The detection and role of molecular tension in focal adhesion dynamics.

Journal Article (Review;Journal Article)

Cells are exquisitely sensitive to the mechanical nature of their environment, including applied force and the stiffness of the extracellular matrix (ECM). Recent evidence has shown that these variables are critical regulators of diverse processes mediating embryonic development, adult tissue physiology, and many disease states, including cancer, atherosclerosis, and myopathies. Often, detection of mechanical stimuli is mediated by the structures that link cells that surround ECM, the focal adhesions (FAs). FAs are intrinsically force sensitive and display altered dynamics, structure, and composition in response to applied load. While much progress has been made in determining the proteins that localize to and regulate the formation of these structures, less is known about the role of tension across specific proteins in this process. A recently developed class of force-sensitive biosensors is enabling a greater understanding of the molecular bases of cellular mechanosensitivity and cell migration.

Full Text

Duke Authors

Cited Authors

  • Hoffman, BD

Published Date

  • January 2014

Published In

Volume / Issue

  • 126 /

Start / End Page

  • 3 - 24

PubMed ID

  • 25081612

Electronic International Standard Serial Number (EISSN)

  • 1878-0814

International Standard Serial Number (ISSN)

  • 1877-1173

Digital Object Identifier (DOI)

  • 10.1016/b978-0-12-394624-9.00001-4


  • eng