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Lingchong You

Professor of Biomedical Engineering
Biomedical Engineering
Box 90281, Durham, NC 27708-0281
1381 CIEMAS, 101 Science Drive, Durham, NC 27708

Research Interests


Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiome

Selected Grants


Tradeoffs between fitness costs and transfer rates in horizontal gene transfer

ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027

NSF Engineering Research Center for Precision Microbiome Engineering (PreMiEr)

ResearchInvestigator · Awarded by National Science Foundation · 2022 - 2027

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Evolutionary dynamics of combinational antimicrobial treatments

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2026

Summer Scholars in Genome Sciences & Medicine

Inst. Training Prgm or CMESignificant Contributor · Awarded by National Institutes of Health · 2017 - 2026

Bacterial antibiotic response and population dynamics in microscopic surface wetness

ResearchPrincipal Investigator · Awarded by US-Israel Binational Science Foundation · 2022 - 2025

Uncovering and applying the design principles of multiphasic natural and synthetic organelles

ResearchCo-Principal Investigator · Awarded by Princeton University · 2020 - 2025

Targeted control of self-transmissible plasmids by using engineered interfering plasmids

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2025

ECO-COATING - Engineering Control of Organic Coatings on Autonomous Navy Gliders

ResearchPrincipal Investigator · Awarded by Clemson University · 2022 - 2024

Inductive repair of human kidney tissues by cell type-specific sensing and reprogramming

ResearchCollaborator · Awarded by University of Michigan · 2021 - 2024

Predictable Engineering of Self-organized Spatial Patterns in Bacteria

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2020 - 2024

RoL: Modulation of microbial community dynamics by spatial partitioning

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2019 - 2023

Enhancing computational capability for quantitative and synthetic biology

EquipmentPrincipal Investigator · Awarded by Office of Naval Research · 2022 - 2023

Bioinformatics and Computational Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2021

A synthetic-biology approach to study scaling properties of self-organized patterns

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2014 - 2020

Understanding the Skin Microbiome through the Integration of Metagenomics, Bioinformatics, Spatial Ecology, and Synthetic Biology

ResearchPrincipal Investigator · Awarded by Johns Hopkins University Applied Physics Laboratory · 2014 - 2019

Programming bacteria for materials fabrication

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2015 - 2019

Temporal E2F Dynamics and Cell-Fate Decisions in Single Mammalian Cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2019

Enhancing imaging capability for quantitative and synthetic biology research and education

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2018 - 2019

Reprogramming cellular behavior with synthetic gene circuits

ResearchPrincipal Investigator · Awarded by E.I. duPont de Nemours and Company, Inc. · 2008 - 2018

Supplement - Understanding the Skin Microbiome through the Integration of Metagenomics, Bioinformatics, Spatial Ecology, and Synthetic Biology

ResearchPrincipal Investigator · Awarded by Johns Hopkins University Applied Physics Laboratory · 2018 - 2018

A synthetic biology approach to analyze evolution of programmed bacterial death

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2018

DURIP: Enhancing capability of quantitative biology research and education

EquipmentPrincipal Investigator · Awarded by Office of Naval Research · 2015 - 2016

Programming bacteria for materials fabrication

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2012 - 2015

Development of a Microfluidic Platform to Analyze Evolution of Programmed Bacterial Death

ResearchPrincipal Investigator · Awarded by Army Research Office · 2014 - 2015

Engineering Microbial Swarmbots

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2010 - 2015

Delivery of Bacterial Therapeutics to Solid Tumors

ResearchInvestigator · Awarded by National Science Foundation · 2009 - 2013

Coordinating Cell Killing by Communication: Biological Control and Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2012

High-performance Computing System for Bioinformatics

EquipmentMajor User · Awarded by National Institutes of Health · 2009 - 2010

Modeling, Predicting, and Reprogramming Dynamic Cellular Networks

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2006 - 2008

External Relationships


  • Andrea Weiss
  • Cambridge University
  • Oxford University
  • Shenzhen Institute of Advanced Technologies, Shenzhen, China
  • The Hebrew University of Jerusalem
  • Universitat Pompeu Fabra
  • University of Copenhagen
  • University of Essex

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.