Human renal allograft rejection despite the absence of allogeneic passenger leukocytes.

Journal Article (Journal Article)

Passenger leukocytes have been suggested to be both pro-tolerant and immunogenic. The opportunity to evaluate the role of allogeneic passenger leukocytes in humans was presented by a 47-year-old man who donated bone marrow to his HLA-identical leukemic sister. Eleven years later he developed renal failure. The sister's marrow was noted to be 100% XY karyotype and free of malignancy. She donated a kidney to her brother. Immunosuppression was tapered following transplantation. After 6 months, the recipient was on monotherapy sirolimus, 1 mg every third day. A surveillance biopsy was normal and sirolimus was stopped. Eight weeks later, he presented with severe rejection that reversed with Thymoglobulin. Renal function returned to baseline and has been stable on conventional immunosuppression.

Full Text

Duke Authors

Cited Authors

  • Preston, EH; Light, JA; Kampen, RL; Kirk, AD

Published Date

  • February 2004

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 283 - 285

PubMed ID

  • 14974953

International Standard Serial Number (ISSN)

  • 1600-6135

Digital Object Identifier (DOI)

  • 10.1046/j.1600-6143.2003.00320.x


  • eng

Conference Location

  • United States