Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
Sorge, RE; Mapplebeck, JCS; Rosen, S; Beggs, S; Taves, S; Alexander, JK; Martin, LJ; Austin, J-S; Sotocinal, SG; Chen, D; Yang, M; Shi, XQ; Huang, H; Pillon, NJ; Bilan, PJ; Tu, Y; Klip, A; Ji, R-R; Zhang, J; Salter, MW; Mogil, JS
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