Ru-Rong Ji | Scholars@Duke

Ru-Rong Ji
Distinguished Professor of Anesthesiology, in the School of Medicine

Chronic pain is a major health problem in the US, affecting 100 million Americans. The long-term goal of the lab is to identify molecular and cellular mechanisms that underlie the genesis of chronic pain and, furthermore, to develop novel pain therapeutics that can target these mechanisms. We are interested in the following questions. (1) How do neuroinflammation and activation of glial cells (microglia and astrocytes) regulate pain and spinal cord synaptic plasticity via neuro-glial and neuro-immune interactions? (2) How do secreted miRNAs regulate neuronal signaling and synaptic transmission and pain as novel neuromodulators and pain mediators? (3) How do pro-resolution lipid mediators such as resolvins and protectin control pain via GPCR and arrestin signaling? (4) Do pain and itch share similar mechanisms? (5) How does Toll-like receptor (TLR) signaling in primary sensory neurons regulate pain and itch? (6) How can bone marrow stem cells produce long-term pain relief via secreting anti-inflammatory and trophic factors? We employ a multidisciplinary approach that covers in vitro, ex vivo, and in vivo electrophysiology, neuronal and glial cell biology, transgenic mice, and behaviors.

Current Appointments & Affiliations

Distinguished Professor of Anesthesiology, in the School of Medicine, Anesthesiology, Clinical Science Departments 2012
Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2012
Professor in Neurobiology, Neurobiology, Basic Science Departments 2012

Contact Information

ru-rong.ji@duke.edu

Background
Education, Training, & Certifications
- Ph.D., Chinese Academy of Sciences (China) 1990
Recognition
In the News
- MAY 23, 2017
  
  Immunotherapy Target Suppresses Pain to Mask Cancer
- DEC 1, 2016
  
  Autism-Linked Protein Crucial For Feeling Pain
- JUL 14, 2015 The Daily Mail
  
  Jab that could kill back pain: Injection of stem cells found to release natural painkiller that can last 'for five weeks'
- JUL 13, 2015
  
  Stem Cells Provide Lasting Pain Relief in Mice
- MAY 22, 2014
  
  One Molecule To Block Both Pain And Itch
- APR 7, 2014 Duke Research Blog
  
  Duke Study Takes a Molecular Look at Pain
- JUL 17, 2013
  
  Uncovering a Healthier Remedy for Chronic Pain
Research
Selected Grants
- Structure, function, and pharmacology of neuronal membrane transport proteins awarded by National Institutes of Health 2016 - 2024
- Dynamic Control of Innate Antiviral Immunity in Skin Homeostasis and Inflammation awarded by National Institutes of Health 2018 - 2023
- Control of Astrocyte Development and Astrocyte-Synapse Interactions awarded by National Institutes of Health 2018 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Neuronal and glial interactions of neuropathic pain awarded by National Institutes of Health 2006 - 2022
- Modeling Activation and Block of Autonomic Nerves for Analysis and Design awarded by National Institutes of Health 2017 - 2021
- Neuroimmune mechanisms governing neuropathic cancer pain pathologies awarded by International Association for the Study of Pain 2018 - 2020
- Notch Signaling in Joint Cartilage Maintenance and Arthritis awarded by National Institutes of Health 2012 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Resolution pathway of pain awarded by National Institutes of Health 2014 - 2019
- VIPER: Chronic Pain after Amputation awarded by Department of Defense 2015 - 2018
- Hemichannels, Astrocytic Release, and Neuropathic Pain awarded by National Institutes of Health 2012 - 2018
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Development of novel therapeutics for pain and itch relief awarded by National Institutes of Health 2014 - 2018
- Treating chemotherapy-induced neuropathic pain by targeted silencing of A-fibers awarded by National Institutes of Health 2015 - 2018
- Functional Characterization of Parabrachial Circuits Processing Noxious Thermal Pain awarded by National Institutes of Health 2015 - 2018
- Control of Tripartite Synapse Formation by Astrocytic Neuroligins awarded by National Institutes of Health 2015 - 2018
- Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant awarded by University of Alabama at Birmingham 2013 - 2016
- Neuronal and glial interactions of neuropathic pain awarded by National Institutes of Health 2006 - 2016
- Resolvins, protectins, and chronic pain resolution awarded by National Institutes of Health 2009 - 2015
- Resolvin modulation of TRP channel function and evoked hyperexcitability in human sensory neurons awarded by Pfizer, Inc. 2014 - 2015
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Xu, ZZ, and Ji, RR. "Protection of neuropathic pain by pro-resolution lipid mediators." : SPRINGER, March 1, 2014. Link to Item
- Journal Articles
  - Bang, S, Xie, Y-K, Zhang, Z-J, Wang, Z, Xu, Z-Z, and Ji, R-R. "GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain." The Journal of Clinical Investigation 128, no. 8 (August 2018): 3568-3582. Full Text
  - Han, Q, Liu, D, Convertino, M, Wang, Z, Jiang, C, Kim, YH, Luo, X, Zhang, X, Nackley, A, Dokholyan, NV, and Ji, R-R. "miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus." Neuron 99, no. 3 (August 2018): 449-463.e6. Full Text
  - Ji, R-R, Nackley, A, Huh, Y, Terrando, N, and Maixner, W. "Neuroinflammation and Central Sensitization in Chronic and Widespread Pain." Anesthesiology 129, no. 2 (August 2018): 343-366. Full Text
  - Luo, X, Fitzsimmons, B, Mohan, A, Zhang, L, Terrando, N, Kordasiewicz, H, and Ji, R-R. "Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice." Brain, Behavior, and Immunity 72 (August 2018): 34-44. Full Text
  - Price, TJ, Basbaum, AI, Bresnahan, J, Chambers, JF, De Koninck, Y, Edwards, RR, Ji, R-R, Katz, J, Kavelaars, A, Levine, JD, Porter, L, Schechter, N, Sluka, KA, Terman, GW, Wager, TD, Yaksh, TL, and Dworkin, RH. "Transition to chronic pain: opportunities for novel therapeutics." Nature Reviews. Neuroscience (May 15, 2018). Full Text
  - Chamessian, A, Young, M, Qadri, Y, Berta, T, Ji, R-R, and Van de Ven, T. "Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn." Scientific Reports 8, no. 1 (May 2018): 6809-null. Full Text
  - Qadri, YJ, and Ji, R-R. "Dorsal root ganglia pulsed radiofrequency treatment alters the spinal immune environment." Brain, Behavior, and Immunity 70 (May 2018): 6-7. Full Text
  - Bang, S, Yoo, J, Gong, X, Liu, D, Han, Q, Luo, X, Chang, W, Chen, G, Im, S-T, Kim, YH, Strong, JA, Zhang, M-Z, Zhang, J-M, Lee, S-Y, and Ji, R-R. "Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies." Neuroscience Bulletin 34, no. 1 (February 2018): 22-41. Full Text
  - Chang, W, Berta, T, Kim, YH, Lee, S, Lee, S-Y, and Ji, R-R. "Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel." Neuroscience Bulletin 34, no. 1 (February 2018): 4-12. Full Text
  - Chen, G, Luo, X, Qadri, MY, Berta, T, and Ji, R-R. "Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes." Neuroscience Bulletin 34, no. 1 (February 2018): 98-108. Full Text
  - Ji, R-R. "Recent Progress in Understanding the Mechanisms of Pain and Itch: the Second Special Issue." Neuroscience bulletin 34, no. 1 (February 2018): 1-3. Full Text
  - Miao, X, Huang, Y, Liu, T-T, Guo, R, Wang, B, Wang, X-L, Chen, L-H, Zhou, Y, Ji, R-R, and Liu, T. "TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms." Neuroscience Bulletin 34, no. 1 (February 2018): 42-53. Full Text
  - Xie, R-G, Gao, Y-J, Park, C-K, Lu, N, Luo, C, Wang, W-T, Wu, S-X, and Ji, R-R. "Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms." Neuroscience Bulletin 34, no. 1 (February 2018): 13-21. Full Text
  - Zhang, L, Terrando, N, Xu, Z-Z, Bang, S, Jordt, S-E, Maixner, W, Serhan, CN, and Ji, R-R. "Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice." Frontiers in Pharmacology 9 (January 2018): 412-null. Full Text
  - Chamessian, A, and Ji, R-R. "A new optogenetic device for spinal cord control of pain." Pain 158, no. 11 (November 2017): 2059-2060. Full Text
  - Stogsdill, JA, Ramirez, J, Liu, D, Kim, YH, Baldwin, KT, Enustun, E, Ejikeme, T, Ji, R-R, and Eroglu, C. "Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis." Nature 551, no. 7679 (November 2017): 192-197. Full Text
  - Pappas, AL, Bey, AL, Wang, X, Rossi, M, Kim, YH, Yan, H, Porkka, F, Duffney, LJ, Phillips, SM, Cao, X, Ding, J-D, Rodriguiz, RM, Yin, HH, Weinberg, RJ, Ji, R-R, Wetsel, WC, and Jiang, Y-H. "Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers." Jci Insight 2, no. 20 (October 19, 2017). Full Text
  - Berta, T, Perrin, FE, Pertin, M, Tonello, R, Liu, Y-C, Chamessian, A, Kato, AC, Ji, R-R, and Decosterd, I. "Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain." Scientific Reports 7, no. 1 (August 24, 2017): 9367-null. Full Text
  - Berta, T, Qadri, Y, Tan, P-H, and Ji, R-R. "Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain." Expert Opinion on Therapeutic Targets 21, no. 7 (July 2017): 695-703. (Review) Full Text
  - Chen, G, Kim, YH, Li, H, Luo, H, Liu, D-L, Zhang, Z-J, Lay, M, Chang, W, Zhang, Y-Q, and Ji, R-R. "PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1." Nature Neuroscience 20, no. 7 (July 2017): 917-926. Full Text
  - Huh, Y, Ji, R-R, and Chen, G. "Neuroinflammation, Bone Marrow Stem Cells, and Chronic Pain." Frontiers in immunology 8 (January 2017): 1014-. (Review) Full Text
  - Han, Q, Kim, YH, Wang, X, Liu, D, Zhang, Z-J, Bey, AL, Lay, M, Chang, W, Berta, T, Zhang, Y, Jiang, Y-H, and Ji, R-R. "SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons." Neuron 92, no. 6 (December 2016): 1279-1293. Full Text Open Access Copy
  - Ji, R-R, Chamessian, A, and Zhang, Y-Q. "Pain regulation by non-neuronal cells and inflammation." Science (New York, N.Y.) 354, no. 6312 (November 2016): 572-577. (Review) Full Text Open Access Copy
  - Sisignano, M, Angioni, C, Park, C-K, Meyer Dos Santos, S, Jordan, H, Kuzikov, M, Liu, D, Zinn, S, Hohman, SW, Schreiber, Y, Zimmer, B, Schmidt, M, Lu, R, Suo, J, Zhang, D-D, Schäfer, SMG, Hofmann, M, Yekkirala, AS, de Bruin, N, Parnham, MJ, Woolf, CJ, Ji, R-R, Scholich, K, and Geisslinger, G. "Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain." Proceedings of the National Academy of Sciences of the United States of America 113, no. 44 (November 2016): 12544-12549. Full Text Open Access Copy
  - Liu, C-C, Gao, Y-J, Luo, H, Berta, T, Xu, Z-Z, Ji, R-R, and Tan, P-H. "Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions." Scientific reports 6 (September 27, 2016): 34356-. Full Text Open Access Copy
  - Berta, T, Qadri, YJ, Chen, G, and Ji, RR. "Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence." Journal of Dental Research 95, no. 10 (September 2016): 1124-1131. (Review) Full Text
  - Chen, G, Xie, R-G, Gao, Y-J, Xu, Z-Z, Zhao, L-X, Bang, S, Berta, T, Park, C-K, Lay, M, Chen, W, and Ji, R-R. "β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain." Nature Communications 7 (August 19, 2016): 12531-null. Full Text Open Access Copy
  - Taves, S, Berta, T, Liu, D-L, Gan, S, Chen, G, Kim, YH, Van de Ven, T, Laufer, S, and Ji, R-R. "Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord." Brain, Behavior, and Immunity 55 (July 2016): 70-81. Full Text
  - Liu, X-J, Liu, T, Chen, G, Wang, B, Yu, X-L, Yin, C, and Ji, R-R. "TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation." Scientific Reports 6 (June 17, 2016): 28188-null. Full Text
  - Martini, AC, Berta, T, Forner, S, Chen, G, Bento, AF, Ji, R-R, and Rae, GA. "Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection." Journal of Neuroinflammation 13, no. 1 (April 8, 2016): 75-null. Full Text
  - Liu, T, Han, Q, Chen, G, Huang, Y, Zhao, L-X, Berta, T, Gao, Y-J, and Ji, R-R. "Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice." Pain 157, no. 4 (April 2016): 806-817. Full Text
  - Jiang, B-C, Cao, D-L, Zhang, X, Zhang, Z-J, He, L-N, Li, C-H, Zhang, W-W, Wu, X-B, Berta, T, Ji, R-R, and Gao, Y-J. "CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5." The Journal of Clinical Investigation 126, no. 2 (February 2016): 745-761. Full Text
  - Singh, SK, Stogsdill, JA, Pulimood, NS, Dingsdale, H, Kim, YH, Pilaz, L-J, Kim, IH, Manhaes, AC, Rodrigues, WS, Pamukcu, A, Enustun, E, Ertuz, Z, Scheiffele, P, Soderling, SH, Silver, DL, Ji, R-R, Medina, AE, and Eroglu, C. "Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin." Cell 164, no. 1-2 (January 2016): 183-196. Full Text
  - Ji, R-R. "Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms?." Pulmonary pharmacology & therapeutics 35 (December 2015): 81-86. (Review) Full Text
  - Xu, Z-Z, Kim, YH, Bang, S, Zhang, Y, Berta, T, Wang, F, Oh, SB, and Ji, R-R. "Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade." Nature Medicine 21, no. 11 (November 2015): 1326-1331. Full Text
  - Chen, G, Park, C-K, Xie, R-G, and Ji, R-R. "Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion." The Journal of Clinical Investigation 125, no. 8 (August 2015): 3226-3240. Full Text Open Access Copy
  - Sorge, RE, Mapplebeck, JCS, Rosen, S, Beggs, S, Taves, S, Alexander, JK, Martin, LJ, Austin, J-S, Sotocinal, SG, Chen, D, Yang, M, Shi, XQ, Huang, H, Pillon, NJ, Bilan, PJ, Tu, Y, Klip, A, Ji, R-R, Zhang, J, Salter, MW, and Mogil, JS. "Different immune cells mediate mechanical pain hypersensitivity in male and female mice." Nature Neuroscience 18, no. 8 (August 2015): 1081-1083. Full Text
  - Zhang, TC, Janik, JJ, Peters, RV, Chen, G, Ji, R-R, and Grill, WM. "Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control." Journal of Neurophysiology 114, no. 1 (July 2015): 284-300. Full Text
  - Yang, Y, Li, H, Li, T-T, Luo, H, Gu, X-Y, Lü, N, Ji, R-R, and Zhang, Y-Q. "Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 35, no. 20 (May 2015): 7950-7963. Full Text
  - Loggia, ML, Chonde, DB, Akeju, O, Arabasz, G, Catana, C, Edwards, RR, Hill, E, Hsu, S, Izquierdo-Garcia, D, Ji, R-R, Riley, M, Wasan, AD, Zürcher, NR, Albrecht, DS, Vangel, MG, Rosen, BR, Napadow, V, and Hooker, JM. "Evidence for brain glial activation in chronic pain patients." Brain : a Journal of Neurology 138, no. Pt 3 (March 2015): 604-615. Full Text
  - McKelvey, R, Berta, T, Old, E, Ji, R-R, and Fitzgerald, M. "Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 35, no. 2 (January 2015): 457-466. Full Text
  - Taves, S, and Ji, R-R. "Itch control by Toll-like receptors." Handbook of experimental pharmacology 226 (January 2015): 135-150. (Review) Full Text
  - Lu, Y, Jiang, B-C, Cao, D-L, Zhang, Z-J, Zhang, X, Ji, R-R, and Gao, Y-J. "TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling." Pain 155, no. 12 (December 2014): 2618-2629. Full Text
  - Cao, D-L, Zhang, Z-J, Xie, R-G, Jiang, B-C, Ji, R-R, and Gao, Y-J. "Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2." Experimental neurology 261 (November 2014): 328-336. Full Text
  - Chen, G, Park, C-K, Xie, R-G, Berta, T, Nedergaard, M, and Ji, R-R. "Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice." Brain : a Journal of Neurology 137, no. Pt 8 (August 2014): 2193-2209. Full Text
  - Ji, R-R, Xu, Z-Z, and Gao, Y-J. "Emerging targets in neuroinflammation-driven chronic pain." Nature Reviews. Drug Discovery 13, no. 7 (July 2014): 533-548. (Review) Full Text
  - Lee, J-H, Park, C-K, Chen, G, Han, Q, Xie, R-G, Liu, T, Ji, R-R, and Lee, S-Y. "A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief." Cell 157, no. 6 (June 2014): 1393-1404. Full Text
  - Doyle, JR, Krishnaji, ST, Zhu, G, Xu, Z-Z, Heller, D, Ji, R-R, Levy, BD, Kumar, K, and Kopin, AS. "Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain." The Journal of Biological Chemistry 289, no. 19 (May 2014): 13385-13396. Full Text
  - Park, C-K, Xu, Z-Z, Berta, T, Han, Q, Chen, G, Liu, X-J, and Ji, R-R. "Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1." Neuron 82, no. 1 (April 2014): 47-54. Full Text
  - Berta, T, Park, C-K, Xu, Z-Z, Xie, R-G, Liu, T, Lü, N, Liu, Y-C, and Ji, R-R. "Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion." The Journal of Clinical Investigation 124, no. 3 (March 2014): 1173-1186. Full Text
  - Liu, XJ, Zhang, Y, Liu, T, Xu, ZZ, Park, CK, Berta, T, Jiang, D, and Ji, RR. "Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter." Cell Research 24, no. 11 (January 1, 2014): 1374-1377. (Letter) Full Text
  - Liu, T, and Ji, R-R. "New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?." Pflugers Archiv : European Journal of Physiology 465, no. 12 (December 2013): 1671-1685. (Review) Full Text
  - Wang, JCF, Hung, CH, Gerner, P, Ji, RR, and Strichartz, GR. "The qualitative hyperalgesia profile: A new metric to assess chronic post-thoracotomy pain." Open Pain Journal 6, no. 1 (November 26, 2013): 190-198. Full Text
  - Xu, Z-Z, Liu, X-J, Berta, T, Park, C-K, Lü, N, Serhan, CN, and Ji, R-R. "Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma." Annals of Neurology 74, no. 3 (September 4, 2013): 490-495. Full Text
  - Berta, T, Liu, Y-C, Xu, Z-Z, and Ji, R-R. "Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice." Neuroscience 247 (September 2013): 376-385. Full Text
  - Lu, Y, Dong, H, Gao, Y, Gong, Y, Ren, Y, Gu, N, Zhou, S, Xia, N, Sun, Y-Y, Ji, R-R, and Xiong, L. "A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia." The Journal of Clinical Investigation 123, no. 9 (September 2013): 4050-4062. Full Text
  - Pagadala, P, Park, C-K, Bang, S, Xu, Z-Z, Xie, R-G, Liu, T, Han, B-X, Tracey, WD, Wang, F, and Ji, R-R. "Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 33, no. 33 (August 2013): 13425-13430. Full Text
  - Xu, Z-Z, Berta, T, and Ji, R-R. "Resolvin E1 Inhibits Neuropathic Pain and Spinal Cord Microglial Activation Following Peripheral Nerve Injury." Journal of Neuroimmune Pharmacology 8, no. 1 (March 2013): 37-41. Full Text
  - Xu, Z-Z, Berta, T, and Ji, R-R. "Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury." Journal of Neuroimmune Pharmacology : the Official Journal of the Society on Neuroimmune Pharmacology 8, no. 1 (March 2013): 37-41. Full Text
  - Berta, T, Liu, Y-C, Xu, Z-Z, and Ji, R-R. "Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice." Neuroscience 247 (2013): 376-385. Full Text
  - Ji, RR, Berta, T, and Nedergaard, M. "Glia and pain: Is chronic pain a gliopathy?." Pain 154, no. SUPPL. 1 (January 1, 2013). Full Text
  - Taves, S, Berta, T, Chen, G, and Ji, R-R. "Microglia and spinal cord synaptic plasticity in persistent pain." Neural Plasticity 2013 (January 2013): 753656-null. (Review) Full Text
  - Van De Ven, T, and Ji, RR. "Dietary control of chronic headache: Involvement of pro-resolution lipid mediators." Pain 154, no. 11 (January 1, 2013): 2247-2248. Full Text
  - Zhang, Z-J, Cao, D-L, Zhang, X, Ji, R-R, and Gao, Y-J. "Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons." Pain (2013). Full Text
  - Liu, T, Berta, T, Xu, Z-Z, Park, C-K, Zhang, L, Lü, N, Liu, Q, Liu, Y, Gao, Y-J, Liu, Y-C, Ma, Q, Dong, X, and Ji, R-R. "TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice." The Journal of Clinical Investigation 122, no. 6 (June 2012): 2195-2207. Full Text
  - Sisignano, M, Park, C-K, Angioni, C, Zhang, DD, von Hehn, C, Cobos, EJ, Ghasemlou, N, Xu, Z-Z, Kumaran, V, Lu, R, Grant, A, Fischer, MJM, Schmidtko, A, Reeh, P, Ji, R-R, Woolf, CJ, Geisslinger, G, Scholich, K, and Brenneis, C. "5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 32, no. 18 (May 2012): 6364-6372. Full Text
  - Liu, T, Gao, Y-J, and Ji, R-R. "Emerging role of Toll-like receptors in the control of pain and itch." Neuroscience Bulletin 28, no. 2 (April 2012): 131-144. (Review) Full Text
  - Serhan, CN, Dalli, J, Karamnov, S, Choi, A, Park, C-K, Xu, Z-Z, Ji, R-R, Zhu, M, and Petasis, NA. "Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 26, no. 4 (April 2012): 1755-1765. Full Text
  - Berta, T, Liu, T, Liu, Y-C, Xu, Z-Z, and Ji, R-R. "Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9." Molecular Pain 8 (March 22, 2012): 18-null. Full Text
  - Chen, MJ, Kress, B, Han, X, Moll, K, Peng, W, Ji, R-R, and Nedergaard, M. "Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury." GLIA 60, no. 11 (2012): 1660-1670. Full Text
  - Ji, R-R. "Recent progress in understanding the mechanisms of pain and itch." Neuroscience Bulletin 28, no. 2 (2012): 89-90. Full Text
  - Liu, T, and Ru-Rong, J. "Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice." Neuroscience Bulletin 28, no. 2 (2012): 145-154. Full Text
  - Liu, Y-C, Berta, T, Liu, T, Tan, P-H, and Ji, R-R. "Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice." Molecular Pain 8 (2012). Full Text
  - Tan, PH, Gao, YJ, Berta, T, Xu, ZZ, and Ji, RR. "Short small-interfering RNAs produce interferon-α-mediated analgesia." British Journal of Anaesthesia 108, no. 4 (2012): 662-669. Full Text
  - Park, C-K, Xu, Z-Z, Liu, T, Lü, N, Serhan, CN, and Ji, R-R. "Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 31, no. 50 (December 2011): 18433-18438. Full Text
  - Ji, R-R, Xu, Z-Z, Strichartz, G, and Serhan, CN. "Emerging roles of resolvins in the resolution of inflammation and pain." Trends in Neurosciences 34, no. 11 (November 2011): 599-609. (Review) Full Text
  - Park, C-K, Lü, N, Xu, Z-Z, Liu, T, Serhan, CN, and Ji, R-R. "Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 31, no. 42 (October 2011): 15072-15085. Full Text
  - Xu, Z-Z, and Ji, R-R. "Resolvins are potent analgesics for arthritic pain." British Journal of Pharmacology 164, no. 2 (September 2011): 274-277. Full Text
  - Wen, Y-R, Tan, P-H, Cheng, J-K, Liu, Y-C, and Ji, R-R. "Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance." Journal of the Formosan Medical Association = Taiwan Yi Zhi 110, no. 8 (August 2011): 487-494. (Review) Full Text
  - Brittain, JM, Duarte, DB, Wilson, SM, Zhu, W, Ballard, C, Johnson, PL, Liu, N, Xiong, W, Ripsch, MS, Wang, Y, Fehrenbacher, JC, Fitz, SD, Khanna, M, Park, C-K, Schmutzler, BS, Cheon, BM, Due, MR, Brustovetsky, T, Ashpole, NM, Hudmon, A, Meroueh, SO, Hingtgen, CM, Brustovetsky, N, Ji, R-R, Hurley, JH, Jin, X, Shekhar, A, Xu, X-M, Oxford, GS, Vasko, MR, White, FA, and Khanna, R. "Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex." Nature Medicine 17, no. 7 (June 5, 2011): 822-829. Full Text
  - Tsuda, M, Kohro, Y, Yano, T, Tsujikawa, T, Kitano, J, Tozaki-Saitoh, H, Koyanagi, S, Ohdo, S, Ji, R-R, Salter, MW, and Inoue, K. "JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats." Brain : a Journal of Neurology 134, no. Pt 4 (April 2011): 1127-1139. Full Text
  - Zhang, L, Berta, T, Xu, Z-Z, Liu, T, Park, JY, and Ji, R-R. "TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2." Pain 152, no. 2 (February 2011): 419-427. Full Text
  - Suter, MR, Siegenthaler, A, Decosterd, I, and Ji, RR. "Perioperative nerve blockade: clues from the bench." Anesthesiology Research and Practice 2011 (January 2011): 124898-null. Full Text
  - Ji, RR, and Kawasaki, Y. "Pain and Plasticity." (December 1, 2010): 361-369. (Chapter) Full Text
  - Liu, T, Xu, Z-Z, Park, C-K, Berta, T, and Ji, R-R. "Toll-like receptor 7 mediates pruritus." Nature Neuroscience 13, no. 12 (December 2010): 1460-1462. Full Text
  - Gao, Y-J, and Ji, R-R. "Targeting astrocyte signaling for chronic pain." Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics 7, no. 4 (October 2010): 482-493. (Review) Full Text
  - Gosselin, R-D, Suter, MR, Ji, R-R, and Decosterd, I. "Glial cells and chronic pain." The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry 16, no. 5 (October 2010): 519-531. (Review) Full Text
  - Ji, R-R. "Targeting microglial purinergic signaling to improve morphine analgesia." Pain 150, no. 3 (September 2010): 377-378. Full Text
  - Xu, Z-Z, Zhang, L, Liu, T, Park, JY, Berta, T, Yang, R, Serhan, CN, and Ji, R-R. "Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions." Nature Medicine 16, no. 5 (May 2010): 592-597. Full Text
  - Gao, Y-J, Xu, Z-Z, Liu, Y-C, Wen, Y-R, Decosterd, I, and Ji, R-R. "The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition." Pain 148, no. 2 (February 2010): 309-319. Full Text
  - Gao, Y-J, Zhang, L, and Ji, R-R. "Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1." GLIA 58, no. 15 (2010): 1871-1880. Full Text
  - Gao, Y-J, and Ji, R-R. "Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: Involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia." Journal of Neurochemistry 115, no. 2 (2010): 505-514. Full Text
  - Gao, Y-J, and Ji, R-R. "Chemokines, neuronal-glial interactions, and central processing of neuropathic pain." Pharmacology and Therapeutics 126, no. 1 (2010): 56-68. Full Text
  - Liu, Y, Samad, OA, Zhang, L, Duan, B, Tong, Q, Lopes, C, Ji, R-R, Lowell, BB, and Ma, Q. "VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch." Neuron 68, no. 3 (2010): 543-556. Full Text
  - Zeng, Q, Yang, Z, Gao, Y-J, Yuan, H, Cui, K, Shi, Y, Wang, H, Huang, X, Wong, STC, Wang, Y, Kesari, S, Ji, R-R, and Xu, X. "Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: An in vivo bioluminescence imaging study." European Journal of Cancer 46, no. 6 (2010): 1132-1143. Full Text
  - Gao, Y-J, Zhang, L, Samad, OA, Suter, MR, Yasuhiko, K, Xu, Z-Z, Park, J-Y, Lind, A-L, Ma, Q, and Ji, R-R. "JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29, no. 13 (April 2009): 4096-4108. Full Text
  - Ji, R-R, Gereau, RW, Malcangio, M, and Strichartz, GR. "MAP kinase and pain." Brain Research Reviews 60, no. 1 (April 2009): 135-148. (Review) Full Text
  - Kato, G, Kawasaki, Y, Koga, K, Uta, D, Kosugi, M, Yasaka, T, Yoshimura, M, Ji, R-R, and Strassman, AM. "Organization of intralaminar and translaminar neuronal connectivity in the superficial spinal dorsal horn." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29, no. 16 (April 2009): 5088-5099. Full Text
  - Cao, H, Gao, Y-J, Ren, W-H, Li, T-T, Duan, K-Z, Cui, Y-H, Cao, X-H, Zhao, Z-Q, Ji, R-R, and Zhang, Y-Q. "Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29, no. 10 (March 2009): 3307-3321. Full Text
  - Gao, Y-J, Cheng, J-K, Zeng, Q, Xu, Z-Z, Decosterd, I, Xu, X, and Ji, R-R. "Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model." Experimental Neurology 219, no. 1 (2009): 146-155. Full Text
  - Ji, R-R, Xu, Z-Z, Wang, X, and Lo, EH. "Matrix metalloprotease regulation of neuropathic pain." Trends in Pharmacological Sciences 30, no. 7 (2009): 336-340. Full Text
  - Ji, RR. "MAP kinase and cell signaling in DRG neurons and spinal microglia in neuropathic pain." (January 1, 2009): 425-438. (Chapter) Full Text
  - Suter, MR, Berta, T, Gao, Y-J, Decosterd, I, and Ji, R-R. "Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: Different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury." Molecular Pain 5 (2009). Full Text
  - Wen, Y-R, Suter, MR, Ji, R-R, Yeh, G-C, Wu, Y-S, Wang, K-C, Kohno, T, Sun, W-Z, and Wang, C-C. "Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia." Anesthesiology 110, no. 1 (2009): 155-165. Full Text
  - Binshtok, AM, Wang, H, Zimmermann, K, Amaya, F, Vardeh, D, Shi, L, Brenner, GJ, Ji, R-R, Bean, BP, Woolf, CJ, and Samad, TA. "Nociceptors are interleukin-1beta sensors." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 28, no. 52 (December 2008): 14062-14073. Full Text
  - Cheng, J-K, and Ji, R-R. "Intracellular signaling in primary sensory neurons and persistent pain." Neurochemical Research 33, no. 10 (October 2008): 1970-1978. (Review) Full Text
  - Gao, Y-J, and Ji, R-R. "Activation of JNK pathway in persistent pain." Neuroscience Letters 437, no. 3 (June 2008): 180-183. (Review) Full Text
  - Constantin, CE, Mair, N, Sailer, CA, Andratsch, M, Xu, Z-Z, Blumer, MJF, Scherbakov, N, Davis, JB, Bluethmann, H, Ji, R-R, and Kress, M. "Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 28, no. 19 (May 2008): 5072-5081. Full Text
  - Kawasaki, Y, Zhang, L, Cheng, J-K, and Ji, R-R. "Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 28, no. 20 (May 2008): 5189-5194. Full Text
  - Kohno, T, Wang, H, Amaya, F, Brenner, GJ, Cheng, J-K, Ji, R-R, and Woolf, CJ. "Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 28, no. 17 (April 2008): 4533-4540. Full Text
  - Kawasaki, Y, Xu, Z-Z, Wang, X, Park, JY, Zhuang, Z-Y, Tan, P-H, Gao, Y-J, Roy, K, Corfas, G, Lo, EH, and Ji, R-R. "Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain." Nature Medicine 14, no. 3 (March 2008): 331-336. Full Text
  - Berta, T, Poirot, O, Pertin, M, Ji, R-R, Kellenberger, S, and Decosterd, I. "Transcriptional and functional profiles of voltage-gated Na⁺ channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain." Molecular and Cellular Neuroscience 37, no. 2 (2008): 196-208. Full Text
  - Wang, C-F, Gerner, P, Schmidt, B, Xu, ZZ, Nau, C, Wang, S-Y, Ji, R-R, and Wang, GK. "Use of bulleyaconitine a as an adjuvant for prolonged cutaneous analgesia in the rat." Anesthesia and Analgesia 107, no. 4 (2008): 1397-1405. Full Text
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  - Ji, R-R, Kawasaki, Y, Zhuang, Z-Y, Wen, Y-R, and Zhang, Y-Q. "Protein Kinases as potential targets for the treatment of pathological Pain." Handbook of Experimental Pharmacology 177 (2007): 359-389. Full Text
  - Kato, G, Kawasaki, Y, Ji, R-R, and Strassman, AM. "Differential wiring of local excitatory and inhibitory synaptic inputs to islet cells in rat spinal lamina II demonstrated by laser scanning photostimulation." Journal of Physiology 580, no. 3 (2007): 815-833. Full Text
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  - Zhang, H, Cang, C-L, Kawasaki, Y, Liang, L-L, Zhang, Y-Q, Ji, R-R, and Zhao, Z-Q. "Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCε: A novel pathway for heat hyperalgesia." Journal of Neuroscience 27, no. 44 (2007): 12067-12077. Full Text
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  - Beloeil, H, Ji, R-R, and Berde, CB. "Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord." Anesthesiology 105, no. 1 (July 2006): 139-145. Full Text
  - Zhuang, Z-Y, Wen, Y-R, Zhang, D-R, Borsello, T, Bonny, C, Strichartz, GR, Decosterd, I, and Ji, R-R. "A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 26, no. 13 (March 2006): 3551-3560. Full Text
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  - Ji, RR, Zhang, X, Wiesenfeld-Hallin, Z, and Hökfelt, T. "Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 14, no. 11 Pt 1 (November 1994): 6423-6434.
  - Zhang, X, Dagerlind, A, Bao, L, Ji, RR, Lundberg, JM, and Hökfelt, T. "Increased expression of galanin in the rat superior cervical ganglion after pre- and postganglionic nerve lesions." Experimental Neurology 127, no. 1 (May 1994): 9-22. Full Text
  - Ji, R-R, Zhang, Q, Bedecs, K, Arvidsson, J, Zhang, X, Xu, X-J, Wiesenfeld-Hallin, Z, Bartfai, T, and Hokfelt, T. "Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy." Proceedings of the National Academy of Sciences of the United States of America 91, no. 26 (1994): 12540-12543. Full Text
  - Zhang, M, Ji, RR, Fang, Y, and Han, J-S. "Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord." Acta Pharmacologica Sinica 15, no. 1 (1994): 43-46.
  - Ji, RR, Zhang, Q, and Han, JS. "Electroacupuncture enhances enkephalin mRNA expression in the spinal cord and medulla, an in situ hybridization study." Acta Physiologica Sinica 45, no. 4 (1993): 395-399.
  - Ji, RR, Zhang, ZW, Zhou, Y, Zhang, Q, and Han, JS. "Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation." International Journal of Neuroscience 72, no. 3-4 (1993): 183-191.
  - Xu, T, Ji, R-R, Wang, T, and Han, J-S. "Expression of preprodynorphin and preproenkephalin mRNA in nucleus tractus solitarii of rats subjected to endotoxin (and effect of naltrexone on the expression)." Chinese Journal of Physiological Sciences 9, no. 4 (1993): 331-334.
  - Ji, RR, Wang, XM, and Han, JS. "Induction of Fos-like protein in the rat spinal cord following electroacupuncture stimulation." Acta Physiologica Sinica 44, no. 4 (1992): 394-400.
  - Ji, RR. "Histochemical studies on the medial regions of the brainstem in guinea pigs." Sheng li ke xue jin zhan [Progress in physiology] 23, no. 1 (1992): 52-54.
  - Wang, XM, Ji, RR, and Han, JS. "Proto-oncogene and pain modulation." Sheng li ke xue jin zhan [Progress in physiology] 22, no. 4 (1991): 293-298.

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