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Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.

Publication ,  Journal Article
Hall, BJ; Slade, S; Allenby, C; Kutlu, MG; Levin, ED
Published in: Neuropharmacology
December 2015

Dopaminergic signaling has long been known to be a critical factor in nicotine addiction, as well as other drugs of abuse. Dopaminergic projections from the VTA to the nucleus accumbens and prefrontal cortex have been well established to be critical to the reinforcing effects of these drugs. However, other projections of dopamine neurons are likely to have significant roles in this process. Also, the relative contributions of D1 and D2 dopamine receptors in drug addiction and its treatment remain to be fully understood. In this study, we examined the effects of blocking D1 and D2 receptors in the nucleus accumbens shell (AcS), anterior cingulate cortex (ACC), and parietal association cortex (PtA) on nicotine self-administration in rats. Female Sprague-Dawley rats were fitted with jugular catheters and allowed to self-administer nicotine (0.03 mg/kg/infusion) on an FR1 schedule. Rats were fitted with bilateral infusion cannulae to allow infusion of D1 or D2 antagonists (SCH-23390 or haloperidol) into each targeted brain area. Acute local infusions of SCH-23390 (1-4 μg/side) into the AcS and PtA significantly reduced nicotine self-administration by up to 75%. SCH-23390 infusion into the ACC was less effective with only suggestive non-significant reductions of nicotine self-administration. Acute, local infusions of haloperidol (0.5-2 μg/side) in any of the brain regions targeted did not have significant effects on nicotine self-administration. These results demonstrate a more significant role for D1 receptor mechanisms in the process of nicotine reinforcement and help provide a more detailed neuroanatomic map of nicotine dependence in the brain.

Duke Scholars

Published In

Neuropharmacology

DOI

EISSN

1873-7064

Publication Date

December 2015

Volume

99

Start / End Page

689 / 695

Location

England

Related Subject Headings

  • Tobacco Use Disorder
  • Self Administration
  • Receptors, Dopamine D2
  • Receptors, Dopamine D1
  • Rats, Sprague-Dawley
  • Parietal Lobe
  • Nucleus Accumbens
  • Nicotinic Agonists
  • Nicotine
  • Neurology & Neurosurgery
 

Citation

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Hall, B. J., Slade, S., Allenby, C., Kutlu, M. G., & Levin, E. D. (2015). Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. Neuropharmacology, 99, 689–695. https://doi.org/10.1016/j.neuropharm.2015.03.005
Hall, Brandon J., Susan Slade, Cheyenne Allenby, Munir G. Kutlu, and Edward D. Levin. “Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.Neuropharmacology 99 (December 2015): 689–95. https://doi.org/10.1016/j.neuropharm.2015.03.005.
Hall BJ, Slade S, Allenby C, Kutlu MG, Levin ED. Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. Neuropharmacology. 2015 Dec;99:689–95.
Hall, Brandon J., et al. “Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.Neuropharmacology, vol. 99, Dec. 2015, pp. 689–95. Pubmed, doi:10.1016/j.neuropharm.2015.03.005.
Hall BJ, Slade S, Allenby C, Kutlu MG, Levin ED. Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. Neuropharmacology. 2015 Dec;99:689–695.
Journal cover image

Published In

Neuropharmacology

DOI

EISSN

1873-7064

Publication Date

December 2015

Volume

99

Start / End Page

689 / 695

Location

England

Related Subject Headings

  • Tobacco Use Disorder
  • Self Administration
  • Receptors, Dopamine D2
  • Receptors, Dopamine D1
  • Rats, Sprague-Dawley
  • Parietal Lobe
  • Nucleus Accumbens
  • Nicotinic Agonists
  • Nicotine
  • Neurology & Neurosurgery