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Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry.

Publication ,  Journal Article
Davis, RM; Zhou, Z; Chung, H; Warren, WS
Published in: Magnetic resonance in medicine
May 2016

Intermolecular multiple quantum coherences (iMQCs) are a source of MR contrast with applications including temperature imaging, anisotropy mapping, and brown fat imaging. Because all applications are limited by signal-to-noise ratio (SNR), we developed a pulse sequence that detects intermolecular zero quantum coherences with improved SNR.A previously developed pulse sequence that detects iMQCs, HOMOGENIZED with off resonance transfer (HOT), was modified with a multi-spin echo spatial encoding scheme (MSE-HOT). MSE-HOT uses a series of refocusing pulses to generate a stack of images that are averaged in postprocessing for higher SNR. MSE-HOT performance was quantified by measuring its temperature accuracy and precision during hyperthermia of ex vivo red bone marrow samples.MSE-HOT yielded a three-fold improvement in temperature precision relative to previous pulse sequences. Sources of improved precision were 1) echo averaging and 2) suppression of J-coupling in the methylene protons of fat. MSE-HOT measured temperature change with an accuracy of 0.6°C.MSE-HOT improved the temperature accuracy and precision of HOT to a level that is sufficient for hyperthermia of bone marrow.

Duke Scholars

Published In

Magnetic resonance in medicine

DOI

EISSN

1522-2594

ISSN

0740-3194

Publication Date

May 2016

Volume

75

Issue

5

Start / End Page

1958 / 1966

Related Subject Headings

  • Temperature
  • Signal-To-Noise Ratio
  • Reproducibility of Results
  • Quantum Theory
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Models, Statistical
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davis, R. M., Zhou, Z., Chung, H., & Warren, W. S. (2016). Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry. Magnetic Resonance in Medicine, 75(5), 1958–1966. https://doi.org/10.1002/mrm.25789
Davis, Ryan M., Zijian Zhou, Hyunkoo Chung, and Warren S. Warren. “Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry.Magnetic Resonance in Medicine 75, no. 5 (May 2016): 1958–66. https://doi.org/10.1002/mrm.25789.
Davis RM, Zhou Z, Chung H, Warren WS. Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry. Magnetic resonance in medicine. 2016 May;75(5):1958–66.
Davis, Ryan M., et al. “Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry.Magnetic Resonance in Medicine, vol. 75, no. 5, May 2016, pp. 1958–66. Epmc, doi:10.1002/mrm.25789.
Davis RM, Zhou Z, Chung H, Warren WS. Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry. Magnetic resonance in medicine. 2016 May;75(5):1958–1966.
Journal cover image

Published In

Magnetic resonance in medicine

DOI

EISSN

1522-2594

ISSN

0740-3194

Publication Date

May 2016

Volume

75

Issue

5

Start / End Page

1958 / 1966

Related Subject Headings

  • Temperature
  • Signal-To-Noise Ratio
  • Reproducibility of Results
  • Quantum Theory
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Models, Statistical
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted
  • Image Enhancement