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Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.

Publication ,  Journal Article
Dong, P; Maddali, MV; Srimani, JK; Thélot, F; Nevins, JR; Mathey-Prevot, B; You, L
Published in: Nat Commun
September 1, 2014

A body of evidence has shown that the control of E2F transcription factor activity is critical for determining cell cycle entry and cell proliferation. However, an understanding of the precise determinants of this control, including the role of other cell-cycle regulatory activities, has not been clearly defined. Here, recognizing that the contributions of individual regulatory components could be masked by heterogeneity in populations of cells, we model the potential roles of individual components together with the use of an integrated system to follow E2F dynamics at the single-cell level and in real time. These analyses reveal that crossing a threshold amplitude of E2F accumulation determines cell cycle commitment. Importantly, we find that Myc is critical in modulating the amplitude, whereas cyclin D/E activities have little effect on amplitude but do contribute to the modulation of duration of E2F activation, thereby affecting the pace of cell cycle progression.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

September 1, 2014

Volume

5

Start / End Page

4750

Location

England

Related Subject Headings

  • Time-Lapse Imaging
  • Single-Cell Analysis
  • Signal Transduction
  • Rats
  • Pyridines
  • Purines
  • Proto-Oncogene Proteins c-myc
  • Protein Kinase Inhibitors
  • Promoter Regions, Genetic
  • Piperazines
 

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Dong, P., Maddali, M. V., Srimani, J. K., Thélot, F., Nevins, J. R., Mathey-Prevot, B., & You, L. (2014). Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. Nat Commun, 5, 4750. https://doi.org/10.1038/ncomms5750
Dong, Peng, Manoj V. Maddali, Jaydeep K. Srimani, François Thélot, Joseph R. Nevins, Bernard Mathey-Prevot, and Lingchong You. “Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.Nat Commun 5 (September 1, 2014): 4750. https://doi.org/10.1038/ncomms5750.
Dong P, Maddali MV, Srimani JK, Thélot F, Nevins JR, Mathey-Prevot B, et al. Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. Nat Commun. 2014 Sep 1;5:4750.
Dong, Peng, et al. “Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.Nat Commun, vol. 5, Sept. 2014, p. 4750. Pubmed, doi:10.1038/ncomms5750.
Dong P, Maddali MV, Srimani JK, Thélot F, Nevins JR, Mathey-Prevot B, You L. Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. Nat Commun. 2014 Sep 1;5:4750.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

September 1, 2014

Volume

5

Start / End Page

4750

Location

England

Related Subject Headings

  • Time-Lapse Imaging
  • Single-Cell Analysis
  • Signal Transduction
  • Rats
  • Pyridines
  • Purines
  • Proto-Oncogene Proteins c-myc
  • Protein Kinase Inhibitors
  • Promoter Regions, Genetic
  • Piperazines