Cell fate commitment during mammalian sex determination.

Journal Article (Journal Article;Review)

The gonads form bilaterally as bipotential organs that can develop as testes or ovaries. All secondary sex characteristics that we associate with 'maleness' or 'femaleness' depend on whether testes or ovaries form. The fate of the gonads depends on a cell fate decision that occurs in a somatic cell referred to as the 'supporting cell lineage'. Once supporting cell progenitors commit to Sertoli (male) or granulosa (female) fate, they propagate this decision to the other cells within the organ. In this review, we will describe what is known about the bipotential state of somatic and germ cell lineages in the gonad and the transcriptional and antagonistic signaling networks that lead to commitment, propagation, and maintenance of testis or ovary fate.

Full Text

Duke Authors

Cited Authors

  • Lin, Y-T; Capel, B

Published Date

  • June 2015

Published In

Volume / Issue

  • 32 /

Start / End Page

  • 144 - 152

PubMed ID

  • 25841206

Pubmed Central ID

  • PMC4470863

Electronic International Standard Serial Number (EISSN)

  • 1879-0380

Digital Object Identifier (DOI)

  • 10.1016/j.gde.2015.03.003


  • eng

Conference Location

  • England