Matthew A. Sparks | Scholars@Duke

Matthew A. Sparks
Associate Professor of Medicine

I serve as the Program Director for the Nephrology Fellowship Program. My goal is to work with each fellow to ensure they develop a successful career in whatever direction they choose. I am the lead for the newly established Society for Early Education Scholars (SEEDS) in the Department of Medicine. The SEEDS Program is a year-long mentored education program designed for fellows planning careers as clinician educators or education scholars.

Nephrology Fellowship Program

My interest is in finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I serve as program director for the Nephrology Social Media Collective (NSMC) internship and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Nephrology Board of the American Board of Internal Medicine, the Scientific and Clinical Education Lifelong learning Committee Chair, Kidney in Cardiovascular Disease Council of the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation.

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

Listen to my podcast "The Nephron Segment"

@Nephro_Sparks on Twitter

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Nephrology, Medicine 2021

Contact Information

2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
Duke Box 103015, Durham, NC 27710
matthew.sparks@duke.edu (919) 684-9737
AJKD Blog
NephJC
Renal Fellow Network

Background
Education, Training, & Certifications
- Fellow in Nephrology, Medicine, Duke University School of Medicine 2007 - 2011
- Chief Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine 2006 - 2007
- Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine 2003 - 2006
- M.D., University of Arkansas for Medical Sciences, College of Medicine 2003
Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2015 - 2021
- Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2011 - 2015
Leadership & Clinical Positions at Duke
- Program Director- Nephrology Fellowship
  
  Director of Medical Student Research- Department of Medicine
  
  Lead, Society for Early Education Scholars (SEEDS)- Department of Medicine
Recognition
In the News
- AUG 3, 2015 Smithsonian
  
  Top five myths about human kidneys
- AUG 3, 2015 Smithsonian
  
  Top five myths about human kidneys
Awards & Honors
- Midcareer Distinguished Educator Award. American Society of Nephrology. 2022
- Volunteerism and Community Service Award. American College of Physicians. 2006
Expertise
Subject Headings
Research
Selected Grants
- The Paired Undergraduate Mentoring Program (PUMP) in Uronephrology awarded by National Institutes of Health 2022 - 2027
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2023
- Hepato-renal Regulation of Water Conservation in Salt-sensitive and Renal Hypertension awarded by Renal Research Institute, LLC 2020 - 2022
- Lymphatic Regulation of Skin Electrolyte Metabolism and Blood Pressure awarded by National Institutes of Health 2013 - 2020
External Relationships
- Alnylam Pharmaceutical, Inc.
- American Board of Internal Medicine
- American Heart Association
- NephJC
Publications & Artistic Works
Selected Publications
- Books
  - Lerma, E. V., Sparks, M. A., & Topf, J. (2018). Nephrology Secrets.
- Academic Articles
  - Okuno, K., Torimoto, K., Cicalese, S. M., Preston, K., Rizzo, V., Hashimoto, T., … Eguchi, S. (2023). Angiotensin II Type 1A Receptor Expressed in Smooth Muscle Cells is Required for Hypertensive Vascular Remodeling in Mice Infused With Angiotensin II. Hypertension. https://doi.org/10.1161/HYPERTENSIONAHA.122.20601
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  - Rajagopal, M., Sikri, H., Ward, S. C., Sparks, M. A., & Farouk, S. S. (2022). Acute Kidney Injury in a Patient With a Kidney Transplant and Posttransplant Lymphoproliferative Disorder: A Quiz. Am J Kidney Dis, 80(5), A20–A22. https://doi.org/10.1053/j.ajkd.2022.05.019
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  - Yang, T., Song, C., Ralph, D. L., Andrews, P., Sparks, M. A., Koller, B. H., … Coffman, T. M. (2022). Cell-Specific Actions of the Prostaglandin E-Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages. J Am Heart Assoc, 11(19), e026581. https://doi.org/10.1161/JAHA.122.026581
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  - Shah, C. V., Robbins, T. S., & Sparks, M. A. (2022). Sodium-Glucose Cotransporter 2 Inhibitors and Management of Refractory Hypomagnesemia Without Overt Urinary Magnesium Wasting: A Report of 2 Cases. Kidney Med, 4(10), 100533. https://doi.org/10.1016/j.xkme.2022.100533
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  - Savedchuk, S., Raslan, R., Nystrom, S., & Sparks, M. A. (2022). Emerging Viral Infections and the Potential Impact on Hypertension, Cardiovascular Disease, and Kidney Disease. Circ Res, 130(10), 1618–1641. https://doi.org/10.1161/CIRCRESAHA.122.320873
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  - Dave, N. N., Sparks, M. A., & Farouk, S. S. (2021). An introduction and guide to becoming a social media savvy nephrologist. Nephrology Dialysis Transplantation, 37(1), 14–20. https://doi.org/10.1093/ndt/gfaa067
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  - Hassler, L., Reyes, F., Sparks, M. A., Welling, P., & Batlle, D. (2021). Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19. Clinical Journal of the American Society of Nephrology : Cjasn, 16(11), 1755–1765. https://doi.org/10.2215/cjn.04560421
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  - Sparks, J. A., Vanni, K. M. M., Sparks, M. A., Xu, C., Santacroce, L. M., Glynn, R. J., … Solomon, D. H. (2021). Effect of Low-Dose Methotrexate on eGFR and Kidney Adverse Events: A Randomized Clinical Trial. J Am Soc Nephrol, 32(12), 3197–3207. https://doi.org/10.1681/ASN.2021050598
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  - DeOliveira, M., Feeney, C., Leahy, C., Nystrom, S., Howell, D. N., Farouk, S. S., … Sparks, M. A. (2021). Collapsing Glomerulopathy in Identical Twins With Lupus and High-Risk Apolipoprotein L1 (APOL1) Genotype. Kidney Int Rep, 6(9), 2501–2504. https://doi.org/10.1016/j.ekir.2021.06.005
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  - Gudsoorkar, P., Ruf, R., Adnani, H., Safdar, K., & Sparks, M. A. (2021). Onco-hypertension: An Emerging Specialty. Adv Chronic Kidney Dis, 28(5), 477-489.e1. https://doi.org/10.1053/j.ackd.2021.09.011
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  - Amin, K., Choksi, V., Farouk, S. S., & Sparks, M. A. (2021). Diarrhea in a Patient With Combined Kidney-Pancreas Transplant. Am J Kidney Dis, 78(2), A13–A16. https://doi.org/10.1053/j.ajkd.2021.01.023
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  - Yau, T. T., Sparks, M. A., & Topf, J. M. (2021). Eight Years of AJKD Blog-Lessons Learned and What Lies Ahead. Am J Kidney Dis, 78(2), 168–170. https://doi.org/10.1053/j.ajkd.2020.12.021
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  - Xiong, X., Nazo, N., Revoori, R., Rajagopal, S., & Sparks, M. A. (2021). G protein- and β-arrestin Signaling Profiles of Endothelin Derivatives at the Type A Endothelin Receptor. Kidney360, 2(7), 1124–1131. https://doi.org/10.34067/KID.0005462020
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  - Rianto, F., & Sparks, M. A. (2021). Shining More Light on RAS Inhibition during the COVID-19 Pandemic. Clin J Am Soc Nephrol, 16(7), 1002–1004. https://doi.org/10.2215/CJN.06000521
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  - Rianto, F., Hoang, T., Revoori, R., & Sparks, M. A. (2021). Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease. Mol Cell Endocrinol, 529, 111259. https://doi.org/10.1016/j.mce.2021.111259
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  - Sparks, M. A., Dilmen, E., Ralph, D. L., Rianto, F., Hoang, T. A., Hollis, A., … Coffman, T. M. (2021). Vascular control of kidney epithelial transporters. Am J Physiol Renal Physiol, 320(6), F1080–F1092. https://doi.org/10.1152/ajprenal.00084.2021
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  - Geherty, R. A., & Sparks, M. A. (2021). From confusion to clarity: RAS blockade in patients hospitalized with COVID-19. Kidney Int, 99(5), 1059–1061. https://doi.org/10.1016/j.kint.2021.02.034
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  - Cohen, J. B., South, A. M., Shaltout, H. A., Sinclair, M. R., & Sparks, M. A. (2021). Renin-angiotensin system blockade in the COVID-19 pandemic. Clin Kidney J, 14(Suppl 1), i48–i59. https://doi.org/10.1093/ckj/sfab026
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  - Kirby, B. S., Sparks, M. A., Lazarowski, E. R., Lopez Domowicz, D. A., Zhu, H., & McMahon, T. J. (2021). Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood. Am J Physiol Heart Circ Physiol, 320(3), H1055–H1065. https://doi.org/10.1152/ajpheart.00651.2020
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  - Atiq, S. O., Gokhale, T., Atiq, Z., Holmes, R., & Sparks, M. A. (2021). A case of pembrolizumab induced distal renal tubular acidosis. Journal of Onco Nephrology, 5(1), 23–26. https://doi.org/10.1177/2399369321992776
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  - Ruf, R., Yarandi, N., Ortiz-Melo, D. I., & Sparks, M. A. (2021). Onco-hypertension: Overview of hypertension with anti-cancer agents. Journal of Onco Nephrology, 5(1), 57–69. https://doi.org/10.1177/23993693211001374
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  - Sparks, M. A., Rianto, F., Diaz, E., Revoori, R., Hoang, T., Bouknight, L., … Coffman, T. M. (2021). Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy. Hypertension, 77(2), 393–404. https://doi.org/10.1161/HYPERTENSIONAHA.119.14079
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  - Chancay, J., Eswarappa, M., Sanchez Russo, L., Sparks, M. A., & Farouk, S. S. (2021). Urine Microscopy for Internal Medicine Residents: A Needs Assessment and Implementation of Virtual Teaching Sessions. Kidney360, 2(1), 79–85. https://doi.org/10.34067/KID.0006282020
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  - Rein, J. L., Sparks, M. A., Hilburg, R., & Farouk, S. S. (2020). Tackling acid-base disorders, one Twitter poll at a time. Advances in Physiology Education, 44(4), 706–708. https://doi.org/10.1152/advan.00099.2020
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  - Sparks, M. A., South, A. M., Badley, A. D., Baker-Smith, C. M., Batlle, D., Bozkurt, B., … Garovic, V. D. (2020). Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices. Hypertension, 76(5), 1350–1367. https://doi.org/10.1161/HYPERTENSIONAHA.120.15948
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  - Tio, M. C., Sparks, M. A., & Neyra, J. A. (2020). The International Biomedical Workforce is Critical to Our Response to COVID-19 in the United States. Mayo Clin Proc, 95(11), 2336–2338. https://doi.org/10.1016/j.mayocp.2020.09.012
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  - Norouzi, S., Farouk, S. S., & Sparks, M. A. (2020). Back off baclofen when the kidneys don't work. Kidney Int, 98(4), 829–831. https://doi.org/10.1016/j.kint.2020.05.026
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  - Edmonston, D. L., & Sparks, M. A. (2020). Therapeutic options for chronic kidney disease-associated pulmonary hypertension. Curr Opin Nephrol Hypertens, 29(5), 497–507. https://doi.org/10.1097/MNH.0000000000000624
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  - Provenzano, A. M., & Sparks, M. A. (2020). The renin-angiotensin-aldosterone system update: full-court press. Nephrol Dial Transplant, 35(9), 1488–1490. https://doi.org/10.1093/ndt/gfz123
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  - Edmonston, D. L., South, A. M., Sparks, M. A., & Cohen, J. B. (2020). Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System. Adv Chronic Kidney Dis, 27(5), 404–411. https://doi.org/10.1053/j.ackd.2020.07.002
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  - Hindi, J., Fuca, N., Sparks, M. A., Rein, J. L., & Farouk, S. S. (2020). Severe Acidemia in a Patient With Waldenström Macroglobulinemia. Kidney Int Rep, 5(9), 1586–1589. https://doi.org/10.1016/j.ekir.2020.06.023
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  - Ng, J. H., Bijol, V., Sparks, M. A., Sise, M. E., Izzedine, H., & Jhaveri, K. D. (2020). Pathophysiology and Pathology of Acute Kidney Injury in Patients With COVID-19. Adv Chronic Kidney Dis, 27(5), 365–376. https://doi.org/10.1053/j.ackd.2020.09.003
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  - Shah, S., & Sparks, M. A. (2020). COVID-19 and the Kidney Community: Coalescing in Crisis. Adv Chronic Kidney Dis, 27(5), 362–364. https://doi.org/10.1053/j.ackd.2020.10.001
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  - Batlle, D., Soler, M. J., Sparks, M. A., Hiremath, S., South, A. M., Welling, P. A., … COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group, . (2020). Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology. J Am Soc Nephrol, 31(7), 1380–1383. https://doi.org/10.1681/ASN.2020040419
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  - Farouk, S. S., & Sparks, M. A. (2020). Reenvisioning the Adult Nephrology Workforce: The Future of Kidney Care in the United States. Adv Chronic Kidney Dis, 27(4), 279–280. https://doi.org/10.1053/j.ackd.2020.08.006
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  - Cohen, J. B., Hanff, T. C., South, A. M., Sparks, M. A., Hiremath, S., Bress, A. P., … Chirinos, J. A. (2020). Response by Cohen et al to Letter Regarding Article, "Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19". Circ Res, 126(12), e140–e141. https://doi.org/10.1161/CIRCRESAHA.120.317205
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  - South, A. M., Tomlinson, L., Edmonston, D., Hiremath, S., & Sparks, M. A. (2020). Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. Nat Rev Nephrol, 16(6), 305–307. https://doi.org/10.1038/s41581-020-0279-4
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  - Sparks, M. A., South, A., Welling, P., Luther, J. M., Cohen, J., Byrd, J. B., … Hiremath, S. (2020). Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19. Clin J Am Soc Nephrol, 15(5), 714–716. https://doi.org/10.2215/CJN.03530320
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  - Edmonston, D. L., Parikh, K. S., Rajagopal, S., Shaw, L. K., Abraham, D., Grabner, A., … Wolf, M. (2020). Pulmonary Hypertension Subtypes and Mortality in CKD. Am J Kidney Dis, 75(5), 713–724. https://doi.org/10.1053/j.ajkd.2019.08.027
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  - Ramakrishnan, M., Sparks, M. A., & Farouk, S. S. (2020). Training the Public Physician: The Nephrology Social Media Collective Internship. Semin Nephrol, 40(3), 320–327. https://doi.org/10.1016/j.semnephrol.2020.04.012
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  - Tignanelli, C. J., Ingraham, N. E., Sparks, M. A., Reilkoff, R., Bezdicek, T., Benson, B., … Puskarich, M. A. (2020). Antihypertensive drugs and risk of COVID-19? Lancet Respir Med, 8(5), e30–e31. https://doi.org/10.1016/S2213-2600(20)30153-3
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  - Welling, P. A., Batlle, D., Byrd, J. B., Burrell, L. M., South, A. M., & Sparks, M. A. (2020). Rigor before speculation in COVID-19 therapy. Am J Physiol Lung Cell Mol Physiol, 318(5), L1027–L1028. https://doi.org/10.1152/ajplung.00152.2020
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  - Ingraham, N. E., Boulware, D., Sparks, M. A., Schacker, T., Benson, B., Sparks, J. A., … Tignanelli, C. J. (2020). Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2. Crit Care, 24(1), 182. https://doi.org/10.1186/s13054-020-02894-7
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  - Farouk, S., & Sparks, M. A. (2020). Editorial commentary: The public physician in cardiology: The solution to information pollution. Trends Cardiovasc Med, 30(1), 36–38. https://doi.org/10.1016/j.tcm.2019.02.002
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  - Lu, X., Rudemiller, N. P., Wen, Y., Ren, J., Hammer, G. E., Griffiths, R., … Crowley, S. D. (2019). A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation. Circ Res, 125(12), 1055–1066. https://doi.org/10.1161/CIRCRESAHA.119.315343
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  - Farouk, S. S., Hilburg, R., & Sparks, M. A. (2019). Design, Dissemination, and Assessment of NephSIM: A Mobile-Optimized Nephrology Teaching Tool. J Grad Med Educ, 11(6), 708–712. https://doi.org/10.4300/JGME-D-19-00443.1
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  - Prince, L. K., Nee, R., Yuan, C. M., & Nephrology Education Research and Development Consortium (NERDC), . (2019). The Acute Dialysis Orders Objective Structured Clinical Examination (OSCE): Fellow Performance on a Formative Assessment of Acute Kidney Replacement Therapy Competence. Clin J Am Soc Nephrol, 14(9), 1346–1354. https://doi.org/10.2215/CJN.02900319
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  - Panigrahy, D., Gartung, A., Yang, J., Yang, H., Gilligan, M. M., Sulciner, M. L., … Sukhatme, V. P. (2019). Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. J Clin Invest, 129(7), 2964–2979. https://doi.org/10.1172/JCI127282
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  - Dave, N. N., & Sparks, M. A. (2019). A Delicate Balance: Intraglomerular Hemodynamics Across Ages in Type 1 Diabetes. Am J Kidney Dis, 73(6), 759–761. https://doi.org/10.1053/j.ajkd.2019.02.009
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  - Shah, R., & Sparks, M. A. (2019). Renin-angiotensin system inhibition in advanced chronic kidney disease: how low can the kidney function go? Curr Opin Nephrol Hypertens, 28(2), 171–177. https://doi.org/10.1097/MNH.0000000000000484
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  - Herrera, M., Yang, T., Sparks, M. A., Manning, M. W., Koller, B. H., & Coffman, T. M. (2019). Complex Role for E-Prostanoid 4 Receptors in Hypertension. J Am Heart Assoc, 8(4), e010745. https://doi.org/10.1161/JAHA.118.010745
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  - Farouk, S., & Sparks, M. A. (2018). Renal Fellow Network: Past and Future. Clin J Am Soc Nephrol, 13(12), 1915–1917. https://doi.org/10.2215/CJN.06700518
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  - Carlson, D. A., Singer, M. R., Sutherland, C., Redondo, C., Alexander, L. T., Hughes, P. F., … Haystead, T. A. J. (2018). Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol, 25(10), 1195-1207.e32. https://doi.org/10.1016/j.chembiol.2018.06.006
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  - Wolf, E., Diaz, E. J., Hollis, A. N., Hoang, T. A., Azad, H. A., Bendt, K. M., … Sparks, M. A. (2018). Vascular type 1 angiotensin receptors control blood pressure by augmenting peripheral vascular resistance in female mice. Am J Physiol Renal Physiol, 315(4), F997–F1005. https://doi.org/10.1152/ajprenal.00639.2017
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  - Colbert, G. B., Topf, J., Jhaveri, K. D., Oates, T., Rheault, M. N., Shah, S., … Sparks, M. A. (2018). The Social Media Revolution in Nephrology Education. Kidney Int Rep, 3(3), 519–529. https://doi.org/10.1016/j.ekir.2018.02.003
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  - Sparks, M. A., & Topf, J. M. (2018). NephMadness After 5 Years: A Recap and Game Plan for the Future. Am J Kidney Dis, 71(3), 299–301. https://doi.org/10.1053/j.ajkd.2017.12.001
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  - Wolf, E., Kothari, N. R., Roberts, J. K., & Sparks, M. A. (2018). Baclofen Toxicity in Kidney Disease. Am J Kidney Dis, 71(2), 275–280. https://doi.org/10.1053/j.ajkd.2017.07.005
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  - Wang, L., Sha, Y., Bai, J., Eisner, W., Sparks, M. A., Buckley, A. F., & Spurney, R. F. (2017). Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. Am J Physiol Renal Physiol, 313(2), F430–F439. https://doi.org/10.1152/ajprenal.00614.2016
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  - Topf, J. M., Sparks, M. A., Phelan, P. J., Shah, N., Lerma, E. V., Graham-Brown, M. P. M., … Hiremath, S. (2017). The Evolution of the Journal Club: From Osler to Twitter. Am J Kidney Dis, 69(6), 827–836. https://doi.org/10.1053/j.ajkd.2016.12.012
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  - Stegbauer, J., Chen, D., Herrera, M., Sparks, M. A., Yang, T., Königshausen, E., … Coffman, T. M. (2017). Resistance to hypertension mediated by intercalated cells of the collecting duct. Jci Insight, 2(7), e92720. https://doi.org/10.1172/jci.insight.92720
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  - Roberts, J. K., Sparks, M. A., & Lehrich, R. W. (2016). Medical student attitudes toward kidney physiology and nephrology: a qualitative study. Ren Fail, 38(10), 1683–1693. https://doi.org/10.1080/0886022X.2016.1230459
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  - Zhang, J., Rudemiller, N. P., Patel, M. B., Wei, Q., Karlovich, N. S., Jeffs, A. D., … Crowley, S. D. (2016). Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. J Am Soc Nephrol, 27(8), 2257–2264. https://doi.org/10.1681/ASN.2015060683
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  - Cameron, C. B., Nair, V., Varma, M., Adams, M., Jhaveri, K. D., & Sparks, M. A. (2016). Does Academic Blogging Enhance Promotion and Tenure? A Survey of US and Canadian Medicine and Pediatric Department Chairs. Jmir Med Educ, 2(1), e10. https://doi.org/10.2196/mededu.4867
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  - Chen, D., Stegbauer, J., Sparks, M. A., Kohan, D., Griffiths, R., Herrera, M., … Coffman, T. M. (2016). Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension. Hypertension, 67(6), 1291–1297. https://doi.org/10.1161/HYPERTENSIONAHA.115.06987
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  - Zhang, J., Rudemiller, N. P., Patel, M. B., Karlovich, N. S., Wu, M., McDonough, A. A., … Crowley, S. D. (2016). Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell Metab, 23(2), 360–368. https://doi.org/10.1016/j.cmet.2015.11.013
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  - Sparks, M. A., Stegbauer, J., Chen, D., Gomez, J. A., Griffiths, R. C., Azad, H. A., … Coffman, T. M. (2015). Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. J Am Soc Nephrol, 26(12), 2953–2962. https://doi.org/10.1681/ASN.2014080816
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  - Topf, J. M., Sparks, M. A., Iannuzzella, F., Lerma, E., Oates, T., Phelan, P. J., & Hiremath, S. (2015). Twitter-Based Journal Clubs: Additional Facts and Clarifications. J Med Internet Res, 17(9), e216. https://doi.org/10.2196/jmir.4639
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  - Dimke, H., Sparks, M. A., Thomson, B. R., Frische, S., Coffman, T. M., & Quaggin, S. E. (2015). Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney. J Am Soc Nephrol, 26(5), 1027–1038. https://doi.org/10.1681/ASN.2014010060
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  - Sparks, M. A., Lerma, E. V., Kupin, W., Phelan, P. J., Jhaveri, K. D., & Topf, J. (2015). NephMadness 2015: nephrology as a cornerstone of medicine. Am J Kidney Dis, 65(3), 375–377. https://doi.org/10.1053/j.ajkd.2014.12.002
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  - Roberts, J. K., Westphal, S., & Sparks, M. A. (2015). Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management. Semin Dial, 28(5), 525–529. https://doi.org/10.1111/sdi.12400
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  - Malone, A. F., Phelan, P. J., Hall, G., Cetincelik, U., Homstad, A., Alonso, A. S., … Gbadegesin, R. A. (2014). Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney Int, 86(6), 1253–1259. https://doi.org/10.1038/ki.2014.305
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  - Zhang, J., Patel, M. B., Griffiths, R., Mao, A., Song, Y.-S., Karlovich, N. S., … Crowley, S. D. (2014). Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension. Hypertension, 64(6), 1275–1281. https://doi.org/10.1161/HYPERTENSIONAHA.114.03863
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  - Gbadegesin, R. A., Hall, G., Adeyemo, A., Hanke, N., Tossidou, I., Burchette, J., … Winn, M. P. (2014). Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. J Am Soc Nephrol, 25(9), 1991–2002. https://doi.org/10.1681/ASN.2013090976
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  - Sparks, M. A., Crowley, S. D., Gurley, S. B., Mirotsou, M., & Coffman, T. M. (2014). Classical Renin-Angiotensin system in kidney physiology. Compr Physiol, 4(3), 1201–1228. https://doi.org/10.1002/cphy.c130040
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  - Phelan, P. J., Conlon, P. J., & Sparks, M. A. (2014). Genetic determinants of renal transplant outcome: where do we stand? J Nephrol, 27(3), 247–256. https://doi.org/10.1007/s40620-014-0053-4
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  - Zhang, J.-D., Patel, M. B., Griffiths, R., Dolber, P. C., Ruiz, P., Sparks, M. A., … Crowley, S. D. (2014). Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis. J Clin Invest, 124(5), 2198–2203. https://doi.org/10.1172/JCI61368
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  - Wang, L., Tang, Y., Eisner, W., Sparks, M. A., Buckley, A. F., & Spurney, R. F. (2014). Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice. Biochem Biophys Res Commun, 444(4), 622–627. https://doi.org/10.1016/j.bbrc.2014.01.115
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  - Malone, A. F., Phelan, P. J., Hall, G., Cetincelik, U., Homstad, A., Alonso, A. S., … Gbadegesin, R. A. (2014). Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney International, 86(6), 1253–1259. https://doi.org/10.1038/ki.2014.305
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  - Wysocki, J., Ortiz-Melo, D. I., Mattocks, N. K., Xu, K., Prescott, J., Evora, K., … Gurley, S. B. (2014). ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney. Physiol Rep, 2(3), e00264. https://doi.org/10.1002/phy2.264
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  - Xie, L., Sparks, M. A., Li, W., Qi, Y., Liu, C., Coffman, T. M., & Johnson, G. A. (2013). Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice. Nmr Biomed, 26(12), 1853–1863. https://doi.org/10.1002/nbm.3039
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  - Pippin, J. W., Sparks, M. A., Glenn, S. T., Buitrago, S., Coffman, T. M., Duffield, J. S., … Shankland, S. J. (2013). Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. Am J Pathol, 183(2), 542–557. https://doi.org/10.1016/j.ajpath.2013.04.024
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  - Jhaveri, K. D., Sparks, M. A., & Shah, H. H. (2013). Novel educational approaches to enhance learning and interest in nephrology. Adv Chronic Kidney Dis, 20(4), 336–346. https://doi.org/10.1053/j.ackd.2013.03.006
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  - Jhaveri, K. D., Sparks, M. A., Shah, H. H., Khan, S., Chawla, A., Desai, T., … Kohan, D. E. (2013). Why not nephrology? A survey of US internal medicine subspecialty fellows. Am J Kidney Dis, 61(4), 540–546. https://doi.org/10.1053/j.ajkd.2012.10.025
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  - Desai, T., Sparks, M. A., Nair, V., Sethi, S. K., Topf, J., Calderon, K., … Jhaveri, K. D. (2013). The state of the blog: the first year of eAJKD. Am J Kidney Dis, 61(1), 1–2. https://doi.org/10.1053/j.ajkd.2012.10.013
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  - Sparks, M. A., Makhanova, N. A., Griffiths, R. C., Snouwaert, J. N., Koller, B. H., & Coffman, T. M. (2013). Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension, 61(1), 166–173. https://doi.org/10.1161/HYPERTENSIONAHA.112.193250
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  - Herrera, M., Sparks, M. A., Alfonso-Pecchio, A. R., Harrison-Bernard, L. M., & Coffman, T. M. (2013). Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein. Hypertension, 61(1), 253–258. https://doi.org/10.1161/HYPERTENSIONAHA.112.203679
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  - Malone, A. F., Sparks, M. A., Howell, D. N., Middleton, J. P., Smith, S. R., & Lehrich, R. W. (2013). IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia. J Nephrol, 26(6), 1195–1198. https://doi.org/10.5301/jn.5000298
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  - Shah, H. H., Jhaveri, K. D., Sparks, M. A., & Mattana, J. (2012). Career choice selection and satisfaction among US adult nephrology fellows. Clin J Am Soc Nephrol, 7(9), 1513–1520. https://doi.org/10.2215/CJN.01620212
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  - Zhang, J.-D., Patel, M. B., Song, Y.-S., Griffiths, R., Burchette, J., Ruiz, P., … Crowley, S. D. (2012). A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. Circ Res, 110(12), 1604–1617. https://doi.org/10.1161/CIRCRESAHA.111.261768
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  - Stegbauer, J., Gurley, S. B., Sparks, M. A., Woznowski, M., Kohan, D. E., Yan, M., … Coffman, T. M. (2011). AT1 receptors in the collecting duct directly modulate the concentration of urine. J Am Soc Nephrol, 22(12), 2237–2246. https://doi.org/10.1681/ASN.2010101095
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  - Sparks, M. A., O’Seaghdha, C. M., Sethi, S. K., & Jhaveri, K. D. (2011). Embracing the Internet as a means of enhancing medical education in nephrology. Am J Kidney Dis, 58(4), 512–518. https://doi.org/10.1053/j.ajkd.2011.06.009
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  - Gurley, S. B., Riquier-Brison, A. D. M., Schnermann, J., Sparks, M. A., Allen, A. M., Haase, V. H., … Coffman, T. M. (2011). AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab, 13(4), 469–475. https://doi.org/10.1016/j.cmet.2011.03.001
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  - Eckel, J., Lavin, P. J., Finch, E. A., Mukerji, N., Burch, J., Gbadegesin, R., … Winn, M. P. (2011). TRPC6 enhances angiotensin II-induced albuminuria. J Am Soc Nephrol, 22(3), 526–535. https://doi.org/10.1681/ASN.2010050522
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  - Sparks, M. A., Parsons, K. K., Stegbauer, J., Gurley, S. B., Vivekanandan-Giri, A., Fortner, C. N., … Coffman, T. M. (2011). Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension, 57(3), 577–585. https://doi.org/10.1161/HYPERTENSIONAHA.110.165274
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  - Sparks, M. A., & Coffman, T. M. (2010). The EP4 receptor for prostaglandin E2 in glomerular disease: a good receptor turned bad? J Am Soc Nephrol, 21(10), 1597–1599. https://doi.org/10.1681/ASN.2010080870
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  - Crowley, S. D., Song, Y. S., Sprung, G., Griffiths, R., Sparks, M., Yan, M., … Ruiz, P. (2010). Response to angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1. Hypertension, 56(1). https://doi.org/10.1161/HYPERTENSIONAHA.110.153544
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  - Crowley, S. D., Song, Y.-S., Sprung, G., Griffiths, R., Sparks, M., Yan, M., … Ruiz, P. (2010). A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. Hypertension, 55(1), 99–108. https://doi.org/10.1161/HYPERTENSIONAHA.109.144964
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- Book Sections
  - Schub, M., Savedchuk, S., Franco, S., & Sparks, M. (2021). Acute Tubular Injury – Pathophysiology and Clinical Implications. In Issues in Kidney Disease Acute Kidney Injury. Nova Science Publishers.
  - Schub, M., Savedchuk, S., Franco, S., & Sparks, M. A. (2021). Acute tubular injury - Pathophysiology and clinical implications. In Issues in Kidney Disease - Acute Kidney Injury (pp. 117–146).
  - Sparks, M. A., & Singh, H. (2018). Thrombotic Microangiopathies. In M. Sparks, J. Topf, & E. Lerma (Eds.), Nephrology Secrets.
  - Sparks, M. A., & Singh, H. (2018). Thrombotic Microangiopathies. In M. Sparks, J. Topf, & E. Lerma (Eds.), Nephrology Secrets.
  - 1. Olyaei, A. J., Lerma, E., Tuchman, S. A., & Sparks, M. A. (2015). Rational Dosing of Chemotherapy in Patients with Chronic Kidney Disease. In K. D. Jhaveri & A. Salahudeen (Eds.), Onconephrology Cancer, Chemotherapy and the Kidney (pp. 105–129). Springer.
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  - Olyaei, A. J., Lerma, E. V., Tuchman, S. A., & Sparks, M. A. (2015). Rational dosing of chemotherapy in patients with kidney failure. In Onconephrology: Cancer, Chemotherapy and the Kidney (pp. 105–129). https://doi.org/10.1007/978-1-4939-2659-6_6
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- Conference Papers
  - Garren, A., Katz, G., He, L., Macklin, M., Ben, K., Bair, C., … Leverenz, D. (2022). Scouting Reports as a Social Constructivist Teaching Tool in RheumMadness. In Arthritis & Rheumatology (Vol. 74, pp. 442–445).
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  - He, L., Ben, K., Macklin, M., Bair, C., Katz, G., Garren, A., … Leverenz, D. (2022). RheumMadness: Early Learner Experience and Impact. In Arthritis & Rheumatology (Vol. 74, pp. 438–441).
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  - Katz, G., Garren, A., He, L., Ben, K., Macklin, M., Bair, C., … Leverenz, D. (2022). Educational Experience and Engagement in the First Two Years of RheumMadness, an Online Community of Inquiry. In Arthritis & Rheumatology (Vol. 74, pp. 449–451).
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Teaching & Mentoring
Recent Courses
- CRP 279: Scientific Communication 2023
- CRP 279: Scientific Communication 2022
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- Scientific Communications

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