Lingchong You | Scholars@Duke

Lingchong You
Paul Ruffin Scarborough Associate Professor of Engineering

Dr. You's research interest focus on computational systems biology & synthetic biology, including mathematical modeling of cellular networks; mechanisms of information processing by gene networks; design, modeling and construction of robust gene networks for applications in engineering and medicine.

Current Appointments & Affiliations

Paul Ruffin Scarborough Associate Professor of Engineering, Biomedical Engineering, Pratt School of Engineering 2014
Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2012
Associate Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2016

Contact Information

2355 CIEMAS, 101 Science Drive, Durham, NC 27708
Box 90281, Durham, NC 27708-0281
(919) 660-8408
Google Scholar
Website

Background
Education, Training, & Certifications
- Ph.D., University of Wisconsin at Madison 2002
- M.S., University of Science and Technology of China (China) 1997
- B.S.E., Chengdu University of Science and Technology (China) 1994
Duke Appointment History
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2005 - 2011
Recognition
In the News
- FEB 21, 2018 Pratt School of Engineering
  
  New Tool Tells Bioengineers When to Build Microbial Teams
- DEC 7, 2017 Center for Genomic and Computational Biology
  
  Where Are All the Germs? Students Explore Duke's Microbiome
- MAY 2, 2016 WFDD-Winston-Salem’s “SciWorks Radio”
  
  Lingchong You: Tales of the genetically altered, superhero bacteria swarmbot
- APR 25, 2016
  
  Time Cues Help Keep Humans Looking Human
- APR 11, 2016
  
  Antibiotics Don't Promote Swapping of Resistance Genes
- MAR 2, 2016 Gizmodo
  
  Biologists turn bacteria into 'swarmbots'
- FEB 29, 2016
  
  Bioengineers Design 'Swarmbot' Cells That Die If They Leave the Confines of Their Capsule
- JUN 4, 2015
  
  Why Do Dividing Cells End Up the Same Size?
- OCT 27, 2014 BBC News
  
  Lingchong You comments: Paper test can detect Ebola strains
- JAN 21, 2014
  
  Dispersal Patterns Key to Invasive Species' Success
- NOV 11, 2013 The News & Observer
  
  Chinese-Americans protest Kimmel skit in front of ABC station in downtown Raleigh
- OCT 8, 2013
  
  Growing Bacteria Keep Time, Know Their Place
Awards & Honors
- Faculty Early Career Development (CAREER) Program. National Science Foundation. 2010
- Fellowships for Science and Engineering. David and Lucile Packard Foundation. 2006
Research
Selected Grants
- Personalizing prebiotic therapies that target human gut microbiota awarded by National Institutes of Health 2017 - 2022
- Summer Scholars Program in Genome Sciences and Medicine awarded by National Institutes of Health 2017 - 2022
- A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics awarded by National Institutes of Health 2016 - 2021
- Dynamics of horizontal gene transfer in response to antibiotic treatment awarded by National Institutes of Health 2017 - 2021
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Post-antibiotic effect and design of optimal antibiotic dosing protocols awarded by National Institutes of Health 2011 - 2021
- Enhancing imaging capability for quantitative and synthetic biology research and education awarded by Office of Naval Research 2018 - 2019
- A synthetic-biology approach to study scaling properties of self-organized patterns awarded by National Science Foundation 2014 - 2018
- Reprogramming cellular behavior with synthetic gene circuits awarded by E.I. duPont de Nemours and Company, Inc. 2008 - 2018
- Duke KURe Program awarded by National Institutes of Health 2013 - 2018
- Programming bacteria for materials fabrication awarded by Office of Naval Research 2015 - 2018
- Understanding the Skin Mircrobiome Through the Integration of Metagenomics, Bioinformatics, Spatial Ecology and Syntheti awarded by Johns Hopkins University Applied Physics Laboratory 2014 - 2018
- Temporal E2F Dynamics and Cell-Fate Decisions in Single Mammalian Cells awarded by National Institutes of Health 2014 - 2018
- A synthetic biology approach to analyze evolution of programmed bacterial death awarded by National Institutes of Health 2014 - 2018
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2017
- DURIP: Enhancing capability of quantitative biology research and education awarded by Office of Naval Research 2015 - 2016
- Programming bacteria for materials fabrication awarded by Office of Naval Research 2012 - 2015
- Development of a Microfluidic Platform to Analyze Evolution of Programmed Bacterial Death awarded by Army Research Office 2014 - 2015
- Engineering Microbial Swarmbots awarded by National Science Foundation 2010 - 2015
- Delivery of Bacterial Therapeutics to Solid Tumors awarded by National Science Foundation 2009 - 2013
- Coordinating Cell Killing by Communication: Biological Control and Cancer Therapy awarded by National Institutes of Health 2006 - 2012
- High-performance Computing System for Bioinformatics awarded by National Institutes of Health 2009 - 2010
- Modeling, Predicting, and Reprogramming Dynamic Cellular Networks awarded by National Science Foundation 2006 - 2008
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Tsoi, R, Wu, F, Zhang, C, Bewick, S, Karig, D, and You, L. "Metabolic division of labor in microbial systems." Proceedings of the National Academy of Sciences of the United States of America 115, no. 10 (March 2018): 2526-2531. Full Text
  - Marusak, KE, Krug, JR, Feng, Y, Cao, Y, You, L, and Zauscher, S. "Bacterially driven cadmium sulfide precipitation on porous membranes: Toward platforms for photocatalytic applications." Biointerphases 13, no. 1 (February 9, 2018): 011006-. Full Text
  - Dong, P, Zhang, C, Parker, B-T, You, L, and Mathey-Prevot, B. "Cyclin D/CDK4/6 activity controls G1 length in mammalian cells." PloS one 13, no. 1 (January 8, 2018): e0185637-. Full Text
  - Lopatkin, AJ, Meredith, HR, Srimani, JK, Pfeiffer, C, Durrett, R, and You, L. "Persistence and reversal of plasmid-mediated antibiotic resistance." Nature communications 8, no. 1 (November 22, 2017): 1689-. Full Text
  - Cao, Y, Feng, Y, Ryser, MD, Zhu, K, Herschlag, G, Cao, C, Marusak, K, Zauscher, S, and You, L. "Programmable assembly of pressure sensors using pattern-forming bacteria." Nature biotechnology 35, no. 11 (November 2017): 1087-1093. Full Text
  - Srimani, JK, Huang, S, Lopatkin, AJ, and You, L. "Drug detoxification dynamics explain the postantibiotic effect." Molecular systems biology 13, no. 10 (October 23, 2017): 948-. Full Text
  - Wu, F, and You, L. "Hacking DNA copy number for circuit engineering." Nature genetics 49, no. 8 (July 2017): 1164-1165. Full Text
  - Shats, I, Deng, M, Davidovich, A, Zhang, C, Kwon, JS, Manandhar, D, Gordân, R, Yao, G, and You, L. "Expression level is a key determinant of E2F1-mediated cell fate." Cell death and differentiation 24, no. 4 (April 2017): 626-637. Full Text
  - Tanouchi, Y, Pai, A, Park, H, Huang, S, Buchler, NE, and You, L. "Long-term growth data of Escherichia coli at a single-cell level." Scientific data 4 (March 28, 2017): 170036-. Full Text
  - Feng, Y, Ngaboyamahina, E, Marusak, KE, Cao, Y, You, L, Glass, JT, and Zauscher, S. "Hybrid (Organic/Inorganic) Electrodes from Bacterially Precipitated CdS for PEC/Storage Applications." The Journal of Physical Chemistry C 121, no. 7 (February 23, 2017): 3734-3743. Full Text
  - Cao, Y, Lopatkin, A, and You, L. "Elements of biological oscillations in time and space." Nature structural & molecular biology 23, no. 12 (December 2016): 1030-1034. Full Text
  - Lopatkin, AJ, Sysoeva, TA, and You, L. "Dissecting the effects of antibiotics on horizontal gene transfer: Analysis suggests a critical role of selection dynamics." BioEssays : news and reviews in molecular, cellular and developmental biology 38, no. 12 (December 2016): 1283-1292. (Review) Full Text
  - Zhang, C, Tsoi, R, Wu, F, and You, L. "Processing Oscillatory Signals by Incoherent Feedforward Loops." PLoS computational biology 12, no. 9 (September 13, 2016): e1005101-. Full Text
  - Lopatkin, AJ, Huang, S, Smith, RP, Srimani, JK, Sysoeva, TA, Bewick, S, Karig, DK, and You, L. "Antibiotics as a selective driver for conjugation dynamics." Nature microbiology 1, no. 6 (April 11, 2016): 16044-. Full Text
  - Cao, Y, Ryser, MD, Payne, S, Li, B, Rao, CV, and You, L. "Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria." Cell 165, no. 3 (April 2016): 620-630. Full Text
  - Zhang, C, Tsoi, R, and You, L. "Addressing biological uncertainties in engineering gene circuits." Integrative biology : quantitative biosciences from nano to macro 8, no. 4 (April 2016): 456-464. (Review) Full Text
  - Huang, S, Lee, AJ, Tsoi, R, Wu, F, Zhang, Y, Leong, KW, and You, L. "Coupling spatial segregation with synthetic circuits to control bacterial survival." Molecular systems biology 12, no. 2 (February 29, 2016): 859-. Full Text
  - Marusak, KE, Feng, Y, Eben, CF, Payne, ST, Cao, Y, You, L, and Zauscher, S. "Cadmium sulphide quantum dots with tunable electronic properties by bacterial precipitation." RSC advances 6, no. 80 (January 2016): 76158-76166. Full Text
  - Huang, S, Srimani, JK, Lee, AJ, Zhang, Y, Lopatkin, AJ, Leong, KW, and You, L. "Dynamic control and quantification of bacterial population dynamics in droplets." Biomaterials 61 (August 2015): 239-245. Full Text
  - Tanouchi, Y, Pai, A, Park, H, Huang, S, Stamatov, R, Buchler, NE, and You, L. "A noisy linear map underlies oscillations in cell size and gene expression in bacteria." Nature 523, no. 7560 (July 2015): 357-360. Full Text Open Access Copy
  - Meredith, HR, Lopatkin, AJ, Anderson, DJ, and You, L. "Bacterial temporal dynamics enable optimal design of antibiotic treatment." PLoS computational biology 11, no. 4 (April 23, 2015): e1004201-. Full Text
  - Lee, TJ, Wong, J, Bae, S, Lee, AJ, Lopatkin, A, Yuan, F, and You, L. "A power-law dependence of bacterial invasion on mammalian host receptors." PLoS computational biology 11, no. 4 (April 16, 2015): e1004203-. Full Text
  - Meredith, HR, Srimani, JK, Lee, AJ, Lopatkin, AJ, and You, L. "Collective antibiotic tolerance: mechanisms, dynamics and intervention." Nature chemical biology 11, no. 3 (March 2015): 182-188. (Review) Full Text
  - Eidum, D, Asthana, K, Unni, S, Deng, M, and You, L. "Construction, visualization, and analysis of biological network models in Dynetica." Quantitative Biology 2, no. 4 (December 2014): 142-150. Full Text
  - Srimani, JK, and You, L. "Emergent dynamics from quorum eavesdropping." Chemistry & biology 21, no. 12 (December 2014): 1601-1602. Full Text
  - Lopatkin, AJ, and You, L. "Synthetic biology looks good on paper." Cell 159, no. 4 (November 2014): 718-720. Full Text
  - Dong, P, Maddali, MV, Srimani, JK, Thélot, F, Nevins, JR, Mathey-Prevot, B, and You, L. "Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control." Nature communications 5 (September 2014): 4750-. Full Text
  - Li, B, and You, L. "Stochastic sensitivity analysis and kernel inference via distributional data." Biophysical journal 107, no. 5 (September 2014): 1247-1255. Full Text
  - Tan, C, Smith, RP, Tsai, M-C, Schwartz, R, and You, L. "Phenotypic signatures arising from unbalanced bacterial growth." PLoS computational biology 10, no. 8 (August 7, 2014): e1003751-. Full Text
  - Pai, A, Srimani, JK, Tanouchi, Y, and You, L. "Generic metric to quantify quorum sensing activation dynamics." ACS Synth Biol 3, no. 4 (April 18, 2014): 220-227. Full Text Link to Item
  - Lee, AJ, and You, L. "Cell biology. Cells listen to their inner voice." Science (New York, N.Y.) 343, no. 6171 (February 2014): 624-625. Full Text
  - Smith, R, Tan, C, Srimani, JK, Pai, A, Riccione, KA, Song, H, and You, L. "Programmed Allee effect in bacteria causes a tradeoff between population spread and survival." Proceedings of the National Academy of Sciences of the United States of America 111, no. 5 (February 2014): 1969-1974. Full Text
  - Payne, S, and You, L. "Engineered cell-cell communication and its applications." Adv Biochem Eng Biotechnol 146 (2014): 97-121. (Review) Full Text Link to Item
  - Srimani, JK, Yao, G, Neu, J, Tanouchi, Y, Lee, TJ, and You, L. "Linear population allocation by bistable switches in response to transient stimulation." PLoS ONE 9, no. 8 (January 2014): e105408-. Full Text
  - Payne, S, Li, B, Cao, Y, Schaeffer, D, Ryser, MD, and You, L. "Temporal control of self-organized pattern formation without morphogen gradients in bacteria. (Published online)" Mol Syst Biol 9 (October 8, 2013): 697-. Full Text Link to Item
  - Shats, I, Gatza, ML, Liu, B, Angus, SP, You, L, and Nevins, JR. "FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function." Cancer Res 73, no. 19 (October 1, 2013): 6056-6067. Full Text Link to Item
  - Li, B, and You, L. "Predictive power of cell-to-cell variability." Quantitative Biology 1, no. 2 (June 2013): 131-139. Full Text
  - Tanouchi, Y, Lee, AJ, Meredith, H, and You, L. "Programmed cell death in bacteria and implications for antibiotic therapy." Trends Microbiol 21, no. 6 (June 2013): 265-270. Full Text Link to Item
  - Zhang, Y, Ho, Y-P, Chiu, Y-L, Chan, HF, Chlebina, B, Schuhmann, T, You, L, and Leong, KW. "A programmable microenvironment for cellular studies via microfluidics-generated double emulsions." Biomaterials 34, no. 19 (June 2013): 4564-4572. Full Text Link to Item
  - Smith, RP, Tanouchi, Y, and You, L. "Synthetic Microbial Consortia and their Applications." Synthetic Biology (2013): 243-258. Full Text
  - Tanouchi, Y, Lee, AJ, Meredith, H, and You, L. "Programmed cell death in bacteria and implications for antibiotic therapy." Trends in Microbiology 21, no. 6 (2013): 265-270. Full Text
  - Zhang, Y, Ho, Y-P, Chiu, Y-L, Chan, HF, Chlebina, B, Schuhmann, T, You, L, and Leong, KW. "A programmable microenvironment for cellular studies via microfluidics-generated double emulsions." Biomaterials 34, no. 19 (2013): 4564-4572. Full Text
  - Pai, A, Tanouchi, Y, and You, L. "Optimality and robustness in quorum sensing (QS)-mediated regulation of a costly public good enzyme." Proc Natl Acad Sci U S A 109, no. 48 (November 27, 2012): 19810-19815. Full Text Link to Item
  - Tanouchi, Y, Smith, RP, and You, L. "Engineering microbial systems to explore ecological and evolutionary dynamics." Curr Opin Biotechnol 23, no. 5 (October 2012): 791-797. (Review) Full Text Link to Item
  - Riccione, KA, Smith, RP, Lee, AJ, and You, L. "A synthetic biology approach to understanding cellular information processing." ACS Synth Biol 1, no. 9 (September 21, 2012): 389-402. (Review) Full Text Link to Item
  - Chin, JW, and You, L. "A different life?." Current Opinion in Chemical Biology 16, no. 3-4 (2012): 243-244. Full Text
  - Payne, S, Smith, RP, and You, L. "Quantitative analysis of the spatiotemporal dynamics of a synthetic predator-prey ecosystem." Methods Mol Biol 813 (2012): 315-330. Full Text Link to Item
  - Song, H, and You, L. "Modeling spatiotemporal dynamics of bacterial populations." Methods in molecular biology (Clifton, N.J.) 880 (January 2012): 243-254. (Review) Full Text
  - Stone, JE, Benfey, PN, and You, L. "Promoting collaborative interdisciplinary research at the duke center for systems biology." ACS Synthetic Biology 1, no. 5 (2012): 153-155. Full Text
  - Tan, C, Smith, RP, Srimani, JK, Riccione, KA, Prasada, S, Kuehn, M, and You, L. "The inoculum effect and band-pass bacterial response to periodic antibiotic treatment." Mol Syst Biol 8 (2012): 617-. Full Text Open Access Copy Link to Item
  - Tanouchi, Y, Pai, A, Buchler, NE, and You, L. "Programming stress-induced altruistic death in engineered bacteria." Mol Syst Biol 8 (2012): 626-. Full Text Open Access Copy Link to Item
  - Wong, JV, Li, B, and You, L. "Tension and robustness in multitasking cellular networks." PLoS Comput Biol 8, no. 4 (2012): e1002491-. Full Text Link to Item
  - Bonassi, FV, You, L, and West, M. "Bayesian learning from marginal data in bionetwork models. (Published online)" Stat Appl Genet Mol Biol 10, no. 1 (October 27, 2011). Full Text Link to Item
  - Hallen, M, Li, B, Tanouchi, Y, Tan, C, West, M, and You, L. "Computation of steady-state probability distributions in stochastic models of cellular networks." PLoS Comput Biol 7, no. 10 (October 2011): e1002209-. Full Text Link to Item
  - Wong, JV, Dong, P, Nevins, JR, Mathey-Prevot, B, and You, L. "Network calisthenics: control of E2F dynamics in cell cycle entry." Cell Cycle 10, no. 18 (September 15, 2011): 3086-3094. (Review) Full Text Link to Item
  - Elliott, N, Lee, T, You, L, and Yuan, F. "Proliferation behavior of E. coli in a three-dimensional in vitro tumor model." Integr Biol (Camb) 3, no. 6 (June 2011): 696-705. Full Text Link to Item
  - Wong, JV, Yao, G, Nevins, JR, and You, L. "Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC." Mol Cell 41, no. 3 (February 4, 2011): 275-285. Full Text Link to Item
  - Li, B, and You, L. "Synthetic biology: Division of logic labour." Nature 469, no. 7329 (2011): 171-172. Full Text
  - Song, H, Payne, S, Tan, C, and You, L. "Programming microbial population dynamics by engineered cell-cell communication." Biotechnology Journal 6, no. 7 (2011): 837-849. Full Text
  - Wong, JV, Yao, G, Nevins, JR, and You, L. "Using noisy gene expression mediated by engineered adenovirus to probe signaling dynamics in mammalian cells." Methods in Enzymology 497 (2011): 221-237. Full Text
  - Yao, G, Tan, C, West, M, Nevins, JR, and You, L. "Origin of bistability underlying mammalian cell cycle entry." Molecular Systems Biology 7 (2011). Full Text
  - Lee, TJ, Yao, G, Bennett, DC, Nevins, JR, and You, L. "Stochastic E2F activation and reconciliation of phenomenological cell-cycle models. (Published online)" PLoS Biol 8, no. 9 (September 21, 2010). Full Text Link to Item
  - Marguet, P, Tanouchi, Y, Spitz, E, Smith, C, and You, L. "Oscillations by minimal bacterial suicide circuits reveal hidden facets of host-circuit physiology. (Published online)" PLoS One 5, no. 7 (July 30, 2010): e11909-. Full Text Link to Item
  - Wang, Q, Niemi, J, Tan, C-M, You, L, and West, M. "Image segmentation and dynamic lineage analysis in single-cell fluorescence microscopy." Cytometry A 77, no. 1 (January 2010): 101-110. Full Text Link to Item
  - Song, H, Payne, S, Gray, M, and You, L. "Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem." Nat Chem Biol 5, no. 12 (December 2009): 929-935. Full Text Link to Item
  - Tan, C, Marguet, P, and You, L. "Emergent bistability by a growth-modulating positive feedback circuit." Nat Chem Biol 5, no. 11 (November 2009): 842-848. Full Text Link to Item
  - Pai, A, Tanouchi, Y, Collins, CH, and You, L. "Engineering multicellular systems by cell-cell communication." Curr Opin Biotechnol 20, no. 4 (August 2009): 461-470. (Review) Full Text Link to Item
  - Tanouchi, Y, Pai, A, and You, L. "Decoding biological principles using gene circuits." Mol Biosyst 5, no. 7 (July 2009): 695-703. (Review) Full Text Link to Item
  - Brenner, K, You, L, and Arnold, FH. "Response to Goldman and Brown: Making sense of microbial consortia using ecology and evolution." Trends in Biotechnology 27, no. 1 (2009): 4--. Full Text
  - Isaacs, FJ, and You, L. "A brave new synthetic world. A report of the first meeting on 'Frontiers in Synthetic Biology', Boston, USA, 1-2 December 2008." Genome biology 10, no. 2 (2009): 302--. Full Text
  - Pai, A, and You, L. "Optimal tuning of bacterial sensing potential." Mol Syst Biol 5 (2009): 286-. Full Text Link to Item
  - Smith, C, Song, H, and You, L. "Signal discrimination by differential regulation of protein stability in quorum sensing." J Mol Biol 382, no. 5 (October 24, 2008): 1290-1297. Full Text Link to Item
  - Tanouchi, Y, Tu, D, Kim, J, and You, L. "Noise reduction by diffusional dissipation in a minimal quorum sensing motif. (Published online)" PLoS Comput Biol 4, no. 8 (August 29, 2008): e1000167-. Full Text Link to Item
  - Yao, G, Lee, TJ, Mori, S, Nevins, JR, and You, L. "A bistable Rb-E2F switch underlies the restriction point." Nat Cell Biol 10, no. 4 (April 2008): 476-482. Full Text Link to Item
  - Lee, T, Yao, G, Nevins, J, and You, L. "Sensing and integration of Erk and PI3K signals by Myc. (Published online)" PLoS Comput Biol 4, no. 2 (February 29, 2008): e1000013-. Full Text Link to Item
  - Wong, JV, Song, H, and You, L. "A whole more than the sum of its synthetic parts." ACS Chem Biol 3, no. 1 (January 18, 2008): 27-29. Full Text Link to Item
  - Balagaddé, FK, Song, H, Ozaki, J, Collins, CH, Barnet, M, Arnold, FH, Quake, SR, and You, L. "A synthetic Escherichia coli predator-prey ecosystem." Molecular Systems Biology 4 (2008). Full Text
  - Brenner, K, You, L, and Arnold, FH. "Engineering microbial consortia: a new frontier in synthetic biology." Trends in Biotechnology 26, no. 9 (2008): 483-489. Full Text
  - Song, H, Gray, M, and You, L. "Spatiotemporal modulation of biodiversity in a synthetic predator-prey ecosystem." AIChE Annual Meeting, Conference Proceedings (2008).
  - Tan, C, Reza, F, and You, L. "Noise-limited frequency signal transmission in gene circuits." Biophys J 93, no. 11 (December 1, 2007): 3753-3761. Full Text Link to Item
  - Marguet, P, Balagadde, F, Tan, C, and You, L. "Biology by design: reduction and synthesis of cellular components and behaviour." J R Soc Interface 4, no. 15 (August 22, 2007): 607-623. (Review) Full Text Link to Item
  - Tan, C, Song, H, Niemi, J, and You, L. "A synthetic biology challenge: making cells compute." Mol Biosyst 3, no. 5 (May 2007): 343-353. (Review) Full Text Link to Item
  - Reza, F, Chandran, K, Feltz, M, Heinz, A, Josephs, E, O'Brien, P, Dyke, BV, Chung, H, Indurkhya, S, Lakhani, N, Lee, J, Lin, S, Tang, N, Labean, T, You, L, Yuan, F, and Tian, J. "Engineering novel synthetic biological systems." IET Synthetic Biology 1, no. 1-2 (2007): 48-52. Full Text
  - You, L. "Engineering synthetic killer circuits in bacteria." Proceedings - Design Automation Conference (2007): 636-637. Full Text
  - Song, H, and You, L. "Evolving sensitivity." ACS Chem Biol 1, no. 11 (December 20, 2006): 681-682. (Review) Full Text Link to Item
  - You, L, and Yin, J. "Evolutionary design on a budget: robustness and optimality of bacteriophage T7." Syst Biol (Stevenage) 153, no. 2 (March 2006): 46-52. Link to Item
  - Balagaddé, FK, You, L, Hansen, CL, Arnold, FH, and Quake, SR. "Microbiology: Long-term monitoring of bacteria undergoing programmed population control in a microchemostat." Science 309, no. 5731 (2005): 137-140. Full Text
  - Ozaki, J, Barnet, M, Collins, CH, Arnold, FH, and You, L. "A synthetic E.Coli predator-prey system." AIChE Annual Meeting, Conference Proceedings (2005): 11590--.
  - You, L, III, RSC, Weiss, R, and Arnold, FH. "Programmed population control by cell-cell communication and regulated killing." Nature 428, no. 6985 (2004): 868-871. Full Text
  - You, L. "Toward computational systems biology." Cell Biochemistry and Biophysics 40, no. 2 (2004): 167-184. Full Text
  - You, L, Hoonlor, A, and Yin, J. "Modeling biological systems using Dynetica - A simulator of dynamic networks." Bioinformatics 19, no. 3 (2003): 435-436. Full Text
  - Srivastava, R, You, L, Summers, J, and Yin, J. "Stochastic vs. deterministic modeling of intracellular viral kinetics." Journal of Theoretical Biology 218, no. 3 (2002): 309-321. Full Text
  - You, L, Suthers, PF, and Yin, J. "Effects of Escherichia coli physiology on growth of phage T7 in vivo and in silico." Journal of Bacteriology 184, no. 7 (2002): 1888-1894. Full Text
  - You, L, and Yin, J. "Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage T7." Genetics 160, no. 4 (2002): 1273-1281.
  - You, L, and Yin, J. "Simulating the growth of viruses." Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing (2001): 532-543.
  - Endy, D, You, L, Yin, J, and Molineux, IJ. "Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes." Proceedings of the National Academy of Sciences of the United States of America 97, no. 10 (2000): 5375-5380. Full Text
  - You, L, and Yin, J. "Patterns of regulation from mRNA and protein time series." Metabolic Engineering 2, no. 3 (2000): 210-217. Full Text
  - Endy, D, You, L, Molineux, IJ, and Yin, J. "Prediction, design, and characterization of alternate genetic element orders for bacteriophage T7." Abstracts Of Papers Of The American Chemical Society 217 (March 1999): U205-U205. (Academic Article)
  - You, L, and Yin, J. "Amplification and spread of viruses in a growing plaque." Journal of Theoretical Biology 200, no. 4 (1999): 365-373. Full Text
  - You, L, Liu, Q, Shi, Y, Wang, C-X, Lahaye, M, and Tran, V. "The conformational study of β-D-GlcA-(1,4) -L-Rha in solution by NMR and molecular dynamics simulations." Chemical Physics 224, no. 1 (1997): 81-94.
  - You, L, and Arnold, FH. "Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide." Protein Engineering 9, no. 1 (1996): 77-83.
  - You, L, and Arnold, FH. "Erratum: Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide (Protein Engineering (1996) 9 (78-83))." Protein Engineering 9, no. 8 (1996): 719--.
Teaching & Mentoring
Recent Courses
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Bass Connections Faculty Team Member. Blue Devil Resistome Project. August 2017 - May 2018 2017 - 2018

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Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Journal Articles

Recent Courses

Outreach & Engaged Scholarship