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Clinicopathologic features and prognosis of duodenal adenocarcinoma and comparison with ampullary and pancreatic ductal adenocarcinoma.

Publication ,  Journal Article
Zenali, M; Overman, MJ; Rashid, A; Broaddus, RB; Wang, H; Katz, MH; Fleming, JB; Abbruzzese, JL; Wang, H
Published in: Hum Pathol
December 2013

Because of the rarity of duodenal adenocarcinoma (DAC), the clinicopathologic features and prognostication data for DAC are limited. There are no published studies directly comparing the prognosis of DAC to that of ampullary adenocarcinoma (AA) and of pancreatic ductal adenocarcinoma (PDA) after resection. In this study, we examined the clinicopathologic features of 68 patients with DAC, 92 patients with AA, and 126 patients with PDA who underwent resection. Patient clinicopathologic and survival information were extracted from medical records. Statistical analysis was performed using Statistical Package for the Social Sciences with 2-sided significance level of .05. Patients with DAC had higher American Joint Committee on Cancer (AJCC) stage than AA patients (P = .001). Lymph node metastasis (P = .013) and AJCC stage (P = .02) correlated with overall survival in DAC patients. Patients with DAC or AA had lower frequencies of lymph node metastasis and positive margin and better survival than those with PDA (P < .05). However, no differences in nodal metastasis, margin status, or survival were observed between DAC patients and those with AA. Our study showed that lymph node metastasis and AJCC stage are important prognostic factors for overall survival in DAC patients. Patients with DAC had less frequent nodal metastasis and better prognosis than those with PDA. There was no significant difference in prognosis between DAC and AA.

Duke Scholars

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

December 2013

Volume

44

Issue

12

Start / End Page

2792 / 2798

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Prognosis
  • Pathology
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Lymph Nodes
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Zenali, M., Overman, M. J., Rashid, A., Broaddus, R. B., Wang, H., Katz, M. H., … Abbruzzese, J. L. (2013). Clinicopathologic features and prognosis of duodenal adenocarcinoma and comparison with ampullary and pancreatic ductal adenocarcinoma. Hum Pathol, 44(12), 2792–2798. https://doi.org/10.1016/j.humpath.2013.07.030
Zenali, Maryam, Michael J. Overman, Asif Rashid, Russell B. Broaddus, Hua Wang, Matthew H. Katz, Jason B. Fleming, James L. Abbruzzese, and Huamin Wang. “Clinicopathologic features and prognosis of duodenal adenocarcinoma and comparison with ampullary and pancreatic ductal adenocarcinoma.Hum Pathol 44, no. 12 (December 2013): 2792–98. https://doi.org/10.1016/j.humpath.2013.07.030.
Zenali M, Overman MJ, Rashid A, Broaddus RB, Wang H, Katz MH, et al. Clinicopathologic features and prognosis of duodenal adenocarcinoma and comparison with ampullary and pancreatic ductal adenocarcinoma. Hum Pathol. 2013 Dec;44(12):2792–8.
Zenali, Maryam, et al. “Clinicopathologic features and prognosis of duodenal adenocarcinoma and comparison with ampullary and pancreatic ductal adenocarcinoma.Hum Pathol, vol. 44, no. 12, Dec. 2013, pp. 2792–98. Pubmed, doi:10.1016/j.humpath.2013.07.030.
Zenali M, Overman MJ, Rashid A, Broaddus RB, Wang H, Katz MH, Fleming JB, Abbruzzese JL. Clinicopathologic features and prognosis of duodenal adenocarcinoma and comparison with ampullary and pancreatic ductal adenocarcinoma. Hum Pathol. 2013 Dec;44(12):2792–2798.
Journal cover image

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

December 2013

Volume

44

Issue

12

Start / End Page

2792 / 2798

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Prognosis
  • Pathology
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Lymph Nodes
  • Humans