Overview
Clinical Anesthesia
My principal clinical interest is the use of peripheral nerve blocks in primarily orthopedic joint replacement procedures. I am a member of the Regional Division with responsibilities to spine, trauma & plastic surgery.
I was the co-director of the Carolina Cadaver Course, which was run annually in conjunction with Wake Forest University School of Medicine. I have been involved in teaching the use of ultrasound for the placement of peripheral nerve blocks and have lectured on several national courses.
Human Pharmacology & Physiology Lab (HPPL)
I am the Director of the HPPL which is the the Department of Anesthesiology's clinical research lab designed to conduct studies in healthy volunteers. It is designed to collect comprehensive physiological data in a manner similar to the Operating Room (OR), using both non-invasive and invasive techniques. The key areas of interest are:
- Early human clinical drug trials (Phase 1 & 2) of drugs related to anesthesia
- Conduct of clinical equipment validation studies prior to FDA approval
Current Duke Appointments & Affiliations
Recent Scholarly Works
Brain-derived neurotrophic factor in human cerebrospinal fluid is elevated after exercise.
Journal article J Neurophysiol · July 1, 2026 Brain-derived neurotrophic factor (BDNF) is implicated in neuronal differentiation, maturation, survival, and synaptic plasticity. Circulating BDNF is often quantified to represent brain neuronal plasticity following acute exercise. However, BDNF in the fl ... Full text Link to item CiteFirst characterization of metabolomic and lipidomic exchange over the healthy human brain
Preprint · June 21, 2026 AbstractThe energy turnover and metabolic flexibility of the human brain extend beyond a primary reliance on carbohydrates and oxygen. Building on work in anesthetized patients with cerebrovascular patholog ... Full text CiteThe role of group III/IV afferent feedback in the ventilatory, pressor and metabolic responses to exercise in normoxia and hypoxia.
Journal article J Physiol · June 19, 2026 Group III/IV muscle afferents play a prominent role in ensuring appropriate arterial oxygenation during exercise. Exercise in hypoxia poses a major cardiorespiratory challenge due to reduced inspired oxygen pressure (PIO2). Although humans adapt powerfully ... Full text Link to item CiteRecent Grants
Summative Usability Evaluation of the Argus Oximetry System with Healthcare Providers
Clinical TrialPrincipal Investigator · Awarded by Nirsense, LLC · 2026 - 2028ClearSight System Sp02 Accuracy with or Without Motion Conditions - (ClearSats-Motion), Trial No. 2025-08
Clinical TrialPrincipal Investigator · Awarded by Edwards Lifesciences, LLC · 2026 - 2028Validation Study of the Noninvasix Optoacoustic Saturation Monitor to Estimate the Left Innominate Vein Oxygen Saturation
Clinical TrialPrincipal Investigator · Awarded by Noninvasix, Inc · 2025 - 2027View All Grants