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Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.

Publication ,  Journal Article
Jiang, Y; Li, YR; Tian, H; Ma, M; Matsunami, H
Published in: Nat Commun
March 24, 2015

The olfactory system in rodents serves a critical function in social, reproductive and survival behaviours. Processing of chemosensory signals in the brain is dynamically regulated in part by an animal's physiological state. We previously reported that type 3 muscarinic acetylcholine receptors (M3-Rs) physically interact with odorant receptors (ORs) to promote odour-induced responses in a heterologous expression system. However, it is not known how M3-Rs affect the ability of olfactory sensory neurons (OSNs) to respond to odours. Here, we show that an M3-R antagonist attenuates odour-induced responses in OSNs from wild-type, but not M3-R-null, mice. Using a novel molecular assay, we demonstrate that the activation of M3-Rs inhibits the recruitment of β-arrestin-2 to ORs, resulting in a potentiation of odour-induced responses in OSNs. These results suggest a role for acetylcholine in modulating olfactory processing at the initial stages of signal transduction in the olfactory system.

Duke Scholars

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

March 24, 2015

Volume

6

Start / End Page

6448

Location

England

Related Subject Headings

  • beta-Arrestins
  • beta-Arrestin 2
  • Type C Phospholipases
  • Receptors, Odorant
  • Receptor, Muscarinic M3
  • Pyrrolidines
  • Patch-Clamp Techniques
  • Olfactory Receptor Neurons
  • Odorants
  • Muscarinic Antagonists
 

Citation

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Jiang, Y., Li, Y. R., Tian, H., Ma, M., & Matsunami, H. (2015). Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment. Nat Commun, 6, 6448. https://doi.org/10.1038/ncomms7448
Jiang, Yue, Yun Rose Li, Huikai Tian, Minghong Ma, and Hiroaki Matsunami. “Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.Nat Commun 6 (March 24, 2015): 6448. https://doi.org/10.1038/ncomms7448.
Jiang, Yue, et al. “Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.Nat Commun, vol. 6, Mar. 2015, p. 6448. Pubmed, doi:10.1038/ncomms7448.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

March 24, 2015

Volume

6

Start / End Page

6448

Location

England

Related Subject Headings

  • beta-Arrestins
  • beta-Arrestin 2
  • Type C Phospholipases
  • Receptors, Odorant
  • Receptor, Muscarinic M3
  • Pyrrolidines
  • Patch-Clamp Techniques
  • Olfactory Receptor Neurons
  • Odorants
  • Muscarinic Antagonists