Matthew A. Sparks
Associate Professor of Medicine
I serve as the Program Director for the Nephrology Fellowship Program. My goal is to work with each fellow to ensure they develop a successful career in whatever direction they choose. I am the lead for the newly established Society for Early Education Scholars (SEEDS) in the Department of Medicine. The SEEDS Program is a year-long mentored education program designed for fellows planning careers as clinician educators or education scholars.
Nephrology Fellowship Program
My interest is in finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I serve as program director for the Nephrology Social Media Collective (NSMC) internship and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Nephrology Board of the American Board of Internal Medicine, the Scientific and Clinical Education Lifelong learning Committee Chair, Kidney in Cardiovascular Disease Council of the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation.
I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.
Listen to my podcast "The Nephron Segment"
Current Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 2021
Contact Information
- 2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
- Duke Box 103015, Durham, NC 27710
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matthew.sparks@duke.edu
(919) 684-9737
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AJKD Blog
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NephJC
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Renal Fellow Network
- Background
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Education, Training, & Certifications
- Fellow in Nephrology, Medicine, Duke University School of Medicine 2007 - 2011
- Chief Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine 2006 - 2007
- Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine 2003 - 2006
- M.D., University of Arkansas for Medical Sciences, College of Medicine 2003
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Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2015 - 2021
- Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2011 - 2015
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Leadership & Clinical Positions at Duke
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Program Director- Nephrology Fellowship
Director of Medical Student Research- Department of Medicine
Lead, Society for Early Education Scholars (SEEDS)- Department of Medicine
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- Recognition
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In the News
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AUG 3, 2015 Smithsonian -
AUG 3, 2015 Smithsonian
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Awards & Honors
- Expertise
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Subject Headings
- Adult
- Analysis of Variance
- Angiotensin II
- Animals
- Antibody Specificity
- Aorta
- Biopsy
- Blood Pressure
- Blotting, Western
- Bone Marrow Cells
- CD4-Positive T-Lymphocytes
- Calcium
- Cell Differentiation
- Cell Movement
- Contractile Proteins
- Contrast Media
- Curriculum
- Cytoskeletal Proteins
- Disease Models, Animal
- Disease Susceptibility
- Electrolytes
- Epithelial Cells
- Fibrosis
- Gene Expression
- Glomerular Filtration Barrier
- Hypertension
- Image Processing, Computer-Assisted
- Immunohistochemistry
- Inflammation
- Kidney
- Kidney Diseases
- Kidney Tubules, Collecting
- Kidney Tubules, Proximal
- Learning
- Macrophages
- Magnetic susceptibility
- Mice
- Mice, 129 Strain
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Microvessels
- Muscle, Smooth, Vascular
- Mutant Proteins
- Mutation
- Oxidative Stress
- Pathology
- Pedigree
- Physicians
- Podocytes
- Polycythemia
- Prodrugs
- Program Development
- Program Evaluation
- Questionnaires
- Receptor Cross-Talk
- Receptor, Angiotensin, Type 1
- Renin-Angiotensin System
- Sequence Homology, Amino Acid
- Signal Transduction
- Sodium
- Sodium-Hydrogen Antiporter
- Sodium-Potassium-Chloride Symporters
- Transplantation Chimera
- Urine
- Vasoconstriction
- Vasoconstrictor Agents
- Research
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Selected Grants
- The Paired Undergraduate Mentoring Program (PUMP) in Uronephrology awarded by National Institutes of Health 2022 - 2027
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2023
- Hepato-renal Regulation of Water Conservation in Salt-sensitive and Renal Hypertension awarded by Renal Research Institute, LLC 2020 - 2022
- Lymphatic Regulation of Skin Electrolyte Metabolism and Blood Pressure awarded by National Institutes of Health 2013 - 2020
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External Relationships
- Alnylam Pharmaceutical, Inc.
- American Board of Internal Medicine
- American Heart Association
- NephJC
- Publications & Artistic Works
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Selected Publications
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Books
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Lerma, E. V., Sparks, M. A., & Topf, J. (2018). Nephrology Secrets.
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Academic Articles
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Okuno, K., Torimoto, K., Cicalese, S. M., Preston, K., Rizzo, V., Hashimoto, T., … Eguchi, S. (2023). Angiotensin II Type 1A Receptor Expressed in Smooth Muscle Cells is Required for Hypertensive Vascular Remodeling in Mice Infused With Angiotensin II. Hypertension. https://doi.org/10.1161/HYPERTENSIONAHA.122.20601Full Text Link to Item
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Rajagopal, M., Sikri, H., Ward, S. C., Sparks, M. A., & Farouk, S. S. (2022). Acute Kidney Injury in a Patient With a Kidney Transplant and Posttransplant Lymphoproliferative Disorder: A Quiz. Am J Kidney Dis, 80(5), A20–A22. https://doi.org/10.1053/j.ajkd.2022.05.019Full Text Link to Item
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Yang, T., Song, C., Ralph, D. L., Andrews, P., Sparks, M. A., Koller, B. H., … Coffman, T. M. (2022). Cell-Specific Actions of the Prostaglandin E-Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages. J Am Heart Assoc, 11(19), e026581. https://doi.org/10.1161/JAHA.122.026581Full Text Link to Item
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Shah, C. V., Robbins, T. S., & Sparks, M. A. (2022). Sodium-Glucose Cotransporter 2 Inhibitors and Management of Refractory Hypomagnesemia Without Overt Urinary Magnesium Wasting: A Report of 2 Cases. Kidney Med, 4(10), 100533. https://doi.org/10.1016/j.xkme.2022.100533Full Text Link to Item
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Savedchuk, S., Raslan, R., Nystrom, S., & Sparks, M. A. (2022). Emerging Viral Infections and the Potential Impact on Hypertension, Cardiovascular Disease, and Kidney Disease. Circ Res, 130(10), 1618–1641. https://doi.org/10.1161/CIRCRESAHA.122.320873Full Text Link to Item
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Dave, N. N., Sparks, M. A., & Farouk, S. S. (2021). An introduction and guide to becoming a social media savvy nephrologist. Nephrology Dialysis Transplantation, 37(1), 14–20. https://doi.org/10.1093/ndt/gfaa067Full Text
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Hassler, L., Reyes, F., Sparks, M. A., Welling, P., & Batlle, D. (2021). Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19. Clinical Journal of the American Society of Nephrology : Cjasn, 16(11), 1755–1765. https://doi.org/10.2215/cjn.04560421Full Text
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Sparks, J. A., Vanni, K. M. M., Sparks, M. A., Xu, C., Santacroce, L. M., Glynn, R. J., … Solomon, D. H. (2021). Effect of Low-Dose Methotrexate on eGFR and Kidney Adverse Events: A Randomized Clinical Trial. J Am Soc Nephrol, 32(12), 3197–3207. https://doi.org/10.1681/ASN.2021050598Full Text Link to Item
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DeOliveira, M., Feeney, C., Leahy, C., Nystrom, S., Howell, D. N., Farouk, S. S., … Sparks, M. A. (2021). Collapsing Glomerulopathy in Identical Twins With Lupus and High-Risk Apolipoprotein L1 (APOL1) Genotype. Kidney Int Rep, 6(9), 2501–2504. https://doi.org/10.1016/j.ekir.2021.06.005Full Text Link to Item
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Gudsoorkar, P., Ruf, R., Adnani, H., Safdar, K., & Sparks, M. A. (2021). Onco-hypertension: An Emerging Specialty. Adv Chronic Kidney Dis, 28(5), 477-489.e1. https://doi.org/10.1053/j.ackd.2021.09.011Full Text Link to Item
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Amin, K., Choksi, V., Farouk, S. S., & Sparks, M. A. (2021). Diarrhea in a Patient With Combined Kidney-Pancreas Transplant. Am J Kidney Dis, 78(2), A13–A16. https://doi.org/10.1053/j.ajkd.2021.01.023Full Text Link to Item
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Yau, T. T., Sparks, M. A., & Topf, J. M. (2021). Eight Years of AJKD Blog-Lessons Learned and What Lies Ahead. Am J Kidney Dis, 78(2), 168–170. https://doi.org/10.1053/j.ajkd.2020.12.021Full Text Link to Item
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Xiong, X., Nazo, N., Revoori, R., Rajagopal, S., & Sparks, M. A. (2021). G protein- and β-arrestin Signaling Profiles of Endothelin Derivatives at the Type A Endothelin Receptor. Kidney360, 2(7), 1124–1131. https://doi.org/10.34067/KID.0005462020Full Text Link to Item
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Rianto, F., & Sparks, M. A. (2021). Shining More Light on RAS Inhibition during the COVID-19 Pandemic. Clin J Am Soc Nephrol, 16(7), 1002–1004. https://doi.org/10.2215/CJN.06000521Full Text Link to Item
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Rianto, F., Hoang, T., Revoori, R., & Sparks, M. A. (2021). Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease. Mol Cell Endocrinol, 529, 111259. https://doi.org/10.1016/j.mce.2021.111259Full Text Link to Item
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Sparks, M. A., Dilmen, E., Ralph, D. L., Rianto, F., Hoang, T. A., Hollis, A., … Coffman, T. M. (2021). Vascular control of kidney epithelial transporters. Am J Physiol Renal Physiol, 320(6), F1080–F1092. https://doi.org/10.1152/ajprenal.00084.2021Full Text Link to Item
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Geherty, R. A., & Sparks, M. A. (2021). From confusion to clarity: RAS blockade in patients hospitalized with COVID-19. Kidney Int, 99(5), 1059–1061. https://doi.org/10.1016/j.kint.2021.02.034Full Text Link to Item
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Cohen, J. B., South, A. M., Shaltout, H. A., Sinclair, M. R., & Sparks, M. A. (2021). Renin-angiotensin system blockade in the COVID-19 pandemic. Clin Kidney J, 14(Suppl 1), i48–i59. https://doi.org/10.1093/ckj/sfab026Full Text Link to Item
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Kirby, B. S., Sparks, M. A., Lazarowski, E. R., Lopez Domowicz, D. A., Zhu, H., & McMahon, T. J. (2021). Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood. Am J Physiol Heart Circ Physiol, 320(3), H1055–H1065. https://doi.org/10.1152/ajpheart.00651.2020Full Text Open Access Copy Link to Item
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Atiq, S. O., Gokhale, T., Atiq, Z., Holmes, R., & Sparks, M. A. (2021). A case of pembrolizumab induced distal renal tubular acidosis. Journal of Onco Nephrology, 5(1), 23–26. https://doi.org/10.1177/2399369321992776Full Text
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Ruf, R., Yarandi, N., Ortiz-Melo, D. I., & Sparks, M. A. (2021). Onco-hypertension: Overview of hypertension with anti-cancer agents. Journal of Onco Nephrology, 5(1), 57–69. https://doi.org/10.1177/23993693211001374Full Text
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Sparks, M. A., Rianto, F., Diaz, E., Revoori, R., Hoang, T., Bouknight, L., … Coffman, T. M. (2021). Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy. Hypertension, 77(2), 393–404. https://doi.org/10.1161/HYPERTENSIONAHA.119.14079Full Text Link to Item
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Chancay, J., Eswarappa, M., Sanchez Russo, L., Sparks, M. A., & Farouk, S. S. (2021). Urine Microscopy for Internal Medicine Residents: A Needs Assessment and Implementation of Virtual Teaching Sessions. Kidney360, 2(1), 79–85. https://doi.org/10.34067/KID.0006282020Full Text Link to Item
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Rein, J. L., Sparks, M. A., Hilburg, R., & Farouk, S. S. (2020). Tackling acid-base disorders, one Twitter poll at a time. Advances in Physiology Education, 44(4), 706–708. https://doi.org/10.1152/advan.00099.2020Full Text
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Sparks, M. A., South, A. M., Badley, A. D., Baker-Smith, C. M., Batlle, D., Bozkurt, B., … Garovic, V. D. (2020). Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices. Hypertension, 76(5), 1350–1367. https://doi.org/10.1161/HYPERTENSIONAHA.120.15948Full Text Link to Item
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Tio, M. C., Sparks, M. A., & Neyra, J. A. (2020). The International Biomedical Workforce is Critical to Our Response to COVID-19 in the United States. Mayo Clin Proc, 95(11), 2336–2338. https://doi.org/10.1016/j.mayocp.2020.09.012Full Text Link to Item
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Norouzi, S., Farouk, S. S., & Sparks, M. A. (2020). Back off baclofen when the kidneys don't work. Kidney Int, 98(4), 829–831. https://doi.org/10.1016/j.kint.2020.05.026Full Text Link to Item
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Edmonston, D. L., & Sparks, M. A. (2020). Therapeutic options for chronic kidney disease-associated pulmonary hypertension. Curr Opin Nephrol Hypertens, 29(5), 497–507. https://doi.org/10.1097/MNH.0000000000000624Full Text Link to Item
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Provenzano, A. M., & Sparks, M. A. (2020). The renin-angiotensin-aldosterone system update: full-court press. Nephrol Dial Transplant, 35(9), 1488–1490. https://doi.org/10.1093/ndt/gfz123Full Text Link to Item
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Edmonston, D. L., South, A. M., Sparks, M. A., & Cohen, J. B. (2020). Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System. Adv Chronic Kidney Dis, 27(5), 404–411. https://doi.org/10.1053/j.ackd.2020.07.002Full Text Link to Item
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Hindi, J., Fuca, N., Sparks, M. A., Rein, J. L., & Farouk, S. S. (2020). Severe Acidemia in a Patient With Waldenström Macroglobulinemia. Kidney Int Rep, 5(9), 1586–1589. https://doi.org/10.1016/j.ekir.2020.06.023Full Text Link to Item
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Ng, J. H., Bijol, V., Sparks, M. A., Sise, M. E., Izzedine, H., & Jhaveri, K. D. (2020). Pathophysiology and Pathology of Acute Kidney Injury in Patients With COVID-19. Adv Chronic Kidney Dis, 27(5), 365–376. https://doi.org/10.1053/j.ackd.2020.09.003Full Text Link to Item
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Shah, S., & Sparks, M. A. (2020). COVID-19 and the Kidney Community: Coalescing in Crisis. Adv Chronic Kidney Dis, 27(5), 362–364. https://doi.org/10.1053/j.ackd.2020.10.001Full Text Link to Item
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Batlle, D., Soler, M. J., Sparks, M. A., Hiremath, S., South, A. M., Welling, P. A., … COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group, . (2020). Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology. J Am Soc Nephrol, 31(7), 1380–1383. https://doi.org/10.1681/ASN.2020040419Full Text Link to Item
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Farouk, S. S., & Sparks, M. A. (2020). Reenvisioning the Adult Nephrology Workforce: The Future of Kidney Care in the United States. Adv Chronic Kidney Dis, 27(4), 279–280. https://doi.org/10.1053/j.ackd.2020.08.006Full Text Link to Item
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Cohen, J. B., Hanff, T. C., South, A. M., Sparks, M. A., Hiremath, S., Bress, A. P., … Chirinos, J. A. (2020). Response by Cohen et al to Letter Regarding Article, "Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19". Circ Res, 126(12), e140–e141. https://doi.org/10.1161/CIRCRESAHA.120.317205Full Text Link to Item
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South, A. M., Tomlinson, L., Edmonston, D., Hiremath, S., & Sparks, M. A. (2020). Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. Nat Rev Nephrol, 16(6), 305–307. https://doi.org/10.1038/s41581-020-0279-4Full Text Link to Item
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Sparks, M. A., South, A., Welling, P., Luther, J. M., Cohen, J., Byrd, J. B., … Hiremath, S. (2020). Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19. Clin J Am Soc Nephrol, 15(5), 714–716. https://doi.org/10.2215/CJN.03530320Full Text Link to Item
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Edmonston, D. L., Parikh, K. S., Rajagopal, S., Shaw, L. K., Abraham, D., Grabner, A., … Wolf, M. (2020). Pulmonary Hypertension Subtypes and Mortality in CKD. Am J Kidney Dis, 75(5), 713–724. https://doi.org/10.1053/j.ajkd.2019.08.027Full Text Open Access Copy Link to Item
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Ramakrishnan, M., Sparks, M. A., & Farouk, S. S. (2020). Training the Public Physician: The Nephrology Social Media Collective Internship. Semin Nephrol, 40(3), 320–327. https://doi.org/10.1016/j.semnephrol.2020.04.012Full Text Link to Item
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Tignanelli, C. J., Ingraham, N. E., Sparks, M. A., Reilkoff, R., Bezdicek, T., Benson, B., … Puskarich, M. A. (2020). Antihypertensive drugs and risk of COVID-19? Lancet Respir Med, 8(5), e30–e31. https://doi.org/10.1016/S2213-2600(20)30153-3Full Text Link to Item
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Welling, P. A., Batlle, D., Byrd, J. B., Burrell, L. M., South, A. M., & Sparks, M. A. (2020). Rigor before speculation in COVID-19 therapy. Am J Physiol Lung Cell Mol Physiol, 318(5), L1027–L1028. https://doi.org/10.1152/ajplung.00152.2020Full Text Link to Item
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Ingraham, N. E., Boulware, D., Sparks, M. A., Schacker, T., Benson, B., Sparks, J. A., … Tignanelli, C. J. (2020). Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2. Crit Care, 24(1), 182. https://doi.org/10.1186/s13054-020-02894-7Full Text Link to Item
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Farouk, S., & Sparks, M. A. (2020). Editorial commentary: The public physician in cardiology: The solution to information pollution. Trends Cardiovasc Med, 30(1), 36–38. https://doi.org/10.1016/j.tcm.2019.02.002Full Text Link to Item
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Lu, X., Rudemiller, N. P., Wen, Y., Ren, J., Hammer, G. E., Griffiths, R., … Crowley, S. D. (2019). A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation. Circ Res, 125(12), 1055–1066. https://doi.org/10.1161/CIRCRESAHA.119.315343Full Text Link to Item
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Farouk, S. S., Hilburg, R., & Sparks, M. A. (2019). Design, Dissemination, and Assessment of NephSIM: A Mobile-Optimized Nephrology Teaching Tool. J Grad Med Educ, 11(6), 708–712. https://doi.org/10.4300/JGME-D-19-00443.1Full Text Link to Item
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Prince, L. K., Nee, R., Yuan, C. M., & Nephrology Education Research and Development Consortium (NERDC), . (2019). The Acute Dialysis Orders Objective Structured Clinical Examination (OSCE): Fellow Performance on a Formative Assessment of Acute Kidney Replacement Therapy Competence. Clin J Am Soc Nephrol, 14(9), 1346–1354. https://doi.org/10.2215/CJN.02900319Full Text Link to Item
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Panigrahy, D., Gartung, A., Yang, J., Yang, H., Gilligan, M. M., Sulciner, M. L., … Sukhatme, V. P. (2019). Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. J Clin Invest, 129(7), 2964–2979. https://doi.org/10.1172/JCI127282Full Text Link to Item
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Dave, N. N., & Sparks, M. A. (2019). A Delicate Balance: Intraglomerular Hemodynamics Across Ages in Type 1 Diabetes. Am J Kidney Dis, 73(6), 759–761. https://doi.org/10.1053/j.ajkd.2019.02.009Full Text Link to Item
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Shah, R., & Sparks, M. A. (2019). Renin-angiotensin system inhibition in advanced chronic kidney disease: how low can the kidney function go? Curr Opin Nephrol Hypertens, 28(2), 171–177. https://doi.org/10.1097/MNH.0000000000000484Full Text Link to Item
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Herrera, M., Yang, T., Sparks, M. A., Manning, M. W., Koller, B. H., & Coffman, T. M. (2019). Complex Role for E-Prostanoid 4 Receptors in Hypertension. J Am Heart Assoc, 8(4), e010745. https://doi.org/10.1161/JAHA.118.010745Full Text Open Access Copy Link to Item
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Farouk, S., & Sparks, M. A. (2018). Renal Fellow Network: Past and Future. Clin J Am Soc Nephrol, 13(12), 1915–1917. https://doi.org/10.2215/CJN.06700518Full Text Link to Item
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Carlson, D. A., Singer, M. R., Sutherland, C., Redondo, C., Alexander, L. T., Hughes, P. F., … Haystead, T. A. J. (2018). Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol, 25(10), 1195-1207.e32. https://doi.org/10.1016/j.chembiol.2018.06.006Full Text Link to Item
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Wolf, E., Diaz, E. J., Hollis, A. N., Hoang, T. A., Azad, H. A., Bendt, K. M., … Sparks, M. A. (2018). Vascular type 1 angiotensin receptors control blood pressure by augmenting peripheral vascular resistance in female mice. Am J Physiol Renal Physiol, 315(4), F997–F1005. https://doi.org/10.1152/ajprenal.00639.2017Full Text Link to Item
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Colbert, G. B., Topf, J., Jhaveri, K. D., Oates, T., Rheault, M. N., Shah, S., … Sparks, M. A. (2018). The Social Media Revolution in Nephrology Education. Kidney Int Rep, 3(3), 519–529. https://doi.org/10.1016/j.ekir.2018.02.003Full Text Link to Item
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Sparks, M. A., & Topf, J. M. (2018). NephMadness After 5 Years: A Recap and Game Plan for the Future. Am J Kidney Dis, 71(3), 299–301. https://doi.org/10.1053/j.ajkd.2017.12.001Full Text Link to Item
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Wolf, E., Kothari, N. R., Roberts, J. K., & Sparks, M. A. (2018). Baclofen Toxicity in Kidney Disease. Am J Kidney Dis, 71(2), 275–280. https://doi.org/10.1053/j.ajkd.2017.07.005Full Text Link to Item
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Wang, L., Sha, Y., Bai, J., Eisner, W., Sparks, M. A., Buckley, A. F., & Spurney, R. F. (2017). Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. Am J Physiol Renal Physiol, 313(2), F430–F439. https://doi.org/10.1152/ajprenal.00614.2016Full Text Link to Item
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Topf, J. M., Sparks, M. A., Phelan, P. J., Shah, N., Lerma, E. V., Graham-Brown, M. P. M., … Hiremath, S. (2017). The Evolution of the Journal Club: From Osler to Twitter. Am J Kidney Dis, 69(6), 827–836. https://doi.org/10.1053/j.ajkd.2016.12.012Full Text Link to Item
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Stegbauer, J., Chen, D., Herrera, M., Sparks, M. A., Yang, T., Königshausen, E., … Coffman, T. M. (2017). Resistance to hypertension mediated by intercalated cells of the collecting duct. Jci Insight, 2(7), e92720. https://doi.org/10.1172/jci.insight.92720Full Text Link to Item
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Roberts, J. K., Sparks, M. A., & Lehrich, R. W. (2016). Medical student attitudes toward kidney physiology and nephrology: a qualitative study. Ren Fail, 38(10), 1683–1693. https://doi.org/10.1080/0886022X.2016.1230459Full Text Open Access Copy Link to Item
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Zhang, J., Rudemiller, N. P., Patel, M. B., Wei, Q., Karlovich, N. S., Jeffs, A. D., … Crowley, S. D. (2016). Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. J Am Soc Nephrol, 27(8), 2257–2264. https://doi.org/10.1681/ASN.2015060683Full Text Open Access Copy Link to Item
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Cameron, C. B., Nair, V., Varma, M., Adams, M., Jhaveri, K. D., & Sparks, M. A. (2016). Does Academic Blogging Enhance Promotion and Tenure? A Survey of US and Canadian Medicine and Pediatric Department Chairs. Jmir Med Educ, 2(1), e10. https://doi.org/10.2196/mededu.4867Full Text Link to Item
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Chen, D., Stegbauer, J., Sparks, M. A., Kohan, D., Griffiths, R., Herrera, M., … Coffman, T. M. (2016). Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension. Hypertension, 67(6), 1291–1297. https://doi.org/10.1161/HYPERTENSIONAHA.115.06987Full Text Link to Item
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Zhang, J., Rudemiller, N. P., Patel, M. B., Karlovich, N. S., Wu, M., McDonough, A. A., … Crowley, S. D. (2016). Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell Metab, 23(2), 360–368. https://doi.org/10.1016/j.cmet.2015.11.013Full Text Link to Item
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Sparks, M. A., Stegbauer, J., Chen, D., Gomez, J. A., Griffiths, R. C., Azad, H. A., … Coffman, T. M. (2015). Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. J Am Soc Nephrol, 26(12), 2953–2962. https://doi.org/10.1681/ASN.2014080816Full Text Link to Item
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Topf, J. M., Sparks, M. A., Iannuzzella, F., Lerma, E., Oates, T., Phelan, P. J., & Hiremath, S. (2015). Twitter-Based Journal Clubs: Additional Facts and Clarifications. J Med Internet Res, 17(9), e216. https://doi.org/10.2196/jmir.4639Full Text Link to Item
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Dimke, H., Sparks, M. A., Thomson, B. R., Frische, S., Coffman, T. M., & Quaggin, S. E. (2015). Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney. J Am Soc Nephrol, 26(5), 1027–1038. https://doi.org/10.1681/ASN.2014010060Full Text Link to Item
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Sparks, M. A., Lerma, E. V., Kupin, W., Phelan, P. J., Jhaveri, K. D., & Topf, J. (2015). NephMadness 2015: nephrology as a cornerstone of medicine. Am J Kidney Dis, 65(3), 375–377. https://doi.org/10.1053/j.ajkd.2014.12.002Full Text Link to Item
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Roberts, J. K., Westphal, S., & Sparks, M. A. (2015). Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management. Semin Dial, 28(5), 525–529. https://doi.org/10.1111/sdi.12400Full Text Link to Item
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Malone, A. F., Phelan, P. J., Hall, G., Cetincelik, U., Homstad, A., Alonso, A. S., … Gbadegesin, R. A. (2014). Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney Int, 86(6), 1253–1259. https://doi.org/10.1038/ki.2014.305Full Text Open Access Copy Link to Item
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Zhang, J., Patel, M. B., Griffiths, R., Mao, A., Song, Y.-S., Karlovich, N. S., … Crowley, S. D. (2014). Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension. Hypertension, 64(6), 1275–1281. https://doi.org/10.1161/HYPERTENSIONAHA.114.03863Full Text Link to Item
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Gbadegesin, R. A., Hall, G., Adeyemo, A., Hanke, N., Tossidou, I., Burchette, J., … Winn, M. P. (2014). Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. J Am Soc Nephrol, 25(9), 1991–2002. https://doi.org/10.1681/ASN.2013090976Full Text Link to Item
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Sparks, M. A., Crowley, S. D., Gurley, S. B., Mirotsou, M., & Coffman, T. M. (2014). Classical Renin-Angiotensin system in kidney physiology. Compr Physiol, 4(3), 1201–1228. https://doi.org/10.1002/cphy.c130040Full Text Link to Item
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Phelan, P. J., Conlon, P. J., & Sparks, M. A. (2014). Genetic determinants of renal transplant outcome: where do we stand? J Nephrol, 27(3), 247–256. https://doi.org/10.1007/s40620-014-0053-4Full Text Link to Item
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Zhang, J.-D., Patel, M. B., Griffiths, R., Dolber, P. C., Ruiz, P., Sparks, M. A., … Crowley, S. D. (2014). Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis. J Clin Invest, 124(5), 2198–2203. https://doi.org/10.1172/JCI61368Full Text Link to Item
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Wang, L., Tang, Y., Eisner, W., Sparks, M. A., Buckley, A. F., & Spurney, R. F. (2014). Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice. Biochem Biophys Res Commun, 444(4), 622–627. https://doi.org/10.1016/j.bbrc.2014.01.115Full Text Link to Item
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Malone, A. F., Phelan, P. J., Hall, G., Cetincelik, U., Homstad, A., Alonso, A. S., … Gbadegesin, R. A. (2014). Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney International, 86(6), 1253–1259. https://doi.org/10.1038/ki.2014.305Full Text
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Wysocki, J., Ortiz-Melo, D. I., Mattocks, N. K., Xu, K., Prescott, J., Evora, K., … Gurley, S. B. (2014). ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney. Physiol Rep, 2(3), e00264. https://doi.org/10.1002/phy2.264Full Text Link to Item
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Xie, L., Sparks, M. A., Li, W., Qi, Y., Liu, C., Coffman, T. M., & Johnson, G. A. (2013). Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice. Nmr Biomed, 26(12), 1853–1863. https://doi.org/10.1002/nbm.3039Full Text Link to Item
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Pippin, J. W., Sparks, M. A., Glenn, S. T., Buitrago, S., Coffman, T. M., Duffield, J. S., … Shankland, S. J. (2013). Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. Am J Pathol, 183(2), 542–557. https://doi.org/10.1016/j.ajpath.2013.04.024Full Text Link to Item
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Jhaveri, K. D., Sparks, M. A., & Shah, H. H. (2013). Novel educational approaches to enhance learning and interest in nephrology. Adv Chronic Kidney Dis, 20(4), 336–346. https://doi.org/10.1053/j.ackd.2013.03.006Full Text Link to Item
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Jhaveri, K. D., Sparks, M. A., Shah, H. H., Khan, S., Chawla, A., Desai, T., … Kohan, D. E. (2013). Why not nephrology? A survey of US internal medicine subspecialty fellows. Am J Kidney Dis, 61(4), 540–546. https://doi.org/10.1053/j.ajkd.2012.10.025Full Text Link to Item
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Desai, T., Sparks, M. A., Nair, V., Sethi, S. K., Topf, J., Calderon, K., … Jhaveri, K. D. (2013). The state of the blog: the first year of eAJKD. Am J Kidney Dis, 61(1), 1–2. https://doi.org/10.1053/j.ajkd.2012.10.013Full Text Link to Item
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Sparks, M. A., Makhanova, N. A., Griffiths, R. C., Snouwaert, J. N., Koller, B. H., & Coffman, T. M. (2013). Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension, 61(1), 166–173. https://doi.org/10.1161/HYPERTENSIONAHA.112.193250Full Text Link to Item
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Herrera, M., Sparks, M. A., Alfonso-Pecchio, A. R., Harrison-Bernard, L. M., & Coffman, T. M. (2013). Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein. Hypertension, 61(1), 253–258. https://doi.org/10.1161/HYPERTENSIONAHA.112.203679Full Text Link to Item
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Malone, A. F., Sparks, M. A., Howell, D. N., Middleton, J. P., Smith, S. R., & Lehrich, R. W. (2013). IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia. J Nephrol, 26(6), 1195–1198. https://doi.org/10.5301/jn.5000298Full Text Link to Item
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Shah, H. H., Jhaveri, K. D., Sparks, M. A., & Mattana, J. (2012). Career choice selection and satisfaction among US adult nephrology fellows. Clin J Am Soc Nephrol, 7(9), 1513–1520. https://doi.org/10.2215/CJN.01620212Full Text Link to Item
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Zhang, J.-D., Patel, M. B., Song, Y.-S., Griffiths, R., Burchette, J., Ruiz, P., … Crowley, S. D. (2012). A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. Circ Res, 110(12), 1604–1617. https://doi.org/10.1161/CIRCRESAHA.111.261768Full Text Link to Item
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Stegbauer, J., Gurley, S. B., Sparks, M. A., Woznowski, M., Kohan, D. E., Yan, M., … Coffman, T. M. (2011). AT1 receptors in the collecting duct directly modulate the concentration of urine. J Am Soc Nephrol, 22(12), 2237–2246. https://doi.org/10.1681/ASN.2010101095Full Text Link to Item
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Sparks, M. A., O’Seaghdha, C. M., Sethi, S. K., & Jhaveri, K. D. (2011). Embracing the Internet as a means of enhancing medical education in nephrology. Am J Kidney Dis, 58(4), 512–518. https://doi.org/10.1053/j.ajkd.2011.06.009Full Text Link to Item
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Gurley, S. B., Riquier-Brison, A. D. M., Schnermann, J., Sparks, M. A., Allen, A. M., Haase, V. H., … Coffman, T. M. (2011). AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab, 13(4), 469–475. https://doi.org/10.1016/j.cmet.2011.03.001Full Text Link to Item
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Eckel, J., Lavin, P. J., Finch, E. A., Mukerji, N., Burch, J., Gbadegesin, R., … Winn, M. P. (2011). TRPC6 enhances angiotensin II-induced albuminuria. J Am Soc Nephrol, 22(3), 526–535. https://doi.org/10.1681/ASN.2010050522Full Text Link to Item
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Sparks, M. A., Parsons, K. K., Stegbauer, J., Gurley, S. B., Vivekanandan-Giri, A., Fortner, C. N., … Coffman, T. M. (2011). Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension, 57(3), 577–585. https://doi.org/10.1161/HYPERTENSIONAHA.110.165274Full Text Link to Item
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Sparks, M. A., & Coffman, T. M. (2010). The EP4 receptor for prostaglandin E2 in glomerular disease: a good receptor turned bad? J Am Soc Nephrol, 21(10), 1597–1599. https://doi.org/10.1681/ASN.2010080870Full Text Link to Item
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Crowley, S. D., Song, Y. S., Sprung, G., Griffiths, R., Sparks, M., Yan, M., … Ruiz, P. (2010). Response to angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1. Hypertension, 56(1). https://doi.org/10.1161/HYPERTENSIONAHA.110.153544Full Text
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Crowley, S. D., Song, Y.-S., Sprung, G., Griffiths, R., Sparks, M., Yan, M., … Ruiz, P. (2010). A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. Hypertension, 55(1), 99–108. https://doi.org/10.1161/HYPERTENSIONAHA.109.144964Full Text Link to Item
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Book Sections
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Schub, M., Savedchuk, S., Franco, S., & Sparks, M. (2021). Acute Tubular Injury – Pathophysiology and Clinical Implications. In Issues in Kidney Disease Acute Kidney Injury. Nova Science Publishers.
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Schub, M., Savedchuk, S., Franco, S., & Sparks, M. A. (2021). Acute tubular injury - Pathophysiology and clinical implications. In Issues in Kidney Disease - Acute Kidney Injury (pp. 117–146).
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Sparks, M. A., & Singh, H. (2018). Thrombotic Microangiopathies. In M. Sparks, J. Topf, & E. Lerma (Eds.), Nephrology Secrets.
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Sparks, M. A., & Singh, H. (2018). Thrombotic Microangiopathies. In M. Sparks, J. Topf, & E. Lerma (Eds.), Nephrology Secrets.
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1. Olyaei, A. J., Lerma, E., Tuchman, S. A., & Sparks, M. A. (2015). Rational Dosing of Chemotherapy in Patients with Chronic Kidney Disease. In K. D. Jhaveri & A. Salahudeen (Eds.), Onconephrology Cancer, Chemotherapy and the Kidney (pp. 105–129). Springer.Link to Item
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Olyaei, A. J., Lerma, E. V., Tuchman, S. A., & Sparks, M. A. (2015). Rational dosing of chemotherapy in patients with kidney failure. In Onconephrology: Cancer, Chemotherapy and the Kidney (pp. 105–129). https://doi.org/10.1007/978-1-4939-2659-6_6Full Text
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Conference Papers
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Garren, A., Katz, G., He, L., Macklin, M., Ben, K., Bair, C., … Leverenz, D. (2022). Scouting Reports as a Social Constructivist Teaching Tool in RheumMadness. In Arthritis & Rheumatology (Vol. 74, pp. 442–445).Link to Item
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He, L., Ben, K., Macklin, M., Bair, C., Katz, G., Garren, A., … Leverenz, D. (2022). RheumMadness: Early Learner Experience and Impact. In Arthritis & Rheumatology (Vol. 74, pp. 438–441).Link to Item
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Katz, G., Garren, A., He, L., Ben, K., Macklin, M., Bair, C., … Leverenz, D. (2022). Educational Experience and Engagement in the First Two Years of RheumMadness, an Online Community of Inquiry. In Arthritis & Rheumatology (Vol. 74, pp. 449–451).Link to Item
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- Teaching & Mentoring
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Recent Courses
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Teaching Activities
- Scientific Communications
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