Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction.


Journal Article (Review)

Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.

Full Text

Duke Authors

Cited Authors

  • Hai, OY; Mentz, RJ; Zannad, F; Gasparini, M; De Ferrari, GM; Daubert, J-C; Holzmeister, J; Lam, CSP; Pochet, T; Vincent, A; Linde, C

Published Date

  • February 2015

Published In

Volume / Issue

  • 17 / 2

Start / End Page

  • 135 - 143

PubMed ID

  • 25469668

Pubmed Central ID

  • 25469668

Electronic International Standard Serial Number (EISSN)

  • 1879-0844

International Standard Serial Number (ISSN)

  • 1388-9842

Digital Object Identifier (DOI)

  • 10.1002/ejhf.208


  • eng