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The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude.

Publication ,  Journal Article
Willie, CK; MacLeod, DB; Smith, KJ; Lewis, NC; Foster, GE; Ikeda, K; Hoiland, RL; Ainslie, PN
Published in: J Cereb Blood Flow Metab
May 2015

The effects of partial acclimatization to high altitude (HA; 5,050 m) on cerebral metabolism and cerebrovascular function have not been characterized. We hypothesized (1) increased cerebrovascular reactivity (CVR) at HA; and (2) that CO2 would affect cerebral metabolism more than hypoxia. PaO2 and PaCO2 were manipulated at sea level (SL) to simulate HA exposure, and at HA, SL blood gases were simulated; CVR was assessed at both altitudes. Arterial-jugular venous differences were measured to calculate cerebral metabolic rates and cerebral blood flow (CBF). We observed that (1) partial acclimatization yields a steeper CO2-H(+) relation in both arterial and jugular venous blood; yet (2) CVR did not change, despite (3) mean arterial pressure (MAP)-CO2 reactivity being doubled at HA, thus indicating effective cerebral autoregulation. (4) At SL hypoxia increased CBF, and restoration of oxygen at HA reduced CBF, but neither had any effect on cerebral metabolism. Acclimatization resets the cerebrovasculature to chronic hypocapnia.

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Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

May 2015

Volume

35

Issue

5

Start / End Page

873 / 881

Location

United States

Related Subject Headings

  • Oxygen
  • Neurology & Neurosurgery
  • Male
  • Jugular Veins
  • Hypocapnia
  • Humans
  • Female
  • Cerebrovascular Circulation
  • Carbon Dioxide
  • Blood Pressure
 

Citation

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Willie, C. K., MacLeod, D. B., Smith, K. J., Lewis, N. C., Foster, G. E., Ikeda, K., … Ainslie, P. N. (2015). The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude. J Cereb Blood Flow Metab, 35(5), 873–881. https://doi.org/10.1038/jcbfm.2015.4
Willie, Christopher K., David B. MacLeod, Kurt J. Smith, Nia C. Lewis, Glen E. Foster, Keita Ikeda, Ryan L. Hoiland, and Philip N. Ainslie. “The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude.J Cereb Blood Flow Metab 35, no. 5 (May 2015): 873–81. https://doi.org/10.1038/jcbfm.2015.4.
Willie CK, MacLeod DB, Smith KJ, Lewis NC, Foster GE, Ikeda K, et al. The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude. J Cereb Blood Flow Metab. 2015 May;35(5):873–81.
Willie, Christopher K., et al. “The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude.J Cereb Blood Flow Metab, vol. 35, no. 5, May 2015, pp. 873–81. Pubmed, doi:10.1038/jcbfm.2015.4.
Willie CK, MacLeod DB, Smith KJ, Lewis NC, Foster GE, Ikeda K, Hoiland RL, Ainslie PN. The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude. J Cereb Blood Flow Metab. 2015 May;35(5):873–881.
Journal cover image

Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

May 2015

Volume

35

Issue

5

Start / End Page

873 / 881

Location

United States

Related Subject Headings

  • Oxygen
  • Neurology & Neurosurgery
  • Male
  • Jugular Veins
  • Hypocapnia
  • Humans
  • Female
  • Cerebrovascular Circulation
  • Carbon Dioxide
  • Blood Pressure