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Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.

Publication ,  Journal Article
Chen, C-F; Feng, X; Liao, H-Y; Jin, W-J; Zhang, J; Wang, Y; Gong, L-L; Liu, J-J; Yuan, X-H; Zhao, B-B; Zhang, D; Chen, G-F; Wan, Y; Guo, J ...
Published in: Sci Rep
September 15, 2014

T cell functional exhaustion during chronic hepatitis B virus (HBV) infection may contribute to the failed viral clearance; however, the underlying molecular mechanisms remain largely unknown. Here we demonstrate that jumonji domain-containing protein 6 (JMJD6) is a potential regulator of T cell proliferation during chronic HBV infection. The expression of JMJD6 was reduced in T lymphocytes in chronic hepatitis B (CHB) patients, and this reduction in JMJD6 expression was associated with impaired T cell proliferation. Moreover, silencing JMJD6 expression in primary human T cells impaired T cell proliferation. We found that JMJD6 promotes T cell proliferation by suppressing the mRNA expression of CDKN3. Furthermore, we have identified platelet derived growth factor-BB (PDGF-BB) as a regulator of JMJD6 expression. PDGF-BB downregulates JMJD6 expression and inhibits the proliferation of human primary T cells. Importantly, the expression levels of JMJD6 and PDGF-BB in lymphocytes from CHB patients were correlated with the degree of liver damage and the outcome of chronic HBV infection treatment. Our results demonstrate that PDGF-BB and JMJD6 regulate T cell function during chronic HBV infection and may provide insights for the treatment strategies for CHB patients.

Duke Scholars

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

September 15, 2014

Volume

4

Start / End Page

6359

Location

England

Related Subject Headings

  • Signal Transduction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Real-Time Polymerase Chain Reaction
  • RNA, Messenger
  • Proto-Oncogene Proteins c-sis
  • Lymphocyte Activation
  • Jumonji Domain-Containing Histone Demethylases
  • Humans
  • Hepatitis B, Chronic
  • Hepatitis B virus
 

Citation

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Chicago
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MLA
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Chen, C.-F., Feng, X., Liao, H.-Y., Jin, W.-J., Zhang, J., Wang, Y., … He, Y.-W. (2014). Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. Sci Rep, 4, 6359. https://doi.org/10.1038/srep06359
Chen, Cai-Feng, Xia Feng, Hui-Yu Liao, Wen-Jing Jin, Jian Zhang, Yu Wang, Lu-Lu Gong, et al. “Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.Sci Rep 4 (September 15, 2014): 6359. https://doi.org/10.1038/srep06359.
Chen C-F, Feng X, Liao H-Y, Jin W-J, Zhang J, Wang Y, et al. Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. Sci Rep. 2014 Sep 15;4:6359.
Chen, Cai-Feng, et al. “Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.Sci Rep, vol. 4, Sept. 2014, p. 6359. Pubmed, doi:10.1038/srep06359.
Chen C-F, Feng X, Liao H-Y, Jin W-J, Zhang J, Wang Y, Gong L-L, Liu J-J, Yuan X-H, Zhao B-B, Zhang D, Chen G-F, Wan Y, Guo J, Yan H-P, He Y-W. Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. Sci Rep. 2014 Sep 15;4:6359.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

September 15, 2014

Volume

4

Start / End Page

6359

Location

England

Related Subject Headings

  • Signal Transduction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Real-Time Polymerase Chain Reaction
  • RNA, Messenger
  • Proto-Oncogene Proteins c-sis
  • Lymphocyte Activation
  • Jumonji Domain-Containing Histone Demethylases
  • Humans
  • Hepatitis B, Chronic
  • Hepatitis B virus