Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?


Journal Article

Cardiac fibroblasts have been long recognized as active participants in heart disease; however, their exact physiological and pathological roles remain elusive, mainly due to the lack of specific markers. In this issue of the JCI, Moore-Morris and colleagues used a fibroblast-specific collagen1a1-GFP reporter to demonstrate that fibroblast accumulation after aortic banding in murine hearts arises almost exclusively from proliferation of resident fibroblasts originating from both the epicardium and a previously unrecognized source, the endocardium. Further characterization of fibroblast origin and function in different types and stages of heart disease could lead to development of improved fibroblast-targeted cardiac therapies.

Full Text

Duke Authors

Cited Authors

  • Bursac, N

Published Date

  • July 2014

Published In

Volume / Issue

  • 124 / 7

Start / End Page

  • 2850 - 2853

PubMed ID

  • 24937423

Pubmed Central ID

  • 24937423

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI76628


  • eng