Stacy M. Horner
Assistant Professor of Molecular Genetics and Microbiology
Current Appointments & Affiliations
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2014
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2014
- Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2018
Contact Information
- 213 Research Drive, Room 0030 CARL Bldg, Durham, NC 27710
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stacy.horner@duke.edu
(919) 684-1921
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Horner Lab Webpage
- Background
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Education, Training, & Certifications
- Ph.D., Yale University 2007
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Duke Appointment History
- Instructor, Temporary in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2013 - 2014
- Recognition
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In the News
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JUN 17, 2018 -
OCT 20, 2016
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- Expertise
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Subject Headings
- Research
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Selected Grants
- Regulation of antiviral host response by RNA modifications awarded by Burroughs Wellcome Fund 2017 - 2022
- Defining the role of the RNA modification N6-methyladenosine in the hepatitis C virus lifecycle awarded by National Institutes of Health 2016 - 2021
- Defining a novel function for the post-translational modification ufmylation in the antiviral innate immune response awarded by National Institutes of Health 2019 - 2020
- Mechanisms of RAB1B regulation of antiviral innate immune signaling awarded by American Cancer Society, Inc. 2018 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Amelioration of neural stem cell defects underlying Zika virus induced microcephaly awarded by Hartwell Foundation 2017 - 2020
- Novel Regulatory Controls of Hepatitis C Virus Envelopment and Secretion by the Viral NS4A Protein awarded by National Institutes of Health 2018 - 2020
- Defining how a tyrosine within the hepatitis c virus protease regulates antiviral innate immunity awarded by Burroughs Wellcome Fund 2017 - 2019
- Mapping the RNA modification N6-methyladenosine during Zika virus infection awarded by Weill Medical College of Cornell University 2017 - 2019
- IL-27 in skin host defense and regeneration awarded by National Institutes of Health 2017 - 2019
- Understanding the role of N6-methyladenosine in hepatitis C virus infection awarded by American Heart Association 2017 - 2019
- Viral Oncology Training Grant awarded by National Institutes of Health 1980 - 2019
- Zika virus infection of neural stem cells to model pathogen-induced microcephaly awarded by National Institutes of Health 2016 - 2018
- Defining novel Riplet-activated antiviral innate immune signaling pathways awarded by National Institutes of Health 2016 - 2018
- An RNA-targeted platform for anti-flavivirus drug discovery awarded by Ribometrix LLC 2017
- Innate Immune Regulation during hepatitis C virus infection awarded by National Institutes of Health 2013 - 2015
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Roder, AE, and Horner, SM. "Measuring Hepatitis C Virus Envelopment by Using a Proteinase K Protection Assay." Methods in Molecular Biology (Clifton, N.J.) 1911 (January 2019): 209-217. Full Text
- Dethoff, EA, Boerneke, MA, Gokhale, NS, Muhire, BM, Martin, DP, Sacco, MT, McFadden, MJ, Weinstein, JB, Messer, WB, Horner, SM, and Weeks, KM. "Pervasive tertiary structure in the dengue virus RNA genome." Proceedings of the National Academy of Sciences of the United States of America 115, no. 45 (November 2018): 11513-11518. Full Text
- Imam, H, Khan, M, Gokhale, NS, McIntyre, ABR, Kim, G-W, Jang, JY, Kim, S-J, Mason, CE, Horner, SM, and Siddiqui, A. "N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle." Proceedings of the National Academy of Sciences of the United States of America 115, no. 35 (August 13, 2018): 8829-8834. Full Text
- Wang, L, Pittman, KJ, Barker, JR, Salinas, RE, Stanaway, IB, Williams, GD, Carroll, RJ, Balmat, T, Ingham, A, Gopalakrishnan, AM, Gibbs, KD, Antonia, AL, eMERGE Network, , Heitman, J, Lee, SC, Jarvik, GP, Denny, JC, Horner, SM, DeLong, MR, Valdivia, RH, Crosslin, DR, and Ko, DC. "An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease." Cell Host & Microbe 24, no. 2 (August 2018): 308-323.e6. Full Text
- Liu, B, Merriman, DK, Choi, SH, Schumacher, MA, Plangger, R, Kreutz, C, Horner, SM, Meyer, KD, and Al-Hashimi, HM. "A potentially abundant junctional RNA motif stabilized by m6A and Mg2." Nature Communications 9, no. 1 (July 17, 2018): 2761-null. Full Text
- McFadden, MJ, Mitchell-Dick, A, Vazquez, C, Roder, AE, Labagnara, KF, McMahon, JJ, Silver, DL, and Horner, SM. "A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time." Viruses 10, no. 2 (February 24, 2018). Full Text
- Kennedy, EM, Bogerd, HP, Kornepati, AVR, Kang, D, Ghoshal, D, Marshall, JB, Poling, BC, Tsai, K, Gokhale, NS, Horner, SM, and Cullen, BR. "Posttranscriptional m6A Editing of HIV-1 mRNAs Enhances Viral Gene Expression." Cell Host & Microbe 22, no. 6 (December 2017): 830-830. Full Text
- Gokhale, NS, and Horner, SM. "RNA modifications go viral." Plos Pathogens 13, no. 3 (March 9, 2017): e1006188-null. (Review) Full Text
- McFadden, MJ, Gokhale, NS, and Horner, SM. "Protect this house: cytosolic sensing of viruses." Current Opinion in Virology 22 (February 2017): 36-43. (Review) Full Text
- Gokhale, NS, and Horner, SM. "Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs." Cell Host & Microbe 21, no. 1 (January 2017): 1-2. Full Text
- Vazquez, C, Beachboard, DC, and Horner, SM. "Methods to Visualize MAVS Subcellular Localization." Methods in Molecular Biology (Clifton, N.J.) 1656 (January 2017): 131-142. Full Text
- Jarret, A, McFarland, AP, Horner, SM, Kell, A, Schwerk, J, Hong, M, Badil, S, Joslyn, RC, Baker, DP, Carrington, M, Hagedorn, CH, Gale, M, and Savan, R. "Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling." Nature Medicine 22, no. 12 (December 2016): 1475-1481. Full Text
- Gokhale, NS, McIntyre, ABR, McFadden, MJ, Roder, AE, Kennedy, EM, Gandara, JA, Hopcraft, SE, Quicke, KM, Vazquez, C, Willer, J, Ilkayeva, OR, Law, BA, Holley, CL, Garcia-Blanco, MA, Evans, MJ, Suthar, MS, Bradrick, SS, Mason, CE, and Horner, SM. "N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection." Cell Host & Microbe 20, no. 5 (November 2016): 654-665. Full Text
- Beachboard, DC, and Horner, SM. "Innate immune evasion strategies of DNA and RNA viruses." Current Opinion in Microbiology 32 (August 2016): 113-119. (Review) Full Text
- Kennedy, EM, Bogerd, HP, Kornepati, AVR, Kang, D, Ghoshal, D, Marshall, JB, Poling, BC, Tsai, K, Gokhale, NS, Horner, SM, and Cullen, BR. "Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression." Cell Host & Microbe 19, no. 5 (May 2016): 675-685. Full Text
- Aligeti, M, Roder, A, and Horner, SM. "Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity." Journal of Virology 89, no. 22 (November 2015): 11523-11533. Full Text
- Horner, SM. "Insights into antiviral innate immunity revealed by studying hepatitis C virus." Cytokine 74, no. 2 (August 2015): 190-197. (Review) Full Text
- Vazquez, C, and Horner, SM. "MAVS Coordination of Antiviral Innate Immunity." Journal of Virology 89, no. 14 (July 2015): 6974-6977. (Review) Full Text
- Horner, SM, and Naggie, S. "Successes and Challenges on the Road to Cure Hepatitis C." Plos Pathogens 11, no. 6 (June 18, 2015): e1004854-null. (Review) Full Text Open Access Copy
- "Correction: Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking." Plos One 10, no. 4 (April 13, 2015): e0124226-e0124226. Full Text
- Horner, SM, Wilkins, C, Badil, S, Iskarpatyoti, J, and Gale, M. "Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking." Plos One 10, no. 3 (January 2015): e0117963-null. Full Text
- Horner, SM. "Defining the spatial relationship between hepatitis C virus infection and interferon-stimulated gene induction in the human liver." Hepatology (Baltimore, Md.) 59, no. 6 (June 2014): 2065-2067. Full Text
- "Activation and evasion of antiviral innate immunity by hepatitis c virus." Journal of Molecular Biology 426, no. 6 (March 20, 2014): 1198-1209. (Review) Full Text
- Horner, SM. "Activation and evasion of antiviral innate immunity by hepatitis C virus." Journal of Molecular Biology 426, no. 6 (March 2014): 1198-1209. (Review) Full Text
- Gokhale, NS, Vazquez, C, and Horner, SM. "Hepatitis C Virus. Strategies to Evade Antiviral Responses." Future Virology 9, no. 12 (January 2014): 1061-1075. Full Text
- Horner, SM. "Activation and evasion of antiviral innate immunity by hepatitis c virus." Journal of Molecular Biology 426, no. 6 (2014): 1198-1209.
- Horner, SM. "Defining the spatial relationship between hepatitis C virus infection and interferon-stimulated gene induction in the human liver." Hepatology 59, no. 6 (January 1, 2014): 2065-2067. Full Text
- McFarland, AP, Horner, SM, Jarret, A, Joslyn, RC, Bindewald, E, Shapiro, BA, Delker, DA, Hagedorn, CH, Carrington, M, Gale, M, and Savan, R. "The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus–induced microRNAs." Nature Immunology 15, no. 1 (January 2014): 72-79. Full Text
- Horner, SM, and Gale, M. "Regulation of hepatic innate immunity by hepatitis C virus." Nature Medicine 19, no. 7 (July 2013): 879-888. (Review) Full Text
- Liu, HM, Loo, Y-M, Horner, SM, Zornetzer, GA, Katze, MG, and Gale, M. "The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity." Cell Host & Microbe 11, no. 5 (May 2012): 528-537. Full Text
- Horner, SM, Park, HS, and Gale, M. "Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0." Journal of Virology 86, no. 6 (March 2012): 3112-3120. Full Text
- Patel, MR, Loo, Y-M, Horner, SM, Gale, M, and Malik, HS. "Convergent evolution of escape from hepaciviral antagonism in primates." Plos Biology 10, no. 3 (January 2012): e1001282-null. Full Text
- Horner, SM, Liu, HM, Park, HS, Briley, J, and Gale, M. "Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus." Proceedings of the National Academy of Sciences of the United States of America 108, no. 35 (August 15, 2011): 14590-14595. Full Text
- Horner, SM, and Gale, M. "Intracellular innate immune cascades and interferon defenses that control hepatitis C virus." Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research 29, no. 9 (September 2009): 489-498. (Review) Full Text
- Horner, SM, and DiMaio, D. "The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells." Journal of Virology 81, no. 12 (June 2007): 6254-6264. Full Text
- Horner, SM, DeFilippis, RA, Manuelidis, L, and DiMaio, D. "Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells." Journal of Virology 78, no. 8 (April 2004): 4063-4073. Full Text
- Sherer, NM, Lehmann, MJ, Jimenez-Soto, LF, Ingmundson, A, Horner, SM, Cicchetti, G, Allen, PG, Pypaert, M, Cunningham, JM, and Mothes, W. "Visualization of retroviral replication in living cells reveals budding into multivesicular bodies." Traffic (Copenhagen, Denmark) 4, no. 11 (November 2003): 785-801. Full Text
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Book Sections
- Horner, SM, and Gale, M. "Regulation of Innate Immunity and Interferon Defenses by Hepatitis C Virus." In Chronic Hepatitis B and C, 245-269.: WORLD SCIENTIFIC, December 2012. Full Text
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- Teaching & Mentoring
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Recent Courses
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