Matthew A. Sparks | Scholars@Duke

Matthew A. Sparks
Assistant Professor of Medicine

My lab is interested in understanding how both the renin angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. My lab utilizes a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research is funded by a career development award from the Department of Veterans Affairs Office of Research and Development (IK2BX002240) and a Scientist Development Grant from the American Heart Association. In my role as Director of Undergraduate Medical Research in the Department of Medicine I help promote research in the Department of Medicine during the 3rd year of medical school at Duke University. I also serve as the Associate Program Director for the Nephrology Fellowship Program.

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I am a faculty member of the Nephrology Social Media Collective (NSMC) and member of the online nephrology journal club (NephJC). I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular edutainment project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain an advocate for the site and author the yearly “Top Nephrology Stories of the Year”. I am currently a member of the Communications and Media Committee of the American Society of Nephrology, the American Heart Association and am a fellow of the American Society of Nephrology and the National Kidney Foundation.

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

@Nephro_Sparks on Twitter

Nephrology Fellowship Program

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2015

Contact Information

2 Genome Court, Msrb2 Room 1013, Box_103015, Durham, NC 27710
matthew.sparks@duke.edu (919) 684-9737
eAJKD Blog

Background
Education, Training, & Certifications
- Fellow In Nephrology, Medicine, Duke University School of Medicine 2007 - 2011
- Chief Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine 2006 - 2007
- Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine 2003 - 2006
- M.D., University of Arkansas for Medical Sciences College of Medicine 2003
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2011 - 2015
Recognition
In the News
- AUG 3, 2015 Smithsonian
  
  Top five myths about human kidneys
Awards & Honors
- Volunteerism and Community Service Award. American College of Physicians. 2006
Expertise
Subject Headings
Research
Selected Grants
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
Publications & Artistic Works
Selected Publications
- Book Sections
  - Olyaei, AJ, Lerma, EV, Tuchman, SA, & Sparks, MA. (2015, August 7). Rational dosing of chemotherapy in patients with kidney failure. In Onconephrology: Cancer, Chemotherapy and the Kidney (pp. 105-129). Full Text
- Journal Articles
  - Wolf, E, Kothari, NR, Roberts, JK, & Sparks, MA. (2017, September 9). Baclofen Toxicity in Kidney Disease. American journal of kidney diseases : the official journal of the National Kidney Foundation . Full Text
  - Wang, L, Sha, Y, Bai, J, Eisner, W, Sparks, MA, Buckley, AF, & Spurney, RF. (2017, August). Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. American journal of physiology. Renal physiology , 313 (2), F430-F439. Full Text
  - Topf, JM, Sparks, MA, Phelan, PJ, Shah, N, Lerma, EV, Graham-Brown, MPM, Madariaga, H, Iannuzzella, F, Rheault, MN, Oates, T, Jhaveri, KD, & Hiremath, S. (2017, June). The Evolution of the Journal Club: From Osler to Twitter. American journal of kidney diseases : the official journal of the National Kidney Foundation , 69 (6), 827-836. (Review) Full Text
  - Stegbauer, J, Chen, D, Herrera, M, Sparks, MA, Yang, T, Königshausen, E, Gurley, SB, & Coffman, TM. (2017, April 6). Resistance to hypertension mediated by intercalated cells of the collecting duct. JCI insight , 2 (7), e92720-. Full Text
  - Roberts, JK, Sparks, MA, & Lehrich, RW. (2016, November). Medical student attitudes toward kidney physiology and nephrology: a qualitative study. Renal failure , 38 (10), 1683-1693. Full Text Open Access Copy
  - Zhang, J, Rudemiller, NP, Patel, MB, Wei, Q, Karlovich, NS, Jeffs, AD, Wu, M, Sparks, MA, Privratsky, JR, Herrera, M, Gurley, SB, Nedospasov, SA, & Crowley, SD. (2016, August). Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. Journal of the American Society of Nephrology : JASN , 27 (8), 2257-2264. Full Text Open Access Copy
  - Cameron, CB, Nair, V, Varma, M, Adams, M, Jhaveri, KD, & Sparks, MA. (2016, June 23). Does Academic Blogging Enhance Promotion and Tenure? A Survey of US and Canadian Medicine and Pediatric Department Chairs. JMIR medical education , 2 (1), e10-.
  - Chen, D, Stegbauer, J, Sparks, MA, Kohan, D, Griffiths, R, Herrera, M, Gurley, SB, & Coffman, TM. (2016, June). Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension. Hypertension (Dallas, Tex. : 1979) , 67 (6), 1291-1297. Full Text
  - Zhang, J, Rudemiller, NP, Patel, MB, Karlovich, NS, Wu, M, McDonough, AA, Griffiths, R, Sparks, MA, Jeffs, AD, & Crowley, SD. (2016, February). Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell metabolism , 23 (2), 360-368. Full Text
  - Sparks, MA, Stegbauer, J, Chen, D, Gomez, JA, Griffiths, RC, Azad, HA, Herrera, M, Gurley, SB, & Coffman, TM. (2015, December). Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. Journal of the American Society of Nephrology : JASN , 26 (12), 2953-2962. Full Text
  - Roberts, JK, Westphal, S, & Sparks, MA. (2015, September). Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management. Seminars in dialysis , 28 (5), 525-529. (Letter) Full Text
  - Dimke, H, Sparks, MA, Thomson, BR, Frische, S, Coffman, TM, & Quaggin, SE. (2015, May). Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney. Journal of the American Society of Nephrology : JASN , 26 (5), 1027-1038. Full Text
  - Sparks, MA, Lerma, EV, Kupin, W, Phelan, PJ, Jhaveri, KD, & Topf, J. (2015, March). NephMadness 2015: nephrology as a cornerstone of medicine. American journal of kidney diseases : the official journal of the National Kidney Foundation , 65 (3), 375-377. Full Text
  - Topf, JM, Sparks, MA, Iannuzzella, F, Lerma, E, Oates, T, Phelan, PJ, & Hiremath, S. (2015, January). Twitter-Based Journal Clubs: Additional Facts and Clarifications. Journal of medical Internet research , 17 (9), e216-. (Letter) Full Text
  - Malone, AF, Phelan, PJ, Hall, G, Cetincelik, U, Homstad, A, Alonso, AS, Jiang, R, Lindsey, TB, Wu, G, Sparks, MA, Smith, SR, Webb, NJA, Kalra, PA, Adeyemo, AA, Shaw, AS, Conlon, PJ, Jennette, JC, Howell, DN, Winn, MP, & Gbadegesin, RA. (2014, December). Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney international , 86 (6), 1253-1259. Full Text Open Access Copy
  - Zhang, J, Patel, MB, Griffiths, R, Mao, A, Song, Y-S, Karlovich, NS, Sparks, MA, Jin, H, Wu, M, Lin, EE, & Crowley, SD. (2014, December). Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension. Hypertension (Dallas, Tex. : 1979) , 64 (6), 1275-1281. Full Text
  - Gbadegesin, RA, Hall, G, Adeyemo, A, Hanke, N, Tossidou, I, Burchette, J, Wu, G, Homstad, A, Sparks, MA, Gomez, J, Jiang, R, Alonso, A, Lavin, P, Conlon, P, Korstanje, R, Stander, MC, Shamsan, G, Barua, M, Spurney, R, Singhal, PC, Kopp, JB, Haller, H, Howell, D, Pollak, MR, Shaw, AS, Schiffer, M, & Winn, MP. (2014, September). Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. Journal of the American Society of Nephrology : JASN , 25 (9), 1991-2002. Full Text
  - Sparks, MA, Crowley, SD, Gurley, SB, Mirotsou, M, & Coffman, TM. (2014, July). Classical Renin-Angiotensin system in kidney physiology. Comprehensive Physiology , 4 (3), 1201-1228. (Review) Full Text
  - Phelan, PJ, Conlon, PJ, & Sparks, MA. (2014, June). Genetic determinants of renal transplant outcome: where do we stand?. Journal of Nephrology , 27 (3), 247-256. Full Text
  - Zhang, J-D, Patel, MB, Griffiths, R, Dolber, PC, Ruiz, P, Sparks, MA, Stegbauer, J, Jin, H, Gomez, JA, Buckley, AF, Lefler, WS, Chen, D, & Crowley, SD. (2014, May). Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis. The Journal of clinical investigation , 124 (5), 2198-2203. Full Text
  - Wang, L, Tang, Y, Eisner, W, Sparks, MA, Buckley, AF, & Spurney, RF. (2014, February). Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice. Biochemical and biophysical research communications , 444 (4), 622-627. Full Text
  - Malone, AF, Phelan, PJ, Hall, G, Cetincelik, U, Homstad, A, Alonso, AS, Jiang, R, Lindsey, TB, Wu, G, Sparks, MA, Smith, SR, Webb, NJA, Kalra, PA, Adeyemo, AA, Shaw, AS, Conlon, PJ, Jennette, JC, Howell, DN, Winn, MP, & Gbadegesin, RA. (2014, January 1). Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney International , 86 (6), 1253-1259. Full Text
  - Wysocki, J, Ortiz-Melo, DI, Mattocks, NK, Xu, K, Prescott, J, Evora, K, Ye, M, Sparks, MA, Haque, SK, Batlle, D, & Gurley, SB. (2014, January). ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney. Physiological Reports , 2 (3), e00264-. Full Text
  - Zhang, J, Patel, MB, Griffiths, R, Mao, A, Song, Y-S, Karlovich, NS, Sparks, MA, Jin, H, Wu, M, Lin, EE, & Crowley, SD. (2014). Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension. Hypertension . Full Text
  - Xie, L, Sparks, MA, Li, W, Qi, Y, Liu, C, Coffman, TM, & Johnson, GA. (2013, December). Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice. NMR Biomed , 26 (12), 1853-1863. Full Text Link to Item
  - Malone, AF, Sparks, MA, Howell, DN, Middleton, JP, Smith, SR, & Lehrich, RW. (2013, November). IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia. J Nephrol , 26 (6), 1195-1198. Full Text Link to Item
  - Jhaveri, KD, Sparks, MA, & Shah, HH. (2013, July). Novel educational approaches to enhance learning and interest in nephrology. Adv Chronic Kidney Dis , 20 (4), 336-346. (Review) Full Text Link to Item
  - Desai, T, Sparks, MA, Nair, V, Sethi, SK, Topf, J, Calderon, K, Bury, E, & Jhaveri, KD. (2013). The state of the blog: The first year of eAJKD. American Journal of Kidney Diseases , 61 (1), 1-2. Full Text
  - Herrera, M, Sparks, MA, Alfonso-Pecchio, AR, Harrison-Bernard, LM, & Coffman, TM. (2013, January). Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein. Hypertension , 61 (1), 253-258. Full Text Link to Item
  - Jhaveri, KD, Sparks, MA, Shah, HH, Khan, S, Chawla, A, Desai, T, Iglesia, E, Ferris, M, Parker, MG, & Kohan, DE. (2013). Why not nephrology? A survey of us internal medicine subspecialty fellows. American Journal of Kidney Diseases , 61 (4), 540-546. Full Text
  - Pippin, JW, Sparks, MA, Glenn, ST, Buitrago, S, Coffman, TM, Duffield, JS, Gross, KW, & Shankland, SJ. (2013). Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. American Journal of Pathology , 183 (2), 542-557. Full Text
  - Sparks, MA, Makhanova, NA, Griffiths, RC, Snouwaert, JN, Koller, BH, & Coffman, TM. (2013, January). Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension , 61 (1), 166-173. Full Text Link to Item
  - Shah, HH, Jhaveri, KD, Sparks, MA, & Mattana, J. (2012, September). Career choice selection and satisfaction among US adult nephrology fellows. Clin J Am Soc Nephrol , 7 (9), 1513-1520. Full Text Link to Item
  - Zhang, J-D, Patel, MB, Song, Y-S, Griffiths, R, Burchette, J, Ruiz, P, Sparks, MA, Yan, M, Howell, DN, Gomez, JA, Spurney, RF, Coffman, TM, & Crowley, SD. (2012, June 8). A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. Circ Res , 110 (12), 1604-1617. Full Text Link to Item
  - Stegbauer, J, Gurley, SB, Sparks, MA, Woznowski, M, Kohan, DE, Yan, M, Lehrich, RW, & Coffman, TM. (2011, December). AT1 receptors in the collecting duct directly modulate the concentration of urine. J Am Soc Nephrol , 22 (12), 2237-2246. Full Text Link to Item
  - Gurley, SB, Riquier-Brison, ADM, Schnermann, J, Sparks, MA, Allen, AM, Haase, VH, Snouwaert, JN, Le, TH, McDonough, AA, Koller, BH, & Coffman, TM. (2011, April 6). AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab , 13 (4), 469-475. Full Text Link to Item
  - Eckel, J, Lavin, PJ, Finch, EA, Mukerji, N, Burch, J, Gbadegesin, R, Wu, G, Bowling, B, Byrd, A, Hall, G, Sparks, M, Zhang, ZS, Homstad, A, Barisoni, L, Birbaumer, L, Rosenberg, P, & Winn, MP. (2011, March). TRPC6 enhances angiotensin II-induced albuminuria. J Am Soc Nephrol , 22 (3), 526-535. Full Text Link to Item
  - Sparks, MA, Parsons, KK, Stegbauer, J, Gurley, SB, Vivekanandan-Giri, A, Fortner, CN, Snouwaert, J, Raasch, EW, Griffiths, RC, Haystead, TAJ, Le, TH, Pennathur, S, Koller, B, & Coffman, TM. (2011, March). Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension , 57 (3), 577-585. Full Text Link to Item
  - Sparks, MA, O'Seaghdha, CM, Sethi, SK, & Jhaveri, KD. (2011). Embracing the internet as a means of enhancing medical education in nephrology. American Journal of Kidney Diseases , 58 (4), 512-518. Full Text
  - Crowley, SD, Song, Y-S, Sprung, G, Griffiths, R, Sparks, M, Yan, M, Burchette, JL, Howell, DN, Lin, EE, Okeiyi, B, Stegbauer, J, Yang, Y, Tharaux, P-L, & Ruiz, P. (2010). Response to angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1. Hypertension , 56 (1), e8-. Full Text
  - Crowley, SD, Song, Y-S, Sprung, G, Griffiths, R, Sparks, M, Yan, M, Burchette, JL, Howell, DN, Lin, EE, Okeiyi, B, Stegbauer, J, Yang, Y, Tharaux, P-L, & Ruiz, P. (2010, January). A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. Hypertension , 55 (1), 99-108. Full Text Link to Item
  - Sparks, MA, & Coffman, TM. (2010). The EP4 receptor for prostaglandin E₂in glomerular disease: A good receptor turned bad?. Journal of the American Society of Nephrology , 21 (10), 1597-1599. Full Text

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Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Book Sections

Journal Articles