Stacy M. Horner | Scholars@Duke

Stacy M. Horner
Assistant Professor of Molecular Genetics and Microbiology

Current Appointments & Affiliations

Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2014
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2014
Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2018

Contact Information

213 Research Drive, Room 0030 CARL Bldg, Durham, NC 27710
stacy.horner@duke.edu (919) 684-1921
Horner Lab Webpage

Background
Education, Training, & Certifications
- Ph.D., Yale University 2007
Duke Appointment History
- Instructor, Temporary in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2013 - 2014
Recognition
In the News
- JUN 17, 2018
  
  TWiV 498: Salivating at ASM Microbe
- OCT 20, 2016
  
  Chemical Tags Affect Ability of RNA Viruses to Infect Cells
Expertise
Subject Headings
Research
Selected Grants
- Regulation of antiviral host response by RNA modifications awarded by Burroughs Wellcome Fund 2017 - 2022
- Interferon stimulated genes that regulate viral infection by binding to modified RNAs awarded by National Institutes of Health 2019 - 2022
- Defining the role of the RNA modification N6-methyladenosine in the hepatitis C virus lifecycle awarded by National Institutes of Health 2016 - 2021
- Defining a novel function for the post-translational modification ufmylation in the antiviral innate immune response awarded by National Institutes of Health 2019 - 2020
- Mechanisms of RAB1B regulation of antiviral innate immune signaling awarded by American Cancer Society, Inc. 2018 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Amelioration of neural stem cell defects underlying Zika virus induced microcephaly awarded by Hartwell Foundation 2017 - 2020
- Defining how a tyrosine within the hepatitis c virus protease regulates antiviral innate immunity awarded by Burroughs Wellcome Fund 2017 - 2019
- Mapping the RNA modification N6-methyladenosine during Zika virus infection awarded by Weill Medical College of Cornell University 2017 - 2019
- IL-27 in skin host defense and regeneration awarded by National Institutes of Health 2017 - 2019
- Understanding the role of N6-methyladenosine in hepatitis C virus infection awarded by American Heart Association 2017 - 2019
- Viral Oncology Training Grant awarded by National Institutes of Health 1980 - 2019
- Novel Regulatory Controls of Hepatitis C Virus Envelopment and Secretion by the Viral NS4A Protein awarded by National Institutes of Health 2018
- Zika virus infection of neural stem cells to model pathogen-induced microcephaly awarded by National Institutes of Health 2016 - 2018
- Defining novel Riplet-activated antiviral innate immune signaling pathways awarded by National Institutes of Health 2016 - 2018
- An RNA-targeted platform for anti-flavivirus drug discovery awarded by Ribometrix LLC 2017
- Innate Immune Regulation during hepatitis C virus infection awarded by National Institutes of Health 2013 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Roder, AE, Vazquez, C, and Horner, SM. "The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein." Plos Pathogens 15, no. 2 (February 7, 2019): e1007163-null. Full Text
  - Roder, AE, and Horner, SM. "Measuring Hepatitis C Virus Envelopment by Using a Proteinase K Protection Assay." Methods in Molecular Biology (Clifton, N.J.) 1911 (January 2019): 209-217. Full Text
  - Dethoff, EA, Boerneke, MA, Gokhale, NS, Muhire, BM, Martin, DP, Sacco, MT, McFadden, MJ, Weinstein, JB, Messer, WB, Horner, SM, and Weeks, KM. "Pervasive tertiary structure in the dengue virus RNA genome." Proceedings of the National Academy of Sciences of the United States of America 115, no. 45 (November 2018): 11513-11518. Full Text
  - Imam, H, Khan, M, Gokhale, NS, McIntyre, ABR, Kim, G-W, Jang, JY, Kim, S-J, Mason, CE, Horner, SM, and Siddiqui, A. "N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle." Proceedings of the National Academy of Sciences of the United States of America 115, no. 35 (August 13, 2018): 8829-8834. Full Text
  - Wang, L, Pittman, KJ, Barker, JR, Salinas, RE, Stanaway, IB, Williams, GD, Carroll, RJ, Balmat, T, Ingham, A, Gopalakrishnan, AM, Gibbs, KD, Antonia, AL, eMERGE Network, , Heitman, J, Lee, SC, Jarvik, GP, Denny, JC, Horner, SM, DeLong, MR, Valdivia, RH, Crosslin, DR, and Ko, DC. "An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease." Cell Host & Microbe 24, no. 2 (August 2018): 308-323.e6. Full Text
  - Liu, B, Merriman, DK, Choi, SH, Schumacher, MA, Plangger, R, Kreutz, C, Horner, SM, Meyer, KD, and Al-Hashimi, HM. "A potentially abundant junctional RNA motif stabilized by m6A and Mg2." Nature Communications 9, no. 1 (July 17, 2018): 2761-null. Full Text
  - McFadden, MJ, Mitchell-Dick, A, Vazquez, C, Roder, AE, Labagnara, KF, McMahon, JJ, Silver, DL, and Horner, SM. "A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time." Viruses 10, no. 2 (February 24, 2018). Full Text
  - Kennedy, EM, Bogerd, HP, Kornepati, AVR, Kang, D, Ghoshal, D, Marshall, JB, Poling, BC, Tsai, K, Gokhale, NS, Horner, SM, and Cullen, BR. "Posttranscriptional m6A Editing of HIV-1 mRNAs Enhances Viral Gene Expression." Cell Host & Microbe 22, no. 6 (December 2017): 830-null. Full Text
  - Gokhale, NS, and Horner, SM. "RNA modifications go viral." Plos Pathogens 13, no. 3 (March 9, 2017): e1006188-null. (Review) Full Text
  - McFadden, MJ, Gokhale, NS, and Horner, SM. "Protect this house: cytosolic sensing of viruses." Current Opinion in Virology 22 (February 2017): 36-43. (Review) Full Text
  - Gokhale, NS, and Horner, SM. "Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs." Cell Host & Microbe 21, no. 1 (January 2017): 1-2. Full Text
  - Vazquez, C, Beachboard, DC, and Horner, SM. "Methods to Visualize MAVS Subcellular Localization." Methods in Molecular Biology (Clifton, N.J.) 1656 (January 2017): 131-142. Full Text
  - Jarret, A, McFarland, AP, Horner, SM, Kell, A, Schwerk, J, Hong, M, Badil, S, Joslyn, RC, Baker, DP, Carrington, M, Hagedorn, CH, Gale, M, and Savan, R. "Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling." Nature Medicine 22, no. 12 (December 2016): 1475-1481. Full Text
  - Gokhale, NS, McIntyre, ABR, McFadden, MJ, Roder, AE, Kennedy, EM, Gandara, JA, Hopcraft, SE, Quicke, KM, Vazquez, C, Willer, J, Ilkayeva, OR, Law, BA, Holley, CL, Garcia-Blanco, MA, Evans, MJ, Suthar, MS, Bradrick, SS, Mason, CE, and Horner, SM. "N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection." Cell Host & Microbe 20, no. 5 (November 2016): 654-665. Full Text
  - Beachboard, DC, and Horner, SM. "Innate immune evasion strategies of DNA and RNA viruses." Current Opinion in Microbiology 32 (August 2016): 113-119. (Review) Full Text
  - Kennedy, EM, Bogerd, HP, Kornepati, AVR, Kang, D, Ghoshal, D, Marshall, JB, Poling, BC, Tsai, K, Gokhale, NS, Horner, SM, and Cullen, BR. "Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression." Cell Host & Microbe 19, no. 5 (May 2016): 675-685. Full Text
  - Aligeti, M, Roder, A, and Horner, SM. "Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity." Journal of Virology 89, no. 22 (November 2015): 11523-11533. Full Text
  - Horner, SM. "Insights into antiviral innate immunity revealed by studying hepatitis C virus." Cytokine 74, no. 2 (August 2015): 190-197. (Review) Full Text
  - Vazquez, C, and Horner, SM. "MAVS Coordination of Antiviral Innate Immunity." Journal of Virology 89, no. 14 (July 2015): 6974-6977. (Review) Full Text
  - Horner, SM, and Naggie, S. "Successes and Challenges on the Road to Cure Hepatitis C." Plos Pathogens 11, no. 6 (June 18, 2015): e1004854-null. (Review) Full Text Open Access Copy
  - Horner, SM, Wilkins, C, Badil, S, Iskarpatyoti, J, and Gale, M. "Correction: Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking." Plos One 10, no. 4 (April 13, 2015). Full Text
  - Horner, SM, Wilkins, C, Badil, S, Iskarpatyoti, J, and Gale, M. "Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking." Plos One 10, no. 3 (January 2015): e0117963-null. Full Text
  - Horner, SM. "Defining the spatial relationship between hepatitis C virus infection and interferon-stimulated gene induction in the human liver." Hepatology (Baltimore, Md.) 59, no. 6 (June 2014): 2065-2067. Full Text
  - Horner, SM. "Activation and evasion of antiviral innate immunity by hepatitis c virus." Journal of Molecular Biology 426, no. 6 (March 20, 2014): 1198-1209. (Review) Full Text
  - Horner, SM. "Activation and evasion of antiviral innate immunity by hepatitis C virus." Journal of Molecular Biology 426, no. 6 (March 2014): 1198-1209. (Review) Full Text
  - Gokhale, NS, Vazquez, C, and Horner, SM. "Hepatitis C Virus. Strategies to Evade Antiviral Responses." Future Virology 9, no. 12 (January 2014): 1061-1075. Full Text
  - Horner, SM. "Activation and evasion of antiviral innate immunity by hepatitis c virus." Journal of Molecular Biology 426, no. 6 (2014): 1198-1209.
  - Horner, SM. "Defining the spatial relationship between hepatitis C virus infection and interferon-stimulated gene induction in the human liver." Hepatology 59, no. 6 (January 1, 2014): 2065-2067. Full Text
  - McFarland, AP, Horner, SM, Jarret, A, Joslyn, RC, Bindewald, E, Shapiro, BA, Delker, DA, Hagedorn, CH, Carrington, M, Gale, M, and Savan, R. "The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs." Nature Immunology 15, no. 1 (January 1, 2014): 72-79. Full Text
  - Horner, SM, and Gale, M. "Regulation of hepatic innate immunity by hepatitis C virus." Nature Medicine 19, no. 7 (July 2013): 879-888. (Review) Full Text
  - Liu, HM, Loo, Y-M, Horner, SM, Zornetzer, GA, Katze, MG, and Gale, M. "The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity." Cell Host & Microbe 11, no. 5 (May 2012): 528-537. Full Text
  - Horner, SM, Park, HS, and Gale, M. "Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0." Journal of Virology 86, no. 6 (March 2012): 3112-3120. Full Text
  - Patel, MR, Loo, Y-M, Horner, SM, Gale, M, and Malik, HS. "Convergent evolution of escape from hepaciviral antagonism in primates." Plos Biology 10, no. 3 (January 2012): e1001282-null. Full Text
  - Horner, SM, Liu, HM, Park, HS, Briley, J, and Gale, M. "Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus." Proceedings of the National Academy of Sciences of the United States of America 108, no. 35 (August 15, 2011): 14590-14595. Full Text
  - Horner, SM, and Gale, M. "Intracellular innate immune cascades and interferon defenses that control hepatitis C virus." Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research 29, no. 9 (September 2009): 489-498. (Review) Full Text
  - Horner, SM, and DiMaio, D. "The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells." Journal of Virology 81, no. 12 (June 2007): 6254-6264. Full Text
  - Horner, SM, DeFilippis, RA, Manuelidis, L, and DiMaio, D. "Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells." Journal of Virology 78, no. 8 (April 2004): 4063-4073. Full Text
  - Sherer, NM, Lehmann, MJ, Jimenez-Soto, LF, Ingmundson, A, Horner, SM, Cicchetti, G, Allen, PG, Pypaert, M, Cunningham, JM, and Mothes, W. "Visualization of retroviral replication in living cells reveals budding into multivesicular bodies." Traffic (Copenhagen, Denmark) 4, no. 11 (November 2003): 785-801. Full Text
- Book Sections
  - Horner, SM, and Gale, M. "Regulation of innate immunity and interferon defenses by hepatitis C virus." In Chronic Hepatitis B and C: Basic Science to Clinical Applications, 245-269. January 1, 2012. Full Text
  - DiMaio, D, Johung, K, Goodwin, EC, Horner, SM, and Yates, KE. "Senescence induced by repression of human papillomavirus oncogenes in cervical cancer cells." In Beyond Apoptosis: Cellular Outcomes of Cancer Therapy, 209-222. January 1, 2008.
Teaching & Mentoring
Recent Courses
- MGM 293: Research Independent Study I 2019
- MGM 593: Research Independent Study 2019

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Education, Training, & Certifications

Duke Appointment History

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Recent Courses