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Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.

Publication ,  Journal Article
Jansen, H; Loley, C; Lieb, W; Pencina, MJ; Nelson, CP; Kathiresan, S; Peloso, GM; Voight, BF; Reilly, MP; Assimes, TL; Boerwinkle, E; Rawal, R ...
Published in: Atherosclerosis
August 2015

BACKGROUND: The mechanisms underlying the association between diabetes and coronary artery disease (CAD) risk are unclear. We aimed to assess this association by studying genetic variants that have been shown to associate with type 2 diabetes (T2DM). If the association between diabetes and CAD is causal, we expected to observe an association of these variants with CAD as well. METHODS AND RESULTS: We studied all genetic variants currently known to be associated with T2DM at a genome-wide significant level (p < 5*10(-8)) in CARDIoGRAM, a genome-wide data-set of CAD including 22,233 CAD cases and 64,762 controls. Out of the 44 published T2DM SNPs 10 were significantly associated with CAD in CARDIoGRAM (OR>1, p < 0.05), more than expected by chance (p = 5.0*10(-5)). Considering all 44 SNPs, the average CAD risk observed per individual T2DM risk allele was 1.0076 (95% confidence interval (CI), 0.9973-1.0180). Such average risk increase was significantly lower than the increase expected based on i) the published effects of the SNPs on T2DM risk and ii) the effect of T2DM on CAD risk as observed in the Framingham Heart Study, which suggested a risk of 1.067 per allele (p = 7.2*10(-10) vs. the observed effect). Studying two risk scores based on risk alleles of the diabetes SNPs, one score using individual level data in 9856 subjects, and the second score on average effects of reported beta-coefficients from the entire CARDIoGRAM data-set, we again observed a significant - yet smaller than expected - association with CAD. CONCLUSIONS: Our data indicate that an association between type 2 diabetes related SNPs and CAD exists. However, the effects on CAD risk appear to be by far lower than what would be expected based on the effects of risk alleles on T2DM and the effect of T2DM on CAD in the epidemiological setting.

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Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

August 2015

Volume

241

Issue

2

Start / End Page

419 / 426

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Odds Ratio
  • North America
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Gene Frequency
 

Citation

APA
Chicago
ICMJE
MLA
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Jansen, H., Loley, C., Lieb, W., Pencina, M. J., Nelson, C. P., Kathiresan, S., … Schunkert, H. (2015). Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. Atherosclerosis, 241(2), 419–426. https://doi.org/10.1016/j.atherosclerosis.2015.05.033
Jansen, Henning, Christina Loley, Wolfgang Lieb, Michael J. Pencina, Christopher P. Nelson, Sekar Kathiresan, Gina M. Peloso, et al. “Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.Atherosclerosis 241, no. 2 (August 2015): 419–26. https://doi.org/10.1016/j.atherosclerosis.2015.05.033.
Jansen H, Loley C, Lieb W, Pencina MJ, Nelson CP, Kathiresan S, et al. Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. Atherosclerosis. 2015 Aug;241(2):419–26.
Jansen, Henning, et al. “Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.Atherosclerosis, vol. 241, no. 2, Aug. 2015, pp. 419–26. Pubmed, doi:10.1016/j.atherosclerosis.2015.05.033.
Jansen H, Loley C, Lieb W, Pencina MJ, Nelson CP, Kathiresan S, Peloso GM, Voight BF, Reilly MP, Assimes TL, Boerwinkle E, Hengstenberg C, Laaksonen R, McPherson R, Roberts R, Thorsteinsdottir U, Peters A, Gieger C, Rawal R, Thompson JR, König IR, CARDIoGRAM consortium, Vasan RS, Erdmann J, Samani NJ, Schunkert H. Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. Atherosclerosis. 2015 Aug;241(2):419–426.
Journal cover image

Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

August 2015

Volume

241

Issue

2

Start / End Page

419 / 426

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Odds Ratio
  • North America
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Gene Frequency