Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry.
Journal Article (Journal Article)
Purpose
Intermolecular multiple quantum coherences (iMQCs) are a source of MR contrast with applications including temperature imaging, anisotropy mapping, and brown fat imaging. Because all applications are limited by signal-to-noise ratio (SNR), we developed a pulse sequence that detects intermolecular zero quantum coherences with improved SNR.Methods
A previously developed pulse sequence that detects iMQCs, HOMOGENIZED with off resonance transfer (HOT), was modified with a multi-spin echo spatial encoding scheme (MSE-HOT). MSE-HOT uses a series of refocusing pulses to generate a stack of images that are averaged in postprocessing for higher SNR. MSE-HOT performance was quantified by measuring its temperature accuracy and precision during hyperthermia of ex vivo red bone marrow samples.Results
MSE-HOT yielded a three-fold improvement in temperature precision relative to previous pulse sequences. Sources of improved precision were 1) echo averaging and 2) suppression of J-coupling in the methylene protons of fat. MSE-HOT measured temperature change with an accuracy of 0.6°C.Conclusion
MSE-HOT improved the temperature accuracy and precision of HOT to a level that is sufficient for hyperthermia of bone marrow.Full Text
Duke Authors
Cited Authors
- Davis, RM; Zhou, Z; Chung, H; Warren, WS
Published Date
- May 2016
Published In
Volume / Issue
- 75 / 5
Start / End Page
- 1958 - 1966
PubMed ID
- 26077531
Pubmed Central ID
- PMC4681701
Electronic International Standard Serial Number (EISSN)
- 1522-2594
International Standard Serial Number (ISSN)
- 0740-3194
Digital Object Identifier (DOI)
- 10.1002/mrm.25789
Language
- eng