John P. Kirkpatrick

Malignant and benign tumors of the brain, spine and base of skull. Mathematical modelling of tumor metabolism, mass transfer and the response to ionizing radiation. Enhancing clinical outcome in stereotactic radiosurgery, fractionated stereotactic radiotherapy and stereotactic body radiotherapy.

Current Appointments & Affiliations

Professor of Radiation Oncology · 2018 - Present Radiation Oncology, Clinical Science Departments

Professor in Neurosurgery · 2018 - Present Neurosurgery, Neurosurgery

Member of the Duke Cancer Institute · 2000 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications

Radiogenomic explainable AI with neural ordinary differential equation for identifying post-SRS brain metastasis radionecrosis.

Conference Med Phys · April 2025 BACKGROUND: Stereotactic radiosurgery (SRS) is widely used for managing brain metastases (BMs), but an adverse effect, radionecrosis, complicates post-SRS management. Differentiating radionecrosis from tumor recurrence non-invasively remains a major clinic ... Full text Link to item Cite

Symptomatic Necrosis With Dual Immune-Checkpoint Inhibition and Radiosurgery for Brain Metastases.

Journal Article JAMA Netw Open · April 1, 2025 Full text Link to item Cite

Uncertainty quantification in multi-parametric MRI-based meningioma radiotherapy target segmentation.

Journal Article Front Oncol · 2025 PURPOSE: This work investigates the use of a spherical projection-based U-Net (SPU-Net) segmentation model to improve meningioma segmentation performance and allow for uncertainty quantification. METHODS: A total of 76 supratentorial meningioma patients tr ... Full text Link to item Cite

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Recent Grants

PHASE 1, SINGLE-CENTER, DOSE-ESCALATING, OPEN-LABEL, SAFETY CLINICAL TRIAL OF PARENTERAL ASCORBATE-MEGLUMINE AS A NOVEL MAGNETIC RESONANCE IMAGING-GUIDED ADJUNCTIVE THERAPEUTIC FOR STEREOTACTIC RADIOSURGERY

Clinical TrialPrincipal Investigator · Awarded by LadeRx · 2023 - 2026

BMX-001 AS A THERAPEUTIC AGENT FOR TREATMENT OF MULTIPLE BRAIN METASTASES

Clinical TrialPrincipal Investigator · Awarded by BioMimetix JV LLC · 2018 - 2023

Developing knowledge models to enable rapid learning in radiation therapy

ResearchCo Investigator · Awarded by National Institutes of Health · 2016 - 2020

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Education, Training & Certifications

University of Texas Health Science Center San Antonio · 1999 M.D.

Rice University · 1978 Ph.D.