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(18)F-Fluorothymidine PET-CT for resected malignant gliomas before radiotherapy: tumor extent according to proliferative activity compared with MRI.

Publication ,  Journal Article
Zhao, F; Li, M; Wang, Z; Fu, Z; Cui, Y; Chen, Z; Yu, J
Published in: PLoS One
2015

OBJECTIVE: To compare the presence of post-operative residual disease by magnetic resonance imaging (MRI) and [18F]fluorothymidine (FLT)-positron emission tomography (PET)-computer tomography (CT) in patients with malignant glioma and to estimate the impact of 18F-FLT PET on the delineation of post-operative target volumes for radiotherapy (RT) planning. METHODS: Nineteen patients with post-operative residual malignant gliomas were enrolled in this study. For each patient, 18F- FLT PET-CT and MRI were acquired in the same week, within 4 weeks after surgery but before the initiation of RT. The PET-CT and MRI data were co-registered based on mutual information. The residual tumor volume defined on the 18F-FLT PET (Vol-PET) was compared with that of gadolinium [Gd] enhancement on T1-weighted MRI (Vol-T1) and areas of hyperintensity on T2-weighted MRI (Vol-T2). RESULTS: The mean Vol-PET (14.61 cm3) and Vol-T1 (13.60 cm3) were comparable and smaller than the mean Vol-T2 (32.93 cm3). The regions of 18F-FLT uptake exceeded the contrast enhancement and the hyperintense area on the MRI in 14 (73.68%) and 8 patients (42.11%), respectively. In 5 (26.32%) of the 19 patients, Vol-PET extended beyond 25 mm from the margin of Vol-T1; in 2 (10.53%) patients, Vol-PET extended 20 mm from the margin of Vol-T2. Vol-PET was detected up to 35 mm away from the edge of Vol-T1 and 24 mm away from the edge of Vol-T2. In 16 (84.21%) of the 19 patients, the Vol-T1 extended beyond the Vol-PET. In all of the patients, at least some of the Vol-T2 was located outside of the Vol-PET. CONCLUSIONS: The volumes of post-operative residual tumor in patients with malignant glioma defined by 18F-FLT uptake on PET are not always consistent with the abnormalities shown on post-operative MRI. Incorporation of 18F-FLT-PET in tumor delineation may have the potential to improve the definition of target volume in post-operative radiotherapy.

Duke Scholars

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

3

Start / End Page

e0118769

Location

United States

Related Subject Headings

  • Tumor Burden
  • Tomography, X-Ray Computed
  • Radiotherapy Planning, Computer-Assisted
  • Postoperative Period
  • Positron-Emission Tomography
  • Neoplasm, Residual
  • Multimodal Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
 

Citation

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Chicago
ICMJE
MLA
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Zhao, F., Li, M., Wang, Z., Fu, Z., Cui, Y., Chen, Z., & Yu, J. (2015). (18)F-Fluorothymidine PET-CT for resected malignant gliomas before radiotherapy: tumor extent according to proliferative activity compared with MRI. PLoS One, 10(3), e0118769. https://doi.org/10.1371/journal.pone.0118769
Zhao, Fen, Minghuan Li, Zhiheng Wang, Zheng Fu, Yunfeng Cui, Zhaoqiu Chen, and Jinming Yu. “(18)F-Fluorothymidine PET-CT for resected malignant gliomas before radiotherapy: tumor extent according to proliferative activity compared with MRI.PLoS One 10, no. 3 (2015): e0118769. https://doi.org/10.1371/journal.pone.0118769.
Zhao, Fen, et al. “(18)F-Fluorothymidine PET-CT for resected malignant gliomas before radiotherapy: tumor extent according to proliferative activity compared with MRI.PLoS One, vol. 10, no. 3, 2015, p. e0118769. Pubmed, doi:10.1371/journal.pone.0118769.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

3

Start / End Page

e0118769

Location

United States

Related Subject Headings

  • Tumor Burden
  • Tomography, X-Ray Computed
  • Radiotherapy Planning, Computer-Assisted
  • Postoperative Period
  • Positron-Emission Tomography
  • Neoplasm, Residual
  • Multimodal Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging