Diana Marcella Cardona | Scholars@Duke

Diana Marcella Cardona
Associate Professor of Pathology

I am active in translational research involving gastrointestinal/hepatobiliary pathology [specifically transplant related pathology (GVHD and rejection) and carcinogenesis of the pancreas] and bone and soft tissue malignancies [imaging techniques for intraoperative margin assessment].

Office Hours

M-F 9am-5pm

Current Appointments & Affiliations

Associate Professor of Pathology, Pathology, Clinical Science Departments 2015

Contact Information

Duke Box 3712, Durham, NC 27710
Rm 327A Davison Bldg, Durham, NC 27710
diana.cardona@duke.edu (919) 613-5208

Background
Education, Training, & Certifications
- Fellow, Gastrointestinal and Liver Pathology, Pathology, University of Florida 2008 - 2009
- Resident, Pathology, University of Florida 2004 - 2008
- M.D., University of Miami 2004
Duke Appointment History
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2009 - 2015
- Instructor, Temporary of Pathology, Pathology, Clinical Science Departments 2009
Research
Selected Grants
- Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD awarded by National Institutes of Health 2015 - 2020
- Reducing dietary copper for the treatment of BRaf mutation-positive melanoma awarded by National Institutes of Health 2013 - 2015
- Intraoperative detection and ablation of microscopic residual cancer in the tumor bed awarded by Lumicell Diagnostics 2013 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Song, EJ, Ashcraft, KA, Lowery, CD, Mowery, YM, Luo, L, Ma, Y, Campos, LDS, Cardona, DM, Stancato, L, and Kirsch, DG. "Investigating a chimeric anti-mouse PDGFRα antibody as a radiosensitizer in primary mouse sarcomas." Ebiomedicine 40 (February 2019): 224-230. Full Text
  - Poe, JC, Jia, W, Di Paolo, JA, Reyes, NJ, Kim, JY, Su, H, Sundy, JS, Cardones, AR, Perez, VL, Chen, BJ, Chao, NJ, Cardona, DM, Saban, DR, and Sarantopoulos, S. "SYK inhibitor entospletinib prevents ocular and skin GVHD in mice." Jci Insight 3, no. 19 (October 4, 2018). Full Text
  - Carney, JM, Wang, L, Bentley, R, Cardona, DM, and Zhang, X. "Metastatic squamous cell carcinoma with pseudoangiosarcomatous features and aberrant expression of vascular markers." Pathology, Research and Practice 214, no. 10 (October 2018): 1732-1737. Full Text
  - Cardona, DM, Detweiler, CJ, Shealy, MJ, Sung, AD, Wild, DM, Poleski, MH, Balmadrid, BL, Cirrincione, CT, Howell, DN, and Sullivan, KM. "Use of the National Institutes of Health Consensus Guidelines Improves the Diagnostic Sensitivity of Gastrointestinal Graft-Versus-Host Disease." Archives of Pathology & Laboratory Medicine 142, no. 9 (September 2018): 1098-1105. Full Text
  - Detweiler, CJ, Mueller, SB, Sung, AD, Saullo, JL, Prasad, VK, and Cardona, DM. "Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD." Journal of Pediatric Hematology/Oncology 40, no. 6 (August 2018): e364-e368. Full Text
  - Detweiler, CJ, Mueller, SB, Sung, AD, Saullo, JL, Prasad, VK, and Cardona, DM. "Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD." Journal of Pediatric Hematology Oncology 40, no. 6 (August 1, 2018): E364-E368. (Academic Article) Full Text Link to Item
  - Peacock, JD, Pridgeon, MG, Tovar, EA, Essenburg, CJ, Bowman, M, Madaj, Z, Koeman, J, Boguslawski, EA, Grit, J, Dodd, RD, Khachaturov, V, Cardona, DM, Chen, M, Kirsch, DG, Maina, F, Dono, R, Winn, ME, Graveel, CR, and Steensma, MR. "Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors." Cancer Research 78, no. 13 (July 2018): 3672-3687. Full Text
  - Sung, AD, Hassan, S, Cardona, DM, Wild, D, Nichols, KR, Mehdikhani, H, Balmadrid, B, Detweiler, CJ, Shealy, M, Cirrincione, C, Li, Z, Poleski, M, Dalton, TE, Siamakpour-Reihani, S, Chao, NJ, and Sullivan, KM. "Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 4 (April 2018): 734-740. Full Text
  - J. Lee, H, McCracken, E, Cardona, DM, and G. Blazer, D. "Clear cell sarcoma-like tumor of the gastrointestinal tract presenting as a symptomatic metastasis to the humerus." Human Pathology: Case Reports 11 (March 1, 2018): 73-75. Full Text
  - Hemmerich, A, Shaar, M, Burbridge, R, Guy, CD, McCall, SJ, Cardona, DM, Zhang, X, Lai, J, and Zhang, X. "Metastatic Renal Cell Carcinoma as Solitary Subcentimeter Polypoid Gastric Mucosal Lesions: Clinicopathologic Analysis of Five Cases." Gastroenterology research 11, no. 1 (February 23, 2018): 25-30. Full Text Open Access Copy
  - Harrison, G, Hemmerich, A, Guy, C, Perkinson, K, Fleming, D, McCall, S, Cardona, D, and Zhang, X. "Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas." American Journal of Clinical Pathology 149, no. 1 (December 2017): 67-75. Full Text
  - von Furstenberg, RJ, Li, J, Stolarchuk, C, Feder, R, Campbell, A, Kruger, L, Gonzalez, LM, Blikslager, AT, Cardona, DM, McCall, SJ, Henning, SJ, and Garman, KS. "Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation." Cellular and Molecular Gastroenterology and Hepatology 4, no. 3 (November 2017): 385-404. Full Text
  - O'Connor, SM, Wobker, SE, Cardona, DM, Eward, W, Esther, RJ, and Dodd, LG. "Iatrogenic lesions of soft tissue and bone." Seminars in diagnostic pathology (September 28, 2017). (Review) Full Text
  - Dodd, RD, Lee, C-L, Overton, T, Huang, W, Eward, WC, Luo, L, Ma, Y, Ingram, DR, Torres, KE, Cardona, DM, Lazar, AJ, and Kirsch, DG. "NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response." Cancer Research 77, no. 16 (August 2017): 4486-4497. Full Text
  - Huang, J, Chen, M, Whitley, MJ, Kuo, H-C, Xu, ES, Walens, A, Mowery, YM, Van Mater, D, Eward, WC, Cardona, DM, Luo, L, Ma, Y, Lopez, OM, Nelson, CE, Robinson-Hamm, JN, Reddy, A, Dave, SS, Gersbach, CA, Dodd, RD, and Kirsch, DG. "Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma." Nature Communications 8 (July 10, 2017): 15999-null. Full Text
  - Myles, JL, Cardona, DM, Klemp, T, Wooding, A, and Black-Schaffer, WS. "Current Valuation of Pathology Service." Advances in anatomic pathology 24, no. 4 (July 2017): 222-225. Full Text
  - Cardona, DM, Black-Schaffer, S, Shamanski, F, and Myles, JL. "Medicare's New Quality Payment Program Has Started-Are You Ready?." Archives of pathology & laboratory medicine 141, no. 6 (June 2017): 741-745. Full Text
  - Tan, QK-G, Cardona, DM, Rehder, CW, and McDonald, MT. "Identification of EPCAM mutation: clinical use of microarray." Clinical Case Reports 5, no. 6 (June 2017): 980-985. Full Text
  - Cogswell, J, Inzunza, HD, Wu, Q, Feder, JN, Mintier, G, Novotny, J, and Cardona, DM. "An Analytical Comparison of Dako 28-8 PharmDx Assay and an E1L3N Laboratory-Developed Test in the Immunohistochemical Detection of Programmed Death-Ligand 1." Molecular Diagnosis & Therapy 21, no. 1 (February 2017): 85-93. Full Text
  - Lazarides, AL, Scott, EJ, Cardona, DM, Blazer, DG, Brigman, BE, and Eward, WC. "Simultaneous Primary Presacral Myelolipomas: Case Report and Review of the Literature." Journal of gastrointestinal cancer 47, no. 3 (September 2016): 331-335. (Review) Full Text
  - Nussbaum, DP, Rushing, CN, Lane, WO, Cardona, DM, Kirsch, DG, Peterson, BL, and Blazer, DG. "Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database." The Lancet. Oncology 17, no. 7 (July 2016): 966-975. Full Text
  - Ludmir, EB, McCall, SJ, Cardona, DM, Perkinson, KR, Guy, CD, and Zhang, X. "Mixed Adenoneuroendocrine Carcinoma, Amphicrine Type, of the Small Bowel." American Journal of Clinical Pathology 145, no. 5 (May 2016): 703-709. Full Text
  - Sachdeva, M, Mito, JK, Lee, C-L, Zhang, M, Li, Z, Dodd, RD, Cason, D, Luo, L, Ma, Y, Van Mater, D, Gladdy, R, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes." Journal of Clinical Investigation 126, no. 4 (April 1, 2016): 1606-1606. Full Text
  - Wild, D, Sung, AD, Cardona, D, Cirricione, C, Sullivan, K, Detweiler, C, Shealy, M, Balmadrid, B, Rowes, KL, Chao, N, Piryani, S, Karimabad, HM, Martin, P, and Poleski, M. "The Diagnostic Yield of Site and Symptom-Based Biopsies for Acute Gastrointestinal Graft-Versus-Host Disease: A 5-Year Retrospective Review." Digestive Diseases and Sciences 61, no. 3 (March 2016): 806-813. Full Text
  - Detweiler, CJ, Cardona, DM, Hsu, DS, and McCall, SJ. "Primary high-grade neuroendocrine carcinoma emerging from an adenomatous polyp in the setting of familial adenomatous polyposis." BMJ case reports 2016 (February 16, 2016). Full Text
  - Lazarides, AL, Whitley, MJ, Strasfeld, DB, Cardona, DM, Ferrer, JM, Mueller, JL, Fu, HL, Bartholf DeWitt, S, Brigman, BE, Ramanujam, N, Kirsch, DG, and Eward, WC. "A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma." Theranostics 6, no. 2 (January 2016): 155-166. Full Text Open Access Copy
  - Whitley, MJ, Cardona, DM, Lazarides, AL, Spasojevic, I, Ferrer, JM, Cahill, J, Lee, C-L, Snuderl, M, Blazer, DG, Hwang, ES, Greenup, RA, Mosca, PJ, Mito, JK, Cuneo, KC, Larrier, NA, O'Reilly, EK, Riedel, RF, Eward, WC, Strasfeld, DB, Fukumura, D, Jain, RK, Lee, WD, Griffith, LG, Bawendi, MG, Kirsch, DG, and Brigman, BE. "A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer." Science Translational Medicine 8, no. 320 (January 2016): 320ra4-null. Full Text
  - Zhang, X, Burbridge, R, Branch, M, Xiao, S, Zhao, L, McCall, SJ, Guy, C, Cardona, D, Garman, K, Waxman, I, and Hart, J. "Delayed specimen collection may artifactually damage the mucosal surface in endoscopic mucosal resection specimens from Barrett's esophagus." American Journal of Digestive Disease 2, no. 2 (December 30, 2016): 90-94. Link to Item
  - Sachdeva, M, Dodd, RD, Huang, Z, Grenier, C, Ma, Y, Lev, DC, Cardona, DM, Murphy, SK, and Kirsch, DG. "Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182." Cancer letters 369, no. 1 (December 2015): 202-211. Full Text
  - Mueller, JL, Fu, HL, Mito, JK, Whitley, MJ, Chitalia, R, Erkanli, A, Dodd, L, Cardona, DM, Geradts, J, Willett, RM, Kirsch, DG, and Ramanujam, N. "A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins." International journal of cancer 137, no. 10 (November 2015): 2403-2412. Full Text
  - Lo, DD, Firempong, AO, Cardona, DM, Gulack, BC, and Adibe, OO. "Laparoscopic excision of an extra-biliary gallbladder duplication cyst in a 9-month-old infant." African journal of paediatric surgery : AJPS 12, no. 4 (October 2015): 291-293. Full Text
  - Kreft, A, Mottok, A, Mesteri, I, Cardona, DM, Janin, A, Kühl, AA, Andrulis, M, Brunner, A, Shulman, HM, Negri, G, Tzankov, A, Huber, E, and Gastrointestinal Pathology Group of the German-Austrian-Swiss GvHD Consortium, . "Consensus diagnostic histopathological criteria for acute gastrointestinal graft versus host disease improve interobserver reproducibility." Virchows Archiv : an international journal of pathology 467, no. 3 (September 2015): 255-263. Full Text
  - Sachdeva, M, Whitley, MJ, Mito, JK, Ma, Y, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma." Disease Models & Mechanisms 8, no. 9 (September 1, 2015): 1169-1169. Full Text
  - Lazarides, AL, Eward, WC, Green, K, Cardona, DM, Brigman, BE, and Taylor, DC. "Histological Evaluation of Tendon-Bone Healing of an Anterior Cruciate Ligament Hamstring Graft in a 14-Year-Old Boy." The American Journal of Sports Medicine 43, no. 8 (August 2015): 1935-1940. Full Text
  - Sachdeva, M, Whitley, MJ, Mito, JK, Ma, Y, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma." Disease models & mechanisms 8, no. 8 (August 2015): 867-875. Full Text
  - Vikingstad, EM, de Ridder, GG, Glisson, RR, Cardona, DM, DiPalma, D, Eward, WC, Brigman, BE, Nelson, RC, and Kim, CY. "Comparison of Acute Histologic and Biomechanical Effects of Radiofrequency Ablation and Cryoablation on Periarticular Structures in a Swine Model." Journal of vascular and interventional radiology : JVIR 26, no. 8 (August 2015): 1221-1228.e1. Full Text
  - Zhang, M, Qiu, Q, Li, Z, Sachdeva, M, Min, H, Cardona, DM, DeLaney, TF, Han, T, Ma, Y, Luo, L, Ilkayeva, OR, Lui, K, Nichols, AG, Newgard, CB, Kastan, MB, Rathmell, JC, Dewhirst, MW, and Kirsch, DG. "HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism." Radiation Research 183, no. 6 (June 2015): 594-609. Full Text
  - Shulman, HM, Cardona, DM, Greenson, JK, Hingorani, S, Horn, T, Huber, E, Kreft, A, Longerich, T, Morton, T, Myerson, D, Prieto, VG, Rosenberg, A, Treister, N, Washington, K, Ziemer, M, Pavletic, SZ, Lee, SJ, Flowers, MED, Schultz, KR, Jagasia, M, Martin, PJ, Vogelsang, GB, and Kleiner, DE. "NIH Consensus development project on criteria for clinical trials in chronic graft-versus-host disease: II. The 2014 Pathology Working Group Report." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 21, no. 4 (April 2015): 589-603. Full Text
  - Moding, EJ, Castle, KD, Perez, BA, Oh, P, Min, HD, Norris, H, Ma, Y, Cardona, DM, Lee, C-L, and Kirsch, DG. "Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy." Science Translational Medicine 7, no. 278 (March 2015): 278ra34-null. Full Text
  - Van Mater, D, Añó, L, Blum, JM, Webster, MT, Huang, W, Williams, N, Ma, Y, Cardona, DM, Fan, C-M, and Kirsch, DG. "Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway." Cancer Research 75, no. 3 (February 2015): 605-614. Full Text
  - Jiang, X, Anderson, HB, Guy, CD, Mosca, PJ, Riedel, RF, and Cardona, DM. "Rhabdomyosarcomatous Transformation of a Gastrointestinal Stromal Tumor following Treatment with Imatinib." Case reports in oncological medicine 2015 (January 28, 2015): 317493-. Full Text
  - Sachdeva, M, Dodd, RD, Huang, Z, Grenier, C, Ma, Y, Lev, DC, Cardona, DM, Murphy, SK, and Kirsch, DG. "Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182." Cancer Letters 369, no. 1 (2015): 202-211. Full Text
  - Weyandt, JD, Lampson, BL, Tang, S, Mastrodomenico, M, Cardona, DM, and Counter, CM. "Wild-Type Hras Suppresses the Earliest Stages of Tumorigenesis in a Genetically Engineered Mouse Model of Pancreatic Cancer." PloS one 10, no. 10 (January 2015): e0140253-. Full Text
  - Huang, L, Carney, J, Cardona, DM, and Counter, CM. "Decreased tumorigenesis in mice with a Kras point mutation at C118." Nature communications 5 (November 14, 2014): 5410-. Full Text
  - Sachdeva, M, Mito, JK, Lee, C-L, Zhang, M, Li, Z, Dodd, RD, Cason, D, Luo, L, Ma, Y, Van Mater, D, Gladdy, R, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes." The Journal of Clinical Investigation 124, no. 10 (October 2014): 4305-4319. Full Text
  - Shatila, W, Tsipis, N, Eisenberg, A, Cardona, DM, and Chudgar, SM. "Negative biopsies, deadly disease: metastatic angiosarcoma." The American journal of medicine 127, no. 8 (August 2014): e5-e6. (Letter) Full Text
  - West, KL, Cardona, DM, Su, Z, and Puri, PK. "Immunohistochemical markers in fibrohistiocytic lesions: factor XIIIa, CD34, S-100 and p75." Am J Dermatopathol 36, no. 5 (May 2014): 414-419. Full Text Link to Item
  - Nussbaum, DP, Bhattacharya, SD, Jiang, X, Cardona, DM, Strickler, JH, and Blazer, DG. "Gastroesophageal heterotopia and HER2/neu overexpression in an adenocarcinoma arising from a small bowel duplication." Archives of pathology & laboratory medicine 138, no. 3 (March 2014): 428-431. Full Text
  - West, KL, Cardona, DM, Su, Z, and Puri, PK. "Immunohistochemical markers in fibrohistiocytic lesions: Factor XIIIa, CD34, S-100 and p75." American Journal of Dermatopathology 36, no. 5 (January 1, 2014): 414-419. Full Text
  - Blum, JM, Añó, L, Li, Z, Van Mater, D, Bennett, BD, Sachdeva, M, Lagutina, I, Zhang, M, Mito, JK, Dodd, LG, Cardona, DM, Dodd, RD, Williams, N, Ma, Y, Lepper, C, Linardic, CM, Mukherjee, S, Grosveld, GC, Fan, C-M, and Kirsch, DG. "Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells." Cell Reports 5, no. 4 (November 14, 2013): 933-940. Full Text
  - Ledford, CK, Zelenski, NA, Cardona, DM, Brigman, BE, and Eward, WC. "The phosphaturic mesenchymal tumor: why is definitive diagnosis and curative surgery often delayed?." Clinical Orthopaedics and Related Research 471, no. 11 (November 2013): 3618-3625. Full Text
  - Reddi, DM, Cardona, DM, Burchette, JL, and Puri, PK. "Scleroderma and IgG4-related disease." Am J Dermatopathol 35, no. 4 (June 2013): 458-462. Full Text Link to Item
  - Corbin, KD, Abdelmalek, MF, Spencer, MD, da Costa, K-A, Galanko, JA, Sha, W, Suzuki, A, Guy, CD, Cardona, DM, Torquati, A, Diehl, AM, and Zeisel, SH. "Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 27, no. 4 (April 2013): 1674-1689. Full Text
  - Lunsford, KE, Baird, BJ, Sempowski, GD, Cardona, DM, Li, Z, Weinhold, KJ, Sudan, DL, and Brennan, TV. "Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury." Transplantation 95, no. 8 (April 2013): 1000-1007. Full Text
  - Rand, AJ, Cardona, DM, Proia, AD, and Lagoo, AS. "Clinically undiagnosed enteropathy associated T-cell lymphoma type II presenting with prolonged lower gastrointestinal tract symptoms: report of an autopsy case and review of diagnostic challenges and clinicopathological correlation." J Gastrointest Oncol 4, no. 1 (March 2013): 103-108. Full Text Link to Item
  - Gowdy, KM, Cardona, DM, Nugent, JL, Giamberardino, C, Thomas, JM, Mukherjee, S, Martinu, T, Foster, WM, Plevy, SE, Pastva, AM, Wright, JR, and Palmer, SM. "Correction: Novel Role for Surfactant Protein A in Gastrointestinal Graft-versus-Host Disease." The Journal of Immunology 190, no. 3 (February 1, 2013): 1382-1382. Full Text
  - Ledford, CK, Zelenski, NA, Cardona, DM, Brigman, BE, and Eward, WC. "The phosphaturic mesenchymal tumor: Why is definitive diagnosis and curative surgery often delayed?." Clinical Orthopaedics and Related Research 471, no. 11 (2013): 3618-3625. Full Text
  - Lunsford, KE, Baird, BJ, Sempowski, GD, Cardona, DM, Li, Z, Weinhold, KJ, Sudan, DL, and Brennan, TV. "Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury." Transplantation 95, no. 8 (2013): 1000-1007. Full Text
  - Reddi, DM, Cardona, DM, Burchette, JL, and Puri, PK. "Scleroderma and IgG₄-related disease." American Journal of Dermatopathology 35, no. 4 (2013): 458-462. Full Text
  - Chan, JL, Lin, L, Feiler, M, Wolf, AI, Cardona, DM, and Gellad, ZF. "Comparative effectiveness of i-SCAN™ and high-definition white light characterizing small colonic polyps." World J Gastroenterol 18, no. 41 (November 7, 2012): 5905-5911. Full Text Link to Item
  - Brennan, TV, Lin, L, Huang, X, Cardona, DM, Li, Z, Dredge, K, Chao, NJ, and Yang, Y. "Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation." Blood 120, no. 14 (October 4, 2012): 2899-2908. Full Text Link to Item
  - Lampson, BL, Kendall, SD, Ancrile, BB, Morrison, MM, Shealy, MJ, Barrientos, KS, Crowe, MS, Kashatus, DF, White, RR, Gurley, SB, Cardona, DM, and Counter, CM. "Targeting eNOS in pancreatic cancer." Cancer Res 72, no. 17 (September 1, 2012): 4472-4482. Full Text Link to Item
  - Guy, CD, Suzuki, A, Burchette, JL, Brunt, EM, Abdelmalek, MF, Cardona, D, McCall, SJ, Ünalp, A, Belt, P, Ferrell, LD, Diehl, AM, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease." Hum Pathol 43, no. 6 (June 2012): 790-800. Full Text Link to Item
  - Gowdy, KM, Cardona, DM, Nugent, JL, Giamberardino, C, Thomas, JM, Mukherjee, S, Martinu, T, Foster, WM, Plevy, SE, Pastva, AM, Wright, JR, and Palmer, SM. "Novel role for surfactant protein A in gastrointestinal graft-versus-host disease." J Immunol 188, no. 10 (May 15, 2012): 4897-4905. Full Text Link to Item
  - Cardona, DM, Layne, A, and Lagoo, AS. "Lymphomas of the gastro-intestinal tract - pathophysiology, pathology, and differential diagnosis." Indian J Pathol Microbiol 55, no. 1 (January 2012): 1-16. (Review) Full Text Link to Item
  - Cardona, DM, and Dodd, LG. "Bone Cytology: A Realistic Approach for Clinical Use." Surgical Pathology Clinics 5, no. 1 (2012): 79-100. Full Text
  - Grier, DD, Al-Quran, SZ, Cardona, DM, Li, Y, and Braylan, RC. "Flow cytometric analysis of immunoglobulin heavy chain expression in B-cell lymphoma and reactive lymphoid hyperplasia." International Journal of Clinical and Experimental Pathology 5, no. 2 (2012): 110-118.
  - Jeung, JA, Coran, JJ, Liu, C, and Cardona, DM. "Hepatocyte paraffin 1 antigen as a biomarker for early diagnosis of Barrett esophagus." American Journal of Clinical Pathology 137, no. 1 (January 2012): 111-120. Full Text
  - Watters, TS, Cardona, DM, Menon, KS, Vinson, EN, Bolognesi, MP, and Dodd, LG. "Aseptic lymphocyte-dominated vasculitis-associated lesion: a clinicopathologic review of an underrecognized cause of prosthetic failure." Am J Clin Pathol 134, no. 6 (December 2010): 886-893. Full Text Link to Item
  - Corbin, KD, Spencer, MD, da Costa, K-A, Sha, W, Abdelmalek, MF, Pan, Y, Suzuki, A, Guy, CD, Cardona, DM, Torquati, A, Diehl, AM, and Zeisel, SH. "Genotype-based hierarchical clustering reveals a panel of polymorphisms in one carbon metabolism that are associated with obesity." FASEB JOURNAL 24 (April 2010). Link to Item
  - Jenkins, CP, Cardona, DM, Bowers, JN, Oliai, BR, Allan, RW, and Normann, SJ. "The utility of C4d, C9, and troponin T immunohistochemistry in acute myocardial infarction." Arch Pathol Lab Med 134, no. 2 (February 2010): 256-263. Full Text Link to Item
  - Cardona, DM, Zhang, X, and Liu, C. "Loss of carbamoyl phosphate synthetase I in small-intestinal adenocarcinoma." Am J Clin Pathol 132, no. 6 (December 2009): 877-882. Full Text Link to Item
  - Welling, RD, Cardona, DM, and Thompson, WM. "Esophageal actinomycosis: a case report and review of radiographic findings." J Radiol Case Rep 3, no. 12 (2009): 44-48. Full Text Link to Item
  - Cardona, DM, and Rand, KH. "Evaluation of repeat Clostridium difficile enzyme immunoassay testing." J Clin Microbiol 46, no. 11 (November 2008): 3686-3689. Full Text Link to Item
  - Cardona, DM, Knapik, JA, and Reith, JD. "Dedifferentiated parosteal osteosarcoma with giant cell tumor component." Skeletal Radiology 37, no. 4 (April 2008): 367-371. Full Text
  - Shangguan, D, Meng, L, Cao, ZC, Xiao, Z, Fang, X, Li, Y, Cardona, D, Witek, RP, Liu, C, and Tan, W. "Identification of liver cancer-specific aptamers using whole live cells." Anal Chem 80, no. 3 (February 1, 2008): 721-728. Full Text Link to Item
  - Butler, SL, Dong, H, Cardona, D, Jia, M, Zheng, R, Zhu, H, Crawford, JM, and Liu, C. "The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1." Lab Invest 88, no. 1 (January 2008): 78-88. Full Text Link to Item
  - Cardona, D, Grobmyer, S, Crawford, JM, and Liu, C. "Hepatocellular carcinoma arising from ectopic liver tissue in the pancreas." Virchows Arch 450, no. 2 (February 2007): 225-229. Full Text Link to Item
  - Kraus, G, Geffin, R, Spruill, G, Young, AK, Seivright, R, Cardona, D, Burzawa, J, and Hnatyszyn, HJ. "Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences." Proc Natl Acad Sci U S A 99, no. 6 (March 19, 2002): 3406-3411. Full Text Link to Item
  - Wilder, J, Chang, S, Cardona, D, Patel, K, and Brady, C. "Acute liver failure in the setting of herpes simplex virus and coexistent acute fatty liver of pregnancy(Published online)." Case Reports in Clinical Pathology 2, no. 2. Full Text Open Access Copy
- Conference Papers
  - Huang, J, Chen, M, Whitley, MJ, Kuo, H-C, Xu, ES, Walens, A, Mowery, YM, Van Mater, D, Eward, WC, Cardona, DM, Luo, L, Ma, Y, Lopez, OM, Nelson, CE, Robinson-Hamm, JN, Reddy, A, Dave, SS, Gersbach, CA, Dodd, RD, and Kirsch, DG. "Generation and comparison of CRISPR/Cas9 and Cre-mediated genetically engineered mouse models of sarcoma." January 2018. Link to Item
  - Huang, J, Chen, M, Whitley, MJ, Kuo, H-C, Walens, A, Mowery, YM, Mater, DV, Eward, W, Cardona, DM, Luo, L, Ma, Y, Nelson, CE, Robinson-Hamm, JN, Gersbach, CA, Dodd, RD, and Kirsch, DG. "Abstract 2810: Using CRISPR/Cas9 to generate primary soft tissue sarcoma in genetically engineered and wild-type mice." : American Association for Cancer Research (AACR), July 1, 2017. Full Text
  - Jia, W, Poe, JC, Su, H, Matsushima, GK, Rathmell, J, Imai, K, Reyes, NJ, Cardona, DM, Anand, S, Deoliveira, D, Li, Z, Saban, DR, Chen, BJ, Chao, NJ, and Sarantopoulos, S. "Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd." December 2, 2016. Link to Item
  - Detweiler, CJ, Sung, AD, Saullo, JL, Prasad, VK, and Cardona, DM. "Brincidofovir (CMX001) Toxicity: Another Potential Mimicker of Gastrointestinal Graft Versus Host Disease." February 2016. Link to Item
  - Detweiler, CJ, Sung, AD, Saullo, JL, Prasad, VK, and Cardona, DM. "Brincidofovir (CMX001) Toxicity: Another Potential Mimicker of Gastrointestinal Graft Versus Host Disease." February 2016. Link to Item
  - Harrison, G, Hemmerich, A, Guy, C, McCall, SJ, Cardona, DM, and Zhang, X. "Transcription Factor E3 as a Novel Diagnostic Marker for Solid Pseudopapillary Neoplasm." February 2016. Link to Item
  - Harrison, G, Hemmerich, A, Guy, C, McCall, SJ, Cardona, DM, and Zhang, X. "Transcription Factor E3 as a Novel Diagnostic Marker for Solid Pseudopapillary Neoplasm." February 2016. Link to Item
  - Nussbaum, DP, Rushing, CN, Lane, WO, Cardona, DM, Kirsch, DG, Peterson, BL, and Blazer, D. "Radiation Therapy is Associated with Improved Survival for Retroperitoneal Sarcoma: A Contemporary Analysis of 9,068 Patients." February 2016. Link to Item
  - Whitley, MJ, Cardona, DM, Blazer, DG, Hwang, S, Greenup, RA, Mosca, PJ, Cahill, J, Mito, JK, Cuneo, KC, Larrier, N, O'Reilly, E, Spasojevic, I, Riedel, RF, Eward, WC, Griffith, LG, Bawendi, MG, Ferrer, J, Strasfeld, DB, Lee, WD, Brigman, B, and Kirsch, DG. "Abstract SY36-03: Intraoperative molecular imaging with protease-activated fluorescent imaging agents." : American Association for Cancer Research (AACR), August 1, 2015. Full Text
  - Whitley, MJ, Cardona, DM, Blazer, DG, Hwang, E, Greenup, RA, Mosca, PJ, Cahill, J, Mito, JK, Cuneo, KC, Larrier, N, O'Reilly, E, Spasojevic, I, Riedel, RF, Eward, WC, Griffith, LG, Bawendi, MG, Kirsch, DG, and Brigman, BE. "A Phase I Clinical Trial of LUM015: A Protease-activated Fluorescent Imaging Agent to Detect Cancer during Surgery." February 2015. Link to Item
  - Whitley, MJ, Cardona, DM, Blazer, DG, Hwang, SE, Mosca, PJ, Cahill, J, Ferrer, JM, Strasfeld, DB, Mito, JK, Cuneo, KC, Larrier, N, Williams, N, Spasojevic, I, Riedel, RF, Eward, W, Lee, WD, Griffith, LG, Bawendi, M, Kirsch, DG, and Brigman, BE. "A phase I study of the safety and activation of a cathepsin-activatable fluorescent cancer-specific probe LUM015." : American Society of Clinical Oncology (ASCO), May 20, 2014. Full Text
  - Layne, AC, Cummings, TJ, Guy, CD, Cardona, DM, Bentley, RC, Shealy, MJ, Zhang, X, and McCall, SJ. "TTF-1 Is Expressed in a Subset of Esophageal Adenocarcinomas." February 2014. Link to Item
  - Layne, AC, Cummings, TJ, Guy, CD, Cardona, DM, Bentley, RC, Shealy, MJ, Zhang, X, and McCall, SJ. "TTF-1 Is Expressed in a Subset of Esophageal Adenocarcinomas." February 2014. Link to Item
  - Shealy, MJ, de Ridder, GG, McCall, SJ, Guy, CD, Zhang, X, and Cardona, DM. "The Role of Eosinophils and Neuroendocrine Cell Nests in the Assessment of Gastrointestinal Biopsies in Bone Marrow Transplant Patients." February 2014. Link to Item
  - Shealy, MJ, de Ridder, GG, McCall, SJ, Guy, CD, Zhang, X, and Cardona, DM. "The Role of Eosinophils and Neuroendocrine Cell Nests in the Assessment of Gastrointestinal Biopsies in Bone Marrow Transplant Patients." February 2014. Link to Item
  - Zhang, X, Zhao, L, Guy, CD, McCall, SJ, Cardona, DM, Burbridge, RA, Garman, KS, Branch, MS, Siddiqui, U, Xiao, S-Y, Waxman, I, and Hart, J. "Delayed Specimen Collection May Artifactually Damage the Mucosal Surface in Barrett's EMR Specimens." February 2014. Link to Item
  - Zhang, X, Zhao, L, Guy, CD, McCall, SJ, Cardona, DM, Burbridge, RA, Garman, KS, Branch, MS, Siddiqui, U, Xiao, S-Y, Waxman, I, and Hart, J. "Delayed Specimen Collection May Artifactually Damage the Mucosal Surface in Barrett's EMR Specimens." February 2014. Link to Item
  - Grosso, J, Horak, CE, Inzunza, D, Cardona, DM, Simon, JS, Gupta, AK, Sankar, V, Park, J-S, Kollia, G, Taube, JM, Anders, R, Jure-Kunkel, M, Novotny, J, Taylor, CR, Zhang, X, Phillips, T, Simmons, P, and Cogswell, J. "Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients (pts) with advanced solid tumors treated with nivolumab (anti-PD-1; BMS-936558; ONO-4538)." 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO). Chicago, IL. May 31, 2013 - June 4, 2013.: AMER SOC CLINICAL ONCOLOGY, May 20, 2013. Link to Item
  - Lunsford, KE, Jackson-Baird, B, Sempowski, GD, Cardona, DM, Weinhold, KJ, and Brennan, TV. "Novel Murine Model of Pancreatic Ischemia Reperfusion Injury Up-Regulates Interleukin-1 Beta, Interleukin-6, and CCL-2." American Transplant Congress. Boston, MA. May 2012.: WILEY-BLACKWELL, May 1, 2012. Link to Item
  - Corbin, KD, Spencer, MD, da Costa, K-A, Sha, W, Abdelmalek, MF, Pan, Y, Suzuki, A, Guy, CD, Cardona, DM, Torquati, A, Diehl, AM, and Zeisel, SH. "Genotype-based hierarchical clustering reveals a panel of polymorphisms in one carbon metabolism that are associated with obesity." April 2012. Link to Item
  - Cardona, DM, Shealy, MJ, Bentley, RC, and Veras, E. "An Analysis of the Application and Reproducibility of the NIH Consensus Guidelines for the Histologic Diagnosis of Gastrointestinal Acute Graft Versus Host Disease." February 2012. Link to Item
  - Cardona, DM, Shealy, MJ, Bentley, RC, and Veras, E. "An Analysis of the Application and Reproducibility of the NIH Consensus Guidelines for the Histologic Diagnosis of Gastrointestinal Acute Graft Versus Host Disease." February 2012. Link to Item
  - Lunsford, KE, Jackson-Baird, B, Sempowski, GD, Cardona, DM, and Brennan, TV. "Murine Pancreatic Ischemia-Reperfusion Injury Up-Regulates Interleukin-1 beta, Interleukin-6, and CCL-2." American-Society-of-Transplant-Surgeons (ASTS) 12th Annual State of the Art Winter Symposium/North-American-Transplant-Coordinators-Organization (NATCO) Symposium for Advanced Transplant Professionals. Miami, FL. January 12, 2012 - January 15, 2012.: WILEY-BLACKWELL, January 1, 2012. Link to Item
  - Shealy, MJ, Cardona, DM, Burchette, JL, Cummings, TJ, Smith, AD, Howell, DN, and Guy, CD. "Symptomatic Traumatic Neuroma Causing Common Bile Duct Stricture Following Orthotopic Liver Transplantation: A Retrospective Three and a Half Year Review." February 2010. Link to Item
  - Shealy, MJ, Cardona, DM, Burchette, JL, Cummings, TJ, Smith, AD, Howell, DN, and Guy, CD. "Symptomatic Traumatic Neuroma Causing Common Bile Duct Stricture Following Orthotopic Liver Transplantation: A Retrospective Three and a Half Year Review." February 2010. Link to Item
- Datasets
  - Fu, HL, Mueller, JL, Whitley, MJ, Cardona, DM, Willett, RM, Kirsch, DG, Brown, JQ, and Ramanujam, N. "Structured Illumination Microscopy and a Quantitative Image Analysis for the Detection of Positive Margins in a Pre-Clinical Genetically Engineered Mouse Model of Sarcoma." (January 22, 2016). Data Access Open Access Copy

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Datasets