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The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis.

Publication ,  Journal Article
Roy, A; Gong, J; Thomas, DC; Zhang, J; Kipen, HM; Rich, DQ; Zhu, T; Huang, W; Hu, M; Wang, G; Wang, Y; Zhu, P; Lu, S-E; Ohman-Strickland, P ...
Published in: PloS one
January 2014

Previous studies have investigated the associations between exposure to ambient air pollution and biomarkers of physiological pathways, yet little has been done on the comparison across biomarkers of different pathways to establish the temporal pattern of biological response. In the current study, we aim to compare the relative temporal patterns in responses of candidate pathways to different pollutants. Four biomarkers of pulmonary inflammation and oxidative stress, five biomarkers of systemic inflammation and oxidative stress, ten parameters of autonomic function, and three biomarkers of hemostasis were repeatedly measured in 125 young adults, along with daily concentrations of ambient CO, PM2.5, NO2, SO2, EC, OC, and sulfate, before, during, and after the Beijing Olympics. We used a two-stage modeling approach, including Stage I models to estimate the association between each biomarker and pollutant over each of 7 lags, and Stage II mixed-effect models to describe temporal patterns in the associations when grouping the biomarkers into the four physiological pathways. Our results show that candidate pathway groupings of biomarkers explained a significant amount of variation in the associations for each pollutant, and the temporal patterns of the biomarker-pollutant-lag associations varied across candidate pathways (p<0.0001) and were not linear (from lag 0 to lag 3: p = 0.0629, from lag 3 to lag 6: p = 0.0005). These findings suggest that, among this healthy young adult population, the pulmonary inflammation and oxidative stress pathway is the first to respond to ambient air pollution exposure (within 24 hours) and the hemostasis pathway responds gradually over a 2-3 day period. The initial pulmonary response may contribute to the more gradual systemic changes that likely ultimately involve the cardiovascular system.

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Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

January 2014

Volume

9

Issue

12

Start / End Page

e114913

Related Subject Headings

  • Young Adult
  • Time Factors
  • Pneumonia
  • Oxidative Stress
  • Models, Biological
  • Inflammation
  • Humans
  • Hemostasis
  • General Science & Technology
  • China
 

Citation

APA
Chicago
ICMJE
MLA
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Roy, A., Gong, J., Thomas, D. C., Zhang, J., Kipen, H. M., Rich, D. Q., … Eckel, S. P. (2014). The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis. PloS One, 9(12), e114913. https://doi.org/10.1371/journal.pone.0114913
Roy, Ananya, Jicheng Gong, Duncan C. Thomas, Junfeng Zhang, Howard M. Kipen, David Q. Rich, Tong Zhu, et al. “The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis.PloS One 9, no. 12 (January 2014): e114913. https://doi.org/10.1371/journal.pone.0114913.
Roy A, Gong J, Thomas DC, Zhang J, Kipen HM, Rich DQ, et al. The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis. PloS one. 2014 Jan;9(12):e114913.
Roy, Ananya, et al. “The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis.PloS One, vol. 9, no. 12, Jan. 2014, p. e114913. Epmc, doi:10.1371/journal.pone.0114913.
Roy A, Gong J, Thomas DC, Zhang J, Kipen HM, Rich DQ, Zhu T, Huang W, Hu M, Wang G, Wang Y, Zhu P, Lu S-E, Ohman-Strickland P, Diehl SR, Eckel SP. The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis. PloS one. 2014 Jan;9(12):e114913.

Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

January 2014

Volume

9

Issue

12

Start / End Page

e114913

Related Subject Headings

  • Young Adult
  • Time Factors
  • Pneumonia
  • Oxidative Stress
  • Models, Biological
  • Inflammation
  • Humans
  • Hemostasis
  • General Science & Technology
  • China