Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.

Published

Journal Article

T cell functional exhaustion during chronic hepatitis B virus (HBV) infection may contribute to the failed viral clearance; however, the underlying molecular mechanisms remain largely unknown. Here we demonstrate that jumonji domain-containing protein 6 (JMJD6) is a potential regulator of T cell proliferation during chronic HBV infection. The expression of JMJD6 was reduced in T lymphocytes in chronic hepatitis B (CHB) patients, and this reduction in JMJD6 expression was associated with impaired T cell proliferation. Moreover, silencing JMJD6 expression in primary human T cells impaired T cell proliferation. We found that JMJD6 promotes T cell proliferation by suppressing the mRNA expression of CDKN3. Furthermore, we have identified platelet derived growth factor-BB (PDGF-BB) as a regulator of JMJD6 expression. PDGF-BB downregulates JMJD6 expression and inhibits the proliferation of human primary T cells. Importantly, the expression levels of JMJD6 and PDGF-BB in lymphocytes from CHB patients were correlated with the degree of liver damage and the outcome of chronic HBV infection treatment. Our results demonstrate that PDGF-BB and JMJD6 regulate T cell function during chronic HBV infection and may provide insights for the treatment strategies for CHB patients.

Full Text

Duke Authors

Cited Authors

  • Chen, C-F; Feng, X; Liao, H-Y; Jin, W-J; Zhang, J; Wang, Y; Gong, L-L; Liu, J-J; Yuan, X-H; Zhao, B-B; Zhang, D; Chen, G-F; Wan, Y; Guo, J; Yan, H-P; He, Y-W

Published Date

  • September 15, 2014

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 6359 -

PubMed ID

  • 25219359

Pubmed Central ID

  • 25219359

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

International Standard Serial Number (ISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/srep06359

Language

  • eng