Effects of culture filtrates of blastomyces dermatitidis on neutrophil locomotion


Journal Article

A potent chemotactic activity for neutrophils is detectable in liquid culture filtrates of Blastomyces dermatitidis. The production of this activity is medium-dependent and culture age-dependent. The highest levels of cytotaxin were produced in filtrates of B. dermatitidis grown in tissue culture medium 199 for three or more weeks. This factor(s) stimulates directed as well as random migration. It functions directly and independently of serum. It is stable at -20°C and 56°C, and has a molecular weight greater than 10 000 daltons. These properties define a new microbial chemotactic factor. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Full Text

Duke Authors

Cited Authors

  • Mitchell, TG; Turner, SR

Published Date

  • January 1, 1984

Published In

Volume / Issue

  • 22 / 2

Start / End Page

  • 145 - 153

International Standard Serial Number (ISSN)

  • 1369-3786

Digital Object Identifier (DOI)

  • 10.1080/00362178485380221

Citation Source

  • Scopus