Inhibitory effect of b-AP15 on the 20S proteasome.

Journal Article (Journal Article)

The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome with a potency equivalent to that found to inhibit the 19S regulatory particles.

Full Text

Duke Authors

Cited Authors

  • Huang, L; Jung, K; Chen, CH

Published Date

  • October 14, 2014

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 931 - 939

PubMed ID

  • 25317846

Pubmed Central ID

  • PMC4279163

International Standard Serial Number (ISSN)

  • 2218-273X

Digital Object Identifier (DOI)

  • 10.3390/biom4040931


  • eng

Conference Location

  • Switzerland