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Room-temperature preparation and characterization of poly (ethylene glycol)-coated silica nanoparticles for biomedical applications.

Publication ,  Journal Article
Xu, H; Yan, F; Monson, EE; Kopelman, R
Published in: Journal of biomedical materials research. Part A
September 2003

Monodisperse, spherical, polyethylene glycol (PEG)-coated silica nanoparticles have been prepared at room temperature and characterized for the purpose of biomedical applications. The particles were synthesized by the hydrolysis of tetramethyl orthosilicate (TMOS) in alcohol media under catalysis by ammonia, and their size can range from about 50-350 nm in diameter. We studied the particle size and size distribution using a scanning electron microscope (SEM) and an asymmetric field-flow fractionation (AFFF) multiangle static light-scattering instrument. The chemical and/or physical binding of PEG to the silica nanoparticles was studied by infrared spectroscopy, and the weight percentage of PEG attached to the particles was quantified. The PEG-coated silica nanoparticles showed enhanced colloidal stability when redispersed into aqueous solutions from the dried state as a result of the steric stabilization function of the PEG polymer grafted on the surface of particles. A nonspecific protein-binding test was also carried out to show that the PEG coating can help reduce the protein adsorption onto the surface of the particles, relating to the biocompatibility of these PEG-coated particles. Also, the inclusion of magnetic nanoparticles into the silica particles was shown as an example of the possible applications of PEG-coated silica particles. These silica nanoparticles, as a matrix for encapsulation of certain reagents, have potential for applications to in vivo diagnosis, analysis, and measurements inside intact biologic systems.

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Published In

Journal of biomedical materials research. Part A

DOI

EISSN

1552-4965

ISSN

1549-3296

Publication Date

September 2003

Volume

66

Issue

4

Start / End Page

870 / 879

Related Subject Headings

  • Temperature
  • Spectroscopy, Fourier Transform Infrared
  • Silicon Dioxide
  • Polyethylene Glycols
  • Particle Size
  • Molecular Weight
  • Microscopy, Electron, Scanning
  • Biocompatible Materials
  • 40 Engineering
  • 34 Chemical sciences
 

Citation

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Xu, H., Yan, F., Monson, E. E., & Kopelman, R. (2003). Room-temperature preparation and characterization of poly (ethylene glycol)-coated silica nanoparticles for biomedical applications. Journal of Biomedical Materials Research. Part A, 66(4), 870–879. https://doi.org/10.1002/jbm.a.10057
Xu, Hao, Fei Yan, Eric E. Monson, and Raoul Kopelman. “Room-temperature preparation and characterization of poly (ethylene glycol)-coated silica nanoparticles for biomedical applications.Journal of Biomedical Materials Research. Part A 66, no. 4 (September 2003): 870–79. https://doi.org/10.1002/jbm.a.10057.
Xu H, Yan F, Monson EE, Kopelman R. Room-temperature preparation and characterization of poly (ethylene glycol)-coated silica nanoparticles for biomedical applications. Journal of biomedical materials research Part A. 2003 Sep;66(4):870–9.
Xu, Hao, et al. “Room-temperature preparation and characterization of poly (ethylene glycol)-coated silica nanoparticles for biomedical applications.Journal of Biomedical Materials Research. Part A, vol. 66, no. 4, Sept. 2003, pp. 870–79. Epmc, doi:10.1002/jbm.a.10057.
Xu H, Yan F, Monson EE, Kopelman R. Room-temperature preparation and characterization of poly (ethylene glycol)-coated silica nanoparticles for biomedical applications. Journal of biomedical materials research Part A. 2003 Sep;66(4):870–879.
Journal cover image

Published In

Journal of biomedical materials research. Part A

DOI

EISSN

1552-4965

ISSN

1549-3296

Publication Date

September 2003

Volume

66

Issue

4

Start / End Page

870 / 879

Related Subject Headings

  • Temperature
  • Spectroscopy, Fourier Transform Infrared
  • Silicon Dioxide
  • Polyethylene Glycols
  • Particle Size
  • Molecular Weight
  • Microscopy, Electron, Scanning
  • Biocompatible Materials
  • 40 Engineering
  • 34 Chemical sciences