pratt, Ronald Przygodzki, et al. “Identifying End Users' Preferences about Structuring Pharmacogenetic Test Orders in an Electronic Health Record System.” J Mol Diagn 22, no. 10 (October 2020): 1264–71. https://doi.org/10.1016/j.jmoldx.2020.06.015.
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    • Friede, Kevin A., Margaret M. Infeld, Ru San Tan, Holly J. Knickerbocker, Rachel A. Myers, Laura G. Dubois, J Will Thompson, et al. “Influence of Sex on Platelet Reactivity in Response to Aspirin.” J Am Heart Assoc 9, no. 14 (July 21, 2020): e014726. https://doi.org/10.1161/JAHA.119.014726.
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    • Root, Adam, Randall Johnson, Ann McGee, Hui-Jie Lee, Siyun Yang, and Deepak Voora. “Understanding the state of pharmacogenomic testing for thiopurine methyltransferase within a large health system.” Pharmacogenomics 21, no. 6 (April 2020): 411–18. https://doi.org/10.2217/pgs-2019-0148.
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    • Ananthakumar, Anandita, Yiling Liu, Cristina E. Fernandez, George A. Truskey, and Deepak Voora. “Modeling statin myopathy in a human skeletal muscle microphysiological system.” Plos One 15, no. 11 (2020): e0242422. https://doi.org/10.1371/journal.pone.0242422.
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    • Dong, Olivia M., Stephanie B. Wheeler, Gracelyn Cruden, Craig R. Lee, Deepak Voora, Stacie B. Dusetzina, and Tim Wiltshire. “Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention.” Value Health 23, no. 1 (January 2020): 61–73. https://doi.org/10.1016/j.jval.2019.08.002.
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    • Eudy, A. M., D. Voora, R. A. Myers, and M. E. B. Clowse. “Effect of aspirin response signature gene expression on preterm birth and preeclampsia among women with lupus: a pilot study.” Lupus 28, no. 14 (December 2019): 1640–47. https://doi.org/10.1177/0961203319886069.
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    • Friede, Kevin A., and Deepak Voora. “Genetic influences on aspirin response in patients undergoing percutaneous coronary intervention.” Cardiovasc Res 115, no. 10 (August 1, 2019): 1452–53. https://doi.org/10.1093/cvr/cvz110.
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    • Limkakeng, Alexander T., Ricardo Henao, Deepak Voora, Thomas O’Connell, Michelle Griffin, Ephraim L. Tsalik, Svati Shah, Christopher W. Woods, and Geoffrey S. Ginsburg. “Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.” Plos One 14, no. 2 (2019): e0211762. https://doi.org/10.1371/journal.pone.0211762.
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    • Parker, William A. E., Niclas Eriksson, Richard C. Becker, Deepak Voora, Axel Åkerblom, Anders Himmelmann, Stefan K. James, Lars Wallentin, Robert F. Storey, and Robert F. PLATO Investigators. “Equilibrative nucleoside transporter 1 gene polymorphisms and clinical outcomes following acute coronary syndromes: findings from the PLATelet inhibition and patient Outcomes (PLATO) study.” Platelets 30, no. 5 (2019): 579–88. https://doi.org/10.1080/09537104.2018.1478404.
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    • Peyser, Bruce, Emily P. Perry, Kavisha Singh, Rosalynn D. Gill, Michael R. Mehan, Susanne B. Haga, Michael D. Musty, et al. “Effects of Delivering SLCO1B1 Pharmacogenetic Information in Randomized Trial and Observational Settings.” Circ Genom Precis Med 11, no. 9 (September 2018): e002228. https://doi.org/10.1161/CIRCGEN.118.002228.
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    • Friede, Kevin A., and Deepak Voora. “Future directions in pharmacogenomics discovery in cardiovascular disease.” Pharmacogenomics 19, no. 5 (April 2018): 375–77. https://doi.org/10.2217/pgs-2018-0002.
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    • Voora, Deepak, and Richard C. Becker. “Unraveling the Genetic Basis of Recurrent Venous Thromboembolism.” Circulation: Genomic and Precision Medicine 11, no. 2 (February 2018). https://doi.org/10.1161/circgen.117.002047.
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    • Cavallari, Larisa H., Craig R. Lee, Amber L. Beitelshees, Rhonda M. Cooper-DeHoff, Julio D. Duarte, Deepak Voora, Stephen E. Kimmel, et al. “Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.” Jacc Cardiovasc Interv 11, no. 2 (January 22, 2018): 181–91. https://doi.org/10.1016/j.jcin.2017.07.022.
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    • Wingrove, James A., Karen Fitch, Brian Rhees, Steven Rosenberg, and Deepak Voora. “Peripheral blood gene expression signatures which reflect smoking and aspirin exposure are associated with cardiovascular events.” Bmc Med Genomics 11, no. 1 (January 12, 2018): 1. https://doi.org/10.1186/s12920-017-0318-6.
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    • Mao, Guangfen, Natthapol Songdej, Deepak Voora, Lawrence E. Goldfinger, Fabiola E. Del Carpio-Cano, Rachel A. Myers, and A Koneti Rao. “Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants.” Circulation 136, no. 10 (September 5, 2017): 927–39. https://doi.org/10.1161/CIRCULATIONAHA.116.023711.
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    • Friede, Kevin, and Deepak Voora. “The need for sex-specific precision biomarkers for antiplatelet therapies.” Future Cardiol 13, no. 5 (September 2017): 419–22. https://doi.org/10.2217/fca-2017-0043.
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    • Musunuru, Kiran, Erik Ingelsson, Myriam Fornage, Peter Liu, Anne M. Murphy, L Kristin Newby, Christopher Newton-Cheh, et al. “The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association.” Circ Cardiovasc Genet 10, no. 4 (August 2017). https://doi.org/10.1161/HCG.0000000000000037.
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    • Cavallari, L. H., A. L. Beitelshees, K. V. Blake, L. G. Dressler, J. D. Duarte, A. Elsey, J. N. Eichmeyer, et al. “The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting.” Clin Transl Sci 10, no. 3 (May 2017): 143–46. https://doi.org/10.1111/cts.12456.
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    • Haga, Susanne B., Jivan Moaddeb, Rachel Mills, and Deepak Voora. “Assessing feasibility of delivering pharmacogenetic testing in a community pharmacy setting.” Pharmacogenomics 18, no. 4 (March 2017): 327–35. https://doi.org/10.2217/pgs-2016-0175.
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    • Voora, Deepak, Adrian Coles, Kerry L. Lee, Udo Hoffmann, James A. Wingrove, Brian Rhees, Lin Huang, et al. “An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.” Am Heart J 184 (February 2017): 133–40. https://doi.org/10.1016/j.ahj.2016.11.004.
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    • Friede, Kevin, Josephine Li, and Deepak Voora. “Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease.” Clin Chem 63, no. 1 (January 2017): 177–85. https://doi.org/10.1373/clinchem.2016.255232.
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    • Lucas, Joseph E., Taylor C. Bazemore, Celan Alo, Patrick B. Monahan, and Deepak Voora. “An electronic health record based model predicts statin adherence, LDL cholesterol, and cardiovascular disease in the United States Military Health System.” Plos One 12, no. 11 (2017): e0187809. https://doi.org/10.1371/journal.pone.0187809.
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    • Singh, Kavisha, Bruce Peyser, Gloria Trujillo, Nicholas Milazzo, Dillon Savard, Susanne B. Haga, Michael Musty, and Deepak Voora. “Rationale and design of the SLCO1B1 genotype guided statin therapy trial.” Pharmacogenomics 17, no. 17 (November 2016): 1873–80. https://doi.org/10.2217/pgs-2016-0065.
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    • Doran, Bethany, and Deepak Voora. “Circulating extracellular vesicles containing miRNAs may have utility as early biomarkers for cardiac injury.” Ann Transl Med 4, no. Suppl 1 (October 2016): S60. https://doi.org/10.21037/atm.2016.10.55.
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    • Voora, Deepak, A Koneti Rao, Gauthami S. Jalagadugula, Rachel Myers, Emily Harris, Thomas L. Ortel, and Geoffrey S. Ginsburg. “Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer.” Ebiomedicine 11 (September 2016): 157–64. https://doi.org/10.1016/j.ebiom.2016.08.021.
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    • Voora, Deepak, and Svati H. Shah. “Pharmacometabolomics Meets Genetics: A "Natural" Clinical Trial of Statin Effects.” J Am Coll Cardiol 67, no. 10 (March 15, 2016): 1211–13. https://doi.org/10.1016/j.jacc.2016.01.022.
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    • Xie, Gaoqiang, Phyo Kyaw Myint, Deepak Voora, Daniel T. Laskowitz, Ping Shi, Fuxiu Ren, Hao Wang, et al. “Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort.” Atherosclerosis 243, no. 1 (November 2015): 30–37. https://doi.org/10.1016/j.atherosclerosis.2015.08.034.
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    • Friede, Kevin A., Geoffrey S. Ginsburg, and Deepak Voora. “Gene Expression Signatures and the Spectrum of Coronary Artery Disease.” Journal of Cardiovascular Translational Research 8, no. 6 (August 2015): 339–52. https://doi.org/10.1007/s12265-015-9640-6.
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    • Varenhorst, Christoph, Niclas Eriksson, Åsa Johansson, Bryan J. Barratt, Emil Hagström, Axel Åkerblom, Ann-Christine Syvänen, et al. “Effect of genetic variations on ticagrelor plasma levels and clinical outcomes.” Eur Heart J 36, no. 29 (August 1, 2015): 1901–12. https://doi.org/10.1093/eurheartj/ehv116.
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    • Beitelshees, Amber L., Deepak Voora, and Joshua P. Lewis. “Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics.” Pharmgenomics Pers Med 8 (2015): 43–61. https://doi.org/10.2147/PGPM.S52900.
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    • Li, Josephine H., Sunil Suchindran, Svati H. Shah, William E. Kraus, Geoffrey S. Ginsburg, and Deepak Voora. “SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization.” Pharmacogenomics 16, no. 5 (2015): 449–58. https://doi.org/10.2217/pgs.15.2.
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    • Rose, Jason J., Deepak Voora, Derek D. Cyr, Joseph E. Lucas, Aimee K. Zaas, Christopher W. Woods, L Kristin Newby, William E. Kraus, and Geoffrey S. Ginsburg. “Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.” Plos One 10, no. 7 (2015): e0132259. https://doi.org/10.1371/journal.pone.0132259.
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    • Wang, Zhi, Arnab Maity, Chuhsing Kate Hsiao, Deepak Voora, Rima Kaddurah-Daouk, and Jung-Ying Tzeng. “Module-based association analysis for omics data with network structure.” Plos One 10, no. 3 (2015): e0122309. https://doi.org/10.1371/journal.pone.0122309.
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    • Suchindran, Sunil, Tiffany Himmel, Thomas L. Ortel, Richard C. Becker, William E. Kraus, L. K. Newby, Geoffrey S. Ginsburg, and Deepak Voora. “Aspirin-Responsive Platelet Genes Are Associated With Platelet Function and Cardiovascular Events.” Circulation 130 (November 25, 2014).
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    • Alfirevic, A., D. Neely, J. Armitage, H. Chinoy, R. G. Cooper, R. Laaksonen, D. F. Carr, et al. “Phenotype standardization for statin-induced myotoxicity.” Clin Pharmacol Ther 96, no. 4 (October 2014): 470–76. https://doi.org/10.1038/clpt.2014.121.
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    • Alfirevic, A., D. Neely, J. Armitage, H. Chinoy, R. G. Cooper, R. Laaksonen, D. F. Carr, et al. “Phenotype standardization for statin-induced myotoxicity.” Clinical Pharmacology and Therapeutics 96, no. 4 (October 1, 2014): 470–76. https://doi.org/10.1038/clpt.2014.121.
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    • Ramsey, L. B., S. G. Johnson, K. E. Caudle, C. E. Haidar, D. Voora, R. A. Wilke, W. D. Maxwell, et al. “The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.” Clin Pharmacol Ther 96, no. 4 (October 2014): 423–28. https://doi.org/10.1038/clpt.2014.125.
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    • Voora, Deepak, and Richard C. Becker. “A freeze on tailored antiplatelet therapy?” Circulation 129, no. 21 (May 2014): 2088–90. https://doi.org/10.1161/circulationaha.114.009930.
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    • Kertai, Miklos D., Stephen A. Esper, Igor Akushevich, Deepak Voora, Geoffrey S. Ginsburg, Mark Stafford-Smith, Katherine Grichnik, et al. “Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.” J Thorac Cardiovasc Surg 147, no. 4 (April 2014): 1368-1375.e3. https://doi.org/10.1016/j.jtcvs.2013.09.067.
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    • Varenhorst, Christoph, Niclas Eriksson, Åsa Johansson, Bryan Barratt, Axel Åkerblom, Emil Hagström, Ann-Christine Syvänen, et al. “TICAGRELOR PLASMA LEVELS BUT NOT CLINICAL OUTCOMES ARE ASSOCIATED WITH TRANSPORTER AND METABOLISM ENZYME GENETIC POLYMORPHISMS.” Journal of the American College of Cardiology 63, no. 12 (April 2014): A25–A25. https://doi.org/10.1016/s0735-1097(14)60025-5.
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    • Voora, Deepak. “Expression quantitative trait locus analysis identifies novel genes for statin myopathy.” Circ Cardiovasc Genet 7, no. 2 (April 2014): 220–21. https://doi.org/10.1161/CIRCGENETICS.114.000611.
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    • Li, Josephine H., Scott V. Joy, Susanne B. Haga, Lori A. Orlando, William E. Kraus, Geoffrey S. Ginsburg, and Deepak Voora. “Genetically guided statin therapy on statin perceptions, adherence, and cholesterol lowering: a pilot implementation study in primary care patients.” J Pers Med 4, no. 2 (March 27, 2014): 147–62. https://doi.org/10.3390/jpm4020147.
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    • Voora, D. “The last line of defense against atherosclerosis.” Science Translational Medicine 6, no. 228 (March 19, 2014). https://doi.org/10.1126/scitranslmed.3008868.
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    • Voora, D. “Pharmacogenetics: PREDICTing the era of personalized medicine.” Science Translational Medicine 6, no. 222 (February 5, 2014). https://doi.org/10.1126/scitranslmed.3008567.
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    • Voora, D. “A powerful (Re)purpose for genome-wide association studies.” Science Translational Medicine 6, no. 218 (January 8, 2014). https://doi.org/10.1126/scitranslmed.3008136.
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    • Voora, Deepak, Geoffrey S. Ginsburg, and Axel Akerblom. “Platelet RNA as a novel biomarker for the response to antiplatelet therapy.” Future Cardiol 10, no. 1 (January 2014): 9–12. https://doi.org/10.2217/fca.13.90.
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    • Voora, D. “Cardiology: Silencing the sounds of hypertrophic cardiomyopathy.” Science Translational Medicine 5, no. 210 (November 6, 2013). https://doi.org/10.1126/scitranslmed.3007861.
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    • Voora, Deepak, Derek Cyr, Joseph Lucas, Jen-Tsan Chi, Jennifer Dungan, Timothy A. McCaffrey, Richard Katz, et al. “Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events.” J Am Coll Cardiol 62, no. 14 (October 1, 2013): 1267–76. https://doi.org/10.1016/j.jacc.2013.05.073.
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    • Voora, D. “Drug-induced aches and pains.” Science Translational Medicine 5, no. 204 (September 25, 2013). https://doi.org/10.1126/scitranslmed.3007631.
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    • Zaas, Aimee K., Thomas Burke, Minhua Chen, Micah McClain, Bradly Nicholson, Timothy Veldman, Ephraim L. Tsalik, et al. “A host-based RT-PCR gene expression signature to identify acute respiratory viral infection.” Sci Transl Med 5, no. 203 (September 18, 2013): 203ra126. https://doi.org/10.1126/scitranslmed.3006280.
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    • Becker, R. C., D. Voora, and S. H. Shah. “Hemostasis and Thrombosis” 2 (August 29, 2013): 602–11. https://doi.org/10.1016/B978-0-12-382227-7.00052-5.
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    • Voora, D. “XiAP-ping castration-resistant prostate cancer.” Science Translational Medicine 5, no. 192 (July 3, 2013). https://doi.org/10.1126/scitranslmed.3006880.
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    • Voora, D. “A miR-aculous advance for a rare heart disorder.” Science Translational Medicine 5, no. 186 (May 22, 2013). https://doi.org/10.1126/scitranslmed.3006596.
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    • Voora, D. “Diagnosis and prognosis a liquid solution for solid tumors.” Science Translational Medicine 5, no. 180 (April 10, 2013). https://doi.org/10.1126/scitranslmed.3006268.
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    • Voora, Deepak. “A transcriptomics-informed genetic association study identifies RHOA in simvastatin-induced low-density lipoprotein cholesterol lowering.” Circ Cardiovasc Genet 6, no. 1 (February 2013): 137–38. https://doi.org/10.1161/CIRCGENETICS.111.000070.
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    • Mills, Rachel, Deepak Voora, Bruce Peyser, and Susanne B. Haga. “Delivering pharmacogenetic testing in a primary care setting.” Pharmgenomics Pers Med 6 (2013): 105–12. https://doi.org/10.2147/PGPM.S50598.
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    • Rose, J. J., D. Voora, D. D. Cyr, J. E. Lucas, A. K. Zaas, L. K. Newby, W. E. Kraus, and G. S. Ginsburg. “Blood Gene Expression Profiling Reveals An Association Between Viral Infection, Platelet Function, And Acute Myocardial Infarction.” American Journal of Respiratory and Critical Care Medicine 187 (January 1, 2013).
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    • Voora, Deepak. “Building the evidentiary framework for pharmacogenetic testing: is it time to move beyond randomized controlled trials?” Per Med 10, no. 1 (January 2013): 1–3. https://doi.org/10.2217/pme.12.105.
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    • Voora, Deepak, Derek Cyr, Joseph Lucas, Jen-Tsan Chi, Jennifer Dungan, Timothy McCaffrey, Richard Katz, et al. “Aspirin Exposure Reveals Novel Genes Associated with Platelet Function and Cardiovascular Events.” Circulation 126, no. 21 (November 20, 2012).
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    • Voora, Deepak, and Geoffrey S. Ginsburg. “Clinical application of cardiovascular pharmacogenetics.” Journal of the American College of Cardiology 60, no. 1 (July 2012): 9–20. https://doi.org/10.1016/j.jacc.2012.01.067.
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    • Wilke, R. A., L. B. Ramsey, S. G. Johnson, W. D. Maxwell, H. L. McLeod, D. Voora, R. M. Krauss, et al. “The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.” Clin Pharmacol Ther 92, no. 1 (July 2012): 112–17. https://doi.org/10.1038/clpt.2012.57.
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    • Voora, Deepak, Thomas L. Ortel, Joseph E. Lucas, Jen-Tsan Chi, Richard C. Becker, and Geoffrey S. Ginsburg. “Time-dependent changes in non-COX-1-dependent platelet function with daily aspirin therapy.” J Thromb Thrombolysis 33, no. 3 (April 2012): 246–57. https://doi.org/10.1007/s11239-012-0683-0.
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    • Ahmad, Tariq, Deepak Voora, and Richard C. Becker. “The pharmacogenetics of antiplatelet agents: towards personalized therapy?” Nature Reviews. Cardiology 8, no. 10 (August 9, 2011): 560–71. https://doi.org/10.1038/nrcardio.2011.111.
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    • Voora, Deepak, and Geoffrey S. Ginsburg. “A hub for bench-to-bedside pharmacogenomic-based research.” Pharmacogenomics 12, no. 8 (August 2011): 1095–98. https://doi.org/10.2217/pgs.11.62.
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    • Voora, Deepak, John Horton, Svati H. Shah, Linda K. Shaw, and L Kristin Newby. “Polymorphisms associated with in vitro aspirin resistance are not associated with clinical outcomes in patients with coronary artery disease who report regular aspirin use.” American Heart Journal 162, no. 1 (July 2011): 166-72.e1. https://doi.org/10.1016/j.ahj.2011.03.026.
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    • Ahmad, T., D. Voora, and R. C. Becker. “The pharmacogenetics of antiplatelet agents: towards personalized therapy?” Nature Reviews Cardiology, 2011.
    • Voora, Deepak, Thomas L. Ortel, Joseph E. Lucas, Jen-Tsan Chi, Richard C. Becker, and Geoffrey S. Ginsburg. “A Whole Blood RNA Signature Accurately Classifies Multiple Measures of Platelet Function on Aspirin in Healthy Volunteers and Highlights a Common Underlying Pathway.” Circulation 122, no. 21 (November 23, 2010).
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    • Wallace, Thomas W., Brett D. Atwater, James P. Daubert, Deepak Voora, Anna Lisa Crowley, Tristram D. Bahnson, and Patrick M. Hranitzky. “Prevalence and clinical characteristics associated with left atrial appendage thrombus in fully anticoagulated patients undergoing catheter-directed atrial fibrillation ablation.” J Cardiovasc Electrophysiol 21, no. 8 (August 1, 2010): 849–52. https://doi.org/10.1111/j.1540-8167.2010.01729.x.
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    • Ginsburg, Geoffrey S., and Deepak Voora. “The long and winding road to warfarin pharmacogenetic testing.” J Am Coll Cardiol 55, no. 25 (June 22, 2010): 2813–15. https://doi.org/10.1016/j.jacc.2010.04.006.
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    • Voora, D., D. C. Koboldt, C. R. King, P. A. Lenzini, C. S. Eby, R. Porche-Sorbet, E. Deych, et al. “A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans.” Clin Pharmacol Ther 87, no. 4 (April 2010): 445–51. https://doi.org/10.1038/clpt.2009.291.
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    • Voora, D., and G. S. Ginsburg. “Pharmacogenetics of the response to statins.” Current Cardiovascular Risk Reports 3, no. 6 (December 1, 2009): 434–40. https://doi.org/10.1007/s12170-009-0064-1.
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    • Kawamoto, Kensaku, Lori A. Orlando, Deepak Voora, David F. Lobach, Scott Joy, Alex Cho, and Geoffrey S. Ginsburg. “Evaluation of the PharmGKB knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays.” Amia Annu Symp Proc 2009 (November 14, 2009): 307–11.
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    • Voora, Deepak, Svati H. Shah, Ivan Spasojevic, Shazia Ali, Carol R. Reed, Benjamin A. Salisbury, and Geoffrey S. Ginsburg. “The SLCO1B1*5 genetic variant is associated with statin-induced side effects.” J Am Coll Cardiol 54, no. 17 (October 20, 2009): 1609–16. https://doi.org/10.1016/j.jacc.2009.04.053.
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    • Voora, Deepak, Svati H. Shah, Carol R. Reed, Jun Zhai, David R. Crosslin, Chad Messer, Benjamin A. Salisbury, and Geoffrey S. Ginsburg. “Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.” Circ Cardiovasc Genet 1, no. 2 (December 2008): 100–106. https://doi.org/10.1161/CIRCGENETICS.108.795013.
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    • Voora, Deepak, Shazia Ali, Svati H. Shah, Carol R. Reed, Benjamin Salisbury, and Geoffrey S. Ginsburg. “Association of Statin-Induced Musculoskeletal Side Effects with Sex and a Hepatic Uptake Transporter Reduced Function Allele, SLC01B1*5.” Circulation 118, no. 18 (October 28, 2008): S326–S326.
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    • Gage, B. F., C. Eby, J. A. Johnson, E. Deych, M. J. Rieder, P. M. Ridker, P. E. Milligan, et al. “Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.” Clin Pharmacol Ther 84, no. 3 (September 2008): 326–31. https://doi.org/10.1038/clpt.2008.10.
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    • Gage, B. F., C. Eby, J. A. Johnson, E. Deych, M. J. Rieder, P. M. Ridker, P. E. Milligan, et al. “Corrigendum: Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin (Clinical Pharmacology Therapeutics (2008) 84, (326-331) DOI: 10.1038/clpt.2008.10).” Clinical Pharmacology and Therapeutics 84, no. 3 (September 1, 2008): 430. https://doi.org/10.1038/clpt.2008.112.
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    • Voora, Deepalk, Carol R. Reed, Jun Zhai, Benjamin A. Salisbury, Svatj H. Shah, and Geoffrey S. Ginsburg. “Polymorphisms in ABCA1 predict statin mediated LDL cholesterol lowering and suggest an interaction with CETP.” Circulation 116, no. 16 (October 16, 2007): 178–178.
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    • Millican, Eric A., Petra A. Lenzini, Paul E. Milligan, Leonard Grosso, Charles Eby, Elena Deych, Gloria Grice, et al. “Genetic-based dosing in orthopedic patients beginning warfarin therapy.” Blood 110, no. 5 (September 1, 2007): 1511–15. https://doi.org/10.1182/blood-2007-01-069609.
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    • Voora, Deepak, and Brian F. Gage. “Is primary care ready for pharmacogenetics?” Pharmacogenomics 7, no. 1 (January 2006): 1–3. https://doi.org/10.2217/14622416.7.1.1.
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    • Voora, Deepak, Howard L. McLeod, Charles Eby, and Brian F. Gage. “The pharmacogenetics of coumarin therapy.” Pharmacogenomics 6, no. 5 (July 2005): 503–13. https://doi.org/10.2217/14622416.6.5.503.
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    • Voora, Deepak, Charles Eby, Mark W. Linder, Paul E. Milligan, Bonny L. Bukaveckas, Howard L. McLeod, William Maloney, et al. “Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype.” Thromb Haemost 93, no. 4 (April 2005): 700–705. https://doi.org/10.1160/TH04-08-0542.
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    • Voora, Deepak, Howard L. McLeod, Charles Eby, and Brian F. Gage. “Use of pharmacogenetics to guide warfarin therapy.” Drugs Today (Barc) 40, no. 3 (March 2004): 247–57. https://doi.org/10.1358/dot.2004.40.3.820088.
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    • Voora, Deepak, and Anitha Vijayan. “Mesenteric vein thrombosis associated with intravaginal contraceptives: a case report and review of the literature.” J Thromb Thrombolysis 15, no. 2 (April 2003): 105–8. https://doi.org/10.1023/b:thro.0000003323.80742.4d.
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    • Saker, F., D. M. Voora, S. D. Mahajan, I. Kiliç, F. Ismail-Beigi, and S. C. Kalhan. “Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy.” Metabolism 48, no. 6 (June 1999): 738–44. https://doi.org/10.1016/s0026-0495(99)90173-7.
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    • Bardwell, L., J. G. Cook, J. X. Zhu-Shimoni, D. Voora, and J. Thorner. “Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.” Proc Natl Acad Sci U S A 95, no. 26 (December 22, 1998): 15400–405. https://doi.org/10.1073/pnas.95.26.15400.
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    • Bardwell, L., J. G. Cook, D. Voora, D. M. Baggott, A. R. Martinez, and J. Thorner. “Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.” Genes Dev 12, no. 18 (September 15, 1998): 2887–98. https://doi.org/10.1101/gad.12.18.2887.
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  • Book Sections

    • Li, J. H., and D. Voora. “Cardiovascular Pharmacogenetics.” In Genomic and Precision Medicine: Cardiovascular Disease: Third Edition, 291–307, 2018. https://doi.org/10.1016/B978-0-12-801812-5.00012-3.
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    • Voora, D. “Pharmacogenetics and Pharmacogenomics.” In Genomic and Precision Medicine: Foundations, Translation, and Implementation: Third Edition, 233–46, 2017. https://doi.org/10.1016/B978-0-12-800681-8.00016-5.
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  • Conference Papers

    • Limkakeng, A. T., L. -. L. Rowlette, O. Ilkayeva, J. Modliszewski, D. Corcoran, J. C. Leahy, S. M. Griffin, and D. Voora. “99EMF Pilot of Integrated Metabolomic and MicroRNA Analysis to Identify Myocardial Ischemia on Emergency Department Cardiac Stress Tests.” In Annals of Emergency Medicine, 74:S40–S40. Elsevier BV, 2019. https://doi.org/10.1016/j.annemergmed.2019.08.103.
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    • Limkakeng, A. T., P. Manandhar, A. Erkanli, and D. Voora. “129 United States Emergency Department Use of Medications with Pharmacogenetic Recommendations.” In Annals of Emergency Medicine, 74:S52–S52. Elsevier BV, 2019. https://doi.org/10.1016/j.annemergmed.2019.08.134.
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    • Dong, O., C. R. Lee, S. B. Wheeler, D. Voora, S. B. Dusetzina, and T. Wiltshire. “CV1 - A COST-EFFECTIVENESS ANALYSIS OF MULITI-GENE PHARMACOGENETIC TESTING IN ACUTE CORONARY SYNDROME PATIENTS FOLLOWING PERCUTANEOUS CORONARY INTERVENTION.” In Value in Health, 21:S6–S6. Elsevier BV, 2018. https://doi.org/10.1016/j.jval.2018.09.032.
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    • Limkakeng, A. T., M. Griffin, C. Leahy, A. Hatch, L. Rowlette, D. Voora, and A. Nixon. “32EMF Isolating Micro-Ribonucleic Acids from Peripheral Plasma to Identify Myocardial Ischemia During Stress Testing in Emergency Department Patients.” In Annals of Emergency Medicine, 72:S16–S16. Elsevier BV, 2018. https://doi.org/10.1016/j.annemergmed.2018.08.037.
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    • Rowley, Jesse W., Robert A. Campbell, Hansjorg Schwertz, Andrew S. Weyrich, Neal D. Tolley, Deepak Voora, and Matthew T. Rondina. “Transcript Expression, Intron Retention, and RNA Editing Are Conserved in Human Platelets over a 4 Year Period.” In Blood, Vol. 130. AMER SOC HEMATOLOGY, 2017.
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    • Assimes, Themistocles L., Scott M. Damrauer, Jin Li, Yan Sun, Julie A. Lynch, Derek Klarin, Scott L. Duvall, et al. “A GWAS of EHR-Defined CAD Identifies Multiple Novel Loci Including the First 3 Loci on the X-Chromosome: The Million Veteran Program.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • Li, Jin, Julie A. Lynch, Scott M. Damrauer, Mary E. Plomondon, Rebecca J. Song, Kelly Cho, Derek Klarin, et al. “Genetic Variants Associated With Angiographic Burden of CAD in Europeans and African Americans: The Million Veteran Program.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • Wingrove, James A., Karen Fitch, Brian Rhees, Steven Rosenberg, and Deepak Voora. “Peripheral Blood Gene Expression Signatures Which Reflect Smoking and Response to Aspirin Are Associated With Cardiovascular Events.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • Friede, Kevin, Margaret Infeld, Ru-San Tan, Rachel Myers, and Deepak Voora. “INFLUENCE OF SEX ON PLATELET RESPONSE TO ASPIRIN AND TICAGRELOR.” In Journal of the American College of Cardiology, 69:23–23. ELSEVIER SCIENCE INC, 2017.
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    • Infeld, Margaret, Kevin Friede, Rachel A. Myers, Thomas Ortel, Tan Ru San, and Deepak Voora. “THE EFFECT OF RACE ON THE ANTIPLATELET EFFECTS OF TICAGRELOR AND ASPIRIN.” In Journal of the American College of Cardiology, 69:263–263. ELSEVIER SCIENCE INC, 2017.
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    • Cavallari, Larisa H., Joshua C. Denny, Craig R. Lee, Amber L. Beitelshees, Julio D. Duarte, Steve E. Kimmel, Deepak Voora, et al. “Prospective Clinical Implementation of CYP2C19-Genotype Guided Antiplatelet Therapy After PCI: a Multi-Site Investigation of MACE Outcomes in a Real-World Setting.” In Circulation, 134:E711–12. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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    • Songdej, Natthapol, Guangfen Mao, Deepak Voora, Lawrence E. Goldfinger, Fabiola Del Carpio-Cano, Rachel Myers, and Angara Koneti Rao. “PCTP (Phosphatidylcholine Transfer Protein) is Regulated By RUNX1 in Platelets/Megakaryocytes and is Associated with Adverse Cardiovascular Events.” In Blood, 128:365–365. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.365.365.
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    • Klarin, Derek, Yuk-Lam Ho, David R. Gagnon, Jacqueline Honerlaw, Jason L. Vassy, Deepak Voora, Tim Assimes, et al. “Lipid Reduction Measurements in a Veteran Population - Implications for Genetic Modeling in the Million Veteran Program.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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    • Voora, Deepak, Emily Perry, Kavisha Singh, Gloria Trujillo, Nicholas Milazzo, Dillon Savard, Susanne Haga, Michael D. Musty, Yi-Ju Li, and Bruce Peyser. “SLCO1B1 Genotype-Guided Statin Therapy Lowers LDL Cholesterol in Patients With Statin-Intolerance-A Randomized Controlled Trial.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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    • Voora, Deepak, Emily Perry, Kavisha Singh, Gloria Trujillo, Nicholas Milazzo, Dillon Savard, Susanne Haga, Michael D. Musty, Yi-Ju Li, and Bruce Peyser. “SLCO1B1 Genotype-Guided Statin Therapy Lowers LDL Cholesterol in Patients With Statin-Intolerance-A Randomized Controlled Trial.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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    • Voora, Deepak, Adrian Coles, Kerry Lee, Udo Hoffmann, James Wingrove, Brian Rhees, Lin Huang, et al. “AN AGE- AND SEX-SPECIFIC PERIPHERAL BLOOD GENE EXPRESSION SCORE CORRELATES WITH FUTURE CARDIOVASCULAR EVENTS: INSIGHTS FROM THE PROMISE TRIAL.” In Journal of the American College of Cardiology, 67:2094–2094. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)32095-2.
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    • Li, Josephine H., Sunil Suchindran, Svati H. Shah, William E. Kraus, Geoffrey S. Ginsburg, and Deepak Voora. “Effect of SLCO1B1*5 on Low-Density Lipoprotein Cholesterol Levels and Long-Term Clinical Events in Patients During Statin Therapy Following Cardiac Catheterization.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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    • Doss, Jennifer, Dereje Jima, Deepak Voora, Sandeep Dave, and Jen-Tsan Ashley Chi. “Using High-Throughput Sequencing of Red Blood Cells and Platelets to Identify Micrornas Associated with Hematopoiesis.” In Blood, 120:2326–2326. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.2326.2326.
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    • Voora, Deepak, Svati H. Shah, John R. Horton, Linda K. Shaw, and L. K. Newby. “Polymorphisms Associated With in vitro Aspirin Resistance Are Not Associated With Clinical Outcomes During Regular Aspirin Use.” In Circulation, 120:S599–S599. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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    • Voora, Deepak, Dan C. Koboldt, Cristi R. King, Charles S. Eby, Rhonda Porche-Sorbet, Elena Deych, Petra Lenzini, et al. “A comparative genomics approach identifies a polymorphism in calumenin as a predictor of high warfarin dose in African American patients.” In Circulation, 116:177–177. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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    • Gage, B. F., C. S. Eby, J. A. Johnson, M. J. Rieder, P. M. Ridker, A. E. Rettie, C. Aquilante, et al. “Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin.” In Blood, 106:164A-164A. AMER SOC HEMATOLOGY, 2005.
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