Current Appointments & Affiliations
Assistant Professor in Neurology
·
2021 - Present
Neurology, Neurocritical Care,
Neurology
Recent Publications
Clinical Development of the GluN2B-selective NMDA Receptor Inhibitor NP10679 for the Treatment of Neurologic Deficit after Subarachnoid Hemorrhage.
Journal Article J Pharmacol Exp Ther · October 23, 2024 Aneurysmal subarachnoid hemorrhage (aSAH) may be associated with cerebral vasospasm, which can lead to delayed cerebral ischemia, infarction, and worsened functional outcomes. The delayed nature of cerebral ischemia secondary to SAH-related vasculopathy pr ... Full text Link to item CitePD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior.
Journal Article Neuron · September 2023 Programmed death protein 1 (PD-1) and its ligand PD-L1 constitute an immune checkpoint pathway. We report that neuronal PD-1 signaling regulates learning/memory in health and disease. Mice lacking PD-1 (encoded by Pdcd1) exhibit enhanced long-term potentia ... Full text CiteProphylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury.
Journal Article Exp Brain Res · September 2022 The treatment of traumatic brain injury (TBI) in military populations is hindered by underreporting and underdiagnosis. Clinical symptoms and outcomes may be mitigated with an effective pre-injury prophylaxis. This study evaluates whether CN-105, a 5-amino ... Full text Link to item CiteRecent Grants
Duke Testing Site for Stroke Preclinical Assessment Network
ResearchInvestigator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2025Prevention of Pain Chronification and Neuroinflammation After Traumatic Brain Injury by Neuroprotectin D1 and GPR37 Signaling
ResearchCo Investigator · Awarded by Department of Defense · 2021 - 2025Novel anti-neuroinflammatory drug for aneurysmal subarachnoid hemorrhage (aSAH)
ResearchPrincipal Investigator · Awarded by ImmunoChem Therapeutics, LLC · 2022 - 2025View All Grants
Education, Training & Certifications
Hunan Medical University (China) ·
1994
M.D.