The clinical and laboratory evaluation of the patient with erythrocytosis.

Journal Article (Journal Article;Review)

Erythrocytosis is frequently encountered as an incidental abnormality on laboratory testing that reveals persistent elevation of the hematocrit level (>52% in men and >48% in women). In many cases, erythrocytosis is the manifestation of an underlying cardiopulmonary process, drug-induced due to androgens, or secondary to smoking, rather than a primary bone marrow disorder such as polycythemia vera. A systematic approach to the clinical and laboratory evaluation of each patient is indicated to consider diverse differential diagnosis possibilities and to identify the underlying etiology of erythrocytosis in order to formulate appropriate subspecialist referral and management plans. A thorough medical history and meticulous physical examination supplemented by a focused initial laboratory evaluation will enable the general practitioner to ascertain the etiology of erythrocytosis in the majority of cases. Patients with clinical and laboratory features suggestive of polycythemia vera and those patients without an apparent underlying condition known to cause erythrocytosis benefit from early referral to a hematologist for further specialized diagnostic evaluation and therapy considerations.

Full Text

Duke Authors

Cited Authors

  • Lee, G; Arcasoy, MO

Published Date

  • June 2015

Published In

Volume / Issue

  • 26 / 5

Start / End Page

  • 297 - 302

PubMed ID

  • 25837692

Electronic International Standard Serial Number (EISSN)

  • 1879-0828

Digital Object Identifier (DOI)

  • 10.1016/j.ejim.2015.03.007


  • eng

Conference Location

  • Netherlands