Inhibitory effect of b-AP15 on the 20S proteasome.
Journal Article (Journal Article)
The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome with a potency equivalent to that found to inhibit the 19S regulatory particles.
Full Text
Duke Authors
Cited Authors
- Huang, L; Jung, K; Chen, CH
Published Date
- October 14, 2014
Published In
Volume / Issue
- 4 / 4
Start / End Page
- 931 - 939
PubMed ID
- 25317846
Pubmed Central ID
- PMC4279163
International Standard Serial Number (ISSN)
- 2218-273X
Digital Object Identifier (DOI)
- 10.3390/biom4040931
Language
- eng
Conference Location
- Switzerland