Overview
Clinical Anesthesia
My principal clinical interest is the use of peripheral nerve blocks in primarily orthopedic joint replacement procedures. I am a member of the Regional Division with responsibilities to spine, trauma & plastic surgery.
I was the co-director of the Carolina Cadaver Course, which was run annually in conjunction with Wake Forest University School of Medicine. I have been involved in teaching the use of ultrasound for the placement of peripheral nerve blocks and have lectured on several national courses.
Human Pharmacology & Physiology Lab (HPPL)
I am the Director of the HPPL which is the the Department of Anesthesiology's clinical research lab designed to conduct studies in healthy volunteers. It is designed to collect comprehensive physiological data in a manner similar to the Operating Room (OR), using both non-invasive and invasive techniques. The key areas of interest are:
- Early human clinical drug trials (Phase 1 & 2) of drugs related to anesthesia
- Conduct of clinical equipment validation studies prior to FDA approval
Current Appointments & Affiliations
Recent Publications
Lactate accumulates in the cerebrospinal fluid after prolonged exercise.
Journal Article J Cereb Blood Flow Metab · March 2026 The resting brain is fuelled by glucose with a small release of lactate. During exercise, the brain switches to extracting lactate from blood and this increases brain carbohydrate uptake in great excess to that of oxygen. The fate of this excess carbohydra ... Full text Link to item CiteBrain glucose extraction is fixed at 10% despite twofold variability in resting cerebral blood flow in healthy humans.
Journal Article J Cereb Blood Flow Metab · March 2026 In the resting, non-stimulated brain, metabolic demands are met exclusively by the delivery and extraction of glucose and oxygen at an ~6:1 ratio. Amongst healthy people at rest, there is marked variability in resting global cerebral blood flow (CBF) yet r ... Full text Link to item CiteBrain aerobic glycolysis is stable during adulthood: Direct evidence from cross-brain blood sampling in 239 healthy adults.
Journal Article J Cereb Blood Flow Metab · March 2026 The brain is a highly metabolic organ primarily fueled by glucose, and it is well established that a decline in cerebral glucose metabolism accompanies neurodegenerative disease. Recent work using positron emission tomography (PET) has demonstrated that ce ... Full text Link to item CiteRecent Grants
ClearSight System Sp02 Accuracy with or Without Motion Conditions - (ClearSats-Motion), Trial No. 2025-08
Clinical TrialPrincipal Investigator · Awarded by Edwards Lifesciences, LLC · 2026 - 2028Development and evaluation of a multimodal wearable platform for the quantitative evaluation of pain in human subjects
Clinical TrialPrincipal Investigator · Awarded by Empatica Inc. · 2026 - 2027Respiration from Pleth Validation
Clinical TrialPrincipal Investigator · Awarded by Philips Medizin-Systeme Boeblingen GmbH · 2026 - 2027View All Grants