Matthew A. Sparks | Scholars@Duke

Matthew A. Sparks
Associate Professor of Medicine

I serve as the Program Director for the Nephrology Fellowship Program. My goal is to work with each fellow to ensure they develop a successful career in whatever direction they choose. In my role as Director of Medical Student Research in the Department of Medicine I help promote research in the Department of Medicine during the 3rd year of medical school at Duke University. I am the lead for the newly established Society for Early Education Scholars (SEEDS) in the Department of Medicine. The SEEDS Program is a year-long mentored education program designed for fellows planning careers as clinician educators or education scholars.

Nephrology Fellowship Program

My laboratory is interested in understanding how both the renin-angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. We use a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research has been funded by the Department of Veterans Affairs Office of Research and Development and the American Heart Association. We also explore the link between pulmonary hypertension and CKD.

Sparks Laboratory Website

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I serve as the co-program director of the Nephrology Social Media Collective (NSMC) and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Nephrology Board of the American Board of Internal Medicine, the Scientific and Clinical Education Lifelong learning Committee Chair, Kidney in Cardiovascular Disease Council of the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation.

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

@Nephro_Sparks on Twitter

[video:https://warpwire.duke.edu/w/LxcFAA/]

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Nephrology, Medicine 2021

Contact Information

2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
Duke Box 103015, Durham, NC 27710
matthew.sparks@duke.edu (919) 684-9737
AJKD Blog
NephJC
Renal Fellow Network

Background
Education, Training, & Certifications
- Fellow in Nephrology, Medicine, Duke University School of Medicine 2007 - 2011
- Chief Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine 2006 - 2007
- Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine 2003 - 2006
- M.D., University of Arkansas for Medical Sciences, College of Medicine 2003
Duke Appointment History
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2015 - 2021
- Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2011 - 2015
Leadership & Clinical Positions at Duke
- Program Director- Nephrology Fellowship
  
  Director of Medical Student Research- Department of Medicine
  
  Lead, Society for Early Education Scholars (SEEDS)- Department of Medicine
Recognition
In the News
- AUG 3, 2015 Smithsonian
  
  Top five myths about human kidneys
Awards & Honors
- Volunteerism and Community Service Award. American College of Physicians. 2006
Expertise
Subject Headings
Research
Selected Grants
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- Hepato-renal Regulation of Water Conservation in Salt-sensitive and Renal Hypertension awarded by Renal Research Institute, LLC 2020 - 2022
- Lymphatic Regulation of Skin Electrolyte Metabolism and Blood Pressure awarded by National Institutes of Health 2013 - 2020
External Relationships
- American Board of Internal Medicine
- American Heart Association
- NephJC
Publications & Artistic Works
Selected Publications
- Books
  - Lerma, E. V., Sparks, M. A., & Topf, J. (2018). Nephrology Secrets.
- Academic Articles
  - Sparks, J., Vanni, K., Sparks, M., Xu, C., Santacroce, L., Glynn, R., … Solomon, D. (2021). Effect of Low-dose Methotrexate on Estimated Glomerular Filtration Rate and Kidney Adverse Events: A Randomized Clinical Trial. Journal of the American Society of Nephrology : Jasn. https://doi.org/10.1681/asn.2021050598
    Full Text
  - DeOliveira, M., Feeney, C., Leahy, C., Nystrom, S., Howell, D. N., Farouk, S. S., … Sparks, M. A. (2021). Collapsing Glomerulopathy in Identical Twins With Lupus and High-Risk Apolipoprotein L1 (APOL1) Genotype. Kidney International Reports, 6(9), 2501–2504. https://doi.org/10.1016/j.ekir.2021.06.005
    Full Text
  - Amin, K., Choksi, V., Farouk, S. S., & Sparks, M. A. (2021). Diarrhea in a Patient With Combined Kidney-Pancreas Transplant. Am J Kidney Dis, 78(2), A13–A16. https://doi.org/10.1053/j.ajkd.2021.01.023
    Full Text Link to Item
  - Yau, T. T., Sparks, M. A., & Topf, J. M. (2021). Eight Years of AJKD Blog-Lessons Learned and What Lies Ahead. Am J Kidney Dis, 78(2), 168–170. https://doi.org/10.1053/j.ajkd.2020.12.021
    Full Text Link to Item
  - Xiong, X., Nazo, N., Revoori, R., Rajagopal, S., & Sparks, M. A. (2021). G protein- and β-arrestin Signaling Profiles of Endothelin Derivatives at the Type A Endothelin Receptor. Kidney360, 2(7), 1124–1131. https://doi.org/10.34067/kid.0005462020
    Full Text
  - Rianto, F., & Sparks, M. A. (2021). Shining More Light on RAS Inhibition during the COVID-19 Pandemic. Clinical Journal of the American Society of Nephrology : Cjasn, 16(7), 1002–1004. https://doi.org/10.2215/cjn.06000521
    Full Text
  - Hassler, L., Reyes, F., Sparks, M. A., Welling, P., & Batlle, D. (2021). Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19. Clinical Journal of the American Society of Nephrology : Cjasn. https://doi.org/10.2215/cjn.04560421
    Full Text
  - Rianto, F., Hoang, T., Revoori, R., & Sparks, M. A. (2021). Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease. Mol Cell Endocrinol, 529, 111259. https://doi.org/10.1016/j.mce.2021.111259
    Full Text Link to Item
  - Sparks, M. A., Dilmen, E., Ralph, D. L., Rianto, F., Hoang, T. A., Hollis, A., … Coffman, T. M. (2021). Vascular control of kidney epithelial transporters. Am J Physiol Renal Physiol, 320(6), F1080–F1092. https://doi.org/10.1152/ajprenal.00084.2021
    Full Text Link to Item
  - Geherty, R. A., & Sparks, M. A. (2021). From confusion to clarity: RAS blockade in patients hospitalized with COVID-19. Kidney Int, 99(5), 1059–1061. https://doi.org/10.1016/j.kint.2021.02.034
    Full Text Link to Item
  - Cohen, J. B., South, A. M., Shaltout, H. A., Sinclair, M. R., & Sparks, M. A. (2021). Renin-angiotensin system blockade in the COVID-19 pandemic. Clin Kidney J, 14(Suppl 1), i48–i59. https://doi.org/10.1093/ckj/sfab026
    Full Text Link to Item
  - Kirby, B. S., Sparks, M. A., Lazarowski, E. R., Lopez Domowicz, D. A., Zhu, H., & McMahon, T. J. (2021). Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood. Am J Physiol Heart Circ Physiol, 320(3), H1055–H1065. https://doi.org/10.1152/ajpheart.00651.2020
    Full Text Open Access Copy Link to Item
  - Atiq, S. O., Gokhale, T., Atiq, Z., Holmes, R., & Sparks, M. A. (2021). A case of pembrolizumab induced distal renal tubular acidosis. Journal of Onco Nephrology, 5(1), 23–26. https://doi.org/10.1177/2399369321992776
    Full Text
  - Ruf, R., Yarandi, N., Ortiz-Melo, D. I., & Sparks, M. A. (2021). Onco-hypertension: Overview of hypertension with anti-cancer agents. Journal of Onco Nephrology, 5(1), 57–69. https://doi.org/10.1177/23993693211001374
    Full Text
  - Sparks, M. A., Rianto, F., Diaz, E., Revoori, R., Hoang, T., Bouknight, L., … Coffman, T. M. (2021). Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy. Hypertension, 77(2), 393–404. https://doi.org/10.1161/HYPERTENSIONAHA.119.14079
    Full Text Link to Item
  - Chancay, J., Eswarappa, M., Sanchez Russo, L., Sparks, M. A., & Farouk, S. S. (2021). Urine Microscopy for Internal Medicine Residents: A Needs Assessment and Implementation of Virtual Teaching Sessions. Kidney360, 2(1), 79–85. https://doi.org/10.34067/kid.0006282020
    Full Text
  - Rein, J. L., Sparks, M. A., Hilburg, R., & Farouk, S. S. (2020). Tackling acid-base disorders, one Twitter poll at a time. Adv Physiol Educ, 44(4), 706–708. https://doi.org/10.1152/advan.00099.2020
    Full Text Link to Item
  - Sparks, M. A., South, A. M., Badley, A. D., Baker-Smith, C. M., Batlle, D., Bozkurt, B., … Garovic, V. D. (2020). Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices. Hypertension, 76(5), 1350–1367. https://doi.org/10.1161/HYPERTENSIONAHA.120.15948
    Full Text Link to Item
  - Tio, M. C., Sparks, M. A., & Neyra, J. A. (2020). The International Biomedical Workforce is Critical to Our Response to COVID-19 in the United States. Mayo Clin Proc, 95(11), 2336–2338. https://doi.org/10.1016/j.mayocp.2020.09.012
    Full Text Link to Item
  - Norouzi, S., Farouk, S. S., & Sparks, M. A. (2020). Back off baclofen when the kidneys don't work. Kidney Int, 98(4), 829–831. https://doi.org/10.1016/j.kint.2020.05.026
    Full Text Link to Item
  - Edmonston, D. L., & Sparks, M. A. (2020). Therapeutic options for chronic kidney disease-associated pulmonary hypertension. Curr Opin Nephrol Hypertens, 29(5), 497–507. https://doi.org/10.1097/MNH.0000000000000624
    Full Text Link to Item
  - Hindi, J., Fuca, N., Sparks, M. A., Rein, J. L., & Farouk, S. S. (2020). Severe Acidemia in a Patient With Waldenström Macroglobulinemia. Kidney Int Rep, 5(9), 1586–1589. https://doi.org/10.1016/j.ekir.2020.06.023
    Full Text Link to Item
  - Provenzano, A. M., & Sparks, M. A. (2020). The renin-angiotensin-aldosterone system update: full-court press. Nephrol Dial Transplant, 35(9), 1488–1490. https://doi.org/10.1093/ndt/gfz123
    Full Text Link to Item
  - Edmonston, D. L., South, A. M., Sparks, M. A., & Cohen, J. B. (2020). Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System. Advances in Chronic Kidney Disease, 27(5), 404–411. https://doi.org/10.1053/j.ackd.2020.07.002
    Full Text
  - Ng, J. H., Bijol, V., Sparks, M. A., Sise, M. E., Izzedine, H., & Jhaveri, K. D. (2020). Pathophysiology and Pathology of Acute Kidney Injury in Patients With COVID-19. Adv Chronic Kidney Dis, 27(5), 365–376. https://doi.org/10.1053/j.ackd.2020.09.003
    Full Text Link to Item
  - Shah, S., & Sparks, M. A. (2020). COVID-19 and the Kidney Community: Coalescing in Crisis. Advances in Chronic Kidney Disease, 27(5), 362–364. https://doi.org/10.1053/j.ackd.2020.10.001
    Full Text
  - Batlle, D., Soler, M. J., Sparks, M. A., Hiremath, S., South, A. M., Welling, P. A., … COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group, . (2020). Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology. J Am Soc Nephrol, 31(7), 1380–1383. https://doi.org/10.1681/ASN.2020040419
    Full Text Link to Item
  - Farouk, S. S., & Sparks, M. A. (2020). Reenvisioning the Adult Nephrology Workforce: The Future of Kidney Care in the United States. Adv Chronic Kidney Dis, 27(4), 279–280. https://doi.org/10.1053/j.ackd.2020.08.006
    Full Text Link to Item
  - Cohen, J. B., Hanff, T. C., South, A. M., Sparks, M. A., Hiremath, S., Bress, A. P., … Chirinos, J. A. (2020). Response by Cohen et al to Letter Regarding Article, "Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19". Circ Res, 126(12), e140–e141. https://doi.org/10.1161/CIRCRESAHA.120.317205
    Full Text Link to Item
  - South, A. M., Tomlinson, L., Edmonston, D., Hiremath, S., & Sparks, M. A. (2020). Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. Nat Rev Nephrol, 16(6), 305–307. https://doi.org/10.1038/s41581-020-0279-4
    Full Text Link to Item
  - Edmonston, D. L., Parikh, K. S., Rajagopal, S., Shaw, L. K., Abraham, D., Grabner, A., … Wolf, M. (2020). Pulmonary Hypertension Subtypes and Mortality in CKD. Am J Kidney Dis, 75(5), 713–724. https://doi.org/10.1053/j.ajkd.2019.08.027
    Full Text Open Access Copy Link to Item
  - Ramakrishnan, M., Sparks, M. A., & Farouk, S. S. (2020). Training the Public Physician: The Nephrology Social Media Collective Internship. Semin Nephrol, 40(3), 320–327. https://doi.org/10.1016/j.semnephrol.2020.04.012
    Full Text Link to Item
  - Tignanelli, C. J., Ingraham, N. E., Sparks, M. A., Reilkoff, R., Bezdicek, T., Benson, B., … Puskarich, M. A. (2020). Antihypertensive drugs and risk of COVID-19? Lancet Respir Med, 8(5), e30–e31. https://doi.org/10.1016/S2213-2600(20)30153-3
    Full Text Link to Item
  - Sparks, M. A., South, A., Welling, P., Luther, J. M., Cohen, J., Byrd, J. B., … Hiremath, S. (2020). Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19. Clinical Journal of the American Society of Nephrology : Cjasn, 15(5), 714–716. https://doi.org/10.2215/cjn.03530320
    Full Text
  - Welling, P. A., Batlle, D., Byrd, J. B., Burrell, L. M., South, A. M., & Sparks, M. A. (2020). Rigor before speculation in COVID-19 therapy. American Journal of Physiology. Lung Cellular and Molecular Physiology, 318(5), L1027–L1028. https://doi.org/10.1152/ajplung.00152.2020
    Full Text
  - Ingraham, N. E., Boulware, D., Sparks, M. A., Schacker, T., Benson, B., Sparks, J. A., … Tignanelli, C. J. (2020). Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2. Crit Care, 24(1), 182. https://doi.org/10.1186/s13054-020-02894-7
    Full Text Link to Item
  - Farouk, S., & Sparks, M. A. (2020). Editorial commentary: The public physician in cardiology: The solution to information pollution. Trends Cardiovasc Med, 30(1), 36–38. https://doi.org/10.1016/j.tcm.2019.02.002
    Full Text Link to Item
  - Farouk, S. S., Hilburg, R., & Sparks, M. A. (2019). Design, Dissemination, and Assessment of NephSIM: A Mobile-Optimized Nephrology Teaching Tool. J Grad Med Educ, 11(6), 708–712. https://doi.org/10.4300/JGME-D-19-00443.1
    Full Text Link to Item
  - Lu, X., Rudemiller, N. P., Wen, Y., Ren, J., Hammer, G. E., Griffiths, R., … Crowley, S. D. (2019). A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation. Circulation Research, 125(12), 1055–1066. https://doi.org/10.1161/circresaha.119.315343
    Full Text
  - Prince, L. K., Nee, R., Yuan, C. M., & Nephrology Education Research and Development Consortium (NERDC), . (2019). The Acute Dialysis Orders Objective Structured Clinical Examination (OSCE): Fellow Performance on a Formative Assessment of Acute Kidney Replacement Therapy Competence. Clin J Am Soc Nephrol, 14(9), 1346–1354. https://doi.org/10.2215/CJN.02900319
    Full Text Link to Item
  - Panigrahy, D., Gartung, A., Yang, J., Yang, H., Gilligan, M. M., Sulciner, M. L., … Sukhatme, V. P. (2019). Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. J Clin Invest, 129(7), 2964–2979. https://doi.org/10.1172/JCI127282
    Full Text Link to Item
  - Dave, N. N., & Sparks, M. A. (2019). A Delicate Balance: Intraglomerular Hemodynamics Across Ages in Type 1 Diabetes. Am J Kidney Dis, 73(6), 759–761. https://doi.org/10.1053/j.ajkd.2019.02.009
    Full Text Link to Item
  - Shah, R., & Sparks, M. A. (2019). Renin-angiotensin system inhibition in advanced chronic kidney disease: how low can the kidney function go? Curr Opin Nephrol Hypertens, 28(2), 171–177. https://doi.org/10.1097/MNH.0000000000000484
    Full Text Link to Item
  - Herrera, M., Yang, T., Sparks, M. A., Manning, M. W., Koller, B. H., & Coffman, T. M. (2019). Complex Role for E-Prostanoid 4 Receptors in Hypertension. J Am Heart Assoc, 8(4), e010745. https://doi.org/10.1161/JAHA.118.010745
    Full Text Open Access Copy Link to Item
  - Farouk, S., & Sparks, M. A. (2018). Renal Fellow Network: Past and Future. Clin J Am Soc Nephrol, 13(12), 1915–1917. https://doi.org/10.2215/CJN.06700518
    Full Text Link to Item
  - Carlson, D. A., Singer, M. R., Sutherland, C., Redondo, C., Alexander, L. T., Hughes, P. F., … Haystead, T. A. J. (2018). Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol, 25(10), 1195-1207.e32. https://doi.org/10.1016/j.chembiol.2018.06.006
    Full Text Link to Item
  - Wolf, E., Diaz, E. J., Hollis, A. N., Hoang, T. A., Azad, H. A., Bendt, K. M., … Sparks, M. A. (2018). Vascular type 1 angiotensin receptors control blood pressure by augmenting peripheral vascular resistance in female mice. Am J Physiol Renal Physiol, 315(4), F997–F1005. https://doi.org/10.1152/ajprenal.00639.2017
    Full Text Link to Item
  - Colbert, G. B., Topf, J., Jhaveri, K. D., Oates, T., Rheault, M. N., Shah, S., … Sparks, M. A. (2018). The Social Media Revolution in Nephrology Education. Kidney Int Rep, 3(3), 519–529. https://doi.org/10.1016/j.ekir.2018.02.003
    Full Text Link to Item
  - Sparks, M. A., & Topf, J. M. (2018). NephMadness After 5 Years: A Recap and Game Plan for the Future. American Journal of Kidney Diseases : The Official Journal of the National Kidney Foundation, 71(3), 299–301. https://doi.org/10.1053/j.ajkd.2017.12.001
    Full Text
  - Wolf, E., Kothari, N. R., Roberts, J. K., & Sparks, M. A. (2018). Baclofen Toxicity in Kidney Disease. American Journal of Kidney Diseases : The Official Journal of the National Kidney Foundation, 71(2), 275–280. https://doi.org/10.1053/j.ajkd.2017.07.005
    Full Text
  - Wang, L., Sha, Y., Bai, J., Eisner, W., Sparks, M. A., Buckley, A. F., & Spurney, R. F. (2017). Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. Am J Physiol Renal Physiol, 313(2), F430–F439. https://doi.org/10.1152/ajprenal.00614.2016
    Full Text Link to Item
  - Topf, J. M., Sparks, M. A., Phelan, P. J., Shah, N., Lerma, E. V., Graham-Brown, M. P. M., … Hiremath, S. (2017). The Evolution of the Journal Club: From Osler to Twitter. American Journal of Kidney Diseases : The Official Journal of the National Kidney Foundation, 69(6), 827–836. https://doi.org/10.1053/j.ajkd.2016.12.012
    Full Text
  - Stegbauer, J., Chen, D., Herrera, M., Sparks, M. A., Yang, T., Königshausen, E., … Coffman, T. M. (2017). Resistance to hypertension mediated by intercalated cells of the collecting duct. Jci Insight, 2(7), e92720. https://doi.org/10.1172/jci.insight.92720
    Full Text Link to Item
  - Roberts, J. K., Sparks, M. A., & Lehrich, R. W. (2016). Medical student attitudes toward kidney physiology and nephrology: a qualitative study. Ren Fail, 38(10), 1683–1693. https://doi.org/10.1080/0886022X.2016.1230459
    Full Text Open Access Copy Link to Item
  - Zhang, J., Rudemiller, N. P., Patel, M. B., Wei, Q., Karlovich, N. S., Jeffs, A. D., … Crowley, S. D. (2016). Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. J Am Soc Nephrol, 27(8), 2257–2264. https://doi.org/10.1681/ASN.2015060683
    Full Text Open Access Copy Link to Item
  - Cameron, C. B., Nair, V., Varma, M., Adams, M., Jhaveri, K. D., & Sparks, M. A. (2016). Does Academic Blogging Enhance Promotion and Tenure? A Survey of US and Canadian Medicine and Pediatric Department Chairs. Jmir Med Educ, 2(1), e10. https://doi.org/10.2196/mededu.4867
    Full Text Link to Item
  - Chen, D., Stegbauer, J., Sparks, M. A., Kohan, D., Griffiths, R., Herrera, M., … Coffman, T. M. (2016). Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension. Hypertension, 67(6), 1291–1297. https://doi.org/10.1161/HYPERTENSIONAHA.115.06987
    Full Text Link to Item
  - Zhang, J., Rudemiller, N. P., Patel, M. B., Karlovich, N. S., Wu, M., McDonough, A. A., … Crowley, S. D. (2016). Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell Metab, 23(2), 360–368. https://doi.org/10.1016/j.cmet.2015.11.013
    Full Text Link to Item
  - Sparks, M. A., Stegbauer, J., Chen, D., Gomez, J. A., Griffiths, R. C., Azad, H. A., … Coffman, T. M. (2015). Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. J Am Soc Nephrol, 26(12), 2953–2962. https://doi.org/10.1681/ASN.2014080816
    Full Text Link to Item
  - Topf, J. M., Sparks, M. A., Iannuzzella, F., Lerma, E., Oates, T., Phelan, P. J., & Hiremath, S. (2015). Twitter-Based Journal Clubs: Additional Facts and Clarifications. J Med Internet Res, 17(9), e216. https://doi.org/10.2196/jmir.4639
    Full Text Link to Item
  - Roberts, J. K., Westphal, S., & Sparks, M. A. (2015). Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management. Semin Dial, 28(5), 525–529. https://doi.org/10.1111/sdi.12400
    Full Text Link to Item
  - Dimke, H., Sparks, M. A., Thomson, B. R., Frische, S., Coffman, T. M., & Quaggin, S. E. (2015). Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney. J Am Soc Nephrol, 26(5), 1027–1038. https://doi.org/10.1681/ASN.2014010060
    Full Text Link to Item
  - Sparks, M. A., Lerma, E. V., Kupin, W., Phelan, P. J., Jhaveri, K. D., & Topf, J. (2015). NephMadness 2015: nephrology as a cornerstone of medicine. Am J Kidney Dis, 65(3), 375–377. https://doi.org/10.1053/j.ajkd.2014.12.002
    Full Text Link to Item
  - Malone, A. F., Phelan, P. J., Hall, G., Cetincelik, U., Homstad, A., Alonso, A. S., … Gbadegesin, R. A. (2014). Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney Int, 86(6), 1253–1259. https://doi.org/10.1038/ki.2014.305
    Full Text Open Access Copy Link to Item
  - Zhang, J., Patel, M. B., Griffiths, R., Mao, A., Song, Y.-S., Karlovich, N. S., … Crowley, S. D. (2014). Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension. Hypertension, 64(6), 1275–1281. https://doi.org/10.1161/HYPERTENSIONAHA.114.03863
    Full Text Link to Item
  - Gbadegesin, R. A., Hall, G., Adeyemo, A., Hanke, N., Tossidou, I., Burchette, J., … Winn, M. P. (2014). Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. J Am Soc Nephrol, 25(9), 1991–2002. https://doi.org/10.1681/ASN.2013090976
    Full Text Link to Item
  - Sparks, M. A., Crowley, S. D., Gurley, S. B., Mirotsou, M., & Coffman, T. M. (2014). Classical Renin-Angiotensin system in kidney physiology. Comprehensive Physiology, 4(3), 1201–1228. https://doi.org/10.1002/cphy.c130040
    Full Text
  - Phelan, P. J., Conlon, P. J., & Sparks, M. A. (2014). Genetic determinants of renal transplant outcome: where do we stand? J Nephrol, 27(3), 247–256. https://doi.org/10.1007/s40620-014-0053-4
    Full Text Link to Item
  - Zhang, J.-D., Patel, M. B., Griffiths, R., Dolber, P. C., Ruiz, P., Sparks, M. A., … Crowley, S. D. (2014). Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis. J Clin Invest, 124(5), 2198–2203. https://doi.org/10.1172/JCI61368
    Full Text Link to Item
  - Wang, L., Tang, Y., Eisner, W., Sparks, M. A., Buckley, A. F., & Spurney, R. F. (2014). Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice. Biochem Biophys Res Commun, 444(4), 622–627. https://doi.org/10.1016/j.bbrc.2014.01.115
    Full Text Link to Item
  - Malone, A. F., Phelan, P. J., Hall, G., Cetincelik, U., Homstad, A., Alonso, A. S., … Gbadegesin, R. A. (2014). Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney International, 86(6), 1253–1259. https://doi.org/10.1038/ki.2014.305
    Full Text
  - Wysocki, J., Ortiz-Melo, D. I., Mattocks, N. K., Xu, K., Prescott, J., Evora, K., … Gurley, S. B. (2014). ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney. Physiol Rep, 2(3), e00264. https://doi.org/10.1002/phy2.264
    Full Text Link to Item
  - Xie, L., Sparks, M. A., Li, W., Qi, Y., Liu, C., Coffman, T. M., & Johnson, G. A. (2013). Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice. Nmr Biomed, 26(12), 1853–1863. https://doi.org/10.1002/nbm.3039
    Full Text Link to Item
  - Malone, A. F., Sparks, M. A., Howell, D. N., Middleton, J. P., Smith, S. R., & Lehrich, R. W. (2013). IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia. J Nephrol, 26(6), 1195–1198. https://doi.org/10.5301/jn.5000298
    Full Text Link to Item
  - Pippin, J. W., Sparks, M. A., Glenn, S. T., Buitrago, S., Coffman, T. M., Duffield, J. S., … Shankland, S. J. (2013). Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. Am J Pathol, 183(2), 542–557. https://doi.org/10.1016/j.ajpath.2013.04.024
    Full Text Link to Item
  - Jhaveri, K. D., Sparks, M. A., & Shah, H. H. (2013). Novel educational approaches to enhance learning and interest in nephrology. Adv Chronic Kidney Dis, 20(4), 336–346. https://doi.org/10.1053/j.ackd.2013.03.006
    Full Text Link to Item
  - Jhaveri, K. D., Sparks, M. A., Shah, H. H., Khan, S., Chawla, A., Desai, T., … Kohan, D. E. (2013). Why not nephrology? A survey of US internal medicine subspecialty fellows. American Journal of Kidney Diseases : The Official Journal of the National Kidney Foundation, 61(4), 540–546. https://doi.org/10.1053/j.ajkd.2012.10.025
    Full Text
  - Desai, T., Sparks, M. A., Nair, V., Sethi, S. K., Topf, J., Calderon, K., … Jhaveri, K. D. (2013). The state of the blog: the first year of eAJKD. Am J Kidney Dis, 61(1), 1–2. https://doi.org/10.1053/j.ajkd.2012.10.013
    Full Text Link to Item
  - Sparks, M. A., Makhanova, N. A., Griffiths, R. C., Snouwaert, J. N., Koller, B. H., & Coffman, T. M. (2013). Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension, 61(1), 166–173. https://doi.org/10.1161/HYPERTENSIONAHA.112.193250
    Full Text Link to Item
  - Herrera, M., Sparks, M. A., Alfonso-Pecchio, A. R., Harrison-Bernard, L. M., & Coffman, T. M. (2013). Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein. Hypertension (Dallas, Tex. : 1979), 61(1), 253–258. https://doi.org/10.1161/hypertensionaha.112.203679
    Full Text
  - Shah, H. H., Jhaveri, K. D., Sparks, M. A., & Mattana, J. (2012). Career choice selection and satisfaction among US adult nephrology fellows. Clin J Am Soc Nephrol, 7(9), 1513–1520. https://doi.org/10.2215/CJN.01620212
    Full Text Link to Item
  - Zhang, J.-D., Patel, M. B., Song, Y.-S., Griffiths, R., Burchette, J., Ruiz, P., … Crowley, S. D. (2012). A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. Circ Res, 110(12), 1604–1617. https://doi.org/10.1161/CIRCRESAHA.111.261768
    Full Text Link to Item
  - Stegbauer, J., Gurley, S. B., Sparks, M. A., Woznowski, M., Kohan, D. E., Yan, M., … Coffman, T. M. (2011). AT1 receptors in the collecting duct directly modulate the concentration of urine. J Am Soc Nephrol, 22(12), 2237–2246. https://doi.org/10.1681/ASN.2010101095
    Full Text Link to Item
  - Sparks, M. A., O’Seaghdha, C. M., Sethi, S. K., & Jhaveri, K. D. (2011). Embracing the Internet as a means of enhancing medical education in nephrology. Am J Kidney Dis, 58(4), 512–518. https://doi.org/10.1053/j.ajkd.2011.06.009
    Full Text Link to Item
  - Gurley, S. B., Riquier-Brison, A. D. M., Schnermann, J., Sparks, M. A., Allen, A. M., Haase, V. H., … Coffman, T. M. (2011). AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab, 13(4), 469–475. https://doi.org/10.1016/j.cmet.2011.03.001
    Full Text Link to Item
  - Eckel, J., Lavin, P. J., Finch, E. A., Mukerji, N., Burch, J., Gbadegesin, R., … Winn, M. P. (2011). TRPC6 enhances angiotensin II-induced albuminuria. J Am Soc Nephrol, 22(3), 526–535. https://doi.org/10.1681/ASN.2010050522
    Full Text Link to Item
  - Sparks, M. A., Parsons, K. K., Stegbauer, J., Gurley, S. B., Vivekanandan-Giri, A., Fortner, C. N., … Coffman, T. M. (2011). Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension, 57(3), 577–585. https://doi.org/10.1161/HYPERTENSIONAHA.110.165274
    Full Text Link to Item
  - Sparks, M. A., & Coffman, T. M. (2010). The EP4 receptor for prostaglandin E2 in glomerular disease: a good receptor turned bad? J Am Soc Nephrol, 21(10), 1597–1599. https://doi.org/10.1681/ASN.2010080870
    Full Text Link to Item
  - Crowley, S. D., Song, Y. S., Sprung, G., Griffiths, R., Sparks, M., Yan, M., … Ruiz, P. (2010). Response to angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1. Hypertension, 56(1). https://doi.org/10.1161/HYPERTENSIONAHA.110.153544
    Full Text
  - Crowley, S. D., Song, Y.-S., Sprung, G., Griffiths, R., Sparks, M., Yan, M., … Ruiz, P. (2010). A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. Hypertension, 55(1), 99–108. https://doi.org/10.1161/HYPERTENSIONAHA.109.144964
    Full Text Link to Item
  - Dave, N. N., Sparks, M. A., & Farouk, S. S. (n.d.). An introduction and guide to becoming a social media savvy nephrologist. Nephrology Dialysis Transplantation. https://doi.org/10.1093/ndt/gfaa067
    Full Text
- Book Sections
  - Sparks, M. A., & Singh, H. (2018). Thrombotic Microangiopathies. In M. Sparks, J. Topf, & E. Lerma (Eds.), Nephrology Secrets.
  - Sparks, M. A., & Singh, H. (2018). Thrombotic Microangiopathies. In M. Sparks, J. Topf, & E. Lerma (Eds.), Nephrology Secrets.
  - 1. Olyaei, A. J., Lerma, E., Tuchman, S. A., & Sparks, M. A. (2015). Rational Dosing of Chemotherapy in Patients with Chronic Kidney Disease. In K. D. Jhaveri & A. Salahudeen (Eds.), Onconephrology Cancer, Chemotherapy and the Kidney (pp. 105–129). Springer.
    Link to Item
  - Olyaei, A. J., Lerma, E. V., Tuchman, S. A., & Sparks, M. A. (2015). Rational dosing of chemotherapy in patients with kidney failure. In Onconephrology: Cancer, Chemotherapy and the Kidney (pp. 105–129). https://doi.org/10.1007/978-1-4939-2659-6_6
    Full Text
Teaching & Mentoring
Teaching Activities
- Scientific Communications

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Leadership & Clinical Positions at Duke

In the News

Awards & Honors

Subject Headings

Selected Grants

External Relationships

Selected Publications

Books

Academic Articles

Book Sections

Teaching Activities