NIH Consensus development project on criteria for clinical trials in chronic graft-versus-host disease: II. The 2014 Pathology Working Group Report.

Journal Article (Journal Article)

The 2005 National Institute of Health (NIH) Consensus Conference outlined histopathological diagnostic criteria for the major organ systems affected by both acute and chronic graft-versus-host disease (GVHD). The 2014 Consensus Conference led to this updated document with new information from histopathological studies of GVHD in the gut, liver, skin, and oral mucosa and an expanded discussion of GVHD in the lungs and kidneys. The recommendations for final histological diagnostic categories have been simplified from 4 categories to 3: no GVHD, possible GVHD, and likely GVHD, based on better reproducibility achieved by combining the previous categories of "consistent with GVHD" and "definite GVHD" into the single category of "likely GVHD." Issues remain in the histopathological characterization of GVHD, particularly with respect to the threshold of histological changes required for diagnostic certainty. Guidance is provided for the incorporation of biopsy information into prospective clinical studies of GVHD, particularly with respect to biomarker validation.

Full Text

Duke Authors

Cited Authors

  • Shulman, HM; Cardona, DM; Greenson, JK; Hingorani, S; Horn, T; Huber, E; Kreft, A; Longerich, T; Morton, T; Myerson, D; Prieto, VG; Rosenberg, A; Treister, N; Washington, K; Ziemer, M; Pavletic, SZ; Lee, SJ; Flowers, MED; Schultz, KR; Jagasia, M; Martin, PJ; Vogelsang, GB; Kleiner, DE

Published Date

  • April 2015

Published In

Volume / Issue

  • 21 / 4

Start / End Page

  • 589 - 603

PubMed ID

  • 25639770

Pubmed Central ID

  • PMC4359636

Electronic International Standard Serial Number (EISSN)

  • 1523-6536

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2014.12.031


  • eng

Conference Location

  • United States