Hiroaki Matsunami
Professor of Molecular Genetics and Microbiology
We are interested in the molecular mechanisms underlying chemosensation (taste and smell) in mammals. The receptors that detect odorants, pheromones, and many tastants including bitter and sweet chemicals are G-protein coupled receptors (GPCRs), which typically have seven transmembrane domains. There are many important questions that are still unanswered in chemosensory neurobiology. How do tens of thousands of different chemicals (tastants, odorants, or pheromones) interact with more than one thousand chemosensory receptors (about 1000 odorant receptors, 40 taste receptors and 200 vomeronasal receptors in the case of mice or rats)? How is the information coded in sensory cells and in the brain? How does the brain direct appropriate behavioral responses? What are the mechanisms underlying development and regeneration of sensory cells and specific synapse connections? We address these questions using molecular biology, genome information and genetics.
The detection of tastants is mediated by taste receptor cells that are clustered in taste buds in the mouth. Interestingly, some people can taste certain chemicals, such as 6-n-propylthiouracil (a bitter compound) while others can't. Likewise, some strains of mice can taste certain bitter or sweet tastants while others can't. Based on these variations, the bitter and sweet taste loci have been mapped on human or mouse chromosomes. By using the increasingly powerful genome informatics tools, we as well as other groups, have identified families of GPCRs that may detect bitter and sweet compounds. We seek to understand how specific changes in nucleotide sequences cause these differences in taste sensitivity. Another goal is to understand how the gustatory system is organized.
In olfaction, the detection of volatile odorants is mediated by olfactory sensory neurons in the olfactory epithelium of the nose. Odorants are detected by about 1000 different types of odorant receptors that are encoded by a multigene family. Each olfactory sensory neuron expresses only one receptor type out of 1000 receptors. Axons of neurons expressing the same receptor all converge in a few glomeruli in the olfactory bulb of the brain. We wish to understand the mechanisms underlying this convergence.
Finally, we are interested in the pheromone sensing system. Pheromones are chemicals that are released from animals and induce innate behavior, such as mating or aggression, or hormonal changes in members of the same species.
The detection of pheromones is mediated primarily by a second olfactory sense organ, called the vomeronasal organ (VNO). We, as well as other groups, have found families of candidate pheromone receptors by comparing gene expression between single VNO neurons. Pheromone molecules may induce their effects by activating some of these receptors, which ultimately affect particular regions of the brain. We seek to understand how these pheromonal effects are mediated.
The detection of tastants is mediated by taste receptor cells that are clustered in taste buds in the mouth. Interestingly, some people can taste certain chemicals, such as 6-n-propylthiouracil (a bitter compound) while others can't. Likewise, some strains of mice can taste certain bitter or sweet tastants while others can't. Based on these variations, the bitter and sweet taste loci have been mapped on human or mouse chromosomes. By using the increasingly powerful genome informatics tools, we as well as other groups, have identified families of GPCRs that may detect bitter and sweet compounds. We seek to understand how specific changes in nucleotide sequences cause these differences in taste sensitivity. Another goal is to understand how the gustatory system is organized.
In olfaction, the detection of volatile odorants is mediated by olfactory sensory neurons in the olfactory epithelium of the nose. Odorants are detected by about 1000 different types of odorant receptors that are encoded by a multigene family. Each olfactory sensory neuron expresses only one receptor type out of 1000 receptors. Axons of neurons expressing the same receptor all converge in a few glomeruli in the olfactory bulb of the brain. We wish to understand the mechanisms underlying this convergence.
Finally, we are interested in the pheromone sensing system. Pheromones are chemicals that are released from animals and induce innate behavior, such as mating or aggression, or hormonal changes in members of the same species.
The detection of pheromones is mediated primarily by a second olfactory sense organ, called the vomeronasal organ (VNO). We, as well as other groups, have found families of candidate pheromone receptors by comparing gene expression between single VNO neurons. Pheromone molecules may induce their effects by activating some of these receptors, which ultimately affect particular regions of the brain. We seek to understand how these pheromonal effects are mediated.
Current Appointments & Affiliations
- Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2015
- Professor of Neurobiology, Neurobiology, Basic Science Departments 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2001
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011
- Professor of Cell BIology, Cell Biology, Basic Science Departments 2022
- Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2017
Contact Information
- 264 CARL Bldg, Durham, NC 27710
- Duke Box 3054, Durham, NC 27710
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matsu004@mc.duke.edu
(919) 684-2777
- Background
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Education, Training, & Certifications
- Ph.D., Kyoto University (Japan) 1996
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Previous Appointments & Affiliations
- Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2008 - 2015
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2009 - 2015
- Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2002 - 2009
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2008
- Assistant Professor of Genetics, School of Medicine, Duke University 2001 - 2002
- Recognition
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In the News
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JAN 26, 2023 Duke Today -
JAN 11, 2021 Duke Health News -
NOV 19, 2018 -
MAY 29, 2018 -
SEP 25, 2015 -
AUG 14, 2014 -
DEC 30, 2013 Huffington Post -
DEC 13, 2013
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Awards & Honors
- Research
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Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Otolaryngology Surgeon- Scientist career Path (OSSP) program awarded by National Institutes of Health 2022 - 2027
- Enhancing olfactory receptor expression for biochemical studies of odorant-receptor interactions awarded by National Institutes of Health 2022 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- NeuroNex: From Odor to Action: Discovering Principles of Olfactory-Guided Natural Behavior awarded by University of Colorado - Boulder 2020 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- The neurotransmitter for calorie awarded by National Institutes of Health 2021 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Develop new recombinant expression system for human OR's awarded by Givaudan International 2021 - 2023
- Preparing Genetic Counselors for Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- Biogenesis of olfactory G protein-coupled receptors awarded by National Institutes of Health 2017 - 2023
- Copper Homeostasis in Mammals awarded by National Institutes of Health 2004 - 2023
- Engineering bioHybrid chemical sensing systems for diagnostic odor detection awarded by University of Washington 2021 - 2022
- Understanding of G protein-coupled odorant receptors function awarded by National Institutes of Health 2020 - 2022
- High-throughput mapping of mammalian olfactory glomeruli receptor identity by targeted transcriptomics awarded by National Institutes of Health 2018 - 2021
- Peripheral Odor Coding in Mammals awarded by National Institutes of Health 2015 - 2021
- In vivo patterns of receptor activation by odorants awarded by University of Kentucky 2015 - 2020
- Collaborative Research: Analysis of the Mammalian Olfactory Code awarded by National Science Foundation 2015 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Olfactory moding in mammals awarded by University of Pennsylvania 2015 - 2020
- US-France Research Proposal: Predicting odorant-dependent and independent olfactory neuron activation based on receptor awarded by National Science Foundation 2015 - 2019
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- NSF sponsored conference awarded by National Science Foundation 2017 - 2018
- BRAIN EAGER: Solving the Code of Olfaction Using Nano-Robot Switchable Odorants awarded by National Science Foundation 2014 - 2017
- Building archaic hominin olfactory receptors: a functional approach to paleogenomes awarded by University of Alaska - Fairbanks 2015 - 2017
- Modulation of Odorant Receptor Function awarded by National Institutes of Health 2012 - 2017
- Gene expression Profiling in Mammalian Taste Tissue awarded by International Flavors and Fragrances 2015 - 2017
- Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
- Automated Library Preparation System for Next-Generation Sequencing awarded by North Carolina Biotechnology Center 2014 - 2015
- Molecular Mechanisms Underlying Odorant Recognition awarded by National Institutes of Health 2002 - 2014
- Variability in the human odorant receptor repertoire awarded by National Institutes of Health 2010 - 2011
- The Genetic Basis of Specific Anosmia awarded by National Institutes of Health 2007 - 2010
- The in vivo roles of PKD1L3 and PKD2L1 in sour taste detection awarded by National Institutes of Health 2007 - 2010
- Molecular Mechanisms Underlying Specific Anosmia and Sensitization awarded by National Institutes of Health 2006 - 2007
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External Relationships
- Amazon
- CNRS
- Chemcom
- Givaudan
- Kao
- Koniku
- Tokyo University of Agriculture and Technology
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Abaffy, Tatjana, Hsiu-Yi Lu, and Hiroaki Matsunami. “Sex steroid hormone synthesis, metabolism, and the effects on the mammalian olfactory system.” Cell Tissue Res 391, no. 1 (January 2023): 19–42. https://doi.org/10.1007/s00441-022-03707-9.Full Text Link to Item
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March, Claire A. de, Hiroaki Matsunami, Masashi Abe, Matthew Cobb, and Kara C. Hoover. “Genetic and functional odorant receptor variation in the Homo lineage.” Iscience 26, no. 1 (January 2023): 105908. https://doi.org/10.1016/j.isci.2022.105908.Full Text
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Finlay, John B., David H. Brann, Ralph Abi Hachem, David W. Jang, Allison D. Oliva, Tiffany Ko, Rupali Gupta, et al. “Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium.” Sci Transl Med 14, no. 676 (December 21, 2022): eadd0484. https://doi.org/10.1126/scitranslmed.add0484.Full Text Link to Item
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Yoshikawa, Keiichi, Jun Deguchi, Jieying Hu, Hsiu-Yi Lu, and Hiroaki Matsunami. “An odorant receptor that senses four classes of musk compounds.” Curr Biol 32, no. 23 (December 5, 2022): 5172-5179.e5. https://doi.org/10.1016/j.cub.2022.10.038.Full Text Link to Item
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Zhu, Kevin W., Shawn D. Burton, Maira H. Nagai, Justin D. Silverman, Claire A. de March, Matt Wachowiak, and Hiroaki Matsunami. “Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli.” Nat Commun 13, no. 1 (September 1, 2022): 5137. https://doi.org/10.1038/s41467-022-32267-3.Full Text Link to Item
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Xu, Rui, Xiaojing Cong, Qian Zheng, Lun Xu, Mengjue J. Ni, Claire A. de March, Hiroaki Matsunami, Jérôme Golebiowski, Minghong Ma, and Yiqun Yu. “Interactions among key residues regulate mammalian odorant receptor trafficking.” Faseb J 36, no. 7 (July 2022): e22384. https://doi.org/10.1096/fj.202200116RR.Full Text Link to Item
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Cong, Xiaojing, Wenwen Ren, Jody Pacalon, Rui Xu, Lun Xu, Xuewen Li, Claire A. de March, et al. “Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing.” Acs Cent Sci 8, no. 3 (March 23, 2022): 379–87. https://doi.org/10.1021/acscentsci.1c01495.Full Text Link to Item
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Ghosh, Soumadwip, Claire A. de March, Sergio Branciamore, Sahar Kaleem, Hiroaki Matsunami, and Nagarajan Vaidehi. “Sequence coevolution and structure stabilization modulate olfactory receptor expression.” Biophys J 121, no. 5 (March 1, 2022): 830–40. https://doi.org/10.1016/j.bpj.2022.01.015.Full Text Link to Item
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Oliva, Allison D., Rupali Gupta, Khalil Issa, Ralph Abi Hachem, David W. Jang, Sebastian A. Wellford, E Ashley Moseman, Hiroaki Matsunami, and Bradley J. Goldstein. “Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans.” J Clin Invest 132, no. 4 (February 15, 2022). https://doi.org/10.1172/JCI155506.Full Text Link to Item
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Orecchioni, Marco, Kouji Kobiyama, Holger Winkels, Yanal Ghosheh, Sara McArdle, Zbigniew Mikulski, William B. Kiosses, et al. “Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.” Science 375, no. 6577 (January 14, 2022): 214–21. https://doi.org/10.1126/science.abg3067.Full Text Link to Item
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Orecchioni, Marco, Hiroaki Matsunami, and Klaus Ley. “Olfactory receptors in macrophages and inflammation.” Front Immunol 13 (2022): 1029244. https://doi.org/10.3389/fimmu.2022.1029244.Full Text Link to Item
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Fukutani, Yosuke, Yuko Nakamura, Nonoko Muto, Shunta Miyanaga, Reina Kanemaki, Kentaro Ikegami, Keiichi Noguchi, Ikuroh Ohsawa, Hiroaki Matsunami, and Masafumi Yohda. “Hot Spot Mutagenesis Improves the Functional Expression of Unique Mammalian Odorant Receptors.” Int J Mol Sci 23, no. 1 (December 28, 2021). https://doi.org/10.3390/ijms23010277.Full Text Link to Item
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Jabeen, Amara, Claire A. de March, Hiroaki Matsunami, and Shoba Ranganathan. “Machine Learning Assisted Approach for Finding Novel High Activity Agonists of Human Ectopic Olfactory Receptors.” Int J Mol Sci 22, no. 21 (October 26, 2021). https://doi.org/10.3390/ijms222111546.Full Text Link to Item
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Koldaeva, Anzhelika, Cary Zhang, Yu-Pei Huang, Janine Kristin Reinert, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Taha Soliman, Hiroaki Matsunami, and Izumi Fukunaga. “Generation and Characterization of a Cell Type-Specific, Inducible Cre-Driver Line to Study Olfactory Processing.” J Neurosci 41, no. 30 (July 28, 2021): 6449–67. https://doi.org/10.1523/JNEUROSCI.3076-20.2021.Full Text Link to Item
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Abaffy, Tatjana, and Hiroaki Matsunami. “19-hydroxy Steroids in the Aromatase Reaction: Review on Expression and Potential Functions.” J Endocr Soc 5, no. 7 (July 1, 2021): bvab050. https://doi.org/10.1210/jendso/bvab050.Full Text Link to Item
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Choe, Ha Na, Jeevan Tewari, Kevin W. Zhu, Matthew Davenport, Hiroaki Matsunami, and Erich D. Jarvis. “Estrogen and sex-dependent loss of the vocal learning system in female zebra finches.” Horm Behav 129 (March 2021): 104911. https://doi.org/10.1016/j.yhbeh.2020.104911.Full Text Link to Item
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Vihani, Aashutosh, Maira Nagai, Conan Juan, Claire de March, Xiaoyang Hu, John Pearson, and Hiroaki Matsunami. “Encoding of odors by mammalian olfactory receptors,” 2021. https://doi.org/10.1101/2021.12.27.474279.Full Text
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Kaba, Hideto, Hiroko Fujita, Takeshi Agatsuma, and Hiroaki Matsunami. “Maternally inherited peptides as strain-specific chemosignals.” Proc Natl Acad Sci U S A 117, no. 48 (December 1, 2020): 30738–43. https://doi.org/10.1073/pnas.2014712117.Full Text Link to Item
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Vihani, Aashutosh, Xiaoyang Serene Hu, Sivaji Gundala, Sachiko Koyama, Eric Block, and Hiroaki Matsunami. “Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic.” Elife 9 (November 24, 2020). https://doi.org/10.7554/eLife.54501.Full Text Link to Item
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Brann, David H., Tatsuya Tsukahara, Caleb Weinreb, Marcela Lipovsek, Koen Van den Berge, Boying Gong, Rebecca Chance, et al. “Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.” Sci Adv 6, no. 31 (July 31, 2020). https://doi.org/10.1126/sciadv.abc5801.Full Text Link to Item
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March, Claire A. de, William B. Titlow, Tomoko Sengoku, Patrick Breheny, Hiroaki Matsunami, and Timothy S. McClintock. “Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.” Mol Cell Neurosci 104 (April 2020): 103469. https://doi.org/10.1016/j.mcn.2020.103469.Full Text Link to Item
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Durante, Michael A., Stefan Kurtenbach, Zoukaa B. Sargi, J William Harbour, Rhea Choi, Sarah Kurtenbach, Garrett M. Goss, Hiroaki Matsunami, and Bradley J. Goldstein. “Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.” Nat Neurosci 23, no. 3 (March 2020): 323–26. https://doi.org/10.1038/s41593-020-0587-9.Full Text Link to Item
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Ikegami, Kentaro, Claire A. de March, Maira H. Nagai, Soumadwip Ghosh, Matthew Do, Ruchira Sharma, Elise S. Bruguera, et al. “Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors.” Proc Natl Acad Sci U S A 117, no. 6 (February 11, 2020): 2957–67. https://doi.org/10.1073/pnas.1915520117.Full Text Link to Item
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Hunnicutt, Kelsie E., George P. Tiley, Rachel C. Williams, Peter A. Larsen, Marina B. Blanco, Rodin M. Rasoloarison, C Ryan Campbell, et al. “Comparative Genomic Analysis of the Pheromone Receptor Class 1 Family (V1R) Reveals Extreme Complexity in Mouse Lemurs (Genus, Microcebus) and a Chromosomal Hotspot across Mammals.” Genome Biol Evol 12, no. 1 (January 1, 2020): 3562–79. https://doi.org/10.1093/gbe/evz200.Full Text Link to Item
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Hu, Xiaoyang Serene, Kentaro Ikegami, Aashutosh Vihani, Kevin W. Zhu, Marcelo Zapata, Claire A. de March, Matthew Do, et al. “Concentration-Dependent Recruitment of Mammalian Odorant Receptors.” Eneuro 7, no. 2 (2020). https://doi.org/10.1523/ENEURO.0103-19.2019.Full Text Link to Item
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Zamparo, Ilaria, Simona Francia, Sira Angela Franchi, Nelly Redolfi, Elisa Costanzi, Axelle Kerstens, Yosuke Fukutani, et al. “Axonal Odorant Receptors Mediate Axon Targeting.” Cell Rep 29, no. 13 (December 24, 2019): 4334-4348.e7. https://doi.org/10.1016/j.celrep.2019.11.099.Full Text Link to Item
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Fukutani, Yosuke, Ryohei Tamaki, Ryosuke Inoue, Tomoyo Koshizawa, Shuto Sakashita, Kentaro Ikegami, Ikuroh Ohsawa, Hiroaki Matsunami, and Masafumi Yohda. “The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking.” J Biol Chem 294, no. 40 (October 4, 2019): 14661–73. https://doi.org/10.1074/jbc.RA118.007110.Full Text Link to Item
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Trimmer, C., A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland. “Genetic variation across the human olfactory receptor repertoire alters odor perception.” Proc Natl Acad Sci U S A 116, no. 19 (May 7, 2019): 9475–80. https://doi.org/10.1073/pnas.1804106115.Full Text Link to Item
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March, Claire A. de, Yosuke Fukutani, Aashutosh Vihani, Hitoshi Kida, and Hiroaki Matsunami. “Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase.” J Vis Exp, no. 146 (April 23, 2019). https://doi.org/10.3791/59446.Full Text Link to Item
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Jones, Eric M., Rishi Jajoo, Daniel Cancilla, Nathan B. Lubock, Jeffrey Wang, Megan Satyadi, Rocky Cheung, et al. “A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing.” Cell Syst 8, no. 3 (March 27, 2019): 254-260.e6. https://doi.org/10.1016/j.cels.2019.02.009.Full Text Link to Item
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Bushdid, Caroline, Claire A. de March, Jérémie Topin, Matthew Do, Hiroaki Matsunami, and Jérôme Golebiowski. “Mammalian class I odorant receptors exhibit a conserved vestibular-binding pocket.” Cell Mol Life Sci 76, no. 5 (March 2019): 995–1004. https://doi.org/10.1007/s00018-018-2996-4.Full Text Link to Item
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Koyama, Sachiko, Anna Purk, Manpreet Kaur, Helena A. Soini, Milos V. Novotny, Keith Davis, C Cheng Kao, Hiroaki Matsunami, and Anthony Mescher. “Beta-caryophyllene enhances wound healing through multiple routes.” Plos One 14, no. 12 (2019): e0216104. https://doi.org/10.1371/journal.pone.0216104.Full Text Link to Item
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Kida, Hitoshi, Yosuke Fukutani, Joel D. Mainland, Claire A. de March, Aashutosh Vihani, Yun Rose Li, Qiuyi Chi, et al. “Vapor detection and discrimination with a panel of odorant receptors.” Nat Commun 9, no. 1 (November 1, 2018): 4556. https://doi.org/10.1038/s41467-018-06806-w.Full Text Link to Item
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Torres-Torrelo, Hortensia, Patricia Ortega-Sáenz, David Macías, Masayo Omura, Ting Zhou, Hiroaki Matsunami, Randall S. Johnson, Peter Mombaerts, and José López-Barneo. “The role of Olfr78 in the breathing circuit of mice.” Nature 561, no. 7724 (September 2018): E33–40. https://doi.org/10.1038/s41586-018-0545-9.Full Text Link to Item
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Bushdid, C., C. A. de March, S. Fiorucci, H. Matsunami, and J. Golebiowski. “Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features.” J Phys Chem Lett 9, no. 9 (May 3, 2018): 2235–40. https://doi.org/10.1021/acs.jpclett.8b00633.Full Text Link to Item
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Zhou, Ting, and Hiroaki Matsunami. “Lessons from single-cell transcriptome analysis of oxygen-sensing cells.” Cell Tissue Res 372, no. 2 (May 2018): 403–15. https://doi.org/10.1007/s00441-017-2682-0.Full Text Link to Item
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Ahmed, Lucky, Yuetian Zhang, Eric Block, Michael Buehl, Michael J. Corr, Rodrigo A. Cormanich, Sivaji Gundala, et al. “Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.” Proc Natl Acad Sci U S A 115, no. 17 (April 24, 2018): E3950–58. https://doi.org/10.1073/pnas.1713026115.Full Text Link to Item
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March, Claire A. de, Jérémie Topin, Elise Bruguera, Gleb Novikov, Kentaro Ikegami, Hiroaki Matsunami, and Jérôme Golebiowski. “Odorant Receptor 7D4 Activation Dynamics.” Angew Chem Int Ed Engl 57, no. 17 (April 16, 2018): 4554–58. https://doi.org/10.1002/anie.201713065.Full Text Link to Item
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Liu, Min Ting, Jianghai Ho, Jason Karl Liu, Radhanath Purakait, Uriel N. Morzan, Lucky Ahmed, Victor S. Batista, Hiroaki Matsunami, and Kevin Ryan. “Carbon chain shape selectivity by the mouse olfactory receptor OR-I7.” Org Biomol Chem 16, no. 14 (April 4, 2018): 2541–48. https://doi.org/10.1039/C8OB00205C.Full Text Link to Item
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Behrens, Maik, Loïc Briand, Claire A. de March, Hiroaki Matsunami, Atsuko Yamashita, Wolfgang Meyerhof, and Simone Weyand. “Structure-Function Relationships of Olfactory and Taste Receptors.” Chem Senses 43, no. 2 (February 2, 2018): 81–87. https://doi.org/10.1093/chemse/bjx083.Full Text Link to Item
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E, Lezi, Ting Zhou, Sehwon Koh, Marian Chuang, Ruchira Sharma, Nathalie Pujol, Andrew D. Chisholm, Cagla Eroglu, Hiroaki Matsunami, and Dong Yan. “An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection.” Neuron 97, no. 1 (January 3, 2018): 125-138.e5. https://doi.org/10.1016/j.neuron.2017.12.001.Full Text Open Access Copy Link to Item
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Abaffy, Tatjana, James R. Bain, Michael J. Muehlbauer, Ivan Spasojevic, Shweta Lodha, Elisa Bruguera, Sara K. O’Neal, So Young Kim, and Hiroaki Matsunami. “A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor.” Front Oncol 8 (2018): 162. https://doi.org/10.3389/fonc.2018.00162.Full Text Open Access Copy Link to Item
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Bushdid, Caroline, Claire A. de March, Hiroaki Matsunami, and Jérôme Golebiowski. “Numerical Models and In Vitro Assays to Study Odorant Receptors.” Methods Mol Biol 1820 (2018): 77–93. https://doi.org/10.1007/978-1-4939-8609-5_7.Full Text Link to Item
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Hu, Xiaoyang Serene, and Hiroaki Matsunami. “High-Throughput Odorant Receptor Deorphanization Via Phospho-S6 Ribosomal Protein Immunoprecipitation and mRNA Profiling.” Methods Mol Biol 1820 (2018): 95–112. https://doi.org/10.1007/978-1-4939-8609-5_8.Full Text Link to Item
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Zhang, Yuetian, Yi Pan, Hiroaki Matsunami, and Hanyi Zhuang. “Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay.” J Vis Exp, no. 128 (October 2, 2017). https://doi.org/10.3791/55831.Full Text Link to Item
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Asakawa, Masashi, Yosuke Fukutani, Aulaphan Savangsuksa, Keiich Noguchi, Hiroaki Matsunami, and Masafumi Yohda. “Modification of the response of olfactory receptors to acetophenone by CYP1a2.” Sci Rep 7, no. 1 (August 31, 2017): 10167. https://doi.org/10.1038/s41598-017-10862-5.Full Text Link to Item
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Fukutani, Yosuke, Jun Ishii, Akihiko Kondo, Takeaki Ozawa, Hiroaki Matsunami, and Masafumi Yohda. “Split luciferase complementation assay for the analysis of G protein-coupled receptor ligand response in Saccharomyces cerevisiae.” Biotechnol Bioeng 114, no. 6 (June 2017): 1354–61. https://doi.org/10.1002/bit.26255.Full Text Link to Item
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Block, Eric, Victor S. Batista, Hiroaki Matsunami, Hanyi Zhuang, and Lucky Ahmed. “The role of metals in mammalian olfaction of low molecular weight organosulfur compounds.” Nat Prod Rep 34, no. 5 (May 10, 2017): 529–57. https://doi.org/10.1039/c7np00016b.Full Text Link to Item
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Ibarra-Soria, Ximena, Thiago S. Nakahara, Jingtao Lilue, Yue Jiang, Casey Trimmer, Mateus Aa Souza, Paulo Hm Netto, et al. “Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.” Elife 6 (April 25, 2017). https://doi.org/10.7554/eLife.21476.Full Text Link to Item
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Sharma, Ruchira, Yoshiro Ishimaru, Ian Davison, Kentaro Ikegami, Ming-Shan Chien, Helena You, Quiyi Chi, et al. “Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice.” Elife 6 (March 6, 2017). https://doi.org/10.7554/eLife.21895.Full Text Link to Item
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Asakawa, Masahi, Yosuke Fukutani, Aulaphan Savangsuksa, Hiroaki Matsunami, and Masafumi Yohda. “Effect of cytochrome P450 on the response of olfactory receptor.” Chemical Senses 41, no. 9 (November 1, 2016): E159–E159.Link to Item
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Fukutani, Yosuke, Ryohei Tamaki, Kentaro Ikegami, Hiroaki Matsunami, and Masafumi Yohda. “Improving the odorant sensitivity of olfactory receptor-expressing yeast with accessory proteins.” Chemical Senses 41, no. 9 (November 1, 2016): E211–E211.Link to Item
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Hu, Xiaoyang Serene, Yue Jiang, Kentaro Ikegami, and Hiroaki Matsunami. “Receptor repertoire for aversive odorants.” Chemical Senses 41, no. 9 (November 1, 2016): E252–E252.Link to Item
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Ikegami, Kentaro, Ruchira Sharma, Elise Bruguera, Masafumi Yohda, and Hiroaki Matsunami. “Synergistic control of olfactory receptor trafficking to the cell surface membrane in heterologous cells.” Chemical Senses 41, no. 9 (November 1, 2016): E252–E252.Link to Item
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Kida, Hitoshi, Aashutosh Vihani, Joel Mainland, and Hiroaki Matsunami. “Vapor detection and discrimination with a panel of odorant receptors expressed in heterologous cells.” Chemical Senses 41, no. 9 (November 1, 2016): E262–63.Link to Item
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March, Claire A. de, Elise Bruguera, Jeremie Jacques Topin, Hiroaki Matsunami, and Jerome Golebiowski. “Molecular dynamics simulations reveal the ligand-dependent activation of hOR7D4.” Chemical Senses 41, no. 9 (November 1, 2016): E157–E157.Link to Item
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Matsunami, Hiro. “Mammalian odorant receptors: Heterologous expression and deorphanization.” Chemical Senses 41, no. 9 (November 1, 2016): E123–E123.Link to Item
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Sharma, Ruchira, Yoshi Ishimaru, Ian Davison, Kentaro Ikegami, and Hiroaki Matsunami. “Olfactory receptor accessory proteins RTP1 and RTP2 play a crucial role in receptor gene choice, development and odor detection.” Chemical Senses 41, no. 9 (November 1, 2016): E253–E253.Link to Item
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Trimmer, Casey, Jason R. Willer, Andreas Keller, Leslie B. Vosshall, Nicholas Katsanis, Hiroaki Matsunami, and Joel Mainland. “Examining the variable influence of population structure on odor perception.” Chemical Senses 41, no. 9 (November 1, 2016): E255–E255.Link to Item
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Li, Shengju, Lucky Ahmed, Ruina Zhang, Yi Pan, Hiroaki Matsunami, Jessica L. Burger, Eric Block, Victor S. Batista, and Hanyi Zhuang. “Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols.” J Am Chem Soc 138, no. 40 (October 12, 2016): 13281–88. https://doi.org/10.1021/jacs.6b06983.Full Text Link to Item
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Olender, Tsviya, Ifat Keydar, Jayant M. Pinto, Pavlo Tatarskyy, Anna Alkelai, Ming-Shan Chien, Simon Fishilevich, et al. “The human olfactory transcriptome.” Bmc Genomics 17, no. 1 (August 11, 2016): 619. https://doi.org/10.1186/s12864-016-2960-3.Full Text Link to Item
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Zhou, Ting, Ming-Shan Chien, Safa Kaleem, and Hiroaki Matsunami. “Single cell transcriptome analysis of mouse carotid body glomus cells.” J Physiol 594, no. 15 (August 1, 2016): 4225–51. https://doi.org/10.1113/JP271936.Full Text Link to Item
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Yu, Yiqun, Claire A. de March, Mengjue J. Ni, Kaylin A. Adipietro, Jérôme Golebiowski, Hiroaki Matsunami, and Minghong Ma. “Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism.” Proc Natl Acad Sci U S A 112, no. 48 (December 1, 2015): 14966–71. https://doi.org/10.1073/pnas.1517510112.Full Text Link to Item
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Jiang, Yue, and Hiroaki Matsunami. “Mammalian odorant receptors: functional evolution and variation.” Curr Opin Neurobiol 34 (October 2015): 54–60. https://doi.org/10.1016/j.conb.2015.01.014.Full Text Link to Item
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Jiang, Yue, Naihua Natalie Gong, Xiaoyang Serene Hu, Mengjue Jessica Ni, Radhika Pasi, and Hiroaki Matsunami. “Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo.” Nat Neurosci 18, no. 10 (October 2015): 1446–54. https://doi.org/10.1038/nn.4104.Full Text Link to Item
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Hoover, Kara C., Omer Gokcumen, Zoya Qureshy, Elise Bruguera, Aulaphan Savangsuksa, Matthew Cobb, and Hiroaki Matsunami. “Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution.” Chem Senses 40, no. 7 (September 2015): 481–88. https://doi.org/10.1093/chemse/bjv030.Full Text Link to Item
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March, Claire A. de, Yiqun Yu, Mengjue J. Ni, Kaylin A. Adipietro, Hiroaki Matsunami, Minghong Ma, and Jérôme Golebiowski. “Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors.” J Am Chem Soc 137, no. 26 (July 8, 2015): 8611–16. https://doi.org/10.1021/jacs.5b04659.Full Text Link to Item
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Block, Eric, Seogjoo Jang, Hiroaki Matsunami, Victor S. Batista, and Hanyi Zhuang. “Reply to Turin et al.: Vibrational theory of olfaction is implausible.” Proc Natl Acad Sci U S A 112, no. 25 (June 23, 2015): E3155. https://doi.org/10.1073/pnas.1508443112.Full Text Link to Item
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Dey, Sandeepa, Pablo Chamero, James K. Pru, Ming-Shan Chien, Ximena Ibarra-Soria, Kathryn R. Spencer, Darren W. Logan, Hiroaki Matsunami, John J. Peluso, and Lisa Stowers. “Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior.” Cell 161, no. 6 (June 4, 2015): 1334–44. https://doi.org/10.1016/j.cell.2015.04.052.Full Text Link to Item
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Block, Eric, Seogjoo Jang, Hiroaki Matsunami, Sivakumar Sekharan, Bérénice Dethier, Mehmed Z. Ertem, Sivaji Gundala, et al. “Implausibility of the vibrational theory of olfaction.” Proc Natl Acad Sci U S A 112, no. 21 (May 26, 2015): E2766–74. https://doi.org/10.1073/pnas.1503054112.Full Text Link to Item
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Ho, Jianghai, Jose Manuel Perez-Aguilar, Lu Gao, Jeffery G. Saven, Hiroaki Matsunami, and Roderic G. Eckenhoff. “Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors.” Sci Signal 8, no. 370 (March 31, 2015): ra33. https://doi.org/10.1126/scisignal.2005912.Full Text Link to Item
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Jiang, Yue, Yun Rose Li, Huikai Tian, Minghong Ma, and Hiroaki Matsunami. “Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.” Nat Commun 6 (March 24, 2015): 6448. https://doi.org/10.1038/ncomms7448.Full Text Link to Item
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Fukutani, Yosuke, Ayaka Hori, Satoshi Tsukada, Ryoichi Sato, Jun Ishii, Akihiko Kondo, Hiroaki Matsunami, and Masafumi Yohda. “Improving the odorant sensitivity of olfactory receptor-expressing yeast with accessory proteins.” Anal Biochem 471 (February 15, 2015): 1–8. https://doi.org/10.1016/j.ab.2014.10.012.Full Text Link to Item
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Mainland, Joel D., Yun R. Li, Ting Zhou, Wen Ling L. Liu, and Hiroaki Matsunami. “Human olfactory receptor responses to odorants.” Sci Data 2 (2015): 150002. https://doi.org/10.1038/sdata.2015.2.Full Text Link to Item
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Li, Yadi, Zita Peterlin, Jianghai Ho, Tali Yarnitzky, Min Ting Liu, Merav Fichman, Masha Y. Niv, Hiroaki Matsunami, Stuart Firestein, and Kevin Ryan. “Aldehyde recognition and discrimination by mammalian odorant receptors via functional group-specific hydration chemistry.” Acs Chem Biol 9, no. 11 (November 21, 2014): 2563–71. https://doi.org/10.1021/cb400290u.Full Text Link to Item
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McClintock, Timothy S., Kaylin Adipietro, William B. Titlow, Patrick Breheny, Andreas Walz, Peter Mombaerts, and Hiroaki Matsunami. “In vivo identification of eugenol-responsive and muscone-responsive mouse odorant receptors.” J Neurosci 34, no. 47 (November 19, 2014): 15669–78. https://doi.org/10.1523/JNEUROSCI.3625-14.2014.Full Text Link to Item
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Jiang, Yue, Sandeepa Dey, and Hiroaki Matsunami. “Calreticulin: roles in cell-surface protein expression.” Membranes (Basel) 4, no. 3 (September 16, 2014): 630–41. https://doi.org/10.3390/membranes4030630.Full Text Link to Item
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Sekharan, Sivakumar, Mehmed Z. Ertem, Hanyi Zhuang, Eric Block, Hiroaki Matsunami, Ruina Zhang, Jennifer N. Wei, Yi Pan, and Victor S. Batista. “QM/MM model of the mouse olfactory receptor MOR244-3 validated by site-directed mutagenesis experiments.” Biophys J 107, no. 5 (September 2, 2014): L5–8. https://doi.org/10.1016/j.bpj.2014.07.031.Full Text Link to Item
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Jiang, Yue, Naihua N. Gong, and Hiroaki Matsunami. “Astringency: a more stringent definition.” Chem Senses 39, no. 6 (July 2014): 467–69. https://doi.org/10.1093/chemse/bju021.Full Text Link to Item
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Mainland, J. D., A. Keller, Y. R. Li, T. Zhou, C. Trimmer, L. L. Snyder, A. H. Moberly, et al. “The missense of smell: Functional variability in the human odorant receptor repertoire.” Nature Neuroscience 17, no. 1 (January 1, 2014): 114–20. https://doi.org/10.1038/nn.3598.Full Text
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Mainland, Joel D., Andreas Keller, Yun R. Li, Ting Zhou, Casey Trimmer, Lindsey L. Snyder, Andrew H. Moberly, et al. “The missense of smell: functional variability in the human odorant receptor repertoire.” Nat Neurosci 17, no. 1 (January 2014): 114–20. https://doi.org/10.1038/nn.3598.Full Text Open Access Copy Link to Item
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Li, Yadi, Zita Peterlin, Jianghai Ho, Tali Yarnitzky, Min Ting Liu, Merav Fichman, Masha Y. Niv, Hiroaki Matsunami, Stuart Firestein, and Kevin Ryan. “Aldehyde Recognition and Discrimination by Mammalian Odorant Receptors via Functional Group-Specific Hydration Chemistry.” Acs Chemical Biology 9, no. 11 (2014): 2563–71. https://doi.org/10.1021/cb400290u.Full Text Link to Item
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Mainland, J. D., J. R. Willer, H. Matsunami, and N. R. Katsanis. “Next-generation sequencing of the human olfactory receptors.” Methods in Molecular Biology 1003 (December 1, 2013): 133–47. https://doi.org/10.1007/978-1-62703-377-0-10.Full Text
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Li, Yun Rose, and Hiroaki Matsunami. “Unfolding the mystery of olfactory receptor gene expression.” Dev Cell 27, no. 2 (October 28, 2013): 128–29. https://doi.org/10.1016/j.devcel.2013.10.012.Full Text Link to Item
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Chien, M. -. S., and H. Matsunami. “Characterization of allelic-biased genes in single olfactory neurons.” Molecular Biology of the Cell 24 (January 1, 2013).Link to Item
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Keydar, Ifat, Edna Ben-Asher, Ester Feldmesser, Noam Nativ, Arisa Oshimoto, Diego Restrepo, Hiroaki Matsunami, et al. “General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations.” Hum Mutat 34, no. 1 (January 2013): 32–41. https://doi.org/10.1002/humu.22212.Full Text Link to Item
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Dey, Sandeepa, Senmiao Zhan, and Hiroaki Matsunami. “A protocol for heterologous expression and functional assay for mouse pheromone receptors.” Methods Mol Biol 1068 (2013): 121–31. https://doi.org/10.1007/978-1-62703-619-1_9.Full Text Link to Item
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Mainland, Joel D., Jason R. Willer, Hiroaki Matsunami, and Nicholas Katsanis. “Next-generation sequencing of the human olfactory receptors.” Methods Mol Biol 1003 (2013): 133–47. https://doi.org/10.1007/978-1-62703-377-0_10.Full Text Link to Item
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McRae, Jeremy F., Joel D. Mainland, Sara R. Jaeger, Kaylin A. Adipietro, Hiroaki Matsunami, and Richard D. Newcomb. “Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol.” Chem Senses 37, no. 7 (September 2012): 585–93. https://doi.org/10.1093/chemse/bjs049.Full Text Link to Item
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Wu, Lifang, Yi Pan, Guo-Qiang Chen, Hiroaki Matsunami, and Hanyi Zhuang. “Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps.” J Biol Chem 287, no. 26 (June 22, 2012): 22287–94. https://doi.org/10.1074/jbc.M112.345884.Full Text Link to Item
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Duan, Xufang, Eric Block, Zhen Li, Timothy Connelly, Jian Zhang, Zhimin Huang, Xubo Su, et al. “Crucial role of copper in detection of metal-coordinating odorants.” Proc Natl Acad Sci U S A 109, no. 9 (February 28, 2012): 3492–97. https://doi.org/10.1073/pnas.1111297109.Full Text Link to Item
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Adipietro, Kaylin A., Joel D. Mainland, and Hiroaki Matsunami. “Functional evolution of mammalian odorant receptors.” Plos Genet 8, no. 7 (2012): e1002821. https://doi.org/10.1371/journal.pgen.1002821.Full Text Link to Item
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Lunde, Kathrine, Bjørg Egelandsdal, Ellen Skuterud, Joel D. Mainland, Tor Lea, Margrethe Hersleth, and Hiroaki Matsunami. “Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone.” Plos One 7, no. 5 (2012): e35259. https://doi.org/10.1371/journal.pone.0035259.Full Text Link to Item
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Mainland, Joel, and Hiroaki Matsunami. “RAMP like proteins : RTP and REEP family of proteins.” Adv Exp Med Biol 744 (2012): 75–86. https://doi.org/10.1007/978-1-4614-2364-5_7.Full Text Link to Item
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Dey, Sandeepa, and Hiroaki Matsunami. “Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors.” Proc Natl Acad Sci U S A 108, no. 40 (October 4, 2011): 16651–56. https://doi.org/10.1073/pnas.1018140108.Full Text Link to Item
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Chamero, Pablo, Vicky Katsoulidou, Philipp Hendrix, Bernd Bufe, Richard Roberts, Hiroaki Matsunami, Joel Abramowitz, Lutz Birnbaumer, Frank Zufall, and Trese Leinders-Zufall. “G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice.” Proc Natl Acad Sci U S A 108, no. 31 (August 2, 2011): 12898–903. https://doi.org/10.1073/pnas.1107770108.Full Text Link to Item
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Matsunami, H. “Functional Expression of Odorant Receptor In Vitro.” In Vitro Cellular & Developmental Biology Animal 47 (June 1, 2011): S12–S12.Link to Item
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Dey, Sandeepa, Senmiao Zhan, and Hiroaki Matsunami. “Assaying surface expression of chemosensory receptors in heterologous cells.” J Vis Exp, no. 48 (February 23, 2011). https://doi.org/10.3791/2405.Full Text Link to Item
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Li, Yun Rose, and Hiroaki Matsunami. “Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling.” Sci Signal 4, no. 155 (January 11, 2011): ra1. https://doi.org/10.1126/scisignal.2001230.Full Text Link to Item
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Horio, Nao, Ryusuke Yoshida, Keiko Yasumatsu, Yuchio Yanagawa, Yoshiro Ishimaru, Hiroaki Matsunami, and Yuzo Ninomiya. “Sour taste responses in mice lacking PKD channels.” Plos One 6, no. 5 (2011): e20007. https://doi.org/10.1371/journal.pone.0020007.Full Text Link to Item
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Michaloski, Jussara S., Pedro A. F. Galante, Maíra H. Nagai, Lucia Armelin-Correa, Ming-Shan Chien, Hiroaki Matsunami, and Bettina Malnic. “Common promoter elements in odorant and vomeronasal receptor genes.” Plos One 6, no. 12 (2011): e29065. https://doi.org/10.1371/journal.pone.0029065.Full Text Link to Item
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Ishimaru, Yoshiro, Yuka Katano, Kurumi Yamamoto, Masato Akiba, Takumi Misaka, Richard W. Roberts, Tomiko Asakura, Hiroaki Matsunami, and Keiko Abe. “Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae.” Faseb J 24, no. 10 (October 2010): 4058–67. https://doi.org/10.1096/fj.10-162925.Full Text Link to Item
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Horio, Nao, Ryusuke Yoshida, Keiko Yasumatsu, Yuchio Yanagawa, Yoshiro Ishimaru, and Hiroaki Matsunami. “PKD2L1 is associated with the sour taste transduction.” Neuroscience Research 68 (January 2010): e385–e385. https://doi.org/10.1016/j.neures.2010.07.1703.Full Text
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Zhuang, Hanyi, Ming-Shan Chien, and Hiroaki Matsunami. “Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.” Proc Natl Acad Sci U S A 106, no. 50 (December 15, 2009): 21247–51. https://doi.org/10.1073/pnas.0808378106.Full Text Link to Item
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Grosmaitre, Xavier, Stefan H. Fuss, Anderson C. Lee, Kaylin A. Adipietro, Hiroaki Matsunami, Peter Mombaerts, and Minghong Ma. “SR1, a mouse odorant receptor with an unusually broad response profile.” J Neurosci 29, no. 46 (November 18, 2009): 14545–52. https://doi.org/10.1523/JNEUROSCI.2752-09.2009.Full Text Link to Item
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Mainland, Joel D., and Hiroaki Matsunami. “Taste perception: how sweet it is (to be transcribed by you).” Curr Biol 19, no. 15 (August 11, 2009): R655–56. https://doi.org/10.1016/j.cub.2009.06.050.Full Text Link to Item
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Wilson, Donald A., Harriet Baker, Peter Brunjes, Timothy A. Gilbertson, Linda Hermer, David L. Hill, Hiroaki Matsunami, et al. “Chemoreception scientists gather under the Florida sun: The 31st Annual Association for Chemoreception Sciences meeting.” Ann N Y Acad Sci 1170 Suppl 1, no. Suppl 1 (August 2009): 1–11. https://doi.org/10.1111/j.1749-6632.2009.05047.x.Full Text Link to Item
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Matsunami, Hiroaki, Joel D. Mainland, and Sandeepa Dey. “Trafficking of mammalian chemosensory receptors by receptor-transporting proteins.” Ann N Y Acad Sci 1170 (July 2009): 153–56. https://doi.org/10.1111/j.1749-6632.2009.03888.x.Full Text Link to Item
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Saito, Harumi, Qiuyi Chi, Hanyi Zhuang, Hiroaki Matsunami, and Joel D. Mainland. “Odor coding by a Mammalian receptor repertoire.” Sci Signal 2, no. 60 (March 3, 2009): ra9. https://doi.org/10.1126/scisignal.2000016.Full Text Link to Item
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Ishimaru, Y., and H. Matsunami. “Transient receptor potential (TRP) channels and taste sensation.” J Dent Res 88, no. 3 (March 2009): 212–18. https://doi.org/10.1177/0022034508330212.Full Text Link to Item
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Matsunami, Hiroaki. “Odorant Receptor Polymorphisms and Olfactory Perception.” Chemical Senses 34, no. 3 (March 1, 2009): E27–E27.Link to Item
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Sun, Liming, Huayi Wang, Ji Hu, Jinlong Han, Hiroaki Matsunami, and Minmin Luo. “Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate.” Proc Natl Acad Sci U S A 106, no. 6 (February 10, 2009): 2041–46. https://doi.org/10.1073/pnas.0812220106.Full Text Link to Item
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Saito, Harumi, Qiuyi Chi, Hanyi Zhuang, Hiroaki Matsunami, and Joel Mainland. “Odor coding by a mammalian receptor repertoire.” Neuroscience Research 65 (January 2009): S76–S76. https://doi.org/10.1016/j.neures.2009.09.277.Full Text
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Zhuang, Hanyi, Mingshan Chien, and Hiroaki Matsunami. “Dynamic Functional Evolution of an Odorant Receptor for Sex-steroid Derived Odors in Primates.” Neuroscience Research 65 (January 2009): S139–S139. https://doi.org/10.1016/j.neures.2009.09.690.Full Text
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Katz, Donald B., Hiroaki Matsunami, Dmitry Rinberg, Kristin Scott, Matt Wachowiak, and Rachel I. Wilson. “Receptors, circuits, and behaviors: new directions in chemical senses.” J Neurosci 28, no. 46 (November 12, 2008): 11802–5. https://doi.org/10.1523/JNEUROSCI.3613-08.2008.Full Text Link to Item
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Dey, Sandeepa, and Hiroaki Matsunami. “A Putative Endoplasmic Reticulum Chaperone, Calreticulin 4, is Expressed in Mouse Vomeronasal Organ.” Chemical Senses 33, no. 8 (October 1, 2008): S92–S92.Link to Item
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Mainland, Joel D., Harumi Saito, Qiuyi Chi, Hanyi Zhuang, and Hiro Matsunami. “Odor Coding by a Mammalian Receptor Repertoire.” Chemical Senses 33, no. 8 (October 1, 2008): S1–S1.Link to Item
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Matsunami, Hiroaki. “Functional Expression of Mammalian Odorant Receptors by RTP Family Members.” Chemical Senses 33, no. 8 (October 1, 2008): S19–S19.Link to Item
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Zhuang, Hanyi, and Hiroaki Matsunami. “Positive Selection Shapes the Function of an Odorant Receptor for Sex-Steroid Derived Odors in Primates.” Chemical Senses 33, no. 8 (October 1, 2008): S50–S50.Link to Item
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Inada, Hitoshi, Fuminori Kawabata, Yoshiro Ishimaru, Tohru Fushiki, Hiroaki Matsunami, and Makoto Tominaga. “Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.” Embo Rep 9, no. 7 (July 2008): 690–97. https://doi.org/10.1038/embor.2008.89.Full Text Link to Item
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Kataoka, Shinji, Ruibiao Yang, Yoshiro Ishimaru, Hiroaki Matsunami, Jean Sévigny, John C. Kinnamon, and Thomas E. Finger. “The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse.” Chem Senses 33, no. 3 (March 2008): 243–54. https://doi.org/10.1093/chemse/bjm083.Full Text Link to Item
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Zhuang, Hanyi, and Hiroaki Matsunami. “Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells.” Nat Protoc 3, no. 9 (2008): 1402–13. https://doi.org/10.1038/nprot.2008.120.Full Text Link to Item
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Keller, Andreas, Hanyi Zhuang, Qiuyi Chi, Leslie B. Vosshall, and Hiroaki Matsunami. “Genetic variation in a human odorant receptor alters odour perception.” Nature 449, no. 7161 (September 27, 2007): 468–72. https://doi.org/10.1038/nature06162.Full Text Link to Item
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Hu, Ji, Chun Zhong, Cheng Ding, Qiuyi Chi, Andreas Walz, Peter Mombaerts, Hiroaki Matsunami, and Minmin Luo. “Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.” Science 317, no. 5840 (August 17, 2007): 953–57. https://doi.org/10.1126/science.1144233.Full Text Link to Item
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Zhuang, Hanyi, and Hiroaki Matsunami. “Synergism of accessory factors in functional expression of mammalian odorant receptors.” J Biol Chem 282, no. 20 (May 18, 2007): 15284–93. https://doi.org/10.1074/jbc.M700386200.Full Text Link to Item
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Ishimaru, Yoshiro, Hitoshi Inada, Momoka Kubota, Hanyi Zhuang, Makoto Tominaga, and Hiroaki Matsunami. “Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.” Proc Natl Acad Sci U S A 103, no. 33 (August 15, 2006): 12569–74. https://doi.org/10.1073/pnas.0602702103.Full Text Link to Item
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Abaffy, Tatjana, Hiroaki Matsunami, and Charles W. Luetje. “Functional analysis of a mammalian odorant receptor subfamily.” J Neurochem 97, no. 5 (June 2006): 1506–18. https://doi.org/10.1111/j.1471-4159.2006.03859.x.Full Text Link to Item
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Plummer, Nicholas W., Teresa L. Squire, Sudha Srinivasan, Elizabeth Huang, Jon S. Zawistowski, Hiroaki Matsunami, Laura P. Hale, and Douglas A. Marchuk. “Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations.” Mamm Genome 17, no. 2 (February 2006): 119–28. https://doi.org/10.1007/s00335-005-0098-8.Full Text Link to Item
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Matsunami, Hiroaki. “Functional expression of Mammalian odorant receptors.” Chem Senses 30 Suppl 1 (January 2005): i95–96. https://doi.org/10.1093/chemse/bjh131.Full Text Link to Item
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Saito, Harumi, Momoka Kubota, Richard W. Roberts, Qiuyi Chi, and Hiroaki Matsunami. “RTP family members induce functional expression of mammalian odorant receptors.” Cell 119, no. 5 (November 24, 2004): 679–91. https://doi.org/10.1016/j.cell.2004.11.021.Full Text Link to Item
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Mizrahi, Adi, Hiroaki Matsunami, and Lawrence C. Katz. “An imaging-based approach to identify ligands for olfactory receptors.” Neuropharmacology 47, no. 5 (October 2004): 661–68. https://doi.org/10.1016/j.neuropharm.2004.07.020.Full Text Link to Item
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Matsunami, Hiroaki, and Hubert Amrein. “Taste perception: how to make a gourmet mouse.” Curr Biol 14, no. 3 (February 3, 2004): R118–20.Link to Item
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Matsunami, Hiroaki, and Hubert Amrein. “Taste and pheromone perception in mammals and flies.” Genome Biol 4, no. 7 (2003): 220. https://doi.org/10.1186/gb-2003-4-7-220.Full Text Link to Item
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Montmayeur, Jean Pierre, and Hiroaki Matsunami. “Receptors for bitter and sweet taste.” Curr Opin Neurobiol 12, no. 4 (August 2002): 366–71. https://doi.org/10.1016/s0959-4388(02)00345-8.Full Text Link to Item
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Montmayeur, J. P., S. D. Liberles, H. Matsunami, and L. B. Buck. “A candidate taste receptor gene near a sweet taste locus.” Nat Neurosci 4, no. 5 (May 2001): 492–98. https://doi.org/10.1038/87440.Full Text Link to Item
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Matsunami, H., J. P. Montmayeur, and L. B. Buck. “A family of candidate taste receptors in human and mouse.” Nature 404, no. 6778 (April 6, 2000): 601–4. https://doi.org/10.1038/35007072.Full Text Link to Item
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Goto, S., E. Yaoita, H. Matsunami, D. Kondo, T. Yamamoto, K. Kawasaki, M. Arakawa, and I. Kihara. “Involvement of R-cadherin in the early stage of glomerulogenesis.” J Am Soc Nephrol 9, no. 7 (July 1998): 1234–41. https://doi.org/10.1681/ASN.V971234.Full Text Link to Item
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Nakagawa, S., H. Matsunami, and M. Takeichi. “Selective aggregation assays for embryonic brain cells and cell lines.” Curr Top Dev Biol 36 (1998): 197–210. https://doi.org/10.1016/s0070-2153(08)60503-7.Full Text Link to Item
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Matsunami, H., and L. B. Buck. “A multigene family encoding a diverse array of putative pheromone receptors in mammals.” Cell 90, no. 4 (August 22, 1997): 775–84. https://doi.org/10.1016/s0092-8674(00)80537-1.Full Text Link to Item
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Inoue, T., O. Chisaka, H. Matsunami, and M. Takeichi. “Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos.” Dev Biol 183, no. 2 (March 15, 1997): 183–94. https://doi.org/10.1006/dbio.1996.8501.Full Text Link to Item
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Takeichi, M., H. Matsunami, T. Inoue, Y. Kimura, S. Suzuki, and T. Tanaka. “Roles of cadherins in patterning of the developing brain.” Dev Neurosci 19, no. 1 (1997): 86–87. https://doi.org/10.1159/000111189.Full Text Link to Item
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Radice, G. L., H. Rayburn, H. Matsunami, K. A. Knudsen, M. Takeichi, and R. O. Hynes. “Developmental defects in mouse embryos lacking N-cadherin.” Dev Biol 181, no. 1 (January 1, 1997): 64–78. https://doi.org/10.1006/dbio.1996.8443.Full Text Link to Item
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Kimura, Y., H. Matsunami, and M. Takeichi. “Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain.” Dev Dyn 206, no. 4 (August 1996): 455–62. https://doi.org/10.1002/(SICI)1097-0177(199608)206:4<455::AID-AJA11>3.0.CO;2-W.Full Text Link to Item
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Matsunami, H., and M. Takeichi. “Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion.” Dev Biol 172, no. 2 (December 1995): 466–78. https://doi.org/10.1006/dbio.1995.8029.Full Text Link to Item
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Kimura, Y., H. Matsunami, T. Inoue, K. Shimamura, N. Uchida, T. Ueno, T. Miyazaki, and M. Takeichi. “Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos.” Dev Biol 169, no. 1 (May 1995): 347–58. https://doi.org/10.1006/dbio.1995.1149.Full Text Link to Item
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Matsunami, H., S. Miyatani, T. Inoue, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, and M. Takeichi. “Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene.” J Cell Sci 106 ( Pt 1) (September 1993): 401–9. https://doi.org/10.1242/jcs.106.1.401.Full Text Link to Item
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Book Sections
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Dong, P. Y., N. N. Gong, and H. Matsunami. “Cell-based system for identification of olfactory receptors.” In Bioelectronic Nose: Integration of Biotechnology and Nanotechnology, 9789401786133:83–95, 2014. https://doi.org/10.1007/978-94-017-8613-3_5.Full Text
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Sharma, R., and H. Matsunami. “Mechanisms of olfaction.” In Bioelectronic Nose: Integration of Biotechnology and Nanotechnology, 9789401786133:23–45, 2014. https://doi.org/10.1007/978-94-017-8613-3_2.Full Text
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Ho, J., H. Matsunami, and Y. Ishimaru. “The molecular basis of sour sensing in mammals.” In Molecular Genetics of Dysregulated PH Homeostasis, 27–43, 2014. https://doi.org/10.1007/978-1-4939-1683-2_3.Full Text
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Su, X., H. Matsunami, and H. Zhuang. “Odorant-receptor interaction.” In Bioelectronic Nose: Integration of Biotechnology and Nanotechnology, 9789401786133:69–81, 2013. https://doi.org/10.1007/978-94-017-8613-3_4.Full Text
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Conference Papers
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Fukutani, Yosuke, Kentaro Ikegami, Masafumi Yohda, and Hiroaki Matsunami. “Improvement of the functional expression of mouse odorant receptors by site-directed mutagenesis based on RTP independency.” In Chemical Senses, Vol. 46, 2021.Link to Item
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Liang, T. C., K. Chakrabarty, T. Abaffy, H. Matsunami, and R. Karri. “Securing Biochemical Samples Using Molecular Barcoding on Digital Microfluidic Biochips*.” In Biocas 2021 Ieee Biomedical Circuits and Systems Conference, Proceedings, 2021. https://doi.org/10.1109/BioCAS49922.2021.9644945.Full Text
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March, Claire A. de, Kara C. Hoover, Masashi Abe, and Hiroaki Matsunami. “Smelling through old noses via genetic and functional variations in extinct human lineages.” In Chemical Senses, Vol. 46, 2021.Link to Item
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March, Claire A. de, Kara C. Hoover, Masashi Abe, and Hiroaki Matsunami. “Smelling through old noses via genetic and functional variations in extinct human lineages.” In Chemical Senses, Vol. 46, 2021.Link to Item
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Abaffy, Tatjana, James Bain, Michael Muehlbauer, Ivan Spasojevic, Shweta Lodha, Elisa Bruguera, Sara O’Neal, So Young Kim, and Hiroaki Matsunami. “Discovery of endogenous ligands and the function of OR51E2 in prostate cancer.” In Chemical Senses, 45:130–130, 2020.Link to Item
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Belser, Nathalee, Naihua Gong, and Hiroaki Matsunami. “Investigators elucidate the mechanism behind olfactory training and glomerular phenotype pattern formation.” In Chemical Senses, 45:161–161, 2020.Link to Item
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March, Claire de, Kentaro Ikegami, Maira H. Nagai, Soumadwip Ghosh, Yosuke Fukutani, Nagarajan Vaidehi, Masafumi Yohda, and Hiroaki Matsunami. “Expression of the G protein-coupled odorant receptors.” In Chemical Senses, 45:144–144, 2020.Link to Item
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Matsunami, Hiroaki. “De-Orphanizing Mammalian Olfactory Receptors.” In Chemical Senses, 45:141–141, 2020.Link to Item
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Orecchioni, Marco, Kouji Kobiyama, Holger Winkels, Yanal Ghosheh, Sara McArdle, Zbigniew Mikulski, Zhichao Fan, et al. “Olfactory receptor 2 (Olfr2) and its human ortholog OR6A2 expressed in macrophages drive NLRP3 inflammasome activation and exacerbate atherosclerosis in mice.” In Journal of Immunology, Vol. 204, 2020.Link to Item
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March, Claire A. de, Kentaro Ikegami, Maira H. Nagai, Soumadwip Ghosh, Matthew Do, Ruchira Sharma, Elise S. Bruguera, et al. “Expression of the G protein coupled odorant receptors.” In Chemical Senses, 44:E49–E49. OXFORD UNIV PRESS, 2019.Link to Item
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Matsunami, Hiro. “Mapping Olfaction Through Transcriptome Profiling.” In Chemical Senses, 44:E25–E25. OXFORD UNIV PRESS, 2019.Link to Item
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Vihani, Aashutosh, and Hiroaki Matsunami. “Olfactory experience with semiochemicals influences sex-specific olfactory receptor expression.” In Chemical Senses, 44:E95–96. OXFORD UNIV PRESS, 2019.Link to Item
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Zhu, Kevin, Justin Silverman, Shawn Burton, Matt Wachowiak, and Hiroaki Matsunami. “Targeted transcriptomics of olfactory receptors for high-throughput mapping of olfactory bulb glomeruli.” In Chemical Senses, 44:E111–12. OXFORD UNIV PRESS, 2019.Link to Item
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March, Claire A. de, and Hiroaki Matsunami. “Location of odorant-receptor interaction within OR1A1 binding cavity is crucial for their activation potential.” In Chemical Senses, 44:E16–E16. OXFORD UNIV PRESS, 2019.Link to Item
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McClintock, Timothy S., Claire de March, William B. Titlow, Patrick Breheny, and Hiroaki Matsunami. “Pharmacology of odorant interactions at odorant receptors in vivo.” In Chemical Senses, 44:E9–E9. OXFORD UNIV PRESS, 2019.Link to Item
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Belser, Nathalee, Natalie Gong, Ruchira Sharma, Hitoshi Kida, and Hirokai Matsunami. “Experience dependent axon targeting in the olfactory system.” In Chemical Senses, 43:E249–E249. OXFORD UNIV PRESS, 2018.Link to Item
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Fukutani, Yosuke, Hitoshi Kida, Joel Mainland, Masaharu Kameda, Masafumi Yohda, and Hiroaki Matsunami. “Vapor detection and discrimination with a panel of odorant receptors expressed in heterologous cells.” In Chemical Senses, 43:E185–E185. OXFORD UNIV PRESS, 2018.Link to Item
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McClintock, Timothy, Claire De March, Tomoko Sengoku, William Titlow, Patrick Breheny, and Hiroaki Matsunami. “Interactions of Odorants at Odorant Receptors In Vivo Correlate with Perceptions of Odor Mixtures.” In Chemical Senses, 43:E167–68. OXFORD UNIV PRESS, 2018.Link to Item
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Nagai, Maira H., Kentaro Ikegami, and Hiroaki Matsunami. “Consensus Odorant Receptors Support Robust Cell Surface Expression in Non-Olfactory Cells.” In Chemical Senses, 43:E186–E186. OXFORD UNIV PRESS, 2018.Link to Item
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Hu, Xiaoyang Serene, Kentaro Ikegami, Marcelo Zapata, Natasha Vaidya, and Hiroaki Matsunami. “The Receptor Logic Behind Varying Odorant Concentrations.” In Chemical Senses, 43:E105–E105. OXFORD UNIV PRESS, 2018.Link to Item
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Trimmer, Casey, Jason R. Willer, Andreas Keller, Leslie B. Vosshall, Nicholas Katsanis, Hiroaki Matsunami, and Joel D. Mainland. “Genetic and Demographic Influences on Odor Perception.” In Chemical Senses, 43:E107–E107. OXFORD UNIV PRESS, 2018.Link to Item
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Hu, Xiaoyang Serene, Kentaro Ikegami, Marcelo Zapata, Natasha Vaidya, Matthew Do, Claire de March, and Hiroaki Matsunami. “The Receptor Repertoires Behind Varying Odorant Concentrations.” In Chemical Senses, 43:E14–E14. OXFORD UNIV PRESS, 2018.Link to Item
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March, Claire de, Brian Rhee, Hiroaki Matsunami, Veronica Pereda-Loth, and Denis Pierron. “Evolution of olfaction: What did the modern human lose?” In Chemical Senses, 43:E21–E21. OXFORD UNIV PRESS, 2018.Link to Item
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March, Claire de, Elise Bruguera, Jeremie Topin, Jerome Golebiowski, and Hiroaki Matsunami. “Odorant receptors activation dynamics involves specific sequence motifs.” In Protein Science, 26:46–47. WILEY, 2017.Link to Item
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Ikegami, Kentaro, Yue Jiang, Ming-Shan Chien, Masafumi Yohda, and Hiroaki Matsunami. “Refinement of Olfactory Receptor Transcribed Regions Improves the Accuracy of In Vivo Receptor Deorphanization.” In Chemical Senses, 41:E83–E83. OXFORD UNIV PRESS, 2016.Link to Item
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Ahmed, Lucky, Shengju Li, Ruina Zhang, Yi Pan, Hiroaki Matsunami, Eric Block, Hanyi Zhuang, and Victor Batista. “Identification of a human thiol receptor highly responsive to thiols in the presence of Cu(I) and Ag(I) ions: QM/MM and mutagenesis studies.” In Abstracts of Papers of the American Chemical Society, Vol. 252. AMER CHEMICAL SOC, 2016.Link to Item
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Ahmed, Lucky, Yuetian Zhang, Sivakumar Sekharan, Mehmet Ozbil, Yi Pan, Sivaji Gundala, Eric Block, Hiroaki Matsunami, Hanyi Zhuang, and Victor Batista. “QM/MM modeling and activity profiles and mutagenesis studies of the human musk olfactory receptor OR5AN1.” In Abstracts of Papers of the American Chemical Society, Vol. 252. AMER CHEMICAL SOC, 2016.Link to Item
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Gong, Naihua N., and Hiroaki Matsunami. “Experience-dependent Axon Targeting and Guidance Molecule Expression in the Mouse Olfactory System.” In Chemical Senses, 40:629–629. OXFORD UNIV PRESS, 2015.Link to Item
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Jiang, Yue, Naihua N. Gong, Mengjue J. Ni, Radhika Pasi, and Hiroaki Matsunami. “Molecular profiling of activated olfactory neurons using phosphorylated ribosome immunoprecipitation and RNA-Seq identifies odorant receptors responding to odors in vivo.” In Chemical Senses, 40:562–562. OXFORD UNIV PRESS, 2015.Link to Item
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March, Claire A. de, Yiqun Yu, Mengjue J. Ni, Kaylin A. Adipietro, Hiroaki Matsunami, Minghong Ma, and Jerome Golebiowski. “Identification of key residues involved in activation of G-protein Coupled Odorant Receptors.” In Chemical Senses, 40:654–654. OXFORD UNIV PRESS, 2015.Link to Item
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Sharma, Ruchira, Yoshiro Ishimaru, Ian Davison, Kentaro Ikegami, and Hiroaki Matsunami. “Olfactory receptor accessory proteins RTP1 and RTP2 play a crucial role in receptor gene choice, development and odor detection.” In Chemical Senses, 40:535–535. OXFORD UNIV PRESS, 2015.Link to Item
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Trimmer, Casey, Jason R. Willer, Andreas Keller, Leslie B. Vosshall, Nicholas Katsanis, Hiroaki Matsunami, and Joel D. Mainland. “Predicting human odor perception from olfactory receptor activation.” In Chemical Senses, 40:551–551. OXFORD UNIV PRESS, 2015.Link to Item
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Yu, Yiqun, Claire A. de March, Mengjue J. Ni, Kaylin A. Adipietro, Jerome Golebiowski, Hiroaki Matsunami, and Minghong Ma. “Permissive Binding Pocket and Low Activation Threshold Underlie Exceptionally Broad Responsiveness of Some G-Protein Coupled Odorant Receptors.” In Chemical Senses, 40:633–633. OXFORD UNIV PRESS, 2015.Link to Item
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March, Claire A. de, Nicolas Baldovini, Anne-Marie Le Bon, Yiqun Yu, Kaylin Adipietro, Minghong Ma, Hiroaki Matsunami, and Jerome Golebiowski. “Molecular Dynamics simulations reveal the active and inactive states of Olfactory Receptors.” In Chemical Senses, 40:220–220. OXFORD UNIV PRESS, 2015.Link to Item
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Ryan, Kevin, Yadi Li, Zita Peterlin, Jianghai Ho, Stuart Firestein, Hiroaki Matsunami, and Min T. Liu. “Using conformationally restricted odorant ligands to probe the olfactory GPCRs.” In Abstracts of Papers of the American Chemical Society, Vol. 246. AMER CHEMICAL SOC, 2013.Link to Item
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Block, Eric, Hanyi Zhuang, Hiroaki Matsunami, Guo-Qiang Chen, Xufang Duan, Jian Zhang, Zhimin Huang, et al. “Smelling sulfur: An odorant receptor for divalent sulfur compounds employs copper ion as a cofactor.” In Abstracts of Papers of the American Chemical Society, Vol. 242. AMER CHEMICAL SOC, 2011.Link to Item
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Zhuang, Hanyi, Mingshan Chien, and Hiroaki Matsunami. “Positive Selection Shapes the Function of an Odorant Receptor for Sex-Steroid Derived Odors in Primates.” In Chemical Senses, 34:A10–A10. OXFORD UNIV PRESS, 2009.Link to Item
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Abaffy, T., H. Matsunami, and C. Luetje. “Functional analysis of the mouse odorant receptor MOR42 subfamily.” In Chemical Senses, 31:A96–97. OXFORD UNIV PRESS, 2006.Link to Item
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Matsunami, H. “Deorphanizing'' mammalian odorant receptors.” In Chemical Senses, 31:A3–A3. OXFORD UNIV PRESS, 2006.Link to Item
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Repicky, S. E., H. Matsunami, and C. W. Luetje. “Exploring the molecular receptive ranges of mammalian odorant receptors.” In Chemical Senses, 31:A97–A97. OXFORD UNIV PRESS, 2006.Link to Item
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Saito, H., Q. Chi, H. Zhuang, and H. Matsunami. “The functional properties of mammalian odorant receptors.” In Chemical Senses, 31:A65–A65. OXFORD UNIV PRESS, 2006.Link to Item
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Datasets
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De March, Claire, Matthew Do, Nagarajan Vaidehi, Masafumi Yohda, Yosuke Fukutani, Maira Nagai, Yueyang Eric Lu, et al. “Data from: Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors,” December 19, 2019. https://doi.org/10.7924/r40867k2k.Data Access
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- Teaching & Mentoring
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Recent Courses
- MGM 293: Research Independent Study I 2023
- MGM 593: Research Independent Study 2023
- MGM 593: Research Independent Study 2022
- UPGEN 778D: University Program in Genetics and Genomics Biological Solutions Module IV 2022
- MGM 293: Research Independent Study I 2021
- MGM 593: Research Independent Study 2021
- NEUROBIO 393: Research Independent Study 2021
- NEUROBIO 793: Research in Neurobiology 2021
- UPGEN 778E: University Program in Genetics and Genomics Biological Solutions Module V 2021
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