Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.
It is widely appreciated that effective human vaccines directed against viral pathogens elicit neutralizing antibodies (NAbs). The passive transfer of anti-HIV-1 NAbs conferring sterilizing immunity to macaques has been used to determine the plasma neutralization titers, which must be present at the time of exposure, to prevent acquisition of SIV/HIV chimeric virus (SHIV) infections. We administered five recently isolated potent and broadly acting anti-HIV neutralizing monoclonal antibodies (mAbs) to rhesus macaques and challenged them intrarectally 24 h later with either of two different R5-tropic SHIVs. By combining the results obtained from 60 challenged animals, we determined that the protective neutralization titer in plasma preventing virus infection in 50% of the exposed monkeys was relatively modest (∼1:100) and potentially achievable by vaccination.
Duke Scholars
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Related Subject Headings
- Vaccination
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Regression Analysis
- Neutralization Tests
- Mutagenesis
- Macaca mulatta
- Lentivirus Infections
- Immunology
- Humans
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Vaccination
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Regression Analysis
- Neutralization Tests
- Mutagenesis
- Macaca mulatta
- Lentivirus Infections
- Immunology
- Humans