Recurrent malignant gliomas.

Journal Article (Journal Article;Review)

In almost all patients, malignant glioma recurs following initial treatment with maximal safe resection, conformal radiotherapy, and temozolomide. This review describes the many options for treatment of recurrent malignant gliomas, including reoperation, alternating electric field therapy, chemotherapy, stereotactic radiotherapy or radiosurgery, or some combination of these modalities, presenting the evidence for each approach. No standard of care has been established, though the antiangiogenic agent, bevacizumab; stereotactic radiotherapy or radiosurgery; and, perhaps, combined treatment with these 2 modalities appear to offer modest benefits over other approaches. Clearly, randomized trials of these options would be advantageous, and novel, more efficacious approaches are urgently needed.

Full Text

Duke Authors

Cited Authors

  • Kirkpatrick, JP; Sampson, JH

Published Date

  • October 2014

Published In

Volume / Issue

  • 24 / 4

Start / End Page

  • 289 - 298

PubMed ID

  • 25219814

Pubmed Central ID

  • PMC4522935

Electronic International Standard Serial Number (EISSN)

  • 1532-9461

Digital Object Identifier (DOI)

  • 10.1016/j.semradonc.2014.06.006


  • eng

Conference Location

  • United States