Nenad Bursac
Professor of Biomedical Engineering
Bursac's research interests include: Stem cell, tissue engineering, and gene based therapies for heart and muscle regeneration; Cardiac electrophysiology and arrhythmias; Organ-on-chip and tissue engineering technologies for disease modeling and therapeutic screening; Small and large animal models of heart and muscle injury, disease, and regeneration.
The focus of my research is on application of pluripotent stem cells, tissue engineering, and gene therapy technologies for: 1) basic studies of striated muscle biology and disease in vitro and 2) regenerative therapies in small and large animal models in vivo. For in vitro studies, micropatterning of extracellular matrix proteins or protein hydrogels and 3D cell culture are used to engineer rodent and human striated muscle tissues that replicate the structure-function relationships present in healthy and diseased muscles. We use these models to separate and systematically study the roles of structural and genetic factors that contribute cardiac and skeletal muscle function and disease at multiple organizational levels, from single cells to tissues. Combining cardiac and skeletal muscle cells with primary or iPSC-derived non-muscle cells (endothelial cells, smooth muscle cells, immune system cells, neurons) allows us to generate more realistic models of healthy and diseased human tissues and utilize them to mechanistically study molecular and cellular processes of tissue injury, vascularization, innervation, electromechanical integration, fibrosis, and functional repair. Currently, in vitro models of Duchenne Muscular Dystrophy, Pompe disease, dyspherlinopathies, and various cardiomyopathies are studied in the lab. For in vivo studies, we employ rodent models of volumetric skeletal muscle loss, cardiotoxin and BaCl2 injury as well as myocardial infarction and transverse aortic constriction to study how cell, tissue engineering, and gene (viral) therapies can lead to safe and efficient tissue repair and regeneration. In large animal (porcine) models of myocardial injury and arrhythmias, we are exploring how human iPSC derived heart tissue patches and application of engineered ion channels can improve cardiac function and prevent heart failure or sudden cardiac death.
Current Research Interests
Current Appointments & Affiliations
- Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2016
- Associate Professor in Medicine, Medicine, Cardiology, Medicine 2011
- Professor in Cell Biology, Cell Biology, Basic Science Departments 2016
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015
- Co-Director of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- CIEMAS 1141, Durham, NC 27708
- Duke Box 90281, Durham, NC 27708-0281
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(919) 660-5510
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Google Scholar
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http://bursaclab.bme.duke.edu/
- Background
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Education, Training, & Certifications
- Ph.D., Boston University 2000
- B.S.E., University of Belgrade (Serbia) 1994
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Previous Appointments & Affiliations
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2010 - 2015
- Rooney Family Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2014 - 2015
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2003 - 2010
- Recognition
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In the News
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DEC 13, 2022 -
FEB 11, 2022 -
FEB 3, 2022 Pratt School of Engineering -
JAN 25, 2021 Pratt School of Engineering -
NOV 5, 2019 Pratt School of Engineering -
OCT 1, 2018 Pratt School of Engineering -
AUG 6, 2018 Duke Medicine Alumni Magazine -
JUN 27, 2018 -
JAN 9, 2018 Pratt School of Engineering -
NOV 28, 2017 Pratt School of Engineering -
NOV 28, 2017 Pratt School of Engineering -
OCT 18, 2016 -
OCT 18, 2016 Pratt School of Engineering -
OCT 6, 2016 -
OCT 6, 2016 Pratt School of Engineering -
MAR 24, 2015 NBC News -
JAN 13, 2015 -
JAN 13, 2015 Pratt School of Engineering -
MAY 23, 2014 UNC-TV’s "North Carolina Now" -
APR 8, 2014 The Wall Street Journal -
APR 2, 2014 The Independent -
APR 1, 2014 NBC News -
APR 1, 2014 -
APR 1, 2014 BBC News -
MAR 31, 2014 Pratt School of Engineering
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- Expertise
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Subject Headings
- Action Potentials
- Anisotropy
- Arrhythmias, Cardiac
- Biomedical Engineering
- Bioreactors
- Cardiomyopathies
- Connexin 43
- Electrophysiological Processes
- Electrophysiology
- Fibroblasts
- HEK293 Cells
- Hydrogels
- Induced Pluripotent Stem Cells
- Microtechnology
- Muscle, Skeletal
- Muscle, Striated
- Myoblasts, Skeletal
- Myocardial Infarction
- Myocytes, Cardiac
- Pluripotent Stem Cells
- Regenerative Medicine
- Satellite Cells, Skeletal Muscle
- Stem Cell Transplantation
- Stem Cells
- Tissue Engineering
- Tissue Scaffolds
- Voltage-Sensitive Dye Imaging
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Global Scholarship
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Research
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Teaching
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- Research
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Selected Grants
- The role of the sodium potassium ATPase type alpha-3 subunit in sudden cardiac arrest awarded by National Institutes of Health 2022 - 2027
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Myovascular Mechanisms of Cardiac Growth and Regeneration awarded by National Institutes of Health 2022 - 2026
- Stable therapy in Pompe disease through genome editing awarded by National Institutes of Health 2021 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Engineering Human Heart Tissues with Polyploid Cardiomyocytes awarded by National Institutes of Health 2022 - 2026
- Engineered BacNav and BacCav for Improved Excitability and Contraction awarded by National Institutes of Health 2022 - 2026
- Regulation of myocardial GPCRs by USP20 in normal and hypertrophied heart awarded by National Institutes of Health 2021 - 2025
- Investigating Mitogenic Mechanism and Therapeutic Efficacy of Adenosine Deaminase Knockout in Human and Murine Cardiomyocytes awarded by National Institutes of Health 2022 - 2024
- Engineering Highly Functional Pre-Vascularized Human Skeletal Muscle for In Vitro and In Vivo Applications awarded by National Institutes of Health 2022 - 2024
- Investigating Mitogenic Mechanism and Therapeutic Efficacy of Adenosine Deaminase Knockout in Human and Murine Cardiomyocytes awarded by American Heart Association 2022 - 2024
- Mechanical regulation of maturation and pathology of engineered human heart tissues awarded by American Heart Association 2022 - 2024
- Investigating the Role of Polyploidy in the Maturation of hiPSC-derived Cardiomyocytes awarded by National Institutes of Health 2021 - 2024
- Engineered Prokaryotic Ion Channel Gene Therapy for Brugada Syndrome awarded by American Heart Association 2022 - 2023
- Microphysiological Human Tissue Systems for Monitoring of Genome Editing Outcomes awarded by National Institutes of Health 2019 - 2023
- Development of 3-dimensional human skeletal muscle tissue models of MD Type 2B awarded by Jain Foundation 2017 - 2023
- Exercise Induced Muscle Secreted Factors That Modify Osteoarthritis (OA) Severity awarded by National Institutes of Health 2021 - 2023
- Biochemical and functional investigation of the novel enzymatic activities of Mesh1 awarded by National Institutes of Health 2018 - 2023
- Epigenetic Mechanisms Promoting Longevity awarded by National Institutes of Health 2018 - 2023
- Integrated Cellular and Tissue Engineering for Ischemic Heart Disease awarded by University of Alabama at Birmingham 2016 - 2023
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2023
- Muscle-macrophage constructs for skeletal muscle repair awarded by National Institutes of Health 2016 - 2023
- Genome editing for the correction of Pompe disease awarded by National Institutes of Health 2020 - 2022
- Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease awarded by National Institutes of Health 2017 - 2022
- Eliciting heart regeneration through cardiomyocyte division awarded by Fondation Leducq 2016 - 2022
- Engineering of Human Excitable Tissues from Unexcitable Cells awarded by National Institutes of Health 2016 - 2022
- In Vitro and In Situ Engineering of Fibroblasts for Cardiac Repair awarded by National Institutes of Health 2016 - 2022
- A fully biological platform for monitoring mesoscale neural activity awarded by National Institutes of Health 2018 - 2021
- Translational studies of GAA deficiency in bioengineered human muscle awarded by National Institutes of Health 2013 - 2019
- Circulatory system and integrated muscle tissue for drug and tissue toxicity awarded by National Institutes of Health 2012 - 2018
- Bioengineering a Living Tissue Conductor awarded by National Institutes of Health 2015 - 2018
- Skeletal Muscle Bundle Technology to qualify Human Biomarkers for Muscle Degeneration / Necrosis awarded by Pfizer, Inc. 2017 - 2018
- Effects of Chondroitin Sulfate and Chrondroitin Sulfate/Glucosamine on Muscle Immune Signaling and Function in TNF-alpha Stimulated Three Dimensional Muscle Cultures awarded by Bioiberica, S.A. 2016 - 2017
- Functional 3D Cardiac Patches Derived from Human Induced Pluripotent Stem Cells awarded by National Institutes of Health 2014 - 2016
- Function and Integration of Stem Cell-derived Cardiac Tissue Patch awarded by National Institutes of Health 2010 - 2016
- Modeling Cardiac Impulse Propagation at the Microscale awarded by National Institutes of Health 2009 - 2015
- Mechanisms for Stem Cell Differentiation into Cardiac Myocytes awarded by National Institutes of Health 2009 - 2011
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External Relationships
- American Association for the Advancement of Science
- Institute of Molecular Genetics and Genetic Engineering (IMGG), Belgrade, Serbia
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Yan, Ruorong, Valentina Cigliola, Kelsey A. Oonk, Zachary Petrover, Sophia DeLuca, David W. Wolfson, Andrew Vekstein, et al. “An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.” Cell Stem Cell 30, no. 1 (January 5, 2023): 96-111.e6. https://doi.org/10.1016/j.stem.2022.11.012.Full Text Link to Item
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Lee, David E., Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, and James P. White. “Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.” Nat Commun 13, no. 1 (December 9, 2022): 7613. https://doi.org/10.1038/s41467-022-35390-3.Full Text Link to Item
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Scherba, Jacob C., Ravi Karra, Joseph W. Turek, and Nenad Bursac. “Toward improved understanding of cardiac development and congenital heart disease: The advent of cardiac organoids.” J Thorac Cardiovasc Surg 164, no. 6 (December 2022): 2013–18. https://doi.org/10.1016/j.jtcvs.2022.02.028.Full Text Link to Item
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Khodabukus, Alastair, Tyler Guyer, Axel C. Moore, Molly M. Stevens, Robert E. Guldberg, and Nenad Bursac. “Translating musculoskeletal bioengineering into tissue regeneration therapies.” Science Translational Medicine 14, no. 666 (October 2022): eabn9074. https://doi.org/10.1126/scitranslmed.abn9074.Full Text
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Scherba, Jacob C., Marc K. Halushka, Nicholas D. Andersen, Joseph J. Maleszewski, Andrew P. Landstrom, Nenad Bursac, and Carolyn Glass. “BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens.” Sci Rep 12, no. 1 (May 17, 2022): 7996. https://doi.org/10.1038/s41598-022-11829-x.Full Text Link to Item
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Wang, Jason, Torie Broer, Taylor Chavez, Chris J. Zhou, Sabrina Tran, Yu Xiang, Alastair Khodabukus, Yarui Diao, and Nenad Bursac. “Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells.” Biomaterials 284 (May 2022): 121508. https://doi.org/10.1016/j.biomaterials.2022.121508.Full Text Link to Item
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Nguyen, Hung X., Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, et al. “Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.” Nat Commun 13, no. 1 (February 2, 2022): 620. https://doi.org/10.1038/s41467-022-28251-6.Full Text Link to Item
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Janbandhu, Vaibhao, Vikram Tallapragada, Ralph Patrick, Yanzhen Li, Dhanushi Abeygunawardena, David T. Humphreys, Ella M. M. A. Martin, et al. “Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction.” Cell Stem Cell 29, no. 2 (February 2022): 281-297.e12. https://doi.org/10.1016/j.stem.2021.10.009.Full Text
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DeLuca, Sophia, and Nenad Bursac. “CRISPR Library Screening in Cultured Cardiomyocytes.” Methods in Molecular Biology (Clifton, N.J.) 2485 (January 2022): 1–13. https://doi.org/10.1007/978-1-0716-2261-2_1.Full Text
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Vann, Christopher G., Xin Zhang, Alastair Khodabukus, Melissa C. Orenduff, Yu-Hsiu Chen, David L. Corcoran, George A. Truskey, Nenad Bursac, and Virginia B. Kraus. “Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle.” Front Physiol 13 (2022): 937899. https://doi.org/10.3389/fphys.2022.937899.Full Text Link to Item
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Vekstein, Andrew M., David C. Wendell, Sophia DeLuca, Ruorong Yan, Yifan Chen, Muath Bishawi, Garth W. Devlin, et al. “Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.” Front Cardiovasc Med 9 (2022): 833335. https://doi.org/10.3389/fcvm.2022.833335.Full Text Link to Item
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Strash, Nicholas, Sophia DeLuca, Geovanni L. Janer Carattini, Soon Chul Heo, Ryne Gorsuch, and Nenad Bursac. “Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes.” Elife 10 (October 2021): e65512. https://doi.org/10.7554/elife.65512.Full Text
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Wang, Jason, Chris J. Zhou, Alastair Khodabukus, Sabrina Tran, Sang-Oh Han, Aaron L. Carlson, Lauran Madden, Priya S. Kishnani, Dwight D. Koeberl, and Nenad Bursac. “Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease.” Commun Biol 4, no. 1 (May 5, 2021): 524. https://doi.org/10.1038/s42003-021-02059-4.Full Text Open Access Copy Link to Item
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Zhan, Ren-Zhi, Lingjun Rao, Zhaowei Chen, Nicholas Strash, and Nenad Bursac. “Loss of sarcomeric proteins via upregulation of JAK/STAT signaling underlies interferon-γ-induced contractile deficit in engineered human myocardium.” Acta Biomaterialia 126 (May 2021): 144–53. https://doi.org/10.1016/j.actbio.2021.03.007.Full Text
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Saha, Krishanu, Erik J. Sontheimer, P. J. Brooks, Melinda R. Dwinell, Charles A. Gersbach, David R. Liu, Stephen A. Murray, et al. “The NIH Somatic Cell Genome Editing program.” Nature 592, no. 7853 (April 2021): 195–204. https://doi.org/10.1038/s41586-021-03191-1.Full Text Link to Item
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Helfer, Abbigail, and Nenad Bursac. “Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs.” Methods in Molecular Biology (Clifton, N.J.) 2158 (January 2021): 171–86. https://doi.org/10.1007/978-1-0716-0668-1_13.Full Text
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Chen, Zhaowei, Binjie Li, Ren-Zhi Zhan, Lingjun Rao, and Nenad Bursac. “Exercise mimetics and JAK inhibition attenuate IFN-γ-induced wasting in engineered human skeletal muscle.” Science Advances 7, no. 4 (January 2021): eabd9502. https://doi.org/10.1126/sciadv.abd9502.Full Text
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Fralish, Zachary, Ethan M. Lotz, Taylor Chavez, Alastair Khodabukus, and Nenad Bursac. “Neuromuscular Development and Disease: Learning From in vitro and in vivo Models.” Frontiers in Cell and Developmental Biology 9 (January 2021): 764732. https://doi.org/10.3389/fcell.2021.764732.Full Text
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Kondash, Megan E., Anandita Ananthakumar, Alastair Khodabukus, Nenad Bursac, and George A. Truskey. “Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle.” Tissue Engineering and Regenerative Medicine 17, no. 6 (December 2020): 801–13. https://doi.org/10.1007/s13770-020-00242-y.Full Text
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Khodabukus, Alastair, Amulya Kaza, Jason Wang, Neel Prabhu, Richard Goldstein, Vishal S. Vaidya, and Nenad Bursac. “Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers.” Toxicological Sciences : An Official Journal of the Society of Toxicology 176, no. 1 (July 2020): 124–36. https://doi.org/10.1093/toxsci/kfaa049.Full Text
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Broer, Torie, Alastair Khodabukus, and Nenad Bursac. “Can we mimic skeletal muscles for novel drug discovery?” Expert Opinion on Drug Discovery 15, no. 6 (June 2020): 643–45. https://doi.org/10.1080/17460441.2020.1736031.Full Text
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Li, Yanzhen, Daniel Song, Lan Mao, Dennis M. Abraham, and Nenad Bursac. “Lack of Thy1 defines a pathogenic fraction of cardiac fibroblasts in heart failure.” Biomaterials 236 (April 2020): 119824. https://doi.org/10.1016/j.biomaterials.2020.119824.Full Text Link to Item
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Pomeroy, Jordan E., Abbigail Helfer, and Nenad Bursac. “Biomaterializing the promise of cardiac tissue engineering.” Biotechnol Adv 42 (2020): 107353. https://doi.org/10.1016/j.biotechadv.2019.02.009.Full Text Link to Item
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Wang, Jason, Alastair Khodabukus, Lingjun Rao, Keith Vandusen, Nadia Abutaleb, and Nenad Bursac. “Engineered skeletal muscles for disease modeling and drug discovery.” Biomaterials 221 (November 2019): 119416. https://doi.org/10.1016/j.biomaterials.2019.119416.Full Text
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Yifa, Oren, Karen Weisinger, Elad Bassat, Hanjun Li, David Kain, Haim Barr, Noga Kozer, et al. “The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.” Jci Insight 4, no. 22 (November 2019): 128025. https://doi.org/10.1172/jci.insight.128025.Full Text
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Sengupta, Swarnali, Katheryn E. Rothenberg, Hanjun Li, Brenton D. Hoffman, and Nenad Bursac. “Altering integrin engagement regulates membrane localization of Kir2.1 channels.” Journal of Cell Science 132, no. 17 (September 2019): jcs225383. https://doi.org/10.1242/jcs.225383.Full Text
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Nguyen, Hung X., and Nenad Bursac. “Ion channel engineering for modulation and de novo generation of electrical excitability.” Current Opinion in Biotechnology 58 (August 2019): 100–107. https://doi.org/10.1016/j.copbio.2019.01.004.Full Text
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Khodabukus, Alastair, Lauran Madden, Neel K. Prabhu, Timothy R. Koves, Christopher P. Jackman, Deborah M. Muoio, and Nenad Bursac. “Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.” Biomaterials 198 (April 2019): 259–69. https://doi.org/10.1016/j.biomaterials.2018.08.058.Full Text Link to Item
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Berry, Joel L., Wuqiang Zhu, Yao Liang Tang, Prasanna Krishnamurthy, Ying Ge, John P. Cooke, Yabing Chen, et al. “Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.” Circ Res 124, no. 1 (January 4, 2019): 161–69. https://doi.org/10.1161/CIRCRESAHA.118.314216.Full Text Link to Item
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Juhas, Mark, Nadia Abutaleb, Jason T. Wang, Jean Ye, Zohaib Shaikh, Chaichontat Sriworarat, Ying Qian, and Nenad Bursac. “Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration.” Nature Biomedical Engineering 2, no. 12 (December 2018): 942–54. https://doi.org/10.1038/s41551-018-0290-2.Full Text
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Koeberl, Dwight D., Laura E. Case, Edward C. Smith, Crista Walters, Sang-Oh Han, Yanzhen Li, Wei Chen, et al. “Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease.” Mol Ther 26, no. 9 (September 5, 2018): 2304–14. https://doi.org/10.1016/j.ymthe.2018.06.023.Full Text Link to Item
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Jackman, Christopher, Hanjun Li, and Nenad Bursac. “Long-term contractile activity and thyroid hormone supplementation produce engineered rat myocardium with adult-like structure and function.” Acta Biomaterialia 78 (September 2018): 98–110. https://doi.org/10.1016/j.actbio.2018.08.003.Full Text
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Khodabukus, Alastair, Neel Prabhu, Jason Wang, and Nenad Bursac. “In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease.” Advanced Healthcare Materials 7, no. 15 (August 2018): e1701498. https://doi.org/10.1002/adhm.201701498.Full Text
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Gokhale, Tanmay A., Huda Asfour, Shravan Verma, Nenad Bursac, and Craig S. Henriquez. “Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study.” Plos Computational Biology 14, no. 7 (July 2018): e1006276. https://doi.org/10.1371/journal.pcbi.1006276.Full Text
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Nguyen, Hung X., Robert D. Kirkton, and Nenad Bursac. “Generation and customization of biosynthetic excitable tissues for electrophysiological studies and cell-based therapies.” Nature Protocols 13, no. 5 (May 2018): 927–45. https://doi.org/10.1038/nprot.2018.016.Full Text
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Jackman, Christopher P., Asvin M. Ganapathi, Huda Asfour, Ying Qian, Brian W. Allen, Yanzhen Li, and Nenad Bursac. “Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.” Biomaterials 159 (March 2018): 48–58. https://doi.org/10.1016/j.biomaterials.2018.01.002.Full Text Link to Item
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Rao, Lingjun, Ying Qian, Alastair Khodabukus, Thomas Ribar, and Nenad Bursac. “Engineering human pluripotent stem cells into a functional skeletal muscle tissue.” Nature Communications 9, no. 1 (January 2018): 126. https://doi.org/10.1038/s41467-017-02636-4.Full Text
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Shadrin, Ilya Y., Brian W. Allen, Ying Qian, Christopher P. Jackman, Aaron L. Carlson, Mark E. Juhas, and Nenad Bursac. “Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.” Nat Commun 8, no. 1 (November 28, 2017): 1825. https://doi.org/10.1038/s41467-017-01946-x.Full Text Link to Item
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Polstein, Lauren R., Mark Juhas, Gabi Hanna, Nenad Bursac, and Charles A. Gersbach. “An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis.” Acs Synthetic Biology 6, no. 11 (November 2017): 2003–13. https://doi.org/10.1021/acssynbio.7b00147.Full Text
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Cao, Jingli, Jinhu Wang, Christopher P. Jackman, Amanda H. Cox, Michael A. Trembley, Joseph J. Balowski, Ben D. Cox, et al. “Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.” Dev Cell 42, no. 6 (September 25, 2017): 600-615.e4. https://doi.org/10.1016/j.devcel.2017.08.024.Full Text Link to Item
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Yanamandala, Mounica, Wuqiang Zhu, Daniel J. Garry, Timothy J. Kamp, Joshua M. Hare, Ho-Wook Jun, Young-Sup Yoon, et al. “Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering.” Journal of the American College of Cardiology 70, no. 6 (August 2017): 766–75. https://doi.org/10.1016/j.jacc.2017.06.012.Full Text
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Bassat, Elad, Yara Eid Mutlak, Alex Genzelinakh, Ilya Y. Shadrin, Kfir Baruch Umansky, Oren Yifa, David Kain, et al. “The extracellular matrix protein agrin promotes heart regeneration in mice.” Nature 547, no. 7662 (July 2017): 179–84. https://doi.org/10.1038/nature22978.Full Text
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Li, Yanzhen, Huda Asfour, and Nenad Bursac. “Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue.” Acta Biomaterialia 55 (June 2017): 120–30. https://doi.org/10.1016/j.actbio.2017.04.027.Full Text
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Liau, Brian, Christopher P. Jackman, Yanzhen Li, and Nenad Bursac. “Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues.” Scientific Reports 7 (February 2017): 42290. https://doi.org/10.1038/srep42290.Full Text
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Pomeroy, Jordan E., Hung X. Nguyen, Brenton D. Hoffman, and Nenad Bursac. “Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells.” Theranostics 7, no. 14 (2017): 3539–58. https://doi.org/10.7150/thno.20593.Full Text Open Access Copy Link to Item
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Gokhale, Tanmay A., Jong M. Kim, Robert D. Kirkton, Nenad Bursac, and Craig S. Henriquez. “Modeling an Excitable Biosynthetic Tissue with Inherent Variability for Paired Computational-Experimental Studies.” Plos Computational Biology 13, no. 1 (January 2017): e1005342. https://doi.org/10.1371/journal.pcbi.1005342.Full Text Open Access Copy
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Li, Yanzhen, Sophie Dal-Pra, Maria Mirotsou, Tilanthi M. Jayawardena, Conrad P. Hodgkinson, Nenad Bursac, and Victor J. Dzau. “Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs.” Sci Rep 6 (December 12, 2016): 38815. https://doi.org/10.1038/srep38815.Full Text Link to Item
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Jackman, Christopher P., Aaron L. Carlson, and Nenad Bursac. “Dynamic culture yields engineered myocardium with near-adult functional output.” Biomaterials 111 (December 2016): 66–79. https://doi.org/10.1016/j.biomaterials.2016.09.024.Full Text
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Shadrin, I. Y., A. Khodabukus, and N. Bursac. “Striated muscle function, regeneration, and repair.” Cellular and Molecular Life Sciences : Cmls 73, no. 22 (November 2016): 4175–4202. https://doi.org/10.1007/s00018-016-2285-z.Full Text
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Nguyen, Hung X., Robert D. Kirkton, and Nenad Bursac. “Engineering prokaryotic channels for control of mammalian tissue excitability.” Nature Communications 7 (October 2016): 13132. https://doi.org/10.1038/ncomms13132.Full Text
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Ogle, Brenda M., Nenad Bursac, Ibrahim Domian, Ngan F. Huang, Philippe Menasché, Charles E. Murry, Beth Pruitt, et al. “Distilling complexity to advance cardiac tissue engineering.” Science Translational Medicine 8, no. 342 (June 2016): 342ps13. https://doi.org/10.1126/scitranslmed.aad2304.Full Text
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Juhas, Mark, Jean Ye, and Nenad Bursac. “Design, evaluation, and application of engineered skeletal muscle.” Methods (San Diego, Calif.) 99 (April 2016): 81–90. https://doi.org/10.1016/j.ymeth.2015.10.002.Full Text
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Cheng, Cindy S., Lydia Ran, Nenad Bursac, William E. Kraus, and George A. Truskey. “Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues.” Tissue Eng Part A 22, no. 7–8 (April 2016): 573–83. https://doi.org/10.1089/ten.TEA.2015.0359.Full Text Link to Item
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Shadrin, Ilya Y., Woohyun Yoon, Liqing Li, Neal Shepherd, and Nenad Bursac. “Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells.” Scientific Reports 5 (July 2015): 12043. https://doi.org/10.1038/srep12043.Full Text
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Jackman, Christopher P., Ilya Y. Shadrin, Aaron L. Carlson, and Nenad Bursac. “Human Cardiac Tissue Engineering: From Pluripotent Stem Cells to Heart Repair.” Current Opinion in Chemical Engineering 7 (February 2015): 57–64. https://doi.org/10.1016/j.coche.2014.11.004.Full Text
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Madden, Lauran, Mark Juhas, William E. Kraus, George A. Truskey, and Nenad Bursac. “Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.” Elife 4 (January 9, 2015): e04885. https://doi.org/10.7554/eLife.04885.Full Text Open Access Copy Link to Item
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Wang, Li, Ziqing Liu, Chaoying Yin, Huda Asfour, Olivia Chen, Yanzhen Li, Nenad Bursac, Jiandong Liu, and Li Qian. “Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming.” Circulation Research 116, no. 2 (January 2015): 237–44. https://doi.org/10.1161/circresaha.116.305547.Full Text
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Juhas, Mark, and Nenad Bursac. “Roles of adherent myogenic cells and dynamic culture in engineered muscle function and maintenance of satellite cells.” Biomaterials 35, no. 35 (November 2014): 9438–46. https://doi.org/10.1016/j.biomaterials.2014.07.035.Full Text
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Cheng, Cindy S., Brittany N. J. Davis, Lauran Madden, Nenad Bursac, and George A. Truskey. “Physiology and metabolism of tissue-engineered skeletal muscle.” Experimental Biology and Medicine (Maywood, N.J.) 239, no. 9 (September 2014): 1203–14. https://doi.org/10.1177/1535370214538589.Full Text
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Bursac, Nenad. “Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?” The Journal of Clinical Investigation 124, no. 7 (July 2014): 2850–53. https://doi.org/10.1172/jci76628.Full Text
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Hsiai, Tzung, Song Li, and Nenad Bursac. “Introduction to the special issue on tissue engineering and regenerative medicine.” Annals of Biomedical Engineering 42, no. 7 (July 2014): 1355–56. https://doi.org/10.1007/s10439-014-1053-1.Full Text
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Rangarajan, Swathi, Lauran Madden, and Nenad Bursac. “Use of flow, electrical, and mechanical stimulation to promote engineering of striated muscles.” Annals of Biomedical Engineering 42, no. 7 (July 2014): 1391–1405. https://doi.org/10.1007/s10439-013-0966-4.Full Text
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Bian, W., C. P. Jackman, and N. Bursac. “Controlling the structural and functional anisotropy of engineered cardiac tissues.” Biofabrication 6, no. 2 (June 2014): 24109–24109. https://doi.org/10.1088/1758-5082/6/2/024109.Full Text
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Farah, Benjamin L., Lauran Madden, Songtao Li, Sierra Nance, Andrew Bird, Nenad Bursac, Paul M. Yen, Sarah P. Young, and Dwight D. Koeberl. “Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease.” Faseb J 28, no. 5 (May 2014): 2272–80. https://doi.org/10.1096/fj.13-244202.Full Text Open Access Copy Link to Item
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Juhas, Mark, George C. Engelmayr, Andrew N. Fontanella, Gregory M. Palmer, and Nenad Bursac. “Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo.” Proc Natl Acad Sci U S A 111, no. 15 (April 15, 2014): 5508–13. https://doi.org/10.1073/pnas.1402723111.Full Text Open Access Copy Link to Item
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Bian, Weining, Nima Badie, Herman D. Himel, and Nenad Bursac. “Robust T-tubulation and maturation of cardiomyocytes using tissue-engineered epicardial mimetics.” Biomaterials 35, no. 12 (April 2014): 3819–28. https://doi.org/10.1016/j.biomaterials.2014.01.045.Full Text
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Engelmayr, G. C., D. Zhang, and N. Bursac. “Maturation of functional cardiac tissue patches,” January 1, 2014, 248–82. https://doi.org/10.1533/9780857096715.2.248.Full Text
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Nguyen, H., N. Badie, L. McSpadden, D. Pedrotty, and N. Bursac. “Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs.” Methods in Molecular Biology 1181 (2014): 249–62. https://doi.org/10.1007/978-1-4939-1047-2-21.Full Text
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Nguyen, Hung, Nima Badie, Luke McSpadden, Dawn Pedrotty, and Nenad Bursac. “Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs.” Methods in Molecular Biology (Clifton, N.J.) 1181 (January 2014): 249–62. https://doi.org/10.1007/978-1-4939-1047-2_21.Full Text
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Kirkton, Robert D., Nima Badie, and Nenad Bursac. “Spatial profiles of electrical mismatch determine vulnerability to conduction failure across a host-donor cell interface.” Circulation. Arrhythmia and Electrophysiology 6, no. 6 (December 2013): 1200–1207. https://doi.org/10.1161/circep.113.001050.Full Text
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Juhas, Mark, and Nenad Bursac. “Engineering skeletal muscle repair.” Current Opinion in Biotechnology 24, no. 5 (October 2013): 880–86. https://doi.org/10.1016/j.copbio.2013.04.013.Full Text
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Zhang, Donghui, Ilya Y. Shadrin, Jason Lam, Hai-Qian Xian, H Ralph Snodgrass, and Nenad Bursac. “Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes.” Biomaterials 34, no. 23 (July 2013): 5813–20. https://doi.org/10.1016/j.biomaterials.2013.04.026.Full Text Open Access Copy
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Christoforou, Nicolas, Brian Liau, Syandan Chakraborty, Malathi Chellapan, Nenad Bursac, and Kam W. Leong. “Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues.” Plos One 8, no. 6 (January 2013): e65963. https://doi.org/10.1371/journal.pone.0065963.Full Text Open Access Copy
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Christoforou, Nicolas, Malathi Chellappan, Andrew F. Adler, Robert D. Kirkton, Tianyi Wu, Russell C. Addis, Nenad Bursac, and Kam W. Leong. “Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.” Plos One 8, no. 5 (January 2013): e63577. https://doi.org/10.1371/journal.pone.0063577.Full Text Open Access Copy
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Jiang, Wei, Donghui Zhang, Nenad Bursac, and Yi Zhang. “WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs.” Stem Cell Reports 1, no. 1 (January 2013): 46–52. https://doi.org/10.1016/j.stemcr.2013.03.003.Full Text Open Access Copy
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Truskey, George A., Hardean E. Achneck, Nenad Bursac, Hon Chan, Cindy S. Cheng, Cristina Fernandez, Sungmin Hong, et al. “Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing.” Stem Cell Res Ther 4 Suppl 1, no. Suppl 1 (2013): S10. https://doi.org/10.1186/scrt371.Full Text Link to Item
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Zhang, Donghui, Jason Lam, Brian Liau, Ralph Snodgrass, and Nenad Bursac. “Human Embryonic Stem Cell-Derived Cardiac Tissue Patch with Advanced Structure and Function.” Circulation 126, no. 21 (November 20, 2012).Link to Item
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Kirkton, Robert D., and Nenad Bursac. “Genetic engineering of somatic cells to study and improve cardiac function.” Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology 14 Suppl 5 (November 2012): v40–49. https://doi.org/10.1093/europace/eus269.Full Text
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McSpadden, Luke C., Hung Nguyen, and Nenad Bursac. “Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs.” Circulation. Arrhythmia and Electrophysiology 5, no. 4 (August 2012): 821–30. https://doi.org/10.1161/circep.111.969329.Full Text
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Piacentino, Valentino, Carmelo A. Milano, Michael Bolanos, Jacob Schroder, Emily Messina, Adam S. Cockrell, Edward Jones, et al. “X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector.” Hum Gene Ther 23, no. 6 (June 2012): 635–46. https://doi.org/10.1089/hum.2011.186.Full Text Link to Item
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Bian, Weining, Mark Juhas, Terry W. Pfeiler, and Nenad Bursac. “Local tissue geometry determines contractile force generation of engineered muscle networks.” Tissue Engineering. Part A 18, no. 9–10 (May 2012): 957–67. https://doi.org/10.1089/ten.tea.2011.0313.Full Text
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Scull, James A., Luke C. McSpadden, Herman D. Himel, Nima Badie, and Nenad Bursac. “Single-detector simultaneous optical mapping of V(m) and [Ca(2+)](i) in cardiac monolayers.” Annals of Biomedical Engineering 40, no. 5 (May 2012): 1006–17. https://doi.org/10.1007/s10439-011-0478-z.Full Text
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Bursac, Nenad. “Colonizing the heart from the epicardial side.” Stem Cell Research & Therapy 3, no. 2 (April 2012): 15. https://doi.org/10.1186/scrt106.Full Text Open Access Copy
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Liau, Brian, Donghui Zhang, and Nenad Bursac. “Functional cardiac tissue engineering.” Regenerative Medicine 7, no. 2 (March 2012): 187–206. https://doi.org/10.2217/rme.11.122.Full Text
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Badie, Nima, James A. Scull, Rebecca Y. Klinger, Ava Krol, and Nenad Bursac. “Conduction block in micropatterned cardiomyocyte cultures replicating the structure of ventricular cross-sections.” Cardiovasc Res 93, no. 2 (February 1, 2012): 263–71. https://doi.org/10.1093/cvr/cvr304.Full Text Link to Item
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Bian, Weining, and Nenad Bursac. “Soluble miniagrin enhances contractile function of engineered skeletal muscle.” Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 26, no. 2 (February 2012): 955–65. https://doi.org/10.1096/fj.11-187575.Full Text
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Muller-Borer, Barbara, Gwyn Esch, Rob Aldina, Woohyun Woon, Raymond Fox, Nenad Bursac, Sylvia Hiller, et al. “Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage.” Plos One 7, no. 6 (January 2012): e38454. https://doi.org/10.1371/journal.pone.0038454.Full Text Open Access Copy
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Liau, Brian, Nicolas Christoforou, Kam W. Leong, and Nenad Bursac. “Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function.” Biomaterials 32, no. 35 (December 2011): 9180–87. https://doi.org/10.1016/j.biomaterials.2011.08.050.Full Text
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McSpadden, Luke C., and Nenad Bursac. “Size and Ionic Currents of Unexcitable Cells Coupled to Cardiomyocytes Distinctly Modulate Cardiac Action Potential Shape and Pacemaking Activity.” Circulation 124, no. 21 (November 22, 2011).Link to Item
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Wang, Chuan, Jessica A. Hennessey, Robert D. Kirkton, Chaojian Wang, Victoria Graham, Ram S. Puranam, Paul B. Rosenberg, Nenad Bursac, and Geoffrey S. Pitt. “Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.” Circ Res 109, no. 7 (September 16, 2011): 775–82. https://doi.org/10.1161/CIRCRESAHA.111.247957.Full Text Link to Item
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Lin, Na, Nima Badie, Lin Yu, Dennis Abraham, Heping Cheng, Nenad Bursac, Howard A. Rockman, and Matthew J. Wolf. “A method to measure myocardial calcium handling in adult Drosophila.” Circ Res 108, no. 11 (May 27, 2011): 1306–15. https://doi.org/10.1161/CIRCRESAHA.110.238105.Full Text Link to Item
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Hinds, Sara, Weining Bian, Robert G. Dennis, and Nenad Bursac. “The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle.” Biomaterials 32, no. 14 (May 2011): 3575–83. https://doi.org/10.1016/j.biomaterials.2011.01.062.Full Text
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Shaked, N. T., L. L. Satterwhite, N. Bursac, and A. Wax. “Whole cell imaging based on wide-field interferometric phase microscopy and its application to cardiomyocytes.” Progress in Biomedical Optics and Imaging Proceedings of Spie 7904 (April 29, 2011). https://doi.org/10.1117/12.874224.Full Text
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Kirkton, Robert D., and Nenad Bursac. “Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies.” Nature Communications 2 (January 2011): 300. https://doi.org/10.1038/ncomms1302.Full Text
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Bian, Weining, Brian Liau, Nima Badie, and Nenad Bursac. “Engineering of Functional Cardiac Tissue Patch with Realistic Myofiber Orientations.” Circulation 122, no. 21 (November 23, 2010).Link to Item
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Kirkton, Robert D., and Nenad Bursac. “Engineered Somatic Cells for Cardiac Repair.” Circulation 122, no. 21 (November 23, 2010).Link to Item
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Piacentino, Valentino, Michael Bolanos, Jacob Schroder, Emily Messina, Edward Jones, Ava Krol, Nenad Bursac, et al. “X-Linked Inhibitor of Apoptosis Protein (XIAP)-Mediated Attenuation of Apoptosis Using a Novel Cardiac Enhanced Adeno-Associated Viral Vector.” Circulation 122, no. 21 (November 23, 2010).Link to Item
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Shaked, Natan T., Lisa L. Satterwhite, Nenad Bursac, and Adam Wax. “Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy.” Biomedical Optics Express 1, no. 2 (August 2010): 706–19. https://doi.org/10.1364/boe.1.000706.Full Text Open Access Copy
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Christoforou, Nicolas, Behzad N. Oskouei, Paul Esteso, Christine M. Hill, Jeffrey M. Zimmet, Weining Bian, Nenad Bursac, Kam W. Leong, Joshua M. Hare, and John D. Gearhart. “Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts.” Plos One 5, no. 7 (July 2010): e11536. https://doi.org/10.1371/journal.pone.0011536.Full Text Open Access Copy
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Kim, Jong M., Nenad Bursac, and Craig S. Henriquez. “A computer model of engineered cardiac monolayers.” Biophysical Journal 98, no. 9 (May 2010): 1762–71. https://doi.org/10.1016/j.bpj.2010.01.008.Full Text
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Shaked, Natan T., Yizheng Zhu, Nima Badie, Nenad Bursac, and Adam Wax. “Reflective interferometric chamber for quantitative phase imaging of biological sample dynamics.” Journal of Biomedical Optics 15, no. 3 (May 2010): 030503. https://doi.org/10.1117/1.3420179.Full Text
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Tranquillo, Joseph V., Nima Badie, Craig S. Henriquez, and Nenad Bursac. “Collision-based spiral acceleration in cardiac media: roles of wavefront curvature and excitable gap.” Biophysical Journal 98, no. 7 (April 2010): 1119–28. https://doi.org/10.1016/j.bpj.2009.12.4281.Full Text
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Bursac, Nenad, Robert D. Kirkton, Luke C. McSpadden, and Brian Liau. “Characterizing functional stem cell-cardiomyocyte interactions.” Regenerative Medicine 5, no. 1 (January 2010): 87–105. https://doi.org/10.2217/rme.09.69.Full Text
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Badie, Nima, Lisa Satterwhite, and Nenad Bursac. “A method to replicate the microstructure of heart tissue in vitro using DTMRI-based cell micropatterning.” Annals of Biomedical Engineering 37, no. 12 (December 2009): 2510–21. https://doi.org/10.1007/s10439-009-9815-x.Full Text
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Pedrotty, Dawn M., Rebecca Y. Klinger, Robert D. Kirkton, and Nenad Bursac. “Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes.” Cardiovasc Res 83, no. 4 (September 1, 2009): 688–97. https://doi.org/10.1093/cvr/cvp164.Full Text Link to Item
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McSpadden, Luke C., Robert D. Kirkton, and Nenad Bursac. “Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level.” American Journal of Physiology. Cell Physiology 297, no. 2 (August 2009): C339–51. https://doi.org/10.1152/ajpcell.00024.2009.Full Text
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Badie, Nima, and Nenad Bursac. “Novel micropatterned cardiac cell cultures with realistic ventricular microstructure.” Biophysical Journal 96, no. 9 (May 2009): 3873–85. https://doi.org/10.1016/j.bpj.2009.02.019.Full Text
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Bian, Weining, and Nenad Bursac. “Engineered skeletal muscle tissue networks with controllable architecture.” Biomaterials 30, no. 7 (March 2009): 1401–12. https://doi.org/10.1016/j.biomaterials.2008.11.015.Full Text
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Bursac, Nenad. “Cardiac tissue engineering using stem cells.” Ieee Engineering in Medicine and Biology Magazine : The Quarterly Magazine of the Engineering in Medicine & Biology Society 28, no. 2 (March 2009): 80–89. https://doi.org/10.1109/memb.2009.931792.Full Text
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Bian, Weining, Brian Liau, Nima Badie, and Nenad Bursac. “Mesoscopic hydrogel molding to control the 3D geometry of bioartificial muscle tissues.” Nature Protocols 4, no. 10 (January 2009): 1522–34. https://doi.org/10.1038/nprot.2009.155.Full Text
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Badle, Nima, and Nenad Bursac. “Micropatterned Ventricular Slice: Role of Realistic Tissue Microstructure In Impulse Conduction.” Circulation 118, no. 18 (October 28, 2008): S493–S493.Link to Item
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Klinger, Rebecca, and Nenad Bursac. “In Vitro Cellular Implantation Assay To Quantitatively Compare The Ability Of Different Donor Cells To Electrically Conduct Within Cardiac Tissue.” Circulation 118, no. 18 (October 28, 2008): S395–S395.Link to Item
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Bian, Weining, and Nenad Bursac. “Tissue engineering of functional skeletal muscle: challenges and recent advances.” Ieee Engineering in Medicine and Biology Magazine : The Quarterly Magazine of the Engineering in Medicine & Biology Society 27, no. 5 (September 2008): 109–13. https://doi.org/10.1109/memb.2008.928460.Full Text
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Liao, I-Chien, Jason B. Liu, Nenad Bursac, and Kam W. Leong. “Effect of Electromechanical Stimulation on the Maturation of Myotubes on Aligned Electrospun Fibers.” Cellular and Molecular Bioengineering 1, no. 2–3 (September 2008): 133–45. https://doi.org/10.1007/s12195-008-0021-y.Full Text
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Pedrotty, Dawn M., Rebecca Y. Klinger, Nima Badie, Sara Hinds, Ara Kardashian, and Nenad Bursac. “Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay.” Am J Physiol Heart Circ Physiol 295, no. 1 (July 2008): H390–400. https://doi.org/10.1152/ajpheart.91531.2007.Full Text Link to Item
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Kirkton, Robert D., and Nenad Bursac. “Genetic engineering and stem cells: combinatorial approaches for cardiac cell therapy.” Ieee Engineering in Medicine and Biology Magazine : The Quarterly Magazine of the Engineering in Medicine & Biology Society 27, no. 3 (May 2008): 85–88. https://doi.org/10.1109/memb.2008.922356.Full Text
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Klinger, Rebecca, and Nenad Bursac. “Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells.” Ieee Eng Med Biol Mag 27, no. 1 (2008): 72–80. https://doi.org/10.1109/MEMB.2007.913849.Full Text Link to Item
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Bian, Weining, and Nenad Bursac. “Micromolded cardiac network patches for treatment of infarcted heart.” Circulation 116, no. 16 (October 16, 2007): 68–69.Link to Item
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Pedrotty, Dawn, Rebecca Klinger, and Nenad Bursac. “Paracrine factors from cardiac fibroblasts slow conduction velocity and prolong the action potential duration of cardiomyocytes.” Circulation 116, no. 16 (October 16, 2007): 87–87.Link to Item
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Bursac, Nenad, Yihua Loo, Kam Leong, and Leslie Tung. “Novel anisotropic engineered cardiac tissues: studies of electrical propagation.” Biochemical and Biophysical Research Communications 361, no. 4 (October 2007): 847–53. https://doi.org/10.1016/j.bbrc.2007.07.138.Full Text
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Bursac, Nenad. “Stem cell therapies for heart disease: why do we need bioengineers?” Ieee Engineering in Medicine and Biology Magazine : The Quarterly Magazine of the Engineering in Medicine & Biology Society 26, no. 4 (July 2007): 76–79. https://doi.org/10.1109/memb.2007.384101.Full Text
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Zhang, Zhu-Shan, Joseph Tranquillo, Valentina Neplioueva, Nenad Bursac, and Augustus O. Grant. “Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease.” Am J Physiol Heart Circ Physiol 292, no. 1 (January 2007): H399–407. https://doi.org/10.1152/ajpheart.01025.2005.Full Text Link to Item
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Tranquillo, J. V., and N. Bursac. “The role restitution in pacing induced spiral wave acceleration.” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, December 1, 2006, 3919–22.
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Badie, Nima, and Nenad Bursac. “Micropatterned heart slice cultures for studies of intramural cardiac electrophysiology.” Circulation 114, no. 18 (October 31, 2006): 331–331.Link to Item
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Sathaye, Alok, Nenad Bursac, Sean Sheehy, and Leslie Tung. “Electrical pacing counteracts intrinsic shortening of action potential duration of neonatal rat ventricular cells in culture.” Journal of Molecular and Cellular Cardiology 41, no. 4 (October 2006): 633–41. https://doi.org/10.1016/j.yjmcc.2006.06.076.Full Text
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Bursac, Nenad, and Leslie Tung. “Acceleration of functional reentry by rapid pacing in anisotropic cardiac monolayers: formation of multi-wave functional reentries.” Cardiovascular Research 69, no. 2 (February 2006): 381–90. https://doi.org/10.1016/j.cardiores.2005.09.014.Full Text
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Tranquillo, J. V., and N. Bursac. “The role restitution in pacing induced spiral wave acceleration.” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 2006, 3919–22.
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Tranquillo, Joseph V., and Nenad Bursac. “The role restitution in pacing induced spiral wave acceleration.” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference 2006 (January 2006): 3919–22. https://doi.org/10.1109/iembs.2006.260035.Full Text
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Kong, Chae-Ryon, Nenad Bursac, and Leslie Tung. “Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes.” Journal of Applied Physiology (Bethesda, Md. : 1985) 98, no. 6 (June 2005): 2328–2320. https://doi.org/10.1152/japplphysiol.01084.2004.Full Text
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Pedrotty, Dawn M., and Nenad Bursac. “Cardiomyoplasty: the prospect of human stem cells.” Ieee Engineering in Medicine and Biology Magazine : The Quarterly Magazine of the Engineering in Medicine & Biology Society 24, no. 3 (May 2005): 125–27. https://doi.org/10.1109/memb.2005.1436471.Full Text
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Bursac, Nenad, Felipe Aguel, and Leslie Tung. “Multiarm spirals in a two-dimensional cardiac substrate.” Proceedings of the National Academy of Sciences of the United States of America 101, no. 43 (October 2004): 15530–34. https://doi.org/10.1073/pnas.0400984101.Full Text
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Bursac, Nenad, Maria Papadaki, John A. White, Solomon R. Eisenberg, Gordana Vunjak-Novakovic, and Lisa E. Freed. “Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties.” Tissue Engineering 9, no. 6 (December 2003): 1243–53. https://doi.org/10.1089/10763270360728152.Full Text
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Iravanian, Shahriar, Yelena Nabutovsky, Chae-Ryon Kong, Sumita Saha, Nenad Bursac, and Leslie Tung. “Functional reentry in cultured monolayers of neonatal rat cardiac cells.” American Journal of Physiology. Heart and Circulatory Physiology 285, no. 1 (July 2003): H449–56. https://doi.org/10.1152/ajpheart.00896.2002.Full Text
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Bursac, N., K. K. Parker, S. Iravanian, and L. Tung. “Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle.” Circulation Research 91, no. 12 (December 2002): e45–54. https://doi.org/10.1161/01.res.0000047530.88338.eb.Full Text
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Molmenti, Ernesto P., Thomas W. Roodhouse, Hebe Molmenti, Kshama Jaiswal, Ghap Jung, Shigeru Marubashi, Edmund Q. Sanchez, et al. “Thrombendvenectomy for organized portal vein thrombosis at the time of liver transplantation.” Annals of Surgery 235, no. 2 (February 2002): 292–96. https://doi.org/10.1097/00000658-200202000-00019.Full Text
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Aljuri, A. N., N. Bursac, R. Marini, and R. J. Cohen. “System identification of dynamic closed-loop control of total peripheral resistance by arterial and cardiopulmonary baroreceptors.” Acta Astronautica 49, no. 3–10 (August 2001): 167–70. https://doi.org/10.1016/s0094-5765(01)00095-9.Full Text
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Papadaki, M., N. Bursac, R. Langer, J. Merok, G. Vunjak-Novakovic, and L. E. Freed. “Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies.” American Journal of Physiology. Heart and Circulatory Physiology 280, no. 1 (January 2001): H168–78. https://doi.org/10.1152/ajpheart.2001.280.1.h168.Full Text
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Iravanlan, S., Y. Nabutovsky, S. Saha, N. Bursac, and L. Tung. “Optical maps of reentrant activity in cultured monolayers of neonatal rat cardiac myocytes.” Circulation 104, no. 17 (2001): 108–108.Link to Item
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Bursac, N., M. Papadaki, J. White, S. Eisenberg, and L. Freed. “Three-dimensional cultures of cardiomyocytes for electrophysiological studies of cardiac muscle.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
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Bursac, Nenad, Maria Papadaki, John White, Solomon Eisenberg, and Lisa Freed. “Three-dimensional cultures of cardiomyocytes for electrophysiological studies of cardiac muscle.” Annals of Biomedical Engineering 28, no. SUPPL 1 (2000): 54.
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Bursac, N., M. Papadaki, R. Langer, S. R. Eisenberg, G. Vunjak-Novakovic, and L. E. Freed. “Three-dimensional environment promotes in vitro differentiation of cardiac myocytes.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 1 (December 1, 1999): 128.
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Papadaki, M., N. Bursac, P. Gupta, R. Langer, G. Vunjak-Novakovic, and L. E. Freed. “Towards a functional tissue engineered cardiac muscle.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 1 (December 1, 1999): 125.
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Carrier, R. L., M. Papadaki, M. Rupnick, F. J. Schoen, N. Bursac, R. Langer, L. E. Freed, and G. Vunjak-Novakovic. “Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization.” Biotechnology and Bioengineering 64, no. 5 (September 1999): 580–89. https://doi.org/10.1002/(sici)1097-0290(19990905)64:5<580::aid-bit8>3.0.co;2-x.Full Text
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Bursac, N., M. Papadaki, R. J. Cohen, F. J. Schoen, S. R. Eisenberg, R. Carrier, G. Vunjak-Novakovic, and L. E. Freed. “Cardiac muscle tissue engineering: toward an in vitro model for electrophysiological studies.” The American Journal of Physiology 277, no. 2 (August 1999): H433–44. https://doi.org/10.1152/ajpheart.1999.277.2.h433.Full Text
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Van Toi, V., H. Abraham, and N. Bursac. “Post-LSD hallucinosis is associated with decrease in flicker-fusion sensitivities.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
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VanToi, V., H. Abraham, and N. Bursac. “Post-LSD hallucinosis is associated with decrease in flicker-fusion sensitivities.” Investigative Ophthalmology & Visual Science 37, no. 3 (1996): 3307–3307.Link to Item
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Bursac, N., M. Juhas, and M. Rando Thomas. “Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease.” Annual Review of Biomedical Engineering 17 (n.d.): 217–42. https://doi.org/10.1146/annurev-bioeng-071114-040640.Full Text Link to Item
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Book Sections
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Wu, Tianyu, Hung X. Nguyen, and Nenad Bursac. “In vitro discovery of novel prokaryotic ion channel candidates for antiarrhythmic gene therapy.,” 654:407–34, 2021. https://doi.org/10.1016/bs.mie.2021.03.008.Full Text
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Bursac, N. “Cardiac tissue engineering: Matching native architecture and function to develop safe and efficient therapy.” In Tissue Engineering and Artificial Organs, 877–900, 2016.
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Polstein, L. R., and C. A. Gersbach. “Spatiotemporal genetic control of cellular systems.” In Tissue and Organ Regeneration: Advances in Micro- and Nanotechnology, 156–97, 2014. https://doi.org/10.4032/9789814411684.Full Text
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Bursac, N., and J. J. Kim. “Cardiac Fibroblasts and Arrhythmogenesis.” In Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition, 297–308, 2014. https://doi.org/10.1016/B978-1-4557-2856-5.00030-3.Full Text
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Bursac, N. “Cardiac tissue engineering: Matching native architecture and function to develop safe and efficient therapy.” In Tissue Engineering, 437–60, 2007.
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Tung, L., N. Bursac, and F. Aguel. “Rotors and spiral waves in two dimensions.” In Cardiac Electrophysiology: From Cell to Bedside, 336–44, 2004. https://doi.org/10.1016/B0-7216-0323-8/50040-3.Full Text
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Conference Papers
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Arnson, Benjamin, Jason Wang, David Courtney, Sang-oh Han, Songtao Li, Bryan R. Cullen, Nenad Bursac, and Dwight Koeberl. “Single Vector AAV Approach to Genome Editing in Pompe Disease.” In Molecular Therapy, 29:291–291, 2021.Link to Item
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Sklivas, Alexander Byron, Dante I. I. Goss, Nenad Bursac, Alastair Khodahukus, Tim Koves, Deborah Muoio, Lauran Madden, George A. Truskey, William E. Kraus, and Monica J. Hubal. “Gene Expression Differences In Three-dimensional Myobundles Compared To Two-dimensional Myocultures.” In Medicine and Science in Sports and Exercise, 52:781–82, 2020.Link to Item
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Chen, Y. -. H., C. -. H. Chou, A. Khodabukus, N. Bursac, G. Truskey, W. Kraus, and V. B. Kraus. “Effects of simulated muscle exercise on chondrocyte gene expression in a 3D-alginate bead model system.” In Osteoarthritis and Cartilage, 26:S139–40. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.303.Full Text
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Koeberl, Dwight, Laura Case, Edward C. Smith, Yanzhen Li, Crista Walters, Christoph Hornik, Beth Thurberg, Deeksha Bali, Nenad Bursac, and Priya S. Kishnani. “Correction of biochemical abnormalities and gene expression associated with improved muscle function in a phase I/II clinical trial of clenbuterol in Pompe disease patients stably treated with ERT.” In Molecular Genetics and Metabolism, 123:S79–80. Elsevier BV, 2018. https://doi.org/10.1016/j.ymgme.2017.12.202.Full Text
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Pomeroy, Jordan E., and Nenad Bursac. “Selective Gq Activation in Cardiac Fibroblasts Decreases Isometric Force Generation in 3D Engineered Cardiac Tissues.” In Circulation, Vol. 138, 2018.Link to Item
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Jackman, C. P., S. Heo, and N. Bursac. “Tissue-engineered Cardiobundles for In Vitro Development of Heart Regeneration Therapies.” In Tissue Engineering Part A, 23:S2–S2. MARY ANN LIEBERT, INC, 2017.Link to Item
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Juhas, M., N. O. Abutaleb, J. T. Wang, and N. Bursac. “Skeletal Muscle-Macrophage Platform for Modeling Tissue Regeneration.” In Tissue Engineering Part A, 23:S9–S9. MARY ANN LIEBERT, INC, 2017.Link to Item
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Khodabukus, A., L. Madden, C. Jackman, N. Prabhu, T. Koves, and N. Bursac. “Combined Drug and Electrical Stimulation Synergistically Increase Function of Engineered Human Skeletal Muscle.” In Tissue Engineering Part A, 23:S39–40. MARY ANN LIEBERT, INC, 2017.Link to Item
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Khodabukus, A., N. Prabhu, and N. Bursac. “Development of a Human Tissue-Engineered Model of Duchenne Muscular Dystrophy.” In Tissue Engineering Part A, 23:S115–S115. MARY ANN LIEBERT, INC, 2017.Link to Item
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Li, Y., H. Asfour, L. Mao, H. A. Rockman, and N. Bursac. “3D Tissue-engineered Model of Pressure-overload Induced Cardiac Fibrosis.” In Tissue Engineering Part A, 23:S64–S64. MARY ANN LIEBERT, INC, 2017.Link to Item
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Rao, L., Y. Qian, A. Khodabukus, T. Ribar, and N. Bursac. “Contractile hPSC derived Skeletal Muscle Tissues for Human Disease Modeling.” In Tissue Engineering Part A, 23:S128–S128. MARY ANN LIEBERT, INC, 2017.Link to Item
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Wang, J., A. Khodabukus, M. Juhas, N. Abutaleb, and N. Bursac. “In Vitro Bioengineered Model for Studies of Human Muscle Regeneration.” In Tissue Engineering Part A, 23:S71–S71. MARY ANN LIEBERT, INC, 2017.Link to Item
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Albers, A., N. Bursac, and S. Rapp. “PGE - Product generation engineering - Case study of the dual mass flywheel.” In Proceedings of International Design Conference, Design, DS 84:791–800, 2016.
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Hung, Nguyen, and Nenad Bursac. “Engineering Prokaryotic Sodium Channels for Generation and Control of Mammalian Tissue Excitability.” In Circulation, Vol. 134, 2016.Link to Item
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Zhang, Hengtao, Albert Y. Sun, Jong J. Kim, Victoria Graham, Elizabeth A. Finch, Igor Nepliouev, Guiling Zhao, et al. “STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.” In Proc Natl Acad Sci U S A, 112:E5618–27, 2015. https://doi.org/10.1073/pnas.1503847112.Full Text Link to Item
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Juhas, M., J. Wang, J. Ye, I. Shadrin, and N. Bursac. “Engineering Regenerative Skeletal Muscle Tissues.” In Tissue Engineering Part A, 21:S310–S310. MARY ANN LIEBERT, INC, 2015.Link to Item
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Madden, L., C. Jackman, J. Wang, W. Kraus, G. Truskey, and N. Bursac. “Novel In Vitro Exercise Model of Engineered Human Skeletal Muscle.” In Tissue Engineering Part A, 21:S46–S46. MARY ANN LIEBERT, INC, 2015.Link to Item
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Madden, Lauran, Dwight Koeberl, and Nenad Bursac. “BIOENGINEERED HUMAN MUSCLE FOR PHYSIOLOGICAL STUDIES AND DISEASE MODELING.” In Molecular Genetics and Metabolism, 114:304–5. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015.Link to Item
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Hung, Nguyen, and Nenad Bursac. “Gene Therapy for Heart Disease Using Electrically Active Fibroblasts.” In Molecular Therapy, 22:S144–45. NATURE PUBLISHING GROUP, 2014.Link to Item
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Juhas, Mark, George Engelmayr, and Nenad Bursac. “Bioengineered Skeletal Muscle With Functional Stem Cell Pool and Capacity for Vascular Integration and Maturation In Vivo.” In Molecular Therapy, 22:S53–54. NATURE PUBLISHING GROUP, 2014.Link to Item
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Madden, Lauran R., Dwight D. Koeberl, and Nenad Bursac. “Tissue Engineered Human Skeletal Muscle as a Pre-Clinical Model for AAV Treatment of Pompe Disease.” In Molecular Therapy, 22:S157–S157. NATURE PUBLISHING GROUP, 2014.Link to Item
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Shadrin, Ilya Y., Aaron L. Carlson, and Nenad Bursac. “Human Pluripotent Stem Cell-Derived Cardiac Tissue Patch for Use in Cell-Based Cardiac Therapy.” In Molecular Therapy, 22:S206–S206. NATURE PUBLISHING GROUP, 2014.Link to Item
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Christoforou, Nicolas, Brian Liau, Nenad Bursac, and Kam W. Leong. “Engineering an electromechanically functional 3d biosynthetic tissue using embryonic or induced pluripotent stem cells.” In Circulation, 125:E735–E735. LIPPINCOTT WILLIAMS & WILKINS, 2012.Link to Item
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Wang, Chuan, Jessica A. Hennessey, Robert D. Kirkton, Chaojian Wang, Victoria Bryson, Paul B. Rosenberg, Nenad Bursac, and Geoffrey S. Pitt. “FGF13 is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5.” In Biophysical Journal, 100:420–21, 2011.Link to Item
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Bian, Weining, and Nenad Bursac. “Large 3-Dimensional Tissue Engineered Cardiac Patch With Controlled Electrical Anisotropy.” In Circulation, 120:S821–S821. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Bursac, Nenad. “Cardiac Fibroblasts Strongly Affect Cardiac Action Potential Propagation by Paracrine Rather Than Coupling Mechanisms.” In Circulation, 120:S635–S635. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Liau, Brian, Nicolas Christoforou, and Nenad Bursac. “Electromechanically Functional Cardiac Tissue Constructs Engineered From Embryonic Stem Cells.” In Circulation, 120:S810–11. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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McSpadden, Luke C., Robert D. Kirkton, and Nenad Bursac. “Cell Therapies for Arrhythmias: Genetically Engineered Coupling Determines the Effect on Anisotropic Cardiac Conduction.” In Circulation, 120:S765–66. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Tranquillo, Joseph V., and Nenad Bursac. “The role restitution in pacing induced spiral wave acceleration.” In 2006 28th Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Vols 1 15, 2420-+. IEEE, 2006.Link to Item
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Pedrotty, D., L. McSpadden, and N. Bursac. “Paracrine factors from stem cells improve electrical conduction in cardiac tissue.” In Circulation, 112:U145–46. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Bursac, N., and L. Tung. “Novel stable functional Reentrant patterns induced by rapid pacing in uniformly anisotorpic cardiomyocyte cultures.” In Circulation, 106:304–304, 2002.Link to Item
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Preprints
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Strash, Nicholas, Sophia DeLuca, Geovanni Janer Carattini, Yifan Chen, Jacob Scherba, Mehul Jain, Ramona Naseri, Tianyu Wu, and Nenad Bursac. “BRAF-V600E-Mediated Erk Activation Promotes Sustained Cell Cycling and Broad Transcriptional Changes in Neonatal Cardiomyocytes.” BioRxiv, 2022. https://doi.org/10.1101/2022.02.28.482357.Full Text
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Ransey, Elizabeth, Kirill Chesnov, Nenad Bursac, and Kafui Dzirasa. “FETCH: A platform for high-throughput quantification of gap junction hemichannel docking.” Cold Spring Harbor Laboratory, June 7, 2021. https://doi.org/10.1101/2021.06.07.447352.Full Text
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Strash, Nicholas, Sophia DeLuca, Geovanni Janer Carattini, Soon Chul Heo, Ryne Gorsuch, and Nenad Bursac. “Human Erbb2-induced Erk Activity Robustly Stimulates Cycling and Functional Remodeling of Rat and Human Cardiomyocytes.” BioRxiv, 2020. https://doi.org/10.1101/2020.12.15.422603.Full Text
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- Teaching & Mentoring
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Recent Courses
- BME 394: Projects in Biomedical Engineering (GE) 2023
- BME 493: Projects in Biomedical Engineering (GE) 2023
- BME 494: Projects in Biomedical Engineering (GE) 2023
- BME 507: Cardiovascular System Engineering, Disease and Therapy (GE, BB, EL) 2023
- BME 578: Quantitative Cell and Tissue Engineering (GE, BB, MC) 2023
- BME 791: Graduate Independent Study 2023
- EGR 393: Research Projects in Engineering 2023
- BME 301L: Bioelectricity (AC or GE) 2022
- BME 394: Projects in Biomedical Engineering (GE) 2022
- BME 493: Projects in Biomedical Engineering (GE) 2022
- BME 494: Projects in Biomedical Engineering (GE) 2022
- BME 578: Quantitative Cell and Tissue Engineering (GE, BB, MC) 2022
- BME 791: Graduate Independent Study 2022
- EGR 393: Research Projects in Engineering 2022
- NEUROSCI 301L: Bioelectricity (AC or GE) 2022
- BIOLOGY 493: Research Independent Study 2021
- BME 301L: Bioelectricity (AC or GE) 2021
- BME 394: Projects in Biomedical Engineering (GE) 2021
- BME 493: Projects in Biomedical Engineering (GE) 2021
- BME 494: Projects in Biomedical Engineering (GE) 2021
- BME 507: Cardiovascular System Engineering, Disease and Therapy (GE, BB, EL) 2021
- BME 791: Graduate Independent Study 2021
- CELLBIO 493: Research Independent Study 2021
- NEUROSCI 301L: Bioelectricity (AC or GE) 2021
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