Current Appointments & Affiliations
Professor of Medicine
·
2024 - Present
Medicine, Cardiology,
Medicine
Member of the Center for Applied Genomics & Precision Medicine
·
2010 - Present
Duke Clinical Research Institute,
Institutes and Centers
Executive Team Member of Duke Center for Applied Genomics and Precision Medicine
·
2014 - Present
The Precision Medicine Program,
Medicine
Recent Publications
A Primary Open-Angle Glaucoma Locus Near Transcription Factor PRRX1 Identified in the Million Veteran Program.
Journal Article Ophthalmol Sci · July 2026 OBJECTIVE: To identify genetic risk variants for primary open-angle glaucoma (POAG) and prioritize biologically relevant genes through integration of genetic association, regulatory annotation, ocular transcriptomics, and functional modeling. DESIGN: A cas ... Full text Link to item CiteAn Update to the Clinical Pharmacogenetics Implementation Consortium (CPIC) SLCO1B1 Allele Functionality Table Leveraging Evidence from Participants of Predominantly Sub-Saharan African Ancestry.
Journal Article Clin Pharmacol Ther · May 2026 The Clinical Pharmacogenetics Implementation Consortium (CPIC) has formally updated the SLCO1B1 allele functionality table based on new evidence. Notably, the alleles studied (SLCO1B1 *9, *31, *41) are enriched in the genomes of patients historically exclu ... Full text Link to item CiteGenotype-Guided Antidepressant Prescribing for Patients With Depression: A Randomized Clinical Trial.
Journal Article JAMA Netw Open · May 1, 2026 IMPORTANCE: The effectiveness of pharmacogenetics to guide prescribing of selective serotonin reuptake inhibitors (SSRIs) for depression remains unclear, despite the well-established association between SSRI pharmacokinetics and genetic variation. OBJECTIV ... Full text Link to item CiteRecent Grants
The VA Genomic Learning Health System: Implementing genomic medicine across diverse Veteran communities.
ResearchPrincipal Investigator · Awarded by Boston VA Research Institute, Inc. · 2024 - 2029Molecular predictors of cardiovascular events and resilience in chronic coronary artery disease
ResearchPrincipal Investigator · Awarded by NYU Langone Medical Center · 2023 - 2028Hematology & Transfusion Medicine (T32)
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 1975 - 2026View All Grants
Education
Northwestern University ·
2002
M.D.