Inhibitory effect of b-AP15 on the 20S proteasome.
Publication
, Journal Article
Huang, L; Jung, K; Chen, CH
Published in: Biomolecules
October 14, 2014
The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome with a potency equivalent to that found to inhibit the 19S regulatory particles.
Duke Scholars
Published In
Biomolecules
DOI
ISSN
2218-273X
Publication Date
October 14, 2014
Volume
4
Issue
4
Start / End Page
931 / 939
Location
Switzerland
Related Subject Headings
- Ubiquitin
- Proteasome Endopeptidase Complex
- Protease Inhibitors
- Piperidones
- Inhibitory Concentration 50
- Humans
- Hela Cells
- HeLa Cells
- Green Fluorescent Proteins
- 3206 Medical biotechnology
Citation
APA
Chicago
ICMJE
MLA
NLM
Huang, L., Jung, K., & Chen, C. H. (2014). Inhibitory effect of b-AP15 on the 20S proteasome. Biomolecules, 4(4), 931–939. https://doi.org/10.3390/biom4040931
Huang, Li, Katherine Jung, and Chin Ho Chen. “Inhibitory effect of b-AP15 on the 20S proteasome.” Biomolecules 4, no. 4 (October 14, 2014): 931–39. https://doi.org/10.3390/biom4040931.
Huang L, Jung K, Chen CH. Inhibitory effect of b-AP15 on the 20S proteasome. Biomolecules. 2014 Oct 14;4(4):931–9.
Huang, Li, et al. “Inhibitory effect of b-AP15 on the 20S proteasome.” Biomolecules, vol. 4, no. 4, Oct. 2014, pp. 931–39. Pubmed, doi:10.3390/biom4040931.
Huang L, Jung K, Chen CH. Inhibitory effect of b-AP15 on the 20S proteasome. Biomolecules. 2014 Oct 14;4(4):931–939.
Published In
Biomolecules
DOI
ISSN
2218-273X
Publication Date
October 14, 2014
Volume
4
Issue
4
Start / End Page
931 / 939
Location
Switzerland
Related Subject Headings
- Ubiquitin
- Proteasome Endopeptidase Complex
- Protease Inhibitors
- Piperidones
- Inhibitory Concentration 50
- Humans
- Hela Cells
- HeLa Cells
- Green Fluorescent Proteins
- 3206 Medical biotechnology