Preparation and characterization of poly (ethylene glycol)-coated Stöber silica nanoparticles for biomedical applications

Conference Paper

Monodisperse, spherical, polyethylene glycol (PEG)-coated silica nanoparticles have been prepared in the size range of 50-350 nm, and their size and size distribution were characterized by SEM and multi-angle static light scattering experiments. The chemical binding of PEG to the silica nanoparticles was confirmed by infrared spectroscopy. The biocompatibility of these PEGylated nanoparticles was also studied by non-specific protein binding tests and in-vivo toxicology studies in live animals. These silica nanoparticles, as a matrix for encapsulation of certain reagents, have been used for the fabrication of intracellular sensors and have potential for applications to in vivo diagnosis, analysis and measurements, due to their small physical size and their biocompatibility, both stemming from the specialized PEG coating.

Full Text

Duke Authors

Cited Authors

  • Kopelman, R; Xu, H; Yan, F; Monson, EE; Tang, W; Schneider, R; Philbert, MA

Published Date

  • January 1, 2002

Published In

Volume / Issue

  • 4626 /

Start / End Page

  • 383 - 393

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.472104

Citation Source

  • Scopus