Overview
Clinical Anesthesia
My principal clinical interest is the use of peripheral nerve blocks in primarily orthopedic joint replacement procedures. I am a member of the Regional Division with responsibilities to spine, trauma & plastic surgery.
I was the co-director of the Carolina Cadaver Course, which was run annually in conjunction with Wake Forest University School of Medicine. I have been involved in teaching the use of ultrasound for the placement of peripheral nerve blocks and have lectured on several national courses.
Human Pharmacology & Physiology Lab (HPPL)
I am the Director of the HPPL which is the the Department of Anesthesiology's clinical research lab designed to conduct studies in healthy volunteers. It is designed to collect comprehensive physiological data in a manner similar to the Operating Room (OR), using both non-invasive and invasive techniques. The key areas of interest are:
- Early human clinical drug trials (Phase 1 & 2) of drugs related to anesthesia
- Conduct of clinical equipment validation studies prior to FDA approval
Current Appointments & Affiliations
Recent Publications
Cerebral Blood Flow in Orthostatic Intolerance.
Journal Article J Am Heart Assoc · February 4, 2025 Cerebral blood flow (CBF) is vital for delivering oxygen and nutrients to the brain. Many forms of orthostatic intolerance (OI) involve impaired regulation of CBF in the upright posture, which results in disabling symptoms that decrease quality of life. Be ... Full text Link to item CiteIntense exercise at high altitude causes platelet loss across the brain in humans.
Journal Article J Physiol · November 2024 Platelets are known primarily for their role in blood clotting; however, it is becoming clear that they play diverse roles beyond that of haemostasis. Exercise has been shown to activate platelets and stimulate neurogenesis, neuroplasticity and improve cog ... Full text Link to item CiteSevere hypoxaemic hypercapnia compounds cerebral oxidative-nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function.
Journal Article J Physiol · November 2024 We examined the extent to which apnoea-induced extremes of oxygen demand/carbon dioxide production impact redox regulation of cerebral bioenergetic function. Ten ultra-elite apnoeists (six men and four women) performed two maximal dry apnoeas preceded by n ... Full text Link to item CiteRecent Grants
Applied Physiology of CNS Oxygen Toxicity: Mechanisms in Humans
ResearchCo Investigator · Awarded by Office of Naval Research · 2023 - 2026Validation of Argus Oximetry System to Measure Cerebral, Somatic, and Peripheral Tissue Oxygen Saturation, Pulse Rate, and Respiratory Rate in Healthy Volunteers
Clinical TrialPrincipal Investigator · Awarded by Nirsense, LLC · 2023 - 2026OBPM: VOCOM- Cyban
Clinical TrialPrincipal Investigator · Awarded by Cyban Pty Ltd. · 2024 - 2025View All Grants