Insights into antiviral innate immunity revealed by studying hepatitis C virus.

Published

Journal Article (Review)

Experimental studies on the interactions of the positive strand RNA virus hepatitis C virus (HCV) with the host have contributed to several discoveries in the field of antiviral innate immunity. These include revealing the antiviral sensing pathways that lead to the induction of type I interferon (IFN) during HCV infection and also the importance of type III IFNs in the antiviral immune response to HCV. These studies on HCV/host interactions have contributed to our overall understanding of viral sensing and viral evasion of the antiviral intracellular innate immune response. In this review, I will highlight how these studies of HCV/host interactions have led to new insights into antiviral innate immunity. Overall, I hope to emphasize that studying antiviral immunity in the context of virus infection is necessary to fully understand antiviral immunity and how it controls the outcome of viral infection.

Full Text

Duke Authors

Cited Authors

  • Horner, SM

Published Date

  • August 2015

Published In

Volume / Issue

  • 74 / 2

Start / End Page

  • 190 - 197

PubMed ID

  • 25819428

Pubmed Central ID

  • 25819428

Electronic International Standard Serial Number (EISSN)

  • 1096-0023

Digital Object Identifier (DOI)

  • 10.1016/j.cyto.2015.03.007

Language

  • eng

Conference Location

  • England