Platelets deliver costimulatory signals to antigen-presenting cells: A potential bridge between injury and immune activation

Journal Article

The danger model of immunity and tolerance holds that antigen-presenting cells (APCs), activated by stress, injury, or necrosis, but not by physiological (apoptotic) cell death, initiate adaptive immune responses. APC activation is fundamentally associated with binding of CD40 to its ligand CD154. Platelets express CD154 upon activation and are thus potential primal danger signals linking the homeostatic response to trauma to activation of the acquired immune system. Previously, we showed that platelets can undergo gradient-driven migration, or chemotaxis, toward supernatants from cells injured by repeated freeze/thaws, UV light, or ischemia/reperfusion. Herein, we demonstrate that platelet-derived CD154 induces immature dendritic cell maturation with upregulation of costimulatory molecules and IL-12p40 production. Overall, these results provide a mechanism for platelet activation of APC facilitating the induction of adaptive immunity in environments of cell injury. © 2004 International Society for Experimental Hematology. Published by Elsevier Inc.

Full Text

Duke Authors

Cited Authors

  • Czapiga, M; Kirk, AD; Lekstrom-Himes, J

Published Date

  • 2004

Published In

  • Experimental Hematology

Volume / Issue

  • 32 / 2

Start / End Page

  • 135 - 139

PubMed ID

  • 15102473

Pubmed Central ID

  • 15102473

Digital Object Identifier (DOI)

  • 10.1016/j.exphem.2003.11.004