Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

Journal Article (Journal Article)

A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.

Full Text

Duke Authors

Cited Authors

  • Sorge, RE; Mapplebeck, JCS; Rosen, S; Beggs, S; Taves, S; Alexander, JK; Martin, LJ; Austin, J-S; Sotocinal, SG; Chen, D; Yang, M; Shi, XQ; Huang, H; Pillon, NJ; Bilan, PJ; Tu, Y; Klip, A; Ji, R-R; Zhang, J; Salter, MW; Mogil, JS

Published Date

  • August 2015

Published In

Volume / Issue

  • 18 / 8

Start / End Page

  • 1081 - 1083

PubMed ID

  • 26120961

Pubmed Central ID

  • PMC4772157

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.4053


  • eng

Conference Location

  • United States