Mechanism of 1,3-hydrogen migration in a gold bicyclo[3.2.0]heptene complex: The role of brønsted acid in the gold-catalyzed cycloisomerization of 7-aryl-1,6-enynes
Journal Article (Journal Article)
The gold 7-phenylbicyclo[3.2.0]hept-1(7)-ene complex 1 is generated as an intermediate in the gold-catalyzed cycloisomerization of 7-phenyl 1,6-enyne 2 to 7-phenylbicyclo[3.2.0]hept-1(7)-ene 3. We have investigated the kinetics of the isomerization of 1 via formal 1,3-hydrogen migration to form the corresponding gold 6-phenylbicyclo[3.2.0]hept-6-ene complex 4 to obtain direct experimental information regarding the mechanism by which 1 evolves into products. These experiments were in accord with conversion of 1 to 4 through a hidden Brønsted acid catalyzed pathway that occurred outside the coordination sphere of gold. Similarly, in situ spectroscopic analysis of the catalytic cycloisomerization of enyne 2 was consistent with a mechanism involving sequential gold-catalyzed cycloaddition followed by Brønsted acid catalyzed 1,3-hydrogen migration outside the coordination sphere of gold.
Full Text
Duke Authors
Cited Authors
- Brooner, REM; Robertson, BD; Widenhoefer, RA
Published Date
- November 24, 2014
Published In
Volume / Issue
- 33 / 22
Start / End Page
- 6466 - 6473
Electronic International Standard Serial Number (EISSN)
- 1520-6041
International Standard Serial Number (ISSN)
- 0276-7333
Digital Object Identifier (DOI)
- 10.1021/om500815k
Citation Source
- Scopus