David Brett MacLeod

Associate Professor of Anesthesiology

Anesthesiology, Regional

david.macleod@duke.edu

Box 3094 Med Ctr, Durham, NC

2301 Erwin Road, 5695 Hafs Building, Durham, NC 27708

More About This Person

At a Glance

Credentials
1. Education

Academic Experience
1. Current Appointments & Affiliations
2. Previous Appointments & Affiliations

Expertise

Research
1. Selected Grants

Publications
1. Selected Publications

Artistic Works / Events

Teaching

Advising & Mentoring

Recognition

Professional Activities

Selected Grants

Applied Physiology of CNS Oxygen Toxicity: Mechanisms in Humans

ResearchCo Investigator · Awarded by Office of Naval Research · 2023 - 2026

Validation of Argus Oximetry System to Measure Cerebral, Somatic, and Peripheral Tissue Oxygen Saturation, Pulse Rate, and Respiratory Rate in Healthy Volunteers

Clinical TrialPrincipal Investigator · Awarded by Nirsense, LLC · 2023 - 2026

OBPM: VOCOM- Cyban

Clinical TrialPrincipal Investigator · Awarded by Cyban Pty Ltd. · 2024 - 2025

Low Saturation Verification of Investigational Pulse Oximetry Devices in Adult Volunteers

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2024 - 2025

WORK ORDER FOR THE ACCURACY PERFORMANCE VERIFICATION OF THE INVOS¿ PM7100 SYSTEM BY COMPARING RSO2 VALUES TO REFERENCE BLOOD OXYGEN SATURATION MEASUREMENTS IN ADULT HUMAN VOLUNTEERS STUDY

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2024 - 2025

Role of the Splanchnic Vascular Compartment in Heart Failure with Preserved Ejection Fraction

ResearchCollaborator · Awarded by Doris Duke Charitable Foundation, Inc. · 2022 - 2025

ClearSats Study, Trial No. 2023-13

Clinical TrialPrincipal Investigator · Awarded by Edwards Lifesciences, LLC · 2024 - 2025

A Phase 1, Double-Blind, Active- and Placebo-Controlled Dose Escalation Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of Liposomal Bupivacaine 13.3 Administered via a Single Intrathecal Injection to Healthy Volunteers

Clinical TrialPrincipal Investigator · Awarded by Pacira Pharmaceuticals · 2023 - 2025

Data Collection in Generally Healthy Adults Undergoing Desaturation

Clinical TrialPrincipal Investigator · Awarded by Masimo Corporation · 2023 - 2024

Phase I Single Ascending Dose and Multiple Ascending Dose Study of 2R,6R-Hydroxynorketamine

Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2018 - 2024

Performance Comparison between Masimo W1¿ and Apple Watch Series 8

Clinical TrialPrincipal Investigator · Awarded by Masimo Corporation · 2023 - 2024

Prospective study to validate the clinical accuracy of the Norbert Device to measure oxygen saturation

Clinical TrialPrincipal Investigator · Awarded by Norbert Health · 2023 - 2023

Comparison of Submaximal Exercise Tests with Maximal Exercise Test

Clinical TrialPrincipal Investigator · Awarded by Vyaire Medical, Inc. · 2021 - 2023

MDT DIGI2 Study

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2021 - 2023

Cyban Brain Pulse Oximeter - Bsp02

Clinical TrialPrincipal Investigator · Awarded by Cyban Pty Ltd. · 2022 - 2023

Validation Study of the Noninvasix Optoacoustic Saturation Monitor to Estimate the Left Innominate Vein Oxygen Saturation

Clinical TrialPrincipal Investigator · Awarded by Noninvasix, Inc · 2022 - 2023

Medtronic Oliver Study

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2020 - 2023

RTOP 18-0006 Option 1 / Protocol Implementation

Clinical TrialSafety Coordinator · Awarded by National Institute of Allergy and Infectious Diseases · 2019 - 2022

Pacira 402-C-332 STRIDE Ankle

Clinical TrialPrincipal Investigator · Awarded by Pacira Pharmaceuticals · 2019 - 2022

Pacira Exparel Intrathecal

Clinical TrialPrincipal Investigator · Awarded by Pacira Pharmaceuticals · 2019 - 2021

Bispectral Index and Levels of Sedation with Propofol with/without Remifentanil in Healthy Volunteers (SONORA)

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2020 - 2021

RTOP 18-0006 Option 1 / Protocol Implementation

Clinical TrialMedical Monitor · Awarded by National Institute of Allergy and Infectious Diseases · 2019 - 2021

Preoperative exercise to improve vagal tone (PREVENT) study

ResearchSignificant Contributor · Awarded by International Anesthesia Research Society · 2019 - 2020

Exparel Hip Fracture

Clinical TrialPrincipal Investigator · Awarded by Pacira Pharmaceuticals · 2019 - 2020

Medtronic NG INVOS JB4 NI

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2018 - 2019

Venous Pulse Ox Calibration Study

Clinical TrialPrincipal Investigator · Awarded by Cyban Pty Ltd. · 2018 - 2019

Phase I Open Label Study to Determine the Pharmacokinetics, Pharmacodynamics, and Safety of IV Ganaxolone in Healthy Adults

Clinical TrialCo-Principal Investigator · Awarded by Marinus Pharmaceuticals, Inc. · 2016 - 2018

Dysfunctional Hemoglobin Pulse Oximeter Manufacturability Study

Clinical TrialPrincipal Investigator · Awarded by Nonin Medical, Inc. · 2016 - 2017

COVMOPR 0463: Desaturation for the NIRS Technology Calibration

Clinical TrialPrincipal Investigator · Awarded by Covidien Ltd. · 2014 - 2017

Comparison of Compensatory Reserve Index to Changes in Stroke Volume and Intravascular Volume During Continuous Rate Blood Draw & Subsequent Resuscitation via Re-infusion

Clinical TrialPrincipal Investigator · Awarded by Flashback Technologies, Inc. · 2015 - 2016

Nonin 5: Effect of Induced Hypoxia at Multiple Wavelengths

Clinical TrialPrincipal Investigator · Awarded by Nonin Medical, Inc. · 2013 - 2015

Phase I Study of Single IV Dose of AR09 in Healthy Subjects

Clinical TrialPrincipal Investigator · Awarded by Arbor Pharmaceuticals, Inc · 2013 - 2015

Comparison of Compensatory Reserve Index to Intravascular Volume Change and Stroke Volume

Clinical TrialPrincipal Investigator · Awarded by Clinimark Laboratories · 2013 - 2015