John P. Kirkpatrick | Scholars@Duke

John P. Kirkpatrick
Professor of Radiation Oncology

Malignant and benign tumors of the brain, spine and base of skull. Mathematical modelling of tumor metabolism, mass transfer and the response to ionizing radiation. Enhancing clinical outcome in stereotactic radiosurgery, fractionated stereotactic radiotherapy and stereotactic body radiotherapy.

Current Appointments & Affiliations

Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2018
Professor in Neurosurgery, Neurosurgery, Neurosurgery 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2000

Contact Information

DUMC Box 3085, Durham, NC 27710
Department of Radiation Oncology, Durham, NC 27710
john.kirkpatrick@duke.edu (919) 668-7342

Background
Education, Training, & Certifications
- M.D., University of Texas Health Science Center San Antonio 1999
- Ph.D., Rice University 1978
Duke Appointment History
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2014 - 2018
- Associate Professor in Neurosurgery, Neurosurgery, Neurosurgery 2016 - 2018
- Associate Professor in Surgery, Neurosurgery, Neurosurgery 2014 - 2017
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2009 - 2014
- Assistant Professor in Surgery, Neurosurgery, Neurosurgery 2011 - 2014
- Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2004 - 2009
Research
Selected Grants
- BMX-001 AS A THERAPEUTIC AGENT FOR TREATMENT OF MULTIPLE BRAIN METASTASES awarded by BioMimetix JV LLC 2018 - 2021
- Developing knowledge models to enable rapid learning in radiation therapy awarded by National Institutes of Health 2016 - 2020
- Decision support for dose prescription in radiation treatment planning awarded by University of North Carolina - Charlotte 2013 - 2015
- Robotic SPECT for Biological Imaging Onboard Radiation Therapy Machines awarded by National Institutes of Health 2011 - 2013
- Cross-disciplinary Training in Medical Physics awarded by National Institutes of Health 2007 - 2013
External Relationships
- BioMimetix Pharmaceutical, Inc.
- ClearSight RT LLC
- Varian Medical Systems
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lee, Jessica W., John P. Kirkpatrick, Frances McSherry, James E. Herndon, Eric S. Lipp, Annick Desjardins, Dina M. Randazzo, et al. “Adjuvant Radiation in Older Patients With Glioblastoma: A Retrospective Single Institution Analysis.” Front Oncol 11 (2021): 631618. https://doi.org/10.3389/fonc.2021.631618.
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  - Soltys, Scott G., Michael T. Milano, Jinyu Xue, Wolfgang A. Tomé, Ellen Yorke, Jason Sheehan, George X. Ding, et al. “Stereotactic Radiosurgery for Vestibular Schwannomas: Tumor Control Probability Analyses and Recommended Reporting Standards.” Int J Radiat Oncol Biol Phys, December 26, 2020. https://doi.org/10.1016/j.ijrobp.2020.11.019.
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  - Sperduto, Paul W., Shane Mesko, Jing Li, Daniel Cagney, Ayal Aizer, Nancy U. Lin, Eric Nesbit, et al. “Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient.” J Clin Oncol 38, no. 32 (November 10, 2020): 3773–84. https://doi.org/10.1200/JCO.20.01255.
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  - Park, Christine, Elizabeth P. Howell, Vikram A. Mehta, Luis Ramirez, Meghan J. Price, Scott R. Floyd, John P. Kirkpatrick, et al. “Patient outcomes and tumor control in single-fraction versus hypofractionated stereotactic body radiation therapy for spinal metastases.” J Neurosurg Spine, November 6, 2020, 1–10. https://doi.org/10.3171/2020.6.SPINE20349.
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  - Sperduto, Paul W., Shane Mesko, Jing Li, Daniel Cagney, Ayal Aizer, Nancy U. Lin, Eric Nesbit, et al. “Estrogen/progesterone receptor and HER2 discordance between primary tumor and brain metastases in breast cancer and its effect on treatment and survival.” Neuro Oncol 22, no. 9 (September 29, 2020): 1359–67. https://doi.org/10.1093/neuonc/noaa025.
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  - Dial, Brian L., Anthony A. Catanzano, Valentine Esposito, John Steele, Amanda Fletcher, Sean P. Ryan, John P. Kirkpatrick, et al. “Treatment Outcomes in Spinal Metastatic Disease With Indeterminate Stability.” Global Spine J, September 25, 2020, 2192568220956605. https://doi.org/10.1177/2192568220956605.
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  - Cui, Yunfeng, Hao Gao, Jiahan Zhang, John P. Kirkpatrick, and Fang-Fang Yin. “Retrospective quality metrics review of stereotactic radiosurgery plans treating multiple targets using single-isocenter volumetric modulated arc therapy.” J Appl Clin Med Phys 21, no. 6 (June 2020): 93–99. https://doi.org/10.1002/acm2.12869.
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  - Sperduto, Paul W., Shane Mesko, Jing Li, Daniel Cagney, Ayal Aizer, Nancy U. Lin, Eric Nesbit, et al. “Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases From 1985 to Today.” Int J Radiat Oncol Biol Phys 107, no. 2 (June 1, 2020): 334–43. https://doi.org/10.1016/j.ijrobp.2020.01.051.
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  - Moravan, Michael J., Peter E. Fecci, Carey K. Anders, Jeffrey M. Clarke, April K. S. Salama, Justus D. Adamson, Scott R. Floyd, et al. “Current multidisciplinary management of brain metastases.” Cancer 126, no. 7 (April 1, 2020): 1390–1406. https://doi.org/10.1002/cncr.32714.
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  - Patel, Mallika P., John P. Kirkpatrick, Margaret O. Johnson, Patrick Healy, James E. Herndon, Eric S. Lipp, Elizabeth S. Miller, et al. “Patterns of relapse after successful completion of initial therapy in primary central nervous system lymphoma: a case series.” J Neurooncol 147, no. 2 (April 2020): 477–83. https://doi.org/10.1007/s11060-020-03446-3.
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  - Barbour, Andrew B., Corbin D. Jacobs, Hannah Williamson, Scott R. Floyd, Gita Suneja, Jordan A. Torok, and John P. Kirkpatrick. “Radiation Therapy Practice Patterns for Brain Metastases in the United States in the Stereotactic Radiosurgery Era.” Adv Radiat Oncol 5, no. 1 (January 2020): 43–52. https://doi.org/10.1016/j.adro.2019.07.012.
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  - Kirkpatrick, John P., and Peter E. Fecci. “Offer Hypofractionated SRS… If Her Performance Status Is Good.” Int J Radiat Oncol Biol Phys 105, no. 5 (December 1, 2019): 940–41. https://doi.org/10.1016/j.ijrobp.2018.07.001.
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  - Chan, Michael D., Scott G. Soltys, Lia M. Halasz, Nadia N. Laack, Giuseppe Minniti, and John P. Kirkpatrick. “Management of Unruptured AVMs: The Pendulum Swings.” Int J Radiat Oncol Biol Phys 105, no. 4 (November 15, 2019): 687–89. https://doi.org/10.1016/j.ijrobp.2019.08.026.
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  - Fecci, Peter E., Cosette D. Champion, Jacob Hoj, Courtney M. McKernan, C Rory Goodwin, John P. Kirkpatrick, Carey K. Anders, Ann Marie Pendergast, and John H. Sampson. “The Evolving Modern Management of Brain Metastasis.” Clin Cancer Res 25, no. 22 (November 15, 2019): 6570–80. https://doi.org/10.1158/1078-0432.CCR-18-1624.
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  - Johnson, Margaret O., John P. Kirkpatrick, Mallika P. Patel, Annick Desjardins, Dina M. Randazzo, Henry S. Friedman, David M. Ashley, and Katherine B. Peters. “The role of chemotherapy in the treatment of central neurocytoma.” Cns Oncol 8, no. 3 (November 1, 2019): CNS41. https://doi.org/10.2217/cns-2019-0012.
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  - Sperduto, Paul W., Penny Fang, Jing Li, William Breen, Paul D. Brown, Daniel Cagney, Ayal Aizer, et al. “Estimating survival in patients with gastrointestinal cancers and brain metastases: An update of the graded prognostic assessment for gastrointestinal cancers (GI-GPA).” Clin Transl Radiat Oncol 18 (September 2019): 39–45. https://doi.org/10.1016/j.ctro.2019.06.007.
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  - Minniti, Giuseppe, Nadia N. Laack, Lia M. Halasz, Michael D. Chan, Scott G. Soltys, and John P. Kirkpatrick. “Can We Omit Radiation Therapy in the Treatment of Brain Metastases from Melanoma?” International Journal of Radiation Oncology*Biology*Physics 104, no. 3 (July 2019): 473–77. https://doi.org/10.1016/j.ijrobp.2019.02.030.
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  - Sperduto, Paul W., Penny Fang, Jing Li, William Breen, Paul D. Brown, Daniel Cagney, Ayal Aizer, et al. “Survival and prognostic factors in patients with gastrointestinal cancers and brain metastases: have we made progress?” Transl Res 208 (June 2019): 63–72. https://doi.org/10.1016/j.trsl.2019.02.011.
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  - Shen, Erica, Margaret O. Johnson, Jessica W. Lee, Eric S. Lipp, Dina M. Randazzo, Annick Desjardins, Roger E. McLendon, et al. “Performance of a nomogram for IDH-wild-type glioblastoma patient survival in an elderly cohort.” Neurooncol Adv 1, no. 1 (May 2019): vdz036. https://doi.org/10.1093/noajnl/vdz036.
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  - Soltys, Scott G., Nadia N. Laack, Lia M. Halasz, Giuseppe Minniti, Michael D. Chan, and John P. Kirkpatrick. “Treatment of WHO Grade 2 and 3 Gliomas With Potentially Favorable Survival: Is Monotherapy Obsolete?” Int J Radiat Oncol Biol Phys 103, no. 3 (March 1, 2019): 533–36. https://doi.org/10.1016/j.ijrobp.2018.08.025.
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  - Abisheva, Zhanerke, Scott R. Floyd, Joseph K. Salama, John Kirkpatrick, Fang-Fang Yin, Michael J. Moravan, William Giles, and Justus Adamson. “The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.” J Radiosurg Sbrt 6, no. 2 (2019): 131–38.
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  - Batich, Kristen A., Richard F. Riedel, John P. Kirkpatrick, Betty C. Tong, William C. Eward, Char Loo Tan, Patricia D. Pittman, Roger E. McLendon, and Katherine B. Peters. “Recurrent Extradural Myxopapillary Ependymoma With Oligometastatic Spread.” Front Oncol 9 (2019): 1322. https://doi.org/10.3389/fonc.2019.01322.
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  - Chang, Yushi, Kyle Lafata, Wenzheng Sun, Chunhao Wang, Zheng Chang, John P. Kirkpatrick, and Fang-Fang Yin. “An investigation of machine learning methods in delta-radiomics feature analysis.” Plos One 14, no. 12 (2019): e0226348. https://doi.org/10.1371/journal.pone.0226348.
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  - Devi, Gayathri R., Holly Hough, Nadine Barrett, Massimo Cristofanilli, Beth Overmoyer, Neil Spector, Naoto T. Ueno, et al. “Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium.” J Cancer 10, no. 15 (2019): 3344–51. https://doi.org/10.7150/jca.31176.
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  - Duan, Xiaoyu, William Giles, John P. Kirkpatrick, and Fang-Fang Yin. “The effect of setup uncertainty on optimal dosimetric margin in LINAC-based stereotactic radiosurgery with dynamic conformal arc technique.” J Radiosurg Sbrt 6, no. 1 (2019): 55–65.
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  - Natarajan, Brahma D., Christel N. Rushing, Michael A. Cummings, Jessica Ms Jutzy, Kingshuk R. Choudhury, Michael J. Moravan, Peter E. Fecci, et al. “Predicting intracranial progression following stereotactic radiosurgery for brain metastases: Implications for post SRS imaging.” J Radiosurg Sbrt 6, no. 3 (2019): 179–87.
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  - Sperduto, Paul W., Brian J. Deegan, Jing Li, Krishan R. Jethwa, Paul D. Brown, Natalie Lockney, Kathryn Beal, et al. “Estimating survival for renal cell carcinoma patients with brain metastases: an update of the Renal Graded Prognostic Assessment tool.” Neuro Oncol 20, no. 12 (November 12, 2018): 1652–60. https://doi.org/10.1093/neuonc/noy099.
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  - Kirkpatrick, John P., Nadia N. Laack, Lia M. Halasz, Giuseppe Minniti, and Michael D. Chan. “Proton Therapy for Brain Metastases: A Question of Value.” Int J Radiat Oncol Biol Phys 101, no. 4 (July 15, 2018): 830–32. https://doi.org/10.1016/j.ijrobp.2018.05.005.
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  - Sperduto, Paul W., Brian J. Deegan, Jing Li, Krishan R. Jethwa, Paul D. Brown, Natalie Lockney, Kathryn Beal, et al. “Effect of Targeted Therapies on Prognostic Factors, Patterns of Care, and Survival in Patients With Renal Cell Carcinoma and Brain Metastases.” Int J Radiat Oncol Biol Phys 101, no. 4 (July 15, 2018): 845–53. https://doi.org/10.1016/j.ijrobp.2018.04.006.
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  - Minniti, Giuseppe, Scott G. Soltys, Lia M. Halasz, John C. Breneman, Michael Chan, Nadia N. Laack, and John P. Kirkpatrick. “Stereotactic Radiosurgery for Resected Brain Metastases: New Evidence Supports a Practice Shift, but Questions Remain.” Int J Radiat Oncol Biol Phys 100, no. 3 (March 1, 2018): 535–38. https://doi.org/10.1016/j.ijrobp.2017.08.024.
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  - Soliman, Hany, Mark Ruschin, Lilyana Angelov, Paul D. Brown, Veronica L. S. Chiang, John P. Kirkpatrick, Simon S. Lo, et al. “Consensus Contouring Guidelines for Postoperative Completely Resected Cavity Stereotactic Radiosurgery for Brain Metastases.” Int J Radiat Oncol Biol Phys 100, no. 2 (February 1, 2018): 436–42. https://doi.org/10.1016/j.ijrobp.2017.09.047.
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  - Milano, Michael T., Jimm Grimm, Scott G. Soltys, Ellen Yorke, Vitali Moiseenko, Wolfgang A. Tomé, Arjun Sahgal, et al. “Single- and Multi-Fraction Stereotactic Radiosurgery Dose Tolerances of the Optic Pathways.” Int J Radiat Oncol Biol Phys, January 31, 2018. https://doi.org/10.1016/j.ijrobp.2018.01.053.
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  - Wang, Chunhao, Wenzheng Sun, John Kirkpatrick, Zheng Chang, and Fang-Fang Yin. “Assessment of concurrent stereotactic radiosurgery and bevacizumab treatment of recurrent malignant gliomas using multi-modality MRI imaging and radiomics analysis.” J Radiosurg Sbrt 5, no. 3 (2018): 171–81.
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  - Adamson, Justus D., Tabitha Cooney, Farokh Demehri, Andrew Stalnecker, Debra Georgas, Fang-Fang Yin, and John Kirkpatrick. “Characterization of Water-Clear Polymeric Gels for Use as Radiotherapy Bolus.” Technol Cancer Res Treat 16, no. 6 (December 2017): 923–29. https://doi.org/10.1177/1533034617710579.
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  - Sperduto, Paul W., Wen Jiang, Paul D. Brown, Steve Braunstein, Penny Sneed, Daniel A. Wattson, Helen A. Shih, et al. “Estimating Survival in Melanoma Patients With Brain Metastases: An Update of the Graded Prognostic Assessment for Melanoma Using Molecular Markers (Melanoma-molGPA).” Int J Radiat Oncol Biol Phys 99, no. 4 (November 15, 2017): 812–16. https://doi.org/10.1016/j.ijrobp.2017.06.2454.
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  - Aliabadi, H., A. M. Nikpour, D. S. Yoo, J. E. Herndon, J. H. Sampson, and J. P. Kirkpatrick. “Pre-operative stereotactic radiosurgery treatment is preferred to post-operative treatment for smaller solitary brain metastases.” Chinese Neurosurgical Journal 3, no. 1 (October 3, 2017). https://doi.org/10.1186/s41016-017-0092-5.
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  - Limon, Dror, Frances McSherry, James Herndon, John Sampson, Peter Fecci, Justus Adamson, Zhiheng Wang, et al. “Single fraction stereotactic radiosurgery for multiple brain metastases.” Adv Radiat Oncol 2, no. 4 (October 2017): 555–63. https://doi.org/10.1016/j.adro.2017.09.002.
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  - Narloch, Jessica L., S Harrison Farber, Sarah Sammons, Frances McSherry, James E. Herndon, Jenny K. Hoang, Fang-Fang Yin, et al. “Biopsy of enlarging lesions after stereotactic radiosurgery for brain metastases frequently reveals radiation necrosis.” Neuro Oncol 19, no. 10 (October 1, 2017): 1391–97. https://doi.org/10.1093/neuonc/nox090.
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  - Kirkpatrick, John P., Nadia N. Laack, Helen A. Shih, and Vinai Gondi. “Management of GBM: a problem of local recurrence.” J Neurooncol 134, no. 3 (September 2017): 487–93. https://doi.org/10.1007/s11060-016-2347-y.
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  - Lee, Chen-Ting, Yingchun Zhou, Kingshuk Roy-Choudhury, Sharareh Siamakpour-Reihani, Kenneth Young, Peter Hoang, John P. Kirkpatrick, Jen-Tsan Chi, Mark W. Dewhirst, and Janet K. Horton. “Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.” Radiat Res 188, no. 2 (August 2017): 169–80. https://doi.org/10.1667/RR14664.1.
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  - Sperduto, Paul W., Wen Jiang, Paul D. Brown, Steve Braunstein, Penny Sneed, Daniel A. Wattson, Helen A. Shih, et al. “The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases.” Int J Radiat Oncol Biol Phys 98, no. 5 (August 1, 2017): 1069–77. https://doi.org/10.1016/j.ijrobp.2017.03.030.
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  - Wang, Chunhao, Fang-Fang Yin, John P. Kirkpatrick, and Zheng Chang. “Accelerated Brain DCE-MRI Using Iterative Reconstruction With Total Generalized Variation Penalty for Quantitative Pharmacokinetic Analysis: A Feasibility Study.” Technol Cancer Res Treat 16, no. 4 (August 2017): 446–60. https://doi.org/10.1177/1533034616649294.
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  - Halasz, Lia M., Scott G. Soltys, John C. Breneman, Michael D. Chan, Nadia N. Laack, Giuseppe Minniti, and John P. Kirkpatrick. “Treatment of Gliomas: A Changing Landscape.” Int J Radiat Oncol Biol Phys 98, no. 2 (June 1, 2017): 255–58. https://doi.org/10.1016/j.ijrobp.2017.02.223.
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  - Sperduto, Paul W., T Jonathan Yang, Kathryn Beal, Hubert Pan, Paul D. Brown, Ananta Bangdiwala, Ryan Shanley, et al. “Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA).” Jama Oncol 3, no. 6 (June 1, 2017): 827–31. https://doi.org/10.1001/jamaoncol.2016.3834.
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  - Kirkpatrick, John P., Scott G. Soltys, Simon S. Lo, Kathryn Beal, Dennis C. Shrieve, and Paul D. Brown. “The radiosurgery fractionation quandary: single fraction or hypofractionation?” Neuro Oncol 19, no. suppl_2 (April 1, 2017): ii38–49. https://doi.org/10.1093/neuonc/now301.
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  - Birer, S. R., A. C. Olson, J. Adamson, G. J. Kim, J. K. Salama, and J. P. Kirkpatrick. “Hippocampal Dose From Stereotactic Radiosurgery for 4 to 10 Brain Metastases: Risk Factors and Feasibility of Dose Reduction Via Reoptimization.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): E608–9. https://doi.org/10.1016/j.ijrobp.2016.06.2153.
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  - Faught, Austin M., Michael Trager, Fang-Fang Yin, John Kirkpatrick, and Justus Adamson. “Re-examining TG-142 recommendations in light of modern techniques for linear accelerator based radiosurgery.” Med Phys 43, no. 10 (October 2016): 5437. https://doi.org/10.1118/1.4962471.
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  - Kent, C. L., Y. M. Mowery, A. O. Wright, G. J. Kim, A. Desjardins, K. B. Peters, G. Vlahovic, et al. “Long-Term Outcomes for Patients With Atypical or Malignant Meningiomas Treated With Radiation Therapy: A Single-Institution Retrospective Analysis.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): E83–84. https://doi.org/10.1016/j.ijrobp.2016.06.802.
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  - Limon, D., G. J. Kim, F. McSherry, J. Herndon, P. E. Fecci, J. Adamson, J. H. Sampson, et al. “Single-Fraction Radiosurgery for 4 or More Brain Metastases.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): E84–85. https://doi.org/10.1016/j.ijrobp.2016.06.804.
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  - Olson, A. C., K. Patel, Y. M. Mowery, J. Wynne, N. Ready, J. P. Kirkpatrick, A. K. Salama, and M. K. Khan. “Anti-PD-1 Therapy and Stereotactic Radiation for Melanoma and Non-Small Cell Lung Cancer Patients with Brain Metastases: A 2-Institution Series.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): E97–98. https://doi.org/10.1016/j.ijrobp.2016.06.837.
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  - Sperduto, P. W., W. Jiang, P. D. Brown, S. E. Braunstein, P. K. Sneed, D. A. Wattson, H. A. Shih, et al. “The Effect of Gene Mutations on Survival in Patients With Melanoma Following the Development of Brain Metastases.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): S178. https://doi.org/10.1016/j.ijrobp.2016.06.447.
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  - Sperduto, Paul W., T Jonathan Yang, Kathryn Beal, Hubert Pan, Paul D. Brown, Ananta Bangdiwala, Ryan Shanley, et al. “The Effect of Gene Alterations and Tyrosine Kinase Inhibition on Survival and Cause of Death in Patients With Adenocarcinoma of the Lung and Brain Metastases.” Int J Radiat Oncol Biol Phys 96, no. 2 (October 1, 2016): 406–13. https://doi.org/10.1016/j.ijrobp.2016.06.006.
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  - Cabrera, Alvin R., John P. Kirkpatrick, John B. Fiveash, Helen A. Shih, Eugene J. Koay, Stephen Lutz, Joshua Petit, et al. “Radiation therapy for glioblastoma: Executive summary of an American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline.” Pract Radiat Oncol 6, no. 4 (July 2016): 217–25. https://doi.org/10.1016/j.prro.2016.03.007.
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  - Farber, S Harrison, Vadim Tsvankin, Jessica L. Narloch, Grace J. Kim, April K. S. Salama, Gordana Vlahovic, Kimberly L. Blackwell, John P. Kirkpatrick, and Peter E. Fecci. “Embracing rejection: Immunologic trends in brain metastasis.” Oncoimmunology 5, no. 7 (July 2016): e1172153. https://doi.org/10.1080/2162402X.2016.1172153.
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  - Soltys, S. G., J. P. Kirkpatrick, N. N. Laack, B. D. Kavanagh, J. C. Breneman, and H. A. Shih. “Is Less, More? the Evolving Role of Radiation Therapy for Brain Metastases.” International Journal of Radiation Oncology Biology Physics 92, no. 5 (August 1, 2015): 963–66. https://doi.org/10.1016/j.ijrobp.2015.03.003.
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  - Elsamadicy, Aladine A., Ranjith Babu, John P. Kirkpatrick, and David Cory Adamson. “Radiation-induced malignant gliomas: a current review.” World Neurosurg 83, no. 4 (April 2015): 530–42. https://doi.org/10.1016/j.wneu.2014.12.009.
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  - Liu, Jianfei, Q Jackie Wu, John P. Kirkpatrick, Fang-Fang Yin, Lulin Yuan, and Yaorong Ge. “From active shape model to active optical flow model: a shape-based approach to predicting voxel-level dose distributions in spine SBRT.” Phys Med Biol 60, no. 5 (March 7, 2015): N83–92. https://doi.org/10.1088/0031-9155/60/5/N83.
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  - Kirkpatrick, John P., Zhiheng Wang, John H. Sampson, Frances McSherry, James E. Herndon, Karen J. Allen, Eileen Duffy, et al. “Defining the optimal planning target volume in image-guided stereotactic radiosurgery of brain metastases: results of a randomized trial.” Int J Radiat Oncol Biol Phys 91, no. 1 (January 1, 2015): 100–108. https://doi.org/10.1016/j.ijrobp.2014.09.004.
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  - Liu, J., Q. Jackie Wu, F. F. Yin, J. P. Kirkpatrick, A. Cabrera, and Y. Ge. “An active optical flow model for dose prediction in spinal sbrt plans.” Lecture Notes in Computational Vision and Biomechanics 20 (January 1, 2015): 27–35. https://doi.org/10.1007/978-3-319-14148-0_3.
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  - Sperduto, Paul W., Chang W. Song, John P. Kirkpatrick, and Eli Glatstein. “A hypothesis: indirect cell death in the radiosurgery era.” Int J Radiat Oncol Biol Phys 91, no. 1 (January 1, 2015): 11–13. https://doi.org/10.1016/j.ijrobp.2014.08.355.
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  - Kirkpatrick, John P., and John H. Sampson. “Recurrent malignant gliomas.” Semin Radiat Oncol 24, no. 4 (October 2014): 289–98. https://doi.org/10.1016/j.semradonc.2014.06.006.
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  - Kirkpatrick, John P., Christopher R. Kelsey, Manisha Palta, Alvin R. Cabrera, Joseph K. Salama, Pretesh Patel, Bradford A. Perez, Jason Lee, and Fang-Fang Yin. “Stereotactic body radiotherapy: a critical review for nonradiation oncologists.” Cancer 120, no. 7 (April 1, 2014): 942–54. https://doi.org/10.1002/cncr.28515.
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  - Chang, Zheng, John P. Kirkpatrick, Zhiheng Wang, Jing Cai, Justus Adamson, and Fang-Fang Yin. “Evaluating radiation-induced white matter changes in patients treated with stereotactic radiosurgery using diffusion tensor imaging: a pilot study.” Technol Cancer Res Treat 13, no. 1 (February 2014): 21–28. https://doi.org/10.7785/tcrt.2012.500358.
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  - Oh, Daniel S., James A. Vredenburgh, David A. Reardon, Leonard R. Prosnitz, Jon P. Gockerman, John H. Sampson, Christopher R. Kelsey, and John P. Kirkpatrick. “Low-dose whole brain radiotherapy combined with radiosurgery for primary CNS lymphoma achieving partial response to induction methotrexate-based chemotherapy.” J Radiosurg Sbrt 3, no. 1 (2014): 37–42.
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  - Kirkpatrick, J. P. “Oncology scan - Low-grade gliomas: Predicting and changing outcome.” International Journal of Radiation Oncology Biology Physics 87, no. 2 (October 1, 2013): 234–36. https://doi.org/10.1016/j.ijrobp.2013.05.009.
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  - Cabrera, Alvin R., Kyle C. Cuneo, Annick Desjardins, John H. Sampson, Frances McSherry, James E. Herndon, Katherine B. Peters, et al. “Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas: a prospective trial.” Int J Radiat Oncol Biol Phys 86, no. 5 (August 1, 2013): 873–79. https://doi.org/10.1016/j.ijrobp.2013.04.029.
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  - Kirkpatrick, John P., Fang-Fang Yin, and John H. Sampson. “Radiotherapy and radiosurgery for tumors of the central nervous system.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 445–61. https://doi.org/10.1016/j.soc.2013.02.008.
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  - Thomas, A., M. Niebanck, Z. Wang, J. Kirkpatrick, and M. Oldham. “MO-F-108-11: 3D Verification for Multifocal Single Isocenter SRS.” Med Phys 40, no. 6Part24 (June 2013): 409. https://doi.org/10.1118/1.4815287.
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  - Sperduto, Paul W., Norbert Kased, David Roberge, Samuel T. Chao, Ryan Shanley, Xianghua Luo, Penny K. Sneed, et al. “The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer.” J Neurooncol 112, no. 3 (May 2013): 467–72. https://doi.org/10.1007/s11060-013-1083-9.
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  - Kirkpatrick, John P., Kim L. Light, Robyn M. Walker, Debra L. Georgas, Phillip A. Antoine, Robert W. Clough, Heidi B. Cozart, Fang-Fang Yin, Sua Yoo, and Christopher G. Willett. “Implementing and integrating a clinically driven electronic medical record for radiation oncology in a large medical enterprise.” Front Oncol 3 (2013): 69. https://doi.org/10.3389/fonc.2013.00069.
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  - Oh, Daniel S., David C. Adamson, and John P. Kirkpatrick. “Targeted radiotherapy for malignant gliomas.” Curr Drug Discov Technol 9, no. 4 (December 2012): 268–79. https://doi.org/10.2174/157016312803305870.
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  - Sperduto, Paul W., Penny K. Sneed, David Roberge, Ryan Shanley, Xianghua Luo, Robert J. Weil, John Suh, et al. “In regard to Yamamoto et al.” Int J Radiat Oncol Biol Phys 84, no. 4 (November 15, 2012): 875–76. https://doi.org/10.1016/j.ijrobp.2012.03.050.
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  - Salama, Joseph K., John P. Kirkpatrick, and Fang-Fang Yin. “Stereotactic body radiotherapy treatment of extracranial metastases.” Nat Rev Clin Oncol 9, no. 11 (November 2012): 654–65. https://doi.org/10.1038/nrclinonc.2012.166.
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  - Yuan, Lulin, Yaorong Ge, W Robert Lee, Fang Fang Yin, John P. Kirkpatrick, and Q Jackie Wu. “Quantitative analysis of the factors which affect the interpatient organ-at-risk dose sparing variation in IMRT plans.” Med Phys 39, no. 11 (November 2012): 6868–78. https://doi.org/10.1118/1.4757927.
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  - Oldham, Mark, Andrew Thomas, Jennifer O’Daniel, Titania Juang, Geoffrey Ibbott, John Adamovics, and John P. Kirkpatrick. “A quality assurance method that utilizes 3D dosimetry and facilitates clinical interpretation.” Int J Radiat Oncol Biol Phys 84, no. 2 (October 1, 2012): 540–46. https://doi.org/10.1016/j.ijrobp.2011.12.015.
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  - Sperduto, P. W., N. Kased, D. Roberge, Z. Xu, R. Shanley, X. Luo, P. K. Sneed, et al. “Reply to M.C. Chamberlain et al.” Journal of Clinical Oncology 30, no. 26 (September 10, 2012): 3316–17. https://doi.org/10.1200/JCO.2012.43.0256.
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  - Cabrera, Alvin R., Kyle C. Cuneo, James J. Vredenburgh, John H. Sampson, and John P. Kirkpatrick. “Stereotactic radiosurgery and bevacizumab for recurrent glioblastoma multiforme.” J Natl Compr Canc Netw 10, no. 6 (June 1, 2012): 695–99. https://doi.org/10.6004/jnccn.2012.0072.
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  - Cuneo, K. C., T. M. Zagar, D. M. Brizel, D. S. Yoo, J. K. Hoang, Z. Chang, Z. Wang, et al. “Stereotactic radiotherapy for malignancies involving the trigeminal and facial nerves.” Technol Cancer Res Treat 11, no. 3 (June 2012): 221–28. https://doi.org/10.7785/tcrt.2012.500290.
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  - Wang, Z., J. Newton, M. Niebanck, T. Juang, J. Kirkpatrick, and M. Oldham. “TU-E-BRB-09: Validation of Multi-Focal Stereotactic Radiosurgery with Volumetric Modulated Arc Therapy with High-Resolution 3D Dosimetry.” Med Phys 39, no. 6Part24 (June 2012): 3910. https://doi.org/10.1118/1.4735958.
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  - Cuneo, Kyle C., James J. Vredenburgh, John H. Sampson, David A. Reardon, Annick Desjardins, Katherine B. Peters, Henry S. Friedman, Christopher G. Willett, and John P. Kirkpatrick. “Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas.” Int J Radiat Oncol Biol Phys 82, no. 5 (April 1, 2012): 2018–24. https://doi.org/10.1016/j.ijrobp.2010.12.074.
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  - Sperduto, Paul W., Norbert Kased, David Roberge, Zhiyuan Xu, Ryan Shanley, Xianghua Luo, Penny K. Sneed, et al. “Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases.” Int J Radiat Oncol Biol Phys 82, no. 5 (April 1, 2012): 2111–17. https://doi.org/10.1016/j.ijrobp.2011.02.027.
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  - Yoo, David S., John P. Kirkpatrick, Oana Craciunescu, Gloria Broadwater, Bercedis L. Peterson, Madeline D. Carroll, Robert Clough, et al. “Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer.” Clin Cancer Res 18, no. 5 (March 1, 2012): 1404–14. https://doi.org/10.1158/1078-0432.CCR-11-1982.
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  - Sperduto, Paul W., Norbert Kased, David Roberge, Zhiyuan Xu, Ryan Shanley, Xianghua Luo, Penny K. Sneed, et al. “Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases.” J Clin Oncol 30, no. 4 (February 1, 2012): 419–25. https://doi.org/10.1200/JCO.2011.38.0527.
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  - Vredenburgh, James J., Annick Desjardins, John P. Kirkpatrick, David A. Reardon, Katherine B. Peters, James E. Herndon, Jennifer Marcello, et al. “Addition of bevacizumab to standard radiation therapy and daily temozolomide is associated with minimal toxicity in newly diagnosed glioblastoma multiforme.” Int J Radiat Oncol Biol Phys 82, no. 1 (January 1, 2012): 58–66. https://doi.org/10.1016/j.ijrobp.2010.08.058.
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  - Sperduto, P. W., S. T. Chao, J. Suh, P. K. Sneed, X. Luo, D. Roberge, A. Bhatt, et al. “Reply to Drs. mulvenna and holt.” International Journal of Radiation Oncology Biology Physics 81, no. 4 (November 15, 2011): 1194–95. https://doi.org/10.1016/j.ijrobp.2010.09.047.
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  - Vredenburgh, James J., Annick Desjardins, David A. Reardon, Katherine B. Peters, John P. Kirkpatrick, James E. Herndon, April D. Coan, et al. “THE ADDITION OF BEVACIZUMAB TO TEMOZOLOMIDE AND RADIATION THERAPY FOLLOWED BY BEVACIZUMAB, TEMOZOLOMIDE, AND ORAL TOPOTECAN FOR NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME.” Neuro Oncology 13 (November 1, 2011): 89–90.
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  - Cabrera, A. R., O. Craciunescu, K. C. Cuneo, Z. Chang, and J. P. Kirkpatrick. “Evaluating Recurrent Gliomas with Diffusion-weighted MR Imaging Before and After Concurrent Radiosurgery and Bevacizumab.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S793–S793. https://doi.org/10.1016/j.ijrobp.2011.06.1387.
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  - Cuneo, K. C., A. R. Cabrera, J. Sampson, K. Allen, E. Duffy, J. J. Vredenburgh, K. B. Peters, Z. Chang, A. Desjardins, and J. P. Kirkpatrick. “Bevacizumab and Radiosurgery for Recurrent Malignant Glioma: Toxicity Results from a Prospective Pilot Study.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S185–S185. https://doi.org/10.1016/j.ijrobp.2011.06.330.
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  - Horton, J. K., D. R. Fels, J. A. Chi, H. Kung, J. P. Kirkpatrick, and M. Dewhirst. “Protein Pathway Activation after Ionizing Radiation in Luminal and Basal Breast Cancer Cell Lines.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S160–61. https://doi.org/10.1016/j.ijrobp.2011.06.1658.
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  - Kirkpatrick, J. P., S. Green, T. Zagar, and Z. Wang. “Balancing Tumor Kill and Normal Tissue Toxicity in Radiosurgery: Critical Impact of the Peritumoral Zone.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S866–S866. https://doi.org/10.1016/j.ijrobp.2011.06.1543.
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  - Wang, Z., F. Yin, Z. Chang, J. Sampson, and J. P. Kirkpatrick. “Imaging-Guided Localization for Stereotactic Radiosurgery of Multiple Intracranial Lesions with a Single Isocenter Setup.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S860–S860. https://doi.org/10.1016/j.ijrobp.2011.06.1530.
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  - Vredenburgh, James J., Annick Desjardins, David A. Reardon, Katherine B. Peters, James E. Herndon, Jennifer Marcello, John P. Kirkpatrick, et al. “The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma.” Clin Cancer Res 17, no. 12 (June 15, 2011): 4119–24. https://doi.org/10.1158/1078-0432.CCR-11-0120.
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  - Reardon, David A., Scott Turner, Katherine B. Peters, Annick Desjardins, Sridharan Gururangan, John H. Sampson, Roger E. McLendon, et al. “A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma.” J Natl Compr Canc Netw 9, no. 4 (April 2011): 414–27. https://doi.org/10.6004/jnccn.2011.0038.
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  - Keir, Stephen T., Mark W. Dewhirst, John P. Kirkpatrick, Darell D. Bigner, and Ines Batinic-Haberle. “Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors.” Anticancer Agents Med Chem 11, no. 2 (February 2011): 202–12. https://doi.org/10.2174/187152011795255957.
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  - Kirkpatrick, John P., Lawrence B. Marks, Charles S. Mayo, Yaacov R. Lawrence, Niranjan Bhandare, and Samuel Ryu. “Estimating normal tissue toxicity in radiosurgery of the CNS: application and limitations of QUANTEC.” J Radiosurg Sbrt 1, no. 2 (2011): 95–107.
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  - Palta, Manisha, Richard F. Riedel, James J. Vredenburgh, Thomas J. Cummings, Scott Green, Zheng Chang, and John P. Kirkpatrick. “Primary meningeal rhabdomyosarcoma.” Sarcoma 2011 (2011): 312802. https://doi.org/10.1155/2011/312802.
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  - Sperduto, Paul W., Samuel T. Chao, Penny K. Sneed, Xianghua Luo, John Suh, David Roberge, Amit Bhatt, et al. “Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients.” Int J Radiat Oncol Biol Phys 77, no. 3 (July 1, 2010): 655–61. https://doi.org/10.1016/j.ijrobp.2009.08.025.
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  - Chong, Gabriel T., Srinivasan Mukundan, John P. Kirkpatrick, Ali Zomorodi, John H. Sampson, and M Tariq Bhatti. “Stereotactic radiosurgery in the treatment of a dural carotid-cavernous fistula.” J Neuroophthalmol 30, no. 2 (June 2010): 138–44. https://doi.org/10.1097/WNO.0b013e3181ceb3e3.
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  - Chang, Zheng, Zhiheng Wang, Jinli Ma, Jennifer C. O’Daniel, John Kirkpatrick, and Fang-Fang Yin. “6D image guidance for spinal non-invasive stereotactic body radiation therapy: Comparison between ExacTrac X-ray 6D with kilo-voltage cone-beam CT.” Radiother Oncol 95, no. 1 (April 2010): 116–21. https://doi.org/10.1016/j.radonc.2009.12.036.
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  - Kirkpatrick, John P., Albert J. van der Kogel, and Timothy E. Schultheiss. “Radiation dose-volume effects in the spinal cord.” Int J Radiat Oncol Biol Phys 76, no. 3 Suppl (March 1, 2010): S42–49. https://doi.org/10.1016/j.ijrobp.2009.04.095.
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  - Mayo, Charles, Mary K. Martel, Lawrence B. Marks, John Flickinger, Jiho Nam, and John Kirkpatrick. “Radiation dose-volume effects of optic nerves and chiasm.” Int J Radiat Oncol Biol Phys 76, no. 3 Suppl (March 1, 2010): S28–35. https://doi.org/10.1016/j.ijrobp.2009.07.1753.
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  - Kelsey, Chris R., Srinivasan Mukundan, Zhiheng Wang, Carol A. Hahn, Brian J. Soher, and John P. Kirkpatrick. “Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy.” Neuro Oncol 12, no. 2 (February 2010): 145–52. https://doi.org/10.1093/neuonc/nop040.
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  - Ma, Jinli, Zheng Chang, Zhiheng Wang, Q. Jackie Wu, John P. Kirkpatrick, and Fang-Fang Yin. “ExacTrac X-ray 6 degree-of-freedom image-guidance for intracranial non-invasive stereotactic radiotherapy: comparison with kilo-voltage cone-beam CT.” Radiother Oncol 93, no. 3 (December 2009): 602–8. https://doi.org/10.1016/j.radonc.2009.09.009.
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  - Wu, Q Jackie, Sua Yoo, John P. Kirkpatrick, Danthai Thongphiew, and Fang-Fang Yin. “Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment.” Int J Radiat Oncol Biol Phys 75, no. 5 (December 1, 2009): 1596–1604. https://doi.org/10.1016/j.ijrobp.2009.05.005.
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  - Kirkpatrick, John P., David J. Brenner, and Colin G. Orton. “The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery.” Med Phys 36, no. 8 (August 2009): 3381–84. https://doi.org/10.1118/1.3157095.
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  - Chino, Junzo P., John H. Sampson, Debara L. Tucci, David M. Brizel, and John P. Kirkpatrick. “Paraganglioma of the head and neck: long-term local control with radiotherapy.” Am J Clin Oncol 32, no. 3 (June 2009): 304–7. https://doi.org/10.1097/COC.0b013e318187dd94.
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  - Kirkpatrick, J. P., J. J. Vredenburgh, A. Desjardins, S. Gururangan, K. B. Peters, S. T. Boulton, A. H. Friedman, H. S. Friedman, and D. A. Reardon. “Phase I study of vandetanib, imatinib mesylate, and hydroxyurea for recurrent malignant glioma.” J Clin Oncol 27, no. 15_suppl (May 20, 2009): e13007.
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  - Nelson, John W., David S. Yoo, John H. Sampson, Robert E. Isaacs, Nicole A. Larrier, Lawrence B. Marks, Fang-Fang Yin, Q Jackie Wu, Zhiheng Wang, and John P. Kirkpatrick. “Stereotactic body radiotherapy for lesions of the spine and paraspinal regions.” Int J Radiat Oncol Biol Phys 73, no. 5 (April 1, 2009): 1369–75. https://doi.org/10.1016/j.ijrobp.2008.06.1949.
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  - Hahn, Carol A., Su-Min Zhou, Renee Raynor, Andrea Tisch, Kim Light, Timothy Shafman, Terence Wong, et al. “Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction.” Int J Radiat Oncol Biol Phys 73, no. 4 (March 15, 2009): 1082–87. https://doi.org/10.1016/j.ijrobp.2008.05.061.
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  - Reese, Adam S., Shiva K. Das, John P. Kirkpatrick, and Lawrence B. Marks. “Quantifying the dosimetric trade-offs when using intensity-modulated radiotherapy to treat concave targets containing normal tissues.” Int J Radiat Oncol Biol Phys 73, no. 2 (February 1, 2009): 585–93. https://doi.org/10.1016/j.ijrobp.2008.09.044.
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  - Wang, Zhiheng, John W. Nelson, Sua Yoo, Q Jackie Wu, John P. Kirkpatrick, Lawrence B. Marks, and Fang-Fang Yin. “Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy.” Int J Radiat Oncol Biol Phys 73, no. 2 (February 1, 2009): 571–77. https://doi.org/10.1016/j.ijrobp.2008.09.040.
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  - Jackie, Q. J., Z. Wang, J. P. Kirkpatrick, Z. Chang, J. J. Meyer, M. Lu, C. Huntzinger, and F. F. Yin. “Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions.” Radiation Oncology 4 (January 21, 2009). https://doi.org/10.1186/1748-717X-4-3.
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  - Wu, Q Jackie, Zhiheng Wang, John P. Kirkpatrick, Zheng Chang, Jeffrey J. Meyer, Mei Lu, Calvin Huntzinger, and Fang-Fang Yin. “Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions.” Radiat Oncol 4 (January 21, 2009): 3. https://doi.org/10.1186/1748-717X-4-3.
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  - Kirkpatrick, John P., Jeffrey J. Meyer, and Lawrence B. Marks. “The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery.” Semin Radiat Oncol 18, no. 4 (October 2008): 240–43. https://doi.org/10.1016/j.semradonc.2008.04.005.
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  - Boyd, J. A., J. L. Hubbs, D. R. Hollis, J. P. Kirkpatrick, D. W. Kim, L. B. Marks, and C. R. Kelsey. “The actuarial incidence of brain metastases in 975 patients undergoing surgery for early-stage lung cancer.” J Clin Oncol 26, no. 15_suppl (May 20, 2008): 8094.
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  - Boyd, J. A., J. L. Hubbs, D. R. Hollis, J. P. Kirkpatrick, D. W. Kim, L. B. Marks, and C. R. Kelsey. “The actuarial incidence of brain metastases in 975 patients undergoing surgery for early-stage lung cancer.” Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 8094–8094. https://doi.org/10.1200/jco.2008.26.15_suppl.8094.
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  - Kirkpatrick, J. P., J. N. Rich, J. J. Vredenburgh, A. Desjardins, J. A. Quinn, S. Gururangan, S. Sathornsumetee, M. J. Egorin, H. S. Friedman, and D. A. Reardon. “Final report: Phase I trial of imatinib mesylate, hydroxyurea, and vatalanib for patients with recurrent malignant glioma (MG).” J Clin Oncol 26, no. 15_suppl (May 20, 2008): 2057.
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  - Kirkpatrick, J. P., J. N. Rich, J. J. Vredenburgh, A. Desjardins, J. A. Quinn, S. Gururangan, S. Sathornsumetee, M. J. Egorin, H. S. Friedman, and D. A. Reardon. “Final report: Phase I trial of imatinib mesylate, hydroxyurea, and vatalanib for patients with recurrent malignant glioma (MG).” Journal of Clinical Oncology 26, no. 15 (May 20, 2008).
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  - Yin, Fang-Fang, Zhiheng Wang, Sua Yoo, Q Jackie Wu, John Kirkpatrick, Nicole Larrier, Jeffrey Meyer, Christopher G. Willett, and Lawrence B. Marks. “Integration of cone-beam CT in stereotactic body radiation therapy.” Technol Cancer Res Treat 7, no. 2 (April 2008): 133–39. https://doi.org/10.1177/153303460800700206.
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  - Kirkpatrick, John P., and Mark W. Dewhirst. “Analytic solution to steady-state radial diffusion of a substrate with first-order reaction kinetics in the tissue of a Krogh's cylinder.” Radiat Res 169, no. 3 (March 2008): 350–54. https://doi.org/10.1667/RR1166.1.
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  - Kirkpatrick, John P., Zahid N. Rabbani, Rex C. Bentley, Matt E. Hardee, Seth Karol, Jeffrey Meyer, Egbert Oosterwijk, et al. “Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer.” Biomark Insights 3 (February 1, 2008): 45–55. https://doi.org/10.4137/bmi.s570.
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  - Scott, Adrienne W., Thomas J. Cummings, John P. Kirkpatrick, and Prithvi Mruthyunjaya. “Choroidal metastasis of follicular thyroid adenocarcinoma diagnosed by 25-gauge transretinal biopsy.” Ann Ophthalmol (Skokie) 40, no. 2 (2008): 110–12.
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  - Kasibhatla, Mohit, John P. Kirkpatrick, and David M. Brizel. “How much radiation is the chemotherapy worth in advanced head and neck cancer?” Int J Radiat Oncol Biol Phys 68, no. 5 (August 1, 2007): 1491–95. https://doi.org/10.1016/j.ijrobp.2007.03.025.
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  - Miles, Edward F., Chris R. Kelsey, John P. Kirkpatrick, and Lawrence B. Marks. “Estimating the magnitude and field-size dependence of radiotherapy-induced mortality and tumor control after postoperative radiotherapy for non-small-cell lung cancer: calculations from clinical trials.” Int J Radiat Oncol Biol Phys 68, no. 4 (July 15, 2007): 1047–52. https://doi.org/10.1016/j.ijrobp.2007.02.028.
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  - Fleckenstein, Katharina, Larisa Zgonjanin, Liguang Chen, Zahid Rabbani, Isabel L. Jackson, Bradley Thrasher, John Kirkpatrick, W Michael Foster, and Zeljko Vujaskovic. “Temporal onset of hypoxia and oxidative stress after pulmonary irradiation.” Int J Radiat Oncol Biol Phys 68, no. 1 (May 1, 2007): 196–204. https://doi.org/10.1016/j.ijrobp.2006.12.056.
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  - Soper, J. T., M. Spillman, J. H. Sampson, J. P. Kirkpatrick, J. K. Wolf, and D. L. Clarke-Pearson. “High-risk gestational trophoblastic neoplasia with brain metastases: individualized multidisciplinary therapy in the management of four patients.” Gynecol Oncol 104, no. 3 (March 2007): 691–94. https://doi.org/10.1016/j.ygyno.2006.10.027.
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  - Meyer, Jeffrey J., Lawrence B. Marks, Edward C. Halperin, and John P. Kirkpatrick. “Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation.” Radiat Oncol 1 (December 22, 2006): 48. https://doi.org/10.1186/1748-717X-1-48.
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  - Kirkpatrick, John P. “Tumor hypoxia and prognosis in human gliomas.” Cancer J 12, no. 6 (November 2006): 451–54. https://doi.org/10.1097/00130404-200611000-00002.
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  - Oldham, Mark, Harshad Sakhalkar, Tim Oliver, Ying Min Wang, John Kirpatrick, Yiting Cao, Cristian Badea, G Allan Johnson, and Mark Dewhirst. “Three-dimensional imaging of xenograft tumors using optical computed and emission tomography.” Med Phys 33, no. 9 (September 2006): 3193–3202. https://doi.org/10.1118/1.2217109.
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  - Kirkpatrick, J. P., and A. H. Friedman. “Multisession CyberKnife radiosurgery for intramedullary spinal cord arteriovenous malformations: Commentary.” Neurosurgery 58, no. 6 (June 1, 2006): 1089. https://doi.org/10.1227/01.NEU.0000215891.25153.BA.
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  - Yin, Fang-Fang, Shiva Das, John Kirkpatrick, Mark Oldham, Zhiheng Wang, and Su-Min Zhou. “Physics and imaging for targeting of oligometastases.” Semin Radiat Oncol 16, no. 2 (April 2006): 85–101. https://doi.org/10.1016/j.semradonc.2005.12.004.
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  - Hardee, Matthew E., Zahid N. Rabbani, Murat O. Arcasoy, John P. Kirkpatrick, Zeljko Vujaskovic, Mark W. Dewhirst, and Kimberly L. Blackwell. “Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity.” Mol Cancer Ther 5, no. 2 (February 2006): 356–61. https://doi.org/10.1158/1535-7163.MCT-05-0196.
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  - Kirkpatrick, John P., Matthew E. Hardee, Stacey A. Snyder, Catherine M. Peltz, Yulin Zhao, David M. Brizel, Mark W. Dewhirst, and Kimberly L. Blackwell. “The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma.” Radiat Res 165, no. 2 (February 2006): 192–201. https://doi.org/10.1667/rr3499.1.
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  - Koontz, Bridget F., John P. Kirkpatrick, Robert W. Clough, Robert G. Prosnitz, Jon P. Gockerman, Joseph O. Moore, and Leonard R. Prosnitz. “Combined-modality therapy versus radiotherapy alone for treatment of early-stage Hodgkin's disease: cure balanced against complications.” J Clin Oncol 24, no. 4 (February 1, 2006): 605–11. https://doi.org/10.1200/JCO.2005.02.9850.
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  - Hardee, Matthew E., Murat O. Arcasoy, Kimberly L. Blackwell, John P. Kirkpatrick, and Mark W. Dewhirst. “Erythropoietin biology in cancer.” Clin Cancer Res 12, no. 2 (January 15, 2006): 332–39. https://doi.org/10.1158/1078-0432.CCR-05-1771.
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  - Hardee, M. E., J. P. Kirkpatrick, S. Shan, S. A. Snyder, Z. Vujaskovic, Z. N. Rabbani, M. W. Dewhirst, and K. L. Blackwell. “Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis.” Br J Cancer 93, no. 12 (December 12, 2005): 1350–55. https://doi.org/10.1038/sj.bjc.6602846.
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  - Kirkpatrick, John P., and Mitchell S. Anscher. “Radiotherapy for locally recurrent prostate cancer.” Clin Adv Hematol Oncol 3, no. 12 (December 2005): 933–42.
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  - Liu, Shanling, He Wang, Zhonghui Yang, Takashi Kon, Jiangao Zhu, Yiting Cao, Fang Li, John Kirkpatrick, Christopher V. Nicchitta, and Chuan-Yuan Li. “Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression.” Cancer Res 65, no. 20 (October 15, 2005): 9126–31. https://doi.org/10.1158/0008-5472.CAN-05-0945.
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  - Zhang, Xiuwu, Takashi Kon, He Wang, Fang Li, Qian Huang, Zahid N. Rabbani, John P. Kirkpatrick, Zeljko Vujaskovic, Mark W. Dewhirst, and Chuan-Yuan Li. “Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha.” Cancer Res 64, no. 22 (November 15, 2004): 8139–42. https://doi.org/10.1158/0008-5472.CAN-03-2301.
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  - Hardee, M. E., J. P. Kirkpatrick, S. Snyder, S. Shan, Z. Vujaskovic, Z. N. Rabbani, M. W. Dewhirst, and K. L. Blackwell. “Erythropoietin (EPO) has no direct effect on tumor growth or angiogenesis in animal models.” J Clin Oncol 22, no. 14_suppl (July 15, 2004): 9530.
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  - Kirkpatrick, J. P., L. I. Cárdenas-Navia, and M. W. Dewhirst. “Predicting the effect of temporal variations in PO2 on tumor radiosensitivity.” Int J Radiat Oncol Biol Phys 59, no. 3 (July 1, 2004): 822–33. https://doi.org/10.1016/j.ijrobp.2004.02.015.
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  - Huang, Qian, Xiuwu Zhang, He Wang, Bin Yan, John Kirkpatrick, Mark W. Dewhrist, and Chuan-Yuan Li. “A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells.” Clin Cancer Res 10, no. 4 (February 15, 2004): 1439–45. https://doi.org/10.1158/1078-0432.ccr-03-0122.
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  - Kirkpatrick, John P., and Lawrence B. Marks. “Modeling killing and repopulation kinetics of subclinical cancer: direct calculations from clinical data.” Int J Radiat Oncol Biol Phys 58, no. 2 (February 1, 2004): 641–54. https://doi.org/10.1016/j.ijrobp.2003.09.035.
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  - Blackwell, Kimberly L., John P. Kirkpatrick, Stacey A. Snyder, Gloria Broadwater, Francis Farrell, Linda Jolliffe, David M. Brizel, and Mark W. Dewhirst. “Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin.” Cancer Res 63, no. 19 (October 1, 2003): 6162–65.
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  - Kang, Song K., John P. Kirkpatrick, and Edward C. Halperin. “Low-dose radiation for posttransplant lymphoproliferative disorder.” Am J Clin Oncol 26, no. 2 (April 2003): 210–14. https://doi.org/10.1097/00000421-200304000-00023.
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  - Kirkpatrick, John P., David M. Brizel, and Mark W. Dewhirst. “A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics.” Radiat Res 159, no. 3 (March 2003): 336–44. https://doi.org/10.1667/0033-7587(2003)159[0336:ammoto]2.0.co;2.
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  - Braaten, J. V., S. Handt, W. G. Jerome, J. Kirkpatrick, J. C. Lewis, and R. R. Hantgan. “Regulation of fibrinolysis by platelet-released plasminogen activator inhibitor 1: light scattering and ultrastructural examination of lysis of a model platelet-fibrin thrombus.” Blood 81, no. 5 (March 1, 1993): 1290–99.
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  - Kirkpatrick, J. P., L. V. McIntire, J. L. Moake, and P. L. Cimo. “Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents.” Thromb Haemost 42, no. 5 (February 29, 1980): 1483–89.
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  - Kirkpatrick, J. P., L. V. McIntire, J. L. Moake, and D. M. Peterson. “Metabolic requirements of contractile force generation in platelet rich plasma - a rheological study.” Biorheology 17, no. 5–6 (1980): 411–18.
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  - Kirkpatrick, J. P., L. V. McIntire, and W. G. Characklis. “Mass and heat transfer in a circular tube with biofouling.” Water Research 14, no. 2 (January 1, 1980): 117–27. https://doi.org/10.1016/0043-1354(80)90227-4.
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  - Kirkpatrick, J. P., and L. V. McIntire. “Dynamic Rheological Studies of Coagulation and Fibrinolysis.” Journal of Rheology 23, no. 6 (January 1, 1979): 769–87. https://doi.org/10.1122/1.549546.
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  - Kirkpatrick, J. P., L. V. McIntire, and J. L. Moake. “Streptokinase-induced degradation of crosslinked and uncrosslinked clots.” Thromb Res 13, no. 3 (September 1978): 569–75. https://doi.org/10.1016/0049-3848(78)90144-5.
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  - Giles, William M., Edward T. Cullom, Obed A-O Laryea, Ahmad Nobah, Victor G. L. Alves, Fang-Fang Yin, John P. Kirkpatrick, and Justus D. Adamson. “Radiosurgery treatment planning using conformal arc informed volumetric modulated arc therapy.” Med Dosim 46, no. 1 (n.d.): 3–12. https://doi.org/10.1016/j.meddos.2020.06.001.
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  - Morrison, Jay, Rodney Hood, Fang-Fang Yin, Joseph K. Salama, John Kirkpatrick, and Justus Adamson. “Is a single isocenter sufficient for volumetric modulated arc therapy radiosurgery when multiple itracranial metastases are spatially dispersed?” Med Dosim 41, no. 4 (n.d.): 285–89. https://doi.org/10.1016/j.meddos.2016.06.007.
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- Book Sections
  - Kirkpatrick, J. P., G. Kim, and J. H. Sampson. “Radiation therapy for gliomas.” In The Duke Glioma Handbook: Pathology, Diagnosis, and Management, 49–75, 2016. https://doi.org/10.1017/CBO9781107588721.004.
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  - Kirkpatrick, John. “Late Effects and QUANTEC.” In Principles and Practice of Radiation Oncology, edited by Edward Halperin, n.d.
- Conference Papers
  - Lee, J. W. C., M. O. Johnson, J. P. Kirkpatrick, F. McSherry, J. Herndon, E. S. Lipp, A. Desjardins, et al. “Outcomes Following Adjuvant Radiation Therapy in Elderly Patients with Glioblastoma: A Retrospective Single Institution Analysis.” In International Journal of Radiation Oncology*Biology*Physics, 105:E102–E102. Elsevier BV, 2020. https://doi.org/10.1016/j.ijrobp.2019.06.2296.
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  - Fairchild, A., J. A. Torok, J. Adamson, S. R. Floyd, M. J. Moravan, P. Fecci, F. F. Yin, and J. P. Kirkpatrick. “Postoperative Five-Fraction Radiosurgery for Resected Brain Metastases.” In International Journal of Radiation Oncology*Biology*Physics, 105:E74–75. Elsevier BV, 2019. https://doi.org/10.1016/j.ijrobp.2019.06.2332.
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  - Jacobs, C. D., A. B. Barbour, G. Suneja, H. Williamson, S. Floyd, J. A. Torok, and J. P. Kirkpatrick. “Whole Brain Radiotherapy Practice Patterns in the Era of Stereotactic Radiosurgery.” In International Journal of Radiation Oncology*Biology*Physics, 105:E576–77. Elsevier BV, 2019. https://doi.org/10.1016/j.ijrobp.2019.06.1249.
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  - Peters, K. B., J. P. Kirkpatrick, I. Batinic-Haberle, M. L. Affronti, S. Woodring, D. Iden, E. S. Lipp, et al. “First in Human Clinical Trial of a Metalloporphyrin Dual Radioprotectant and Radiosensitizer, BMX-001, in Newly Diagnosed High-Grade Glioma Undergoing Concurrent Chemoradiation.” In International Journal of Radiation Oncology*Biology*Physics, 105:E106–E106. Elsevier BV, 2019. https://doi.org/10.1016/j.ijrobp.2019.06.2305.
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  - Cui, Y., H. Gao, J. P. Kirkpatrick, and F. F. Yin. “A Retrospective Review on Stereotactic Radiosurgery Cases Planned with Dynamic Conformal Arcs Versus Volumetric Modulated Arc Therapy.” In International Journal of Radiation Oncology*Biology*Physics, 102:e211–12. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.07.740.
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  - Jensen, P. J., J. P. Kirkpatrick, S. R. Floyd, J. Torok, C. R. Goodwin, and Q. R. J. J. Wu. “Improving Coverage of Epidural Space in Spinal Stereotactic Body Radiation Therapy without Compromising Spinal Cord Sparing: A Feasibility Study.” In International Journal of Radiation Oncology*Biology*Physics, 102:e511–12. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.07.1447.
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  - Natarajan, B. D., M. A. Cummings, J. Jutzy, C. N. Rushing, K. R. Choudhury, M. J. Moravan, S. J. Chmura, M. T. Milano, J. P. Kirkpatrick, and J. K. Salama. “Patient Factors Predicting Intracranial Progression: Optimizing MRI Surveillance Interval Following Brain Metastases SRS.” In International Journal of Radiation Oncology*Biology*Physics, 102:e308–e308. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.07.965.
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  - Subashi, E. D., Z. Wang, Y. Cui, Z. Chang, J. P. Kirkpatrick, and F. F. Yin. “An Analysis of Geometric Distortion in a 3T MRI Scanner Used for Intracranial Radiosurgery.” In International Journal of Radiation Oncology*Biology*Physics, 102:e518–e518. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.07.1462.
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  - Tanksley, J., J. Adamson, J. Torok, G. J. Kim, S. R. Floyd, P. Fecci, and J. P. Kirkpatrick. “Surgical Cavities Exhibit Substantial Remodeling Post Resection of Brain Metastases: Implications for Stereotactic Radiosurgery (SRS).” In International Journal of Radiation Oncology*Biology*Physics, 102:S151–S151. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.06.365.
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  - Trotter, J., J. P. Kirkpatrick, F. McSherry, A. Rodrigues, M. L. Dworkin, A. Zomorodi, L. F. Gonzalez, J. Herndon, and E. F. Hauck. “Long-term Outcomes and Imaging Response for Image-Guided Stereotactic Radiosurgery (IG-SRS) of Brain Arteriovenous Malformations (AVM).” In International Journal of Radiation Oncology*Biology*Physics, 102:e363–e363. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.07.1090.
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  - Babatunde, Olayode, Collin Kent, Yvonne Mowery, Frances McSherry, James E. Herndon, Ato Wright, Robert Clough, William Sperduto, and John P. Kirkpatrick. “LONG-TERM OUTCOMES FOLLOWING SURGERY AND/OR RADIATION THERAPY IN PATIENTS WITH HIGH-GRADE MENINGIOMA.” In Neuro Oncology, 19:135–135. OXFORD UNIV PRESS INC, 2017.
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  - Johnson, Margaret O., John P. Kirkpatrick, Mallika P. Weant, Anastasie Dunn-Pirio, Annick Desjardins, Dina Randazzo, Henry S. Friedman, and Katherine B. Peters. “A RETROSPECTIVE, SINGLE INSTITUTION STUDY OF CENTRAL NEUROCYTOMA (2004-2016): SURVIVAL, TREATMENT, AND SUPPORTIVE CARE.” In Neuro Oncology, 19:vi215–16. OXFORD UNIV PRESS INC, 2017. https://doi.org/10.1093/neuonc/nox168.871.
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  - Sperduto, P. W., B. J. Deegan, J. Li, K. R. Jethwa, P. D. Brown, N. A. Lockney, K. Beal, et al. “Prognostic Factors in Patients with Renal Cell Carcinoma and Brain Metastases.” In International Journal of Radiation Oncology*Biology*Physics, 99:S169–70. Elsevier BV, 2017. https://doi.org/10.1016/j.ijrobp.2017.06.429.
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  - Wang, C., W. Sun, J. P. Kirkpatrick, J. Sampson, Z. Chang, and F. F. Yin. “Assessment of Concurrent Stereotactic Radiosurgery and Bevacizumab Treatment of Recurrent Malignant Gliomas Using Multiparametric MRI Imaging and Radiomics Analysis.” In International Journal of Radiation Oncology Biology Physics, 99:E734–E734. ELSEVIER SCIENCE INC, 2017.
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  - Xie, T., Y. Ge, J. P. Kirkpatrick, S. Yoo, F. F. Yin, and Q. R. J. Wu. “An Efficient Tool for Structure Label Harmonization.” In International Journal of Radiation Oncology*Biology*Physics, 99:E740–E740. Elsevier BV, 2017. https://doi.org/10.1016/j.ijrobp.2017.06.2382.
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  - Narloch, Jessie, Catherine Luedke, Gloria Broadwater, Nolan Priedigkeit, Allison Hall, Terry Hyslop, Sarah LeNoir Sammons, et al. “Number of tumor-infiltrating lymphocytes in breast cancer brain metastases compared to matched breast primaries.” In Journal of Clinical Oncology, 35:2049–2049. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.2049.
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  - Affronti, Mary Lou, Sarah Woodring, Karen Allen, John Kirkpatrick, Katherine B. Peters, James E. Herndon, Frances McSherry, et al. “Phase II study to evaluate the safety and efficacy of intravenous palonosetron (PAL) in primary malignant glioma (MG) patients receiving standard radiotherapy (RT) and concomitant temozolomide (TMZ).” In Support Care Cancer, 24:4365–75, 2016. https://doi.org/10.1007/s00520-016-3276-1.
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  - Birer, S. R., A. C. Olson, J. Adamson, G. J. Kim, J. K. Salama, and J. P. Kirkpatrick. “Hippocampal Dose From Stereotactic Radiosurgery for 4 to 10 Brain Metastases: Risk Factors and Feasibility of Dose Reduction Via Reoptimization.” In International Journal of Radiation Oncology Biology Physics, 96:E608–9, 2016.
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  - Sperduto, P. W., W. Jiang, P. D. Brown, S. E. Braunstein, P. K. Sneed, D. A. Wattson, H. A. Shih, et al. “The Effect of Gene Mutations on Survival in Patients With Melanoma Following the Development of Brain Metastases.” In International Journal of Radiation Oncology Biology Physics, 96:S178–S178, 2016.
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  - Stanhope, Carl, Zheng Chang, Zhiheng Wang, Fang-Fang Yin, Grace Kim, Joseph K. Salama, John Kirkpatrick, and Justus Adamson. “Physics considerations for single-isocenter, volumetric modulated arc radiosurgery for treatment of multiple intracranial targets.” In Pract Radiat Oncol, 6:207–13, 2016. https://doi.org/10.1016/j.prro.2015.10.010.
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  - Boyle, J. M., J. P. Chino, J. H. Sampson, A. Desjardins, and J. P. Kirkpatrick. “Stereotactic Radiosurgery for Recurrent High Grade Gliomas: Patterns of Failure.” In International Journal of Radiation Oncology*Biology*Physics, 93:E92–E92. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.780.
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  - Brownstein, J., D. Randazzo, G. J. Kim, K. Peters, and J. P. Kirkpatrick. “A Simple Kinetic Model Provides an Early Prediction of Thrombocytopenia in Malignant Glioma Patients Treated With Radiation and Temozolomide.” In International Journal of Radiation Oncology*Biology*Physics, 93:E92–E92. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.781.
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  - Kim, G. J., T. Barkdoll, J. H. Sampson, Z. Wang, J. Hoang, P. E. Fecci, F. F. Yin, and J. P. Kirkpatrick. “Pathologic Evaluation of Radiographically Enlarging Lesions After Stereotactic Radiosurgery for Brain Metastases.” In International Journal of Radiation Oncology*Biology*Physics, 93:E93–E93. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.784.
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  - Mowery, Y. M., G. J. Kim, A. Wright, A. Desjardins, K. B. Peters, G. Vlahovic, H. S. Friedman, J. H. Sampson, and J. P. Kirkpatrick. “Outcomes for Patients With Intracranial Meningiomas Treated With Radiation therapy and Bevacizumab: A Single-Institution Retrospective Analysis.” In International Journal of Radiation Oncology*Biology*Physics, 93:E104–E104. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.813.
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  - Olson, A. C., R. Qin, B. Singh, N. Bhavsar, S. Wolf, J. K. Salama, J. P. Kirkpatrick, and A. K. Salama. “Radiosurgery for Brain Metastases in Melanoma Patients Receiving Ipilimumab.” In International Journal of Radiation Oncology*Biology*Physics, 93:E88–E88. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.771.
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  - Sperduto, P. W., T. J. Yang, K. Beal, H. Y. Pan, P. D. Brown, Y. Y. Ho, N. Yeh, et al. “The Effect of Gene Mutations on Survival in Patients With Adenocarcinoma of the Lung Following the Development of Brain Metastases.” In International Journal of Radiation Oncology*Biology*Physics, 93:S37–38. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.092.
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  - Wang, Z., J. P. Kirkpatrick, G. J. Kim, C. R. Kelsey, and F. F. Yin. “Rotational Corrections for Stereotactic Radiosurgery (SRS) of Multiple Brain Metastases Treated With Single Isocenter Technique.” In International Journal of Radiation Oncology*Biology*Physics, 93:E602–E602. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.2085.
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  - Liu, J., Q. J. Wu, F. F. Yin, J. P. Kirkpatrick, A. Cabrera, and Y. Ge. “An active optical flow model for dose prediction in spinal SBRT plans.” In Lecture Notes in Engineering and Computer Science, 20:27–35, 2015. https://doi.org/10.1007/978-3-319-14148-0_3.
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  - Lee, Chen-Ting, Aaron Blackley, Chelsea Landon, Ivan Spasojevic, John P. Kirkpatrick, and Mark W. Dewhirst. “Abstract 3774: Hyperthermia treatment overcomes temozolomide resistance in glioma cells by downregulatingMGMTexpression and increasing temozolomide uptake.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-3774.
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  - Liu, J., Q. Wu, F. Yin, J. P. Kirkpatrick, A. R. Cabrera, and Y. Ge. “Predicting Dose Distributions in Spinal SBRT Plans Using An Active Appearance Model (AAM).” In International Journal of Radiation Oncology*Biology*Physics, 90:S17–18. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.105.
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  - Kirkpatrick, J. P., Z. Wang, J. Sampson, C. Kelsey, K. Allen, E. Duffy, S. Green, A. Cabrera, M. Palta, and F. Yin. “Early Results of a Randomized Trial to Identify an Optimal PTV in Stereotactic Radiosurgery of Brain Metastases.” In International Journal of Radiation Oncology*Biology*Physics, 87:S50–S50. Elsevier BV, 2013. https://doi.org/10.1016/j.ijrobp.2013.06.131.
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  - Cuneo, K. C., J. Vredenburgh, A. Desjardins, K. Peters, J. Sampson, K. Allen, Z. Chang, E. Duffy, B. Peterson, and J. P. Kirkpatrick. “Impact of Concurrent and Adjuvant Bevacizumab on the Risk of Radiation Necrosis Following Radiosurgery for Recurrent Glioma.” In International Journal of Radiation Oncology*Biology*Physics, 84:S7–S7. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.024.
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  - Lewis, S., J. Vredenburgh, A. Desjardins, K. Peters, S. Green, R. Hood, Y. Yang, J. Sampson, Z. Wang, and J. P. Kirkpatrick. “Patterns of Failure as a Function of Clinical Target Volumes in Patients With GBM Treated With Radiation Therapy (RT), Temozolomide, and Bevacizumab.” In International Journal of Radiation Oncology*Biology*Physics, 84:S266–67. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.694.
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  - Chang, Z., J. Kirkpatrick, J. Cai, Z. Wang, and F. Yin. “Evaluating Radiation-Induced White Matter Changes in Patients with Recurrent Malignant Gliomas Under Treatment of Stereotactic Radiosurgery Using Diffusion Tensor Imaging.” In Medical Physics, 39:3937–3937, 2012. https://doi.org/10.1118/1.4736067.
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  - Huang, C., L. Ren, J. Kirkpatrick, and Z. Wang. “SU-E-T-645: Treatment of Multiple Brain Metastases Using Stereotactic Radiosurgery with Single-Isocenter Volumetric Modulated Arc Therapy: Comparison with Conventional Dynamic Conformal Arc and Static Beam Stereotactic Radiosurgery.” In Med Phys, 39:3854, 2012. https://doi.org/10.1118/1.4735734.
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  - ge, Y., T. Minta, J. Kirkpatrick, L. Yuan, and Q. wu. “SU‐E‐T‐23: Ontological Representation of Radiation Treatment Guidelines.” In Medical Physics, 38:3490, 2011. https://doi.org/10.1118/1.3611973.
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  - Cuneo, Kyle C., James J. Vredenburgh, John H. Sampson, David A. Reardon, Annick Desjardins, Katherine L. Peters, and John P. Kirkpatrick. “USE OF BIOCHEMOTHERAPY AND STEREOTACTIC RADIOSURGERY IN THE MANAGEMENT OF RECURRENT MALIGNANT GLIOMA.” In Neuro Oncology, 12:107–107. OXFORD UNIV PRESS INC, 2010.
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  - Desjardins, Annick, David A. Reardon, Katherine B. Peters, James E. Herndon, John P. Kirkpatrick, Henry S. Friedman, and James J. Vredenburgh. “SURVIVAL AND TOXICITY UPDATE OF THE PHASE 2 TRIAL OF BEVACIZUMAB (BV) IN COMBINATION WITH TEMOZOLOMIDE (TMZ) AND RADIATION THERAPY (RT) FOLLOWED BY BV, TMZ, AND IRINOTECAN (CPT-11) FOR NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME (GBM) PATIENTS.” In Neuro Oncology, 12:77–77. OXFORD UNIV PRESS INC, 2010.
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  - Kirkpatrick, J. P., S. Yoo, K. Light, P. Antoine, R. Walker, R. Clough, M. Robbins, H. Cozart, J. Tabor, and C. Willett. “Implementing a Clinically Driven Electronic Medical Record for Radiation Oncology in a Major Medical Center.” In International Journal of Radiation Oncology*Biology*Physics, 78:S493–94. Elsevier BV, 2010. https://doi.org/10.1016/j.ijrobp.2010.07.1154.
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  - Oh, D. S., D. A. Reardon, L. R. Prosnitz, J. P. Gockerman, J. Sampson, and J. P. Kirkpatrick. “Low-dose Whole Brain Radiotherapy followed by Radiosurgery for Primary CNS Lymphoma Achieving Partial Response to Induction Chemotherapy.” In International Journal of Radiation Oncology*Biology*Physics, 78:S293–S293. Elsevier BV, 2010. https://doi.org/10.1016/j.ijrobp.2010.07.696.
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  - Adamson, J., J. Kirkpatrick, and F. Yin. “SU‐GG‐T‐483: Does Breath‐Hold Immobilization Affect Tumor Radioresistance in Breast?” In Medical Physics, 37:3298, 2010. https://doi.org/10.1118/1.3468881.
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  - Wang, Z., J. Kirkpatrick, Z. Chang, J. Cai, T. Zhuang, and F. Yin. “SU‐GG‐T‐530: Comparison of Coplanar and Non‐Coplanar Intensity Modulated Arc Techniques for Treatment of Intracranial Multi‐Focal Stereotactic Radiosurgery.” In Medical Physics, 37:3309, 2010. https://doi.org/10.1118/1.3468927.
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  - Brizel, D. M., D. S. Yoo, N. Ready, J. P. Kirkpatrick, M. W. Dewhirst, R. L. Scher, E. Cleland, J. MacFall, D. Barboriak, and O. Craciunescu. “Synchronous Chemoradiation and Multiple Targeted Drugs for Advanced Head and Neck Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 75:S175–76. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.409.
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  - Cuneo, K. C., J. J. Vredenburgh, J. H. Sampson, D. A. Reardon, A. Desjardins, C. G. Willett, and J. P. Kirkpatrick. “Bevacizumab in Patients Treated with Stereotactic Radiosurgery for Recurrent Malignant Gliomas is Associated with Improved Overall Survival.” In International Journal of Radiation Oncology*Biology*Physics, 75:S249–50. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.576.
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  - Kirkpatrick, J. P., A. Desjardins, D. A. Reardon, A. H. Friedman, H. S. Friedman, and J. J. Vredenburgh. “Radiotherapy, Temozolomide and Bevacizumab followed by Irinotecan, Temozolomide and Bevacizumab Appears Well-tolerated and Efficacious in Newly Diagnosed Glioblastoma Multiforme: Results from a Phase II Trial.” In International Journal of Radiation Oncology*Biology*Physics, 75:S102–3. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.250.
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  - Wang, Z., J. P. Kirkpatrick, Q. J. Wu, Z. Chang, C. G. Willett, and F. Yin. “Imaging Guided Stereotactic Radiosurgery and its Accuracy Compared to Frame-based Localization.” In International Journal of Radiation Oncology*Biology*Physics, 75:S690–S690. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.1573.
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  - Kirkpatrick, J. P., J. J. Vredenburgh, A. Desjardins, S. Gururangan, K. B. Peters, S. T. Boulton, A. H. Friedman, H. S. Friedman, and D. A. Reardon. “Phase I study of vandetanib, imatinib mesylate, and hydroxyurea for recurrent malignant glioma.” In Journal of Clinical Oncology, Vol. 27. AMER SOC CLINICAL ONCOLOGY, 2009.
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  - Brooks, A., F. Yin, J. Kirkpatrick, and Z. Wang. “SU‐FF‐T‐673: Application of RapidArc Technique to Cervical Spine Stereotactic Treatment.” In Medical Physics, 36:2680, 2009. https://doi.org/10.1118/1.3182171.
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  - Chang, Z., Z. Wang, Q. Wu, J. Kirkpatrick, and F. Yin. “SU‐EE‐A3‐02: Imaging Guided Frameless Stereotactic RadioSurgery Using CBCT 6D Image Registration and 6D Couch On Novalis Tx™ System.” In Medical Physics, 36:2430–31, 2009. https://doi.org/10.1118/1.3181106.
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  - Wang, Z., J. Kirkpatrick, Q. Wu, Z. Chang, C. Willett, and F. Yin. “SU‐FF‐T‐548: Comparison of Cone‐Beam CT and Frame‐Based Localizations for Stereotactic Radiosurgery with Fixed Head Rings and Removable Frames.” In Medical Physics, 36:2650, 2009. https://doi.org/10.1118/1.3182046.
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  - Wang, Z., J. Kirkpatrick, Z. Chang, J. O’daniel, C. Willett, and F. Yin. “SU‐FF‐T‐545: Feasibility Study for Treatment of Intracranial Multi‐Focal Stereotactic Radiosurgery with Multiple Intensity Modulated Arc Technique.” In Medical Physics, 36:2649, 2009. https://doi.org/10.1118/1.3182043.
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  - Wu, Q., S. Yoo, J. Kirkpatrick, R. Mcmahon, D. Thongphiew, and F. Yin. “SU‐FF‐T‐567: Volumetric Modulated Arc Therapy for Spine Body Radiotherapy: Comparison with Static Intensity Modulated Treatment.” In Medical Physics, 36:2655, 2009. https://doi.org/10.1118/1.3182065.
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  - Boyd, J. A., D. W. Kim, J. J. Meyer, Z. Wang, G. W. Britz, J. Wu, F. Yin, and J. P. Kirkpatrick. “High-definition Micro-multileaf Collimator in Radiosurgery Treatment Planning for Arteriovenous Malformations.” In International Journal of Radiation Oncology*Biology*Physics, 72:S531–32. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.064.
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  - Kirkpatrick, J. P., A. Desjardins, D. A. Reardon, and J. J. Vredenburgh. “Radiotherapy, Temozolomide, and Bevacizumab Followed by Irinotecan, Temozolomide and Bevacizumab in Newly Diagnosed Glioblastoma Multiforme: Preliminary Results from an Ongoing Phase II Trial.” In International Journal of Radiation Oncology*Biology*Physics, 72:S209–S209. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.1537.
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  - Nelson, J. W., D. S. Yoo, J. H. Sampson, R. E. Isaacs, N. A. Larrier, L. B. Marks, F. F. Yin, Q. J. Wu, Z. Wang, and J. P. Kirkpatrick. “Stereotactic Body Radiosurgery of the Spine: The Duke Experience.” In International Journal of Radiation Oncology*Biology*Physics, 72:S489–90. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.1438.
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  - Wang, Z., J. P. Kirkpatrick, Q. J. Wu, Z. Chang, C. G. Willett, and F. Yin. “Can Cone Beam CT Replace Frame-based Localization for Stereotactic Radiosurgery?” In International Journal of Radiation Oncology*Biology*Physics, 72:S534–S534. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.070.
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  - Wu, Q. J., Z. Wang, J. P. Kirkpatrick, Z. Chang, S. Zhou, C. G. Willett, and F. Yin. “Dosimetrical Evaluation of SRS/SBRT Techniques.” In International Journal of Radiation Oncology*Biology*Physics, 72:S650–51. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.328.
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  - Yoo, D. S., O. Craciunescu, E. Cleland, D. Barboriak, N. Muradyan, M. Dolguikh, J. P. Kirkpatrick, M. D. Carroll, and D. M. Brizel. “Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) to Assess Changes in Tumor Physiology Caused by Molecular Targeted Agents in Locally Advanced Head and Neck Cancer (LAHNC).” In International Journal of Radiation Oncology*Biology*Physics, 72:S160–S160. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.504.
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  - Hosfeld, V., J. Kirkpatrick, and M. Oldham. “SU‐GG‐T‐438: Rind Radiosurgery: Investigation of a Novel Radiation Therapy Technique for the Treatment of Intracranial Lesions.” In Medical Physics, 35:2825, 2008. https://doi.org/10.1118/1.2962186.
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  - Wang, Z., Q. wu, Z. Chang, J. Kirkpatrick, and F. Yin. “SU‐GG‐T‐454: Localization Accuracy of Cone‐Beam CT Guided Radiosurgery as Investigated Utilizing a Geometric Phantom.” In Medical Physics, 35:2829, 2008. https://doi.org/10.1118/1.2962202.
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  - Kelsey, C. R., S. Mukundan, Z. Wang, M. Fabregas, K. Kelley, and J. P. Kirkpatrick. “Assessing Neurotoxicity From Radiosurgery: Results From a Prospective Study Using Magnetic Resonance Spectroscopy.” In International Journal of Radiation Oncology*Biology*Physics, 69:S245–S245. Elsevier BV, 2007. https://doi.org/10.1016/j.ijrobp.2007.07.1244.
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  - Kirkpatrick, J. P., and Z. Wang. “Increasing the Number of Orthogonal Beam Pairs Does Not Improve the Biologic Effect in Normal Tissue in a Phantom Model.” In International Journal of Radiation Oncology*Biology*Physics, 69:S601–2. Elsevier BV, 2007. https://doi.org/10.1016/j.ijrobp.2007.07.1907.
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  - Wang, Z., Q. Wu, J. P. Kirkpatrick, C. G. Willett, and F. Yin. “Localization for MRI-Based Radiation Treatment of Intracranial Lesions by Using Three-Dimensional MRI and Cone-Beam CT Matching.” In International Journal of Radiation Oncology*Biology*Physics, 69:S189–S189. Elsevier BV, 2007. https://doi.org/10.1016/j.ijrobp.2007.07.341.
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  - Wang, Z., J. Nelson, S. Yoo, Q. J. wu, J. Kirkpatrick, N. Larrier, J. Meyer, C. Willett, and F. Yin. “SU‐FF‐T‐252: Improvement of Localization Accuracy by Using 3D Cone Beam CT for Stereotactic Body Radiation Therapy of Liver, Lung and Spine Lesions.” In Medical Physics, 34:2459, 2007. https://doi.org/10.1118/1.2760913.
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  - Kirkpatrick, J. P., F. R. Irani, S. E. Johnston, A. M. Stalnecker, T. M. Cooney, D. L. Georgas, and M. Oldham. “2875.” In International Journal of Radiation Oncology*Biology*Physics, 66:S704–5. Elsevier BV, 2006. https://doi.org/10.1016/j.ijrobp.2006.07.1294.
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  - Rabbani, Z. N., J. P. Kirkpatrick, F. K. Salahuddin, R. C. Bentley, A. A. Secord, C. S. Greenberg, L. J. Havrilesky, Z. Vujaskovic, E. Jones, and M. W. Dewhirst. “Tissue transglutaminase expression in early-stage cervical cancer.” In International Journal of Radiation Oncology Biology Physics, 66:S167–S167, 2006. https://doi.org/10.1016/j.ijrobp.2006.07.331.
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  - Yin, F., L. Marks, Z. Wang, J. Kirkpatrick, J. Wu, S. Yoo, N. Larrier, J. Meyer, and C. Willett. “SU‐FF‐T‐66: A Technique for Cone‐Beam CT‐Guided Stereotactic Body Radiation Therapy.” In Medical Physics, 33:2063, 2006. https://doi.org/10.1118/1.2240992.
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  - Kirkpatrick, J. P., Z. Rabbani, R. Bentley, M. Hardee, S. Karol, J. Meyer, E. Oosterwijk, et al. “Elevated CAIX Expression Is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 63:S211–12. Elsevier BV, 2005. https://doi.org/10.1016/j.ijrobp.2005.07.364.
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  - Zhou, S., C. Hahn, T. Shafman, J. Kirkpatrick, A. Tisch, L. Marks, T. Hawk, T. Turkington, T. Wong, and R. Coleman. “SU‐FF‐T‐366: Radiation Dose Response Curve of Human Cerebral Cortex Measured with [F‐18]‐FDG and [O‐15]‐H2O PET Imaging.” In Medical Physics, 32:2035, 2005. https://doi.org/10.1118/1.1998095.
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  - KIRKPATRICK, J., B. CALINGAERT, R. CLOUGH, J. OLESON, B. QUARANTA, C. HAHN, G. MONTANA, S. INGRAM, and M. ANSCHER. “Adjuvant and salvage radiotherapy following radical prostatectomy.” In International Journal of Radiation Oncologybiologyphysics, 60:S450–51. Elsevier BV, 2004. https://doi.org/10.1016/s0360-3016(04)01658-x.
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  - Hardee, M. E., J. P. Kirkpatrick, S. Snyder, S. Shan, Z. Vujaskovic, Z. N. Rabbani, M. W. Dewhirst, and K. L. Blackwell. “Erythropoietin (EPO) has no direct effect on tumor growth or angiogenesis in animal models.” In Journal of Clinical Oncology, 22:842S-842S. AMER SOC CLINICAL ONCOLOGY, 2004.
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  - Kirkpatrick, J. P., R. Clough, M. S. Anscher, and G. S. Montana. “Patterns of failure in prostate cancer after primary or post-prostatectomy salvage radiotherapy in the PSA era.” In Radiology, 225:166–166, 2002.
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  - Birer, Samuel R., Adam C. Olson, Justus Adamson, Rodney Hood, Matthew Susen, Grace Kim, Joseph K. Salama, and John P. Kirkpatrick. “Hippocampal dose from stereotactic radiosurgery for 4 to 10 brain metastases: Risk factors, feasibility of dose reduction via re-optimization, and patient outcomes.” In Med Dosim, 42:310–16, n.d. https://doi.org/10.1016/j.meddos.2017.06.007.
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