Diversity and selectivity in mRNA translation on the endoplasmic reticulum.

Published

Journal Article (Review)

Pioneering electron microscopy studies defined two primary populations of ribosomes in eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the surface of the endoplasmic reticulum (ER). Subsequent investigations revealed a specialized function for each population, with secretory and integral membrane protein-encoding mRNAs translated on ER-bound ribosomes, and cytosolic protein synthesis was widely attributed to free ribosomes. Recent findings have challenged this view, and transcriptome-scale studies of mRNA distribution and translation have now demonstrated that ER-bound ribosomes also function in the translation of a large fraction of mRNAs that encode cytosolic proteins. These studies suggest a far more expansive role for the ER in transcriptome expression, where membrane and secretory protein synthesis represents one element of a multifaceted and dynamic contribution to post-transcriptional gene expression.

Full Text

Duke Authors

Cited Authors

  • Reid, DW; Nicchitta, CV

Published Date

  • April 2015

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 221 - 231

PubMed ID

  • 25735911

Pubmed Central ID

  • 25735911

Electronic International Standard Serial Number (EISSN)

  • 1471-0080

Digital Object Identifier (DOI)

  • 10.1038/nrm3958

Language

  • eng

Conference Location

  • England