Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
Publication
, Journal Article
Sorge, RE; Mapplebeck, JCS; Rosen, S; Beggs, S; Taves, S; Alexander, JK; Martin, LJ; Austin, J-S; Sotocinal, SG; Chen, D; Yang, M; Shi, XQ ...
Published in: Nat Neurosci
August 2015
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Nat Neurosci
DOI
EISSN
1546-1726
Publication Date
August 2015
Volume
18
Issue
8
Start / End Page
1081 / 1083
Location
United States
Related Subject Headings
- T-Lymphocytes
- Signal Transduction
- Sex Factors
- Sex Characteristics
- Neurology & Neurosurgery
- Neuralgia
- Microglia
- Mice, Transgenic
- Mice, Inbred C57BL
- Mice
Citation
APA
Chicago
ICMJE
MLA
NLM
Sorge, R. E., Mapplebeck, J. C. S., Rosen, S., Beggs, S., Taves, S., Alexander, J. K., … Mogil, J. S. (2015). Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci, 18(8), 1081–1083. https://doi.org/10.1038/nn.4053
Sorge, Robert E., Josiane C. S. Mapplebeck, Sarah Rosen, Simon Beggs, Sarah Taves, Jessica K. Alexander, Loren J. Martin, et al. “Different immune cells mediate mechanical pain hypersensitivity in male and female mice.” Nat Neurosci 18, no. 8 (August 2015): 1081–83. https://doi.org/10.1038/nn.4053.
Sorge RE, Mapplebeck JCS, Rosen S, Beggs S, Taves S, Alexander JK, et al. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015 Aug;18(8):1081–3.
Sorge, Robert E., et al. “Different immune cells mediate mechanical pain hypersensitivity in male and female mice.” Nat Neurosci, vol. 18, no. 8, Aug. 2015, pp. 1081–83. Pubmed, doi:10.1038/nn.4053.
Sorge RE, Mapplebeck JCS, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin J-S, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji R-R, Zhang J, Salter MW, Mogil JS. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015 Aug;18(8):1081–1083.
Published In
Nat Neurosci
DOI
EISSN
1546-1726
Publication Date
August 2015
Volume
18
Issue
8
Start / End Page
1081 / 1083
Location
United States
Related Subject Headings
- T-Lymphocytes
- Signal Transduction
- Sex Factors
- Sex Characteristics
- Neurology & Neurosurgery
- Neuralgia
- Microglia
- Mice, Transgenic
- Mice, Inbred C57BL
- Mice