Diversity and selectivity in mRNA translation on the endoplasmic reticulum.
Published
Journal Article (Review)
Pioneering electron microscopy studies defined two primary populations of ribosomes in eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the surface of the endoplasmic reticulum (ER). Subsequent investigations revealed a specialized function for each population, with secretory and integral membrane protein-encoding mRNAs translated on ER-bound ribosomes, and cytosolic protein synthesis was widely attributed to free ribosomes. Recent findings have challenged this view, and transcriptome-scale studies of mRNA distribution and translation have now demonstrated that ER-bound ribosomes also function in the translation of a large fraction of mRNAs that encode cytosolic proteins. These studies suggest a far more expansive role for the ER in transcriptome expression, where membrane and secretory protein synthesis represents one element of a multifaceted and dynamic contribution to post-transcriptional gene expression.
Full Text
Duke Authors
Cited Authors
- Reid, DW; Nicchitta, CV
Published Date
- April 2015
Published In
Volume / Issue
- 16 / 4
Start / End Page
- 221 - 231
PubMed ID
- 25735911
Pubmed Central ID
- 25735911
Electronic International Standard Serial Number (EISSN)
- 1471-0080
Digital Object Identifier (DOI)
- 10.1038/nrm3958
Language
- eng
Conference Location
- England