Developing pressures: fluid forces driving morphogenesis.

Journal Article (Review)

Over several decades genetic studies have unraveled many molecular mechanisms that underlie the signaling networks guiding morphogenesis, but the mechanical forces at work remain much less well understood. Accumulation of fluid within a luminal space can generate outward hydrostatic pressure capable of shaping morphogenesis at several scales, ranging from individual organs to the entire vertebrate body-plan. Here, we focus on recent work that uncovered mechanical roles for fluid secretion during morphogenesis. Identifying the roles and regulation of fluid secretion will be instrumental for understanding the mechanics of morphogenesis as well as many human diseases of complex genetic and environmental origin including secretory diarrheas and scoliosis.

Full Text

Duke Authors

Cited Authors

  • Navis, A; Bagnat, M

Published Date

  • June 2015

Published In

Volume / Issue

  • 32 /

Start / End Page

  • 24 - 30

PubMed ID

  • 25698116

Electronic International Standard Serial Number (EISSN)

  • 1879-0380

International Standard Serial Number (ISSN)

  • 0959-437X

Digital Object Identifier (DOI)

  • 10.1016/j.gde.2015.01.010

Language

  • eng