Overview
Positions
- Adjunct Professor in the Department of Biostatistics & Bioinformatics
- Former Chief Data Scientist for Duke Health
Michael J. Pencina, PhD
Adjunct Professor, Biostatistics & Bioinformatics
Former Chief Data Scientist, Duke Health
Duke University School of Medicine
Michael J. Pencina, PhD, currently serves as UnitedHealth Group chief AI scientist, where he leads data science initiatives to enhance the organization’s innovative use of responsible AI systems that deliver real-world impact at scale for patients, providers, consumers and health plan members. He is also adjunct professor of biostatistics and bioinformatics at Duke University School of Medicine. He formerly served as Chief Data Scientist at Duke Health.
Dr. Pencina is an internationally recognized authority in the development, evaluation and responsible application of AI algorithms. His work pioneered new methods for assessment of predictive algorithms and helped establish frameworks for intentional governance of health AI systems. Expert societies and guideline groups have relied on his work to advance best practices for the application of clinical decision support tools in health delivery. Since 2014, Thomson Reuters/Clarivate Analytics has regularly recognized Dr. Pencina as one of the world’s "highly cited researchers" in clinical medicine and social sciences, with more than 400 publications cited over 150,000 times.
He co-founded the national Coalition for Health AI (CHAI), a multi-stakeholder effort whose mission is to increase trustworthiness of AI by developing guidelines to drive high-quality health care through the implementation of innovative, credible, and transparent health AI systems. He also spearheaded establishing and co-led Duke Health’s Algorithm-Based Clinical Decision Support (ABCDS) Oversight Committee.
Dr. Pencina joined the Duke University faculty in 2013, and served as director of biostatistics for the Duke Clinical Research Institute until 2018. Previously, he was an associate professor in the Department of Biostatistics at Boston University and the Framingham Heart Study, and director of statistical consulting at the Harvard Clinical Research Institute. He received his PhD in Mathematics and Statistics from Boston University in 2003 and holds master’s degrees from the University of Warsaw in actuarial mathematics and business culture.
Email: michael.pencina@duke.edu
Web Sites: medschool.duke.edu; aihealth.duke.edu; https://scholars.duke.edu/person/michael.pencina
Phone: 919.613.9066
Address: Duke University School of Medicine; 2424 Erwin Road, Suite 903; Durham, NC 27705
Current Appointments & Affiliations
Recent Publications
Lifetime Adverse Pregnancy Outcome History and Cardiovascular Risk.
Journal Article Hypertension · March 20, 2026 BACKGROUND: Few studies have examined how multiple types of adverse pregnancy outcomes across women's reproductive lives relate to long-term cardiovascular disease. METHODS: In 59 154 parous participants in Nurses' Health Study II, lifetime history of gest ... Full text Link to item CiteCriteria to Assess the Predictive and Clinical Utility of Novel Models, Biomarkers, and Tools for Risk of Cardiovascular Disease: A Scientific Statement From the American Heart Association.
Journal Article Circulation · March 17, 2026 Risk prediction has been used in the primary prevention of cardiovascular disease for >3 decades. Contemporary cardiovascular risk assessment relies on multivariable models, which integrate established cardiovascular risk factors and have evolved over time ... Full text Link to item CiteCorrection to: Pragmatic Approaches to the Evaluation and Monitoring of Artificial Intelligence in Health Care: A Science Advisory From the American Heart Association.
Journal Article Circulation · February 24, 2026 Full text Link to item CiteRecent Grants
1/3 CTSA UM1 at Duke University
ResearchFaculty Member · Awarded by National Institutes of Health · 2025 - 20322/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030Implementation partner-guided strategy to promote health equity in ICU prognostication
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2025 - 2029View All Grants