Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management.

Journal Article (Letter)

Baclofen is an oral derivative of gamma-aminobutyric acid (GABA) used to treat muscular spasticity from disorders of the central nervous system. However, it is also being used for a variety of other conditions such as musculoskeletal pain, myoclonus, and alcohol withdrawal. The elimination of baclofen is heavily dependent on intact renal function, and the contraindication for use in patients with insufficient renal function is not well recognized by healthcare providers. Here, the authors report a series of mild to severe cases of baclofen intoxication in patients with end-stage renal disease. In all cases, baclofen was initiated by either inpatient or outpatient healthcare providers and the patients generally presented with altered mentation, somnolence, and/or respiratory depression. All patients were treated with aggressive hemodialysis and made a full recovery. This paper will briefly review the literature regarding baclofen intoxication, safety of baclofen use in renal disease, and efficacy of extracorporeal therapy in the treatment of baclofen intoxication.

Full Text

Duke Authors

Cited Authors

  • Roberts, JK; Westphal, S; Sparks, MA

Published Date

  • September 2015

Published In

Volume / Issue

  • 28 / 5

Start / End Page

  • 525 - 529

PubMed ID

  • 26096760

Pubmed Central ID

  • PMC5030105

Electronic International Standard Serial Number (EISSN)

  • 1525-139X

Digital Object Identifier (DOI)

  • 10.1111/sdi.12400


  • eng

Conference Location

  • United States