Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice.

Journal Article (Journal Article)

Intravenous immunoglobulin (IVIG) may improve neuroinflammation after traumatic brain injury (TBI). IVIG administration after TBI improved rotarod latencies over the first 7 days (p=0.039) and water maze latencies over 29-32 days (p=0.027), decreased F4/80-positive cells at 2 (p=0.001) and 7 days (p<0.001), decreased Fluoro-Jade B-positive cells (p=0.020), increased NeuN-positive cells (p=0.014), decreased IL-6 production at 4 (p=0.032) and 24h (p=0.023), and decreased blood-brain barrier breakdown by IgG extravasation (p=0.001) and brain edema (p=0.006); however, TNF-α concentration was unchanged. IVIG administration was associated with long-term neurobehavioral and histological improvement through modulation of neuroinflammation and blood-brain barrier permeability in a murine TBI model.

Full Text

Duke Authors

Cited Authors

  • Jeong, S; Lei, B; Wang, H; Dawson, HN; James, ML

Published Date

  • November 15, 2014

Published In

Volume / Issue

  • 276 / 1-2

Start / End Page

  • 112 - 118

PubMed ID

  • 25241288

Electronic International Standard Serial Number (EISSN)

  • 1872-8421

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2014.08.626


  • eng

Conference Location

  • Netherlands